专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

KR20180018838A 일반적인 경쇄 마우스 审中-公开
标题翻译：普通光链鼠标
公开(公告)号：KR20180018838A
公开(公告)日：2018-02-21
申请号：KR20187003853
申请日：2011-02-08
申请人： REGENERON PHARMA
发明人： MCWHIRTER JOHN , MACDONALD LYNN , STEVENS SEAN , DAVIS SAMUEL , MURPHY ANDREW J
IPC分类号： C07K16/46 , A61K38/17 , A61K38/18 , A61K39/395 , C07K14/435 , C07K14/475 , C07K14/54 , C07K16/18 , C07K16/22 , C07K16/24 , C07K16/28
CPC分类号： C07K16/22 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/515 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N15/8509 , C12N2800/204
摘要： 유전적으로변형된마우스가제공되는데, 마우스는내인성마우스면역글로불린경쇄가변서열을재배열하고발현할수 없고, 마우스는내인성마우스 K 로커스에서마우스카파 (κ) 불변유전자와작동가능하게연결된사람면역글로불린서열에의해발현된하나또는두 개의사람경쇄가변도메인만을발현하고, 마우스는단지두 개의사람경쇄가변영역유전자세그먼트중 하나로부터유래한경쇄가변도메인및 마우스κ 불변도메인, 및내인성마우스중쇄로커스의, 사람중쇄가변도메인및 마우스중쇄불변도메인을갖는역 키메라항체를발현한다. 완벽히사람인이중특이적에피토프-결합단백질이제공되고, 두개의다른사람경쇄가변영역유전자세그먼트중 하나로부터유래한가변도메인을포함하는동일한경쇄와연관된두 개의다른중쇄를포함한다.
摘要翻译：提供了一种小鼠，其是表达人免疫球蛋白重链和轻链可变结构域的遗传修饰的小鼠，其中轻链可变结构域由一个或两个人轻链可变基因区段表达。

2. 发明公开

KR20200143511A 하이브리드 경쇄 마우스 审中-公开
公开(公告)号：KR20200143511A
公开(公告)日：2020-12-23
申请号：KR20207036106
申请日：2011-06-22
申请人： REGENERON PHARMA
发明人： MACDONALD LYNN , STEVENS SEAN , GURER CAGAN , MURPHY ANDREW J , HOSIAWA KAROLINA A
IPC分类号： A01K67/027 , C07K16/00 , C07K16/46 , C12N15/85
摘要： 사람λ 가변(hVλ) 서열을발현하는유전적으로변형된마우스가제공되고, 내인성마우스λ 경쇄유전자좌로부터 hVλ서열을발현하는마우스, 내인성마우스κ 경쇄유전자좌로부터 hVλ서열을발현하는마우스, 및전이유전자또는에피솜으로부터 hVλ서열을발현하는마우스(여기서, 상기 hVλ서열은마우스불변서열과연결되어있다)를포함한다. 항원-결합단백질을제조하기위해유용한체세포적으로돌연변이된사람λ 가변서열의공급원인마우스가제공된다. 사람항체를포함하여, 사람λ 가변서열을포함하는항원-결합단백질을제조하기위한조성물및 방법이제공된다.

3. 发明公开

KR20200126439A 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물 审中-公开
公开(公告)号：KR20200126439A
公开(公告)日：2020-11-06
申请号：KR20207031337
申请日：2013-03-07
申请人： REGENERON PHARMA
发明人： MACDONALD LYNN , MCWHIRTHER JOHN , TU NAXIN , STEVENS SEAN , MURPHY ANDREW J
IPC分类号： A01K67/027 , C07K16/46 , C12P21/02
摘要： 제한된면역글로불린중쇄유전자좌및 하나또는그것보다많은 ADAM6 단백질을코드화하는이소성서열을가지는마우스, 배, 세포및 조직이제공된다. 다양한구체예에서, 인간화된내인성면역글로불린중쇄유전자좌를가지고, 수컷마우스에서기능하는 ADAM6 단백질또는그것의이종상동체또는상동체또는기능성단편을발현할수 있는마우스가기술된다. 또한단일인간 VH 유전자절편, 다수의인간 DH 유전자절편및 다수의인간 JH 유전자절편을특징으로하는면역글로불린중쇄유전자좌를가지고있고, ADAM6 단백질또는그것의이종상동체또는상동체또는기능성단편을발현할수 있는마우스, 배, 세포및 조직이제공된다.

4. 发明申请

WO2015077072A1 NON-HUMAN ANIMALS HAVING A HUMANIZED A PROLIFERATION-INDUCING LIGAND GENE 审中-公开
标题翻译：具有人类增殖诱导配体基因的非人动物
公开(公告)号：WO2015077072A1
公开(公告)日：2015-05-28
申请号：PCT/US2014064810
申请日：2014-11-10
申请人： REGENERON PHARMA
发明人： MCWHIRTER JOHN , GURER CAGAN , MACDONALD LYNN , MURPHY ANDREW J
IPC分类号： A01K67/027 , C07K14/705 , C12N15/85
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/07 , A01K2217/072 , A01K2227/105 , A01K2267/03 , A01K2267/0387 , C07K14/47 , C07K14/70575 , C07K2319/00 , C12N15/8509 , G01N33/5005
摘要： Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise a humanized a proliferation-inducing ligand gene. Non-human animals and cells that express a human or humanized a proliferation-inducing ligand protein from an endogenous a proliferation-inducing ligand locus are described.
摘要翻译：提供非人动物，细胞，制备和使用它们的方法和组合物，其中非人动物和细胞包含人源化的增殖诱导配体基因。描述了从内源性增殖诱导配体基因座表达人或人源化增殖诱导配体蛋白的非人动物和细胞。

5. 发明申请

WO2014160202A4 MICE EXPRESSING A LIMITED IMMUNOGLOBULIN LIGHT CHAIN REPERTOIRE 审中-公开
标题翻译：表达有限免疫球蛋白轻链REPETOIRE的小鼠
公开(公告)号：WO2014160202A4
公开(公告)日：2014-11-13
申请号：PCT/US2014026040
申请日：2014-03-13
申请人： REGENERON PHARMA
发明人： BABB ROBERT , MCWHIRTER JOHN , MACDONALD LYNN , STEVENS SEAN , DAVIS SAMUEL , BUCKLER DAVID R , MEAGHER KAROLINA A , MURPHY ANDREW J
IPC分类号： A01K67/027 , C07K16/00 , C07K16/46 , C12N15/85
CPC分类号： A01K67/0275 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/92 , C12N15/8509
摘要： A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that present a choice of two human light chain variable gene segments such that the immunoglobulin light chains expresses by the mouse comprise one of the two human light chain variable gene segments. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided.
摘要翻译：提供了遗传修饰的小鼠，其中小鼠表达以有限数量的轻链可变结构域为特征的免疫球蛋白轻链库。提供了提供两种人轻链可变基因区段选择的小鼠，使得由小鼠表达的免疫球蛋白轻链包含两种人轻链可变基因区段中的一种。提供了使用本文所述的小鼠制备具有通用轻链的双特异性抗体的方法，包括人轻链可变区。提供了制备适用于多特异性结合蛋白例如双特异性抗体的人可变区和宿主细胞的方法。

6. 发明申请

WO2016081923A3 METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATION USING PAIRED GUIDE RNAs 审中-公开
标题翻译：使用成对引导RNA进行靶向遗传修饰的方法和组合物
公开(公告)号：WO2016081923A3
公开(公告)日：2016-07-07
申请号：PCT/US2015062023
申请日：2015-11-20
申请人： REGENERON PHARMA , MURPHY ANDREW J
发明人： MURPHY ANDREW J , FRENDEWEY DAVID , LAI KA-MAN VENUS , AUERBACH WOJTEK , LEE JEFFREY D , MUJICA ALEXANDER O , DROGUETT GUSTAVO , TRZASKA SEAN , HUNT CHARLEEN , GAGLIARDI ANTHONY , VALENZUELA DAVID M , VORONINA VERA , MACDONALD LYNN , YANCOPOULOS GEORGE D
IPC分类号： C12N15/90
CPC分类号： C12N15/907 , A01K67/0275 , A01K2227/105 , C12N9/22 , C12N15/8509 , C12Q1/6888
摘要： Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele. The methods make use of Cas proteins and two or more guide RNAs that target different locations within the same genomic target locus. Also provided are methods of identifying cells with modified genomes.
摘要翻译：提供了组合物和方法，用于创建和促进对细胞内基因组的双等位基因靶向修饰并产生包含修饰的基因组的非人动物。还提供了用于修饰细胞内的基因组的组合物和方法，所述基因组对于等位基因是杂合的以变得对于该等位基因是纯合的。这些方法利用Cas蛋白和两种或更多种指向相同基因组靶基因座内不同位置的指导性RNA。还提供了鉴定具有修饰的基因组的细胞的方法。

7. 发明申请

WO2012148873A3 NON-HUMAN ANIMALS EXPRESSING ANTIBODIES HAVING A COMMON LIGHT CHAIN 审中-公开
标题翻译：非人类动物显示具有普通光链的抗体
公开(公告)号：WO2012148873A3
公开(公告)日：2013-02-07
申请号：PCT/US2012034737
申请日：2012-04-24
申请人： REGENERON PHARMA , MCWHIRTER JOHN , MACDONALD LYNN , STEVENS SEAN , DAVIS SAMUEL , BUCKLER DAVID R , HOSIAWA KAROLINA A , MURPHY ANDREW J
发明人： MCWHIRTER JOHN , MACDONALD LYNN , STEVENS SEAN , DAVIS SAMUEL , BUCKLER DAVID R , HOSIAWA KAROLINA A , MURPHY ANDREW J
IPC分类号： A01K67/027
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/76 , C07K2319/30 , C12N15/8509 , C12N2800/204
摘要： A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making light chain variable regions in mice, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, are provided.
摘要翻译：提供遗传修饰的小鼠，其中小鼠表达免疫球蛋白轻链总谱，其特征在于有限数量的轻链可变结构域。提供的小鼠在其种系中仅来自有限谱系的一个或几个免疫球蛋白轻链可变结构域。提供了在小鼠中制备轻链可变区的方法，包括人轻链可变区。提供了适用于多特异性结合蛋白（例如双特异性抗体）的人可变区的方法。

8. 发明申请

WO2005058953A3 OGH FUSION POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： OGH融合多肽及其治疗方法
公开(公告)号：WO2005058953A3
公开(公告)日：2005-09-01
申请号：PCT/US2004041227
申请日：2004-12-09
申请人： REGENERON PHARMA , MURPHY ANDREW J , MACDONALD LYNN , SLEEMAN MARK W
发明人： MURPHY ANDREW J , MACDONALD LYNN , SLEEMAN MARK W
IPC分类号： A61K38/00 , C07K14/575 , C07K14/59 , C12N15/62 , A61K38/23 , C07K19/00 , C12N15/09 , C12N15/16
CPC分类号： C07K14/59 , C07K14/575 , C12N15/62
摘要： A fusion polypeptide comprising an orphan glyprotein hormone (OGH), OGH-family member, or a fragment thereof; a glycoprotein hormone subunit alpha1 or alpha2, or a fragment thereof, and optionally a peptide (P), and a fusion component (F). in one embodiment, the fusion protein comprises hOGH-hFc-halpha2 or hTSH-hFc-halpha1.
摘要翻译：包含孤儿糖蛋白激素（OGH），OGH家族成员或其片段的融合多肽; 糖蛋白激素亚基α1或α2或其片段，以及任选的肽（P）和融合成分（F）。在一个实施方案中，融合蛋白包含hOGH-hFc-halpha2或hTSH-hFc-halpha1。

9. 发明申请

WO2016164492A3 HUMANIZED T CELL MEDIATED IMMUNE RESPONSES IN NON-HUMAN ANIMALS 审中-公开
标题翻译：人类T细胞介导的非人动物免疫反应
公开(公告)号：WO2016164492A3
公开(公告)日：2016-12-15
申请号：PCT/US2016026260
申请日：2016-04-06
申请人： REGENERON PHARMA
发明人： MACDONALD LYNN , MURPHY ANDREW J , GURER CAGAN , KYRATSOUS CHRISTOS
IPC分类号： A01K67/027
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2267/01 , C07K16/00
摘要： Disclosed herein are non-human animals (e.g., rodents, e.g., mice or rats) genetically engineered to express a humanized T cell co-receptor (e.g., humanized CD4 and/or CD8 (e.g., CD8α and/or CD8β )), a human or humanized T cell receptor (TCR) comprising a variable domain encoded by at least one human TCR variable region gene segment and/or a human or humanized major histocompatibility complex that binds the humanized T cell co-receptor (e.g., human or humanized MHC II (e.g., MHC II α and/or MHC II β chains) and/or MHC I (e.g., MHC I α ) respectively, and optionally human or humanized β2 microglobulin). Also provided are embryos, tissues, and cells expressing the same. Methods for making a genetically engineered animal that expresses at least one humanized T cell co-receptor (e.g., humanized CD4 and/or CD8), at least one humanized MHC that associates with the humanized T cell co-receptor (e.g., humanized MHC II and/or MHC I, respectively) and/or the humanized TCR are also provided. Methods for using the genetically engineered animals that mount a substantially humanized T cell immune response for developing human therapeutics are also provided.
摘要翻译：本文公开了基因工程化以表达人源化T细胞共同受体（例如，人源化CD4和/或CD8（例如CD8α和/或CD8β）），非人动物（例如小鼠或大鼠）包含由至少一个人TCR可变区基因区段编码的可变结构域和/或结合人源化T细胞共同受体的人或人源化主要组织相容性复合物的人或人源化T细胞受体（TCR）（例如人或人源化MHC II（例如，MHC IIα和/或MHC IIβ链）和/或MHC I（例如，MHC Iα）以及任选的人或人源化β2微球蛋白）。还提供了胚胎，组织和表达相同的细胞。制备表达至少一种人源化T细胞共同受体（例如，人源化CD4和/或CD8）的基因工程化动物的方法，至少一种与人源化T细胞共同受体结合的人源化MHC（例如人源化MHC II 和/或MHC I）和/或人源化TCR。还提供了使用基本上人源化T细胞免疫应答的基因工程动物用于开发人类治疗剂的方法。

10. 发明申请

WO2015042250A4 HISTIDINE ENGINEERED LIGHT CHAIN ANTIBODIES AND GENETICALLY MODIFIED NON-HUMAN ANIMALS FOR GENERATING THE SAME 审中-公开
标题翻译： HISTIDINE工程轻链抗体和基因改造的非人动物用于产生它们
公开(公告)号：WO2015042250A4
公开(公告)日：2015-05-28
申请号：PCT/US2014056285
申请日：2014-09-18
申请人： REGENERON PHARMA
发明人： MCWHIRTER JOHN , MACDONALD LYNN , MURPHY ANDREW J
IPC分类号： A01K67/027 , C07K16/00 , C07K16/28
CPC分类号： C07K16/00 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/28 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses human immunoglobulin light chain variable domains derived from a limited repertoire of human immunoglobulin light chain variable gene segments that comprise histidine modifications in their germline sequence. Methods of making non-human animals that express antibodies comprising histidine residues encoded by histidine codons introduced into immunoglobulin light chain nucleotide sequences are provided.
摘要翻译：提供了遗传修饰的非人动物，其中所述非人动物在免疫时表达能够与抗原结合的抗体。提供了一种遗传修饰的非人动物，其表达源自在其种系序列中包含组氨酸修饰的人免疫球蛋白轻链可变基因区段的有限组分的人免疫球蛋白轻链可变结构域。提供了将引入组氨酸密码子编码的组氨酸残基的非人动物表达为引入免疫球蛋白轻链核苷酸序列的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式