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1. 发明申请

WO2002095058A3 EMISSION RATIOMETRIC INDICATORS OF PHOSPHORYLATION 审中-公开
公开(公告)号：WO2002095058A3
公开(公告)日：2002-11-28
申请号：PCT/US2002/016955
申请日：2002-05-24
申请人： REGENTS OF THE UNIVERSITY OF CALIFORNIA , TSIEN, Roger, Y. , TING, Alice, Y. , ZHANG, Jin
发明人： TSIEN, Roger, Y. , TING, Alice, Y. , ZHANG, Jin
IPC分类号： C12N15/00
摘要： A chimeric phosphorylation indicator is provided. A chimeric phosphorylation indicator can contain a donor molecule, a phosphorylatable domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. A chimeric phosphorylation indicator also can contain a phosphorylatable polypeptide and a fluorescent protein, wherein the phosphorylatable polypeptide is contained within the sequence of the fluorescent protein, or wherein the fluorescent protein is contained within the sequence of the phosphorylatable polypeptide. Also provided are polynucleotides encoding such chimeric phosphorylation indicators, as well as kits containing the indicators or the polynucleotides. In addition, a method of using the chimeric phosphorylation indicators to detect a kinase or phosphatase in a sample is provided.

2. 发明申请

WO2005116267A2 EMISSION RATIOMETRIC INDICATORS OF PHOSPHORYLATION BY C-KINASE 审中-公开
标题翻译：通过C-激酶发射磷酸化的发射比率指标
公开(公告)号：WO2005116267A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/018662
申请日：2005-05-26
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , VIOLIN, Jonathan, D. , NEWTON, Alexandra, C. , TSIEN, Roger, Y. , ZHANG, Jin
发明人： VIOLIN, Jonathan, D. , NEWTON, Alexandra, C. , TSIEN, Roger, Y. , ZHANG, Jin
IPC分类号： C12Q1/68
CPC分类号： C12N9/1205 , C07K14/43595 , C07K2319/00 , C07K2319/60 , C12Q1/37 , C12Q1/42 , C12Q1/485 , G01N33/542 , G01N2333/43595
摘要： A chimeric phosphorylation indicator (CPI) as provided herein can contain a donor molecule, a phosphorylatabe domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. Where the phosphorylatable domain is phosphorylatable by protein kinase C (PKC), the CPI is a c-kinase activity reporter (CKAR). Donor and acceptor molecules may be, independently, fluorescent proteins such as non-oligomerizing fluorescent proteins. A CPI can contain a phosphorylatable polypeptide and a fluorescent protein; the phosphorylatable polypeptide may be contained within the sequence of the fluorescent protein, or the fluorescent protein may be contained within the sequence of the phosphorylatable polypeptide. The spatiotemporal properties of the PKC signal pathway may be tested with CKAR, calcium-sensing fluorophores and FRET-based translocation assays. Polynucleotides encoding such CPIs, and kits containing the indicators and/or the polynucleotides, are provided. A method of using the chimeric phosphorylation indicators to detect a kinase or phosphatase in a sample is provided.
摘要翻译：本文提供的嵌合磷酸化指示剂（CPI）可以含有供体分子，磷酰胺结构域，磷酸氨基酸结合结构域（PAABD）和受体分子。当可磷酸化结构域由蛋白激酶C（PKC）磷酸化时，CPI是c-激酶活性报告物（CKAR）。供体和受体分子可以独立地是荧光蛋白，例如非低聚荧光蛋白。 CPI可以含有可磷酸化的多肽和荧光蛋白; 可磷酸化多肽可以包含在荧光蛋白的序列内，或者荧光蛋白可以包含在可磷酸化多肽的序列内。可以用CKAR，钙感应荧光团和基于FRET的易位测定来测试PKC信号通路的时空性质。提供了编码这种CPI的多核苷酸，以及含有指示剂和/或多核苷酸的试剂盒。提供了使用嵌合磷酸化指示剂来检测样品中的激酶或磷酸酶的方法。

3. 发明申请

WO2018102765A1 METHODS OF PRODUCING COBALT NANOPARTICLES AND HOLLOW GOLD NANOSPHERES AND KITS FOR PRACTICING SAME 审中-公开
公开(公告)号：WO2018102765A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/064334
申请日：2017-12-01
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SONG, Frank , ZHANG, Weichun , LINDLEY, Sarah
发明人： SONG, Frank , ZHANG, Weichun , LINDLEY, Sarah , PU, Ying-Chih , ADAMS, Staci , ZHANG, Jin
IPC分类号： B22F1/02 , A61K41/00 , H01F1/00 , A61N5/06
摘要： Provided are methods of producing cobalt nanoparticles (Co NPs). The methods include combining a cobalt salt, a capping agent, and a reducing agent, under Co NP synthesis conditions including a temperature selected to produce cobalt nanoparticles of a pre-selected diameter, where the temperature and pre-selected diameter are inversely related. In certain aspects, the methods further include producing hollow gold nanospheres (HGNs) using the cobalt nanoparticles as scaffolds. Also provided are cobalt nanoparticles and hollow gold nanospheres (HGNs) produced according to the present methods. Kits that find use in practicing the methods of the present disclosure are also provided.

4. 发明申请

WO2018170304A1 METHODS OF PRODUCING COBALT NANOPARTICLES AND HOLLOW METAL NANOSPHERES 审中-公开
公开(公告)号：WO2018170304A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022713
申请日：2018-03-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LINDLEY, Sarah , ZHANG, Jin
IPC分类号： B01J31/02 , B01J31/12 , B01J31/14 , C01B6/15 , C01B6/17 , C01G51/00
摘要： Provided are methods of producing cobalt-based nanoparticles (Co x B y NPs) of a pre-selected diameter. The methods include reducing Co 2+ ions with a sodium borohydride (NaBH 4 ) solution having a selected ratio of tetrahydroxyborate (B(OH) 4 - ) to tetrahydroborate (BH 4 - ) based on the pre-selected diameter, where the ratio of B(OH) 4 - to BH 4 - is positively correlated with the pre-selected diameter. Also provided are methods of using the Co x B y NPs to produce hollow metal nanospheres (HMNs). Methods of producing Co x B y NP core / metal shell structures are also provided, such methods including combining in an anaerobic galvanic exchange reaction a deaerated solution including Co x B y NP scaffolds and a deaerated solution including a metal. Also provided are methods of producing HMNs from the Co x B y NP core / metal shell structures. Compositions and kits that find use in practicing the methods of the present disclosure and using HMNs produced in accordance with the methods of the present disclosure, are also provided.

5. 发明申请

WO2018102317A1 MODULATION OF P53 FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2018102317A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/063537
申请日：2017-11-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： CHEN, Xinbin , LUCCHESI, Christopher A. , ZHANG, Jin
IPC分类号： A61K38/17 , A61K48/00 , C07K14/47 , C12N15/85
摘要： The invention provides compositions and methods for preventing or treating cancer in a subject. In some embodiments, the compositions comprise isolated peptides and/or isolated oligonucleotides. In other embodiments, peptides of the present invention are conjugated with cell-penetrating peptides. Vectors, cells, and kits for preventing or treating cancer are also provided herein.

6. 发明公开

EP1456372A2 EMISSION RATIOMETRIC INDICATORS OF PHOSPHORYLATION 审中-公开
标题翻译：排放量表示磷酸二氢钾
公开(公告)号：EP1456372A2
公开(公告)日：2004-09-15
申请号：EP02739505.2
申请日：2002-05-24
申请人： Regents Of the University Of California
发明人： TSIEN, Roger, Y. , TING, Alice, Y. , ZHANG, Jin
IPC分类号： C12N15/00 , C12N15/09 , C12N15/12 , C12N15/62 , C12N15/70 , C12N15/85 , C12N5/10 , C12N1/21 , C07H21/02 , C07H21/04 , C07K14/435
CPC分类号： C07K14/43595 , C07K2319/00 , C12Q1/37 , C12Q1/42 , C12Q1/485 , G01N33/542 , G01N2333/43595
摘要： A chimeric phosphorylation indicator is provided. A chimeric phosphorylation indicator can contain a donor molecule, a phosphorylatable domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. A chimeric phosphorylation indicator also can contain a phosphorylatable polypeptide and a fluorescent protein, wherein the phosphorylatable polypeptide is contained within the sequence of the fluorescent protein, or wherein the fluorescent protein is contained within the sequence of the phosphorylatable polypeptide. Also provided are polynucleotides encoding such chimeric phosphorylation indicators, as well as kits containing the indicators or the polynucleotides. In addition, a method of using the chimeric phosphorylation indicators to detect a kinase or phosphatase in a sample is provided.

7. 发明申请

WO2012097018A1 COMPOSITIONS AND METHODS RELATING TO CAROTENOIDS 审中-公开
标题翻译：组合物和方法相关的CAROTENOIDS
公开(公告)号：WO2012097018A1
公开(公告)日：2012-07-19
申请号：PCT/US2012/020852
申请日：2012-01-11
申请人： THE IAMS COMPANY , ZHANG, Jin
发明人： ZHANG, Jin
IPC分类号： A23K1/16 , A23K1/18
CPC分类号： A23K1/1606 , A23K20/179 , A23K50/40
摘要： A pet food composition having at least two carotenoids. The carotenoids can include a keto-carotenoid and at least one non-keto-carotenoid. The keto-carotenoid can include astaxanthin. The keto-carotenoid can include astaxanthin ester. The non-keto-carotenoid can include beta-carotene and/or lutein.
摘要翻译：具有至少两种类胡萝卜素的宠物食品组合物。类胡萝卜素可以包括酮类胡萝卜素和至少一种非酮类胡萝卜素。酮类胡萝卜素可以包括虾青素。酮类胡萝卜素可以包括虾青素。非酮类胡萝卜素可以包括β-胡萝卜素和/或叶黄素。

8. 发明申请

WO2012054863A1 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2012054863A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/057337
申请日：2011-10-21
申请人： TANIS, Kevin J. , ZHANG, Jin
发明人： TANIS, Kevin J. , ZHANG, Jin
IPC分类号： G06F19/00
CPC分类号： A61B5/4833 , A61B5/0002 , A61B5/6828 , A61B2560/028 , A61N7/00 , A61N2007/0013 , A61N2007/0078 , G06F19/00 , G06F19/34 , G06F19/3481 , G06Q50/24
摘要： A medical device includes a treatment module configured to apply a medical treatment and one or more storage devices storing a device identifier that identifies the medical device. The medical device also includes one or more processing devices configured to control the treatment module to apply a medical treatment, collect compliance information that reflects a patient's compliance with a treatment regimen, access the device identifier from the one or more storage devices, and send the collected compliance information with the accessed device identifier to a server system. The server system is configured to receive the compliance information and the device identifier, determine a patient identifier based on the device identifier, store the compliance information in association with the determined patient identifier, and provide access to the compliance information in response to an inquiry.
摘要翻译：医疗装置包括被配置为应用医疗处理的治疗模块和存储识别医疗装置的装置标识符的一个或多个存储装置。医疗装置还包括一个或多个处理装置，其被配置为控制治疗模块应用医疗处理，收集反映患者遵从治疗方案的合规信息，从一个或多个存储装置访问装置标识符，并发送将所访问的设备标识符的合规信息收集到服务器系统。服务器系统被配置为接收合规信息和设备标识符，基于设备标识符确定患者标识符，与所确定的患者标识符相关联地存储合规信息，并响应于询问提供对遵从信息的访问。

9. 发明申请

WO2006023972A2 cAMP REPORTERS 审中-公开
标题翻译： cAMP报告员
公开(公告)号：WO2006023972A2
公开(公告)日：2006-03-02
申请号：PCT/US2005/030099
申请日：2005-08-23
申请人： THE JOHNS HOPKINS UNIVERSITY , ZHANG, Jin , DIPILATO, Lisa, Marie
发明人： ZHANG, Jin , DIPILATO, Lisa, Marie
IPC分类号： C12Q1/42
CPC分类号： G01N33/542
摘要： cAMP reporters useful for obtaining measurements of cAMP levels with high spatial and temporal resolution.
摘要翻译： cAMP记者可用于获得具有高空间和时间分辨率的cAMP水平测量。

10. 发明申请

WO2003085908A2 APPARATUS AND METHODS FOR RESTORING TRAFFIC DURING FAILOVER IN A CABLE HEAD END 审中-公开
标题翻译：电缆端头故障时恢复交通的装置及方法
公开(公告)号：WO2003085908A2
公开(公告)日：2003-10-16
申请号：PCT/US2003/002225
申请日：2003-01-24
申请人： CICSO TECHNOLOGY, INC. , LU, Yong , ZHANG, Jin , KHAUNTE, Sunil , CHANDRAN, Kartik
发明人： LU, Yong , ZHANG, Jin , KHAUNTE, Sunil , CHANDRAN, Kartik
IPC分类号： H04L12/56
CPC分类号： H04L47/10 , H04L47/20
摘要： Disclosed are methods and apparatus for guaranteeing restoration of traffic between one or more cable modems and a backup cable modem termination system upon failure of an active cable modem termination system are disclosed. Subscriber information associated with one or more cable modems are received from an active cable modem termination system. The subscriber information includes one or more subscriber identifiers. For instance, the subscriber information may include a primary subscriber identifier that identifies a particular cable modem as well as a secondary subscriber identifier that is assigned to high priority traffic such as that being transmitted in real-time. In addition, the subscriber information may also include a scheduling type that is further used to categorize the real-time traffic, such as into voice or video traffic. The subscriber information is then prioritized in an order in which the transmission of messages between the one or more cable modems and the backup cable modem are to be restored. For instance, the subscriber information may be prioritized according to time of receipt of the subscriber information, presence of secondary subscriber identifier, and/or scheduling type. The cable modems are then polled according to this priority order.
摘要翻译：公开了一种在有源电缆调制解调器终端系统故障时保证一个或多个电缆调制解调器与备用电缆调制解调器终端系统之间的业务恢复的方法和装置。从有源电缆调制解调器终端系统接收与一个或多个电缆调制解调器相关联的订户信息。订户信息包括一个或多个订户标识符。例如，订户信息可以包括识别特定电缆调制解调器的主用户标识符以及被分配给诸如被实时发送的高优先级业务的次用户标识符。此外，订户信息还可以包括进一步用于将实时业务（诸如语音或视频业务）分类的调度类型。然后以用于恢复一个或多个电缆调制解调器和备用电缆调制解调器之间的消息传输的顺序来对订户信息进行优先级排序。例如，可以根据接收到用户信息的时间，次要用户标识符的存在和/或调度类型来对用户信息进行优先级排序。然后根据此优先级顺序轮询有线调制解调器。

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