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1. 发明申请

WO2012068076A3 PHARMACEUTICAL FORMULATIONS CONTAINING SOLUBLE DRUGS 审中-公开
标题翻译：含有可溶性药物的药物制剂
公开(公告)号：WO2012068076A3
公开(公告)日：2012-08-02
申请号：PCT/US2011060742
申请日：2011-11-15
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , WAGH SANJAY CHHAGAN , JAYANTHI SURYAKUMAR , BANERJEE SABYASACHI
发明人： WAGH SANJAY CHHAGAN , JAYANTHI SURYAKUMAR , BANERJEE SABYASACHI
IPC分类号： A61K9/16 , A61K9/14 , A61K9/22 , A61K47/30 , A61K47/38
CPC分类号： A61K9/2054 , A61K9/2027 , A61K9/205 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/445 , A61K31/55 , A61K31/65
摘要： Pharmaceutical compositions providing modified release of water-soluble drugs. In embodiments, a drug, a hydrophilic release rate controlling substance, and a disintegrant are granulated together and granules are used to prepare tablet or capsule dosage forms.
摘要翻译：提供水溶性药物的改良释放的药物组合物。在实施方案中，将药物，亲水释放速率控制物质和崩解剂一起造粒，并使用颗粒制备片剂或胶囊剂型。

2. 发明申请

WO2010127205A3 FIXED DOSE DRUG COMBINATION FORMULATIONS 审中-公开
标题翻译：固定剂量药物组合配方
公开(公告)号：WO2010127205A3
公开(公告)日：2011-03-10
申请号：PCT/US2010033097
申请日：2010-04-30
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , SASMAL BADAL KUMAR , BILLA PRAVEEN REDDY , NASARE VIJAY DINANATHJI , MOHAN MAILATUR SIVARAMAN , JAYANTHI SURYAKUMAR , DUBEY RAJESH , AVVARU SESHASAYANA , SATTI PHANIKUMAR REDDY , MANAS RANJAN MUND , CHIDIPOTHU ANITHA , JAIN VARUN
发明人： SASMAL BADAL KUMAR , BILLA PRAVEEN REDDY , NASARE VIJAY DINANATHJI , MOHAN MAILATUR SIVARAMAN , JAYANTHI SURYAKUMAR , DUBEY RAJESH , AVVARU SESHASAYANA , SATTI PHANIKUMAR REDDY , MANAS RANJAN MUND , CHIDIPOTHU ANITHA , JAIN VARUN
IPC分类号： A61K9/20 , A61K9/48 , A61K31/16 , A61K31/19
CPC分类号： A61K45/06 , A61K9/1652 , A61K9/2054 , A61K9/4808 , A61K9/5084 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/225 , A61K31/366 , A61K31/401 , A61K31/549 , A61K31/616 , A61K2300/00
摘要： Pharmaceutical formulations comprising multiple drugs, for treating or preventing cardiovascular disease. Embodiments are capsules containing individual drugs, or combinations of drugs, in the form of small tablets.
摘要翻译：包含多种药物的药物制剂，用于治疗或预防心血管疾病。实施例是包含小片形式的单独药物或药物组合的胶囊。

3. 发明申请

WO2010117756A2 SUBSTITUTED BENZIMIDAZOLE PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：取代苯并咪唑药物制剂
公开(公告)号：WO2010117756A2
公开(公告)日：2010-10-14
申请号：PCT/US2010029145
申请日：2010-03-30
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , LAD VISHAL , SHAREEF AJMAL , MULEY VINAY , DUBE SUSHANT , REWATKAR ASHWINI , GAWANDE RAHUL SUDHAKAR , IRUKULLA SRINIVAS , JAYANTHI SURYAKUMAR
发明人： LAD VISHAL , SHAREEF AJMAL , MULEY VINAY , DUBE SUSHANT , REWATKAR ASHWINI , GAWANDE RAHUL SUDHAKAR , IRUKULLA SRINIVAS , JAYANTHI SURYAKUMAR
IPC分类号： A61K31/4184 , A61K31/454 , A61P1/04 , A61P9/00 , C07D235/28 , C07D401/12
CPC分类号： C07D401/12 , A61K31/4184 , A61K31/454
摘要： Stable pharmaceutical compositions of dexlansoprazole with pharmaceutical excipients, processes for preparing the stable compositions, packaging and their use in treatment of erosive esophagitis and heartburn associated with non-erosive gastroesophageal reflux disease.
摘要翻译：具有药物赋形剂的右兰索拉唑的稳定药物组合物，用于制备稳定组合物的方法，包装及其在治疗侵蚀性食管炎和与非侵蚀性胃食管反流病相关的胃灼热中的应用。

4. 发明申请

WO2010111264A2 RASAGILINE FORMULATIONS 审中-公开
标题翻译： RASAGILINE配方
公开(公告)号：WO2010111264A2
公开(公告)日：2010-09-30
申请号：PCT/US2010028314
申请日：2010-03-23
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , GUPTA DEEPAK , NAGARAJU NAGESH , TRIPATHI SANJAY , KUMAR M PAVAN , DHOKE SHRIKANT VITTHALRAO , JAYANTHI SURYAKUMAR
发明人： GUPTA DEEPAK , NAGARAJU NAGESH , TRIPATHI SANJAY , KUMAR M PAVAN , DHOKE SHRIKANT VITTHALRAO , JAYANTHI SURYAKUMAR
IPC分类号： A61K9/14 , A61K9/28 , A61K9/32 , A61K9/62 , A61K47/36
CPC分类号： A61K9/2054 , A61K9/2009
摘要： The present invention relates to pharmaceutical formulations comprising rasagiline, or a pharmaceutically acceptable salt thereof. Aspects relate to formulations prepared using rasagiline or a salt with a particle size distribution wherein about 90% of the particles have particle sizes smaller than 1000 µm, and having content uniformity such that the formulation contains 90% to 110% of the label content of rasagiline or its salt. Further aspects relate to stable pharmaceutical formulations comprising rasagiline or a pharmaceutically acceptable salt and at least one pharmaceutically acceptable excipient, wherein the formulations are substantially free of a sugar alcohol.
摘要翻译：本发明涉及包含雷沙吉兰或其药学上可接受的盐的药物制剂。方面涉及使用雷沙吉兰或具有粒度分布的盐制备的制剂，其中约90％的颗粒具有小于1000μm的粒度，并且具有含量均匀性，使得制剂含有雷沙吉兰标签含量的90％至110％或其盐。其它方面涉及包含雷沙吉兰或其药学上可接受的盐和至少一种药学上可接受的赋形剂的稳定的药物制剂，其中所述制剂基本上不含糖醇。

5. 发明公开

EP2424509A4 FIXED DOSE DRUG COMBINATION FORMULATIONS 审中-公开
标题翻译：药物的组合配方固定剂量
公开(公告)号：EP2424509A4
公开(公告)日：2012-11-07
申请号：EP10770398
申请日：2010-04-30
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR
发明人： SASMAL BADAL KUMAR , BILLA PRAVEEN REDDY , NASARE VIJAY DINANATHJI , MOHAN MAILATUR SIVARAMAN , JAYANTHI SURYAKUMAR , DUBEY RAJESH , AVVARU SESHASAYANA , SATTI PHANIKUMAR REDDY , MANAS RANJAN MUND , CHIDIPOTHU ANITHA , JAIN VARUN
IPC分类号： A61K45/06 , A61K9/16 , A61K9/28 , A61P9/10
CPC分类号： A61K45/06 , A61K9/1652 , A61K9/2054 , A61K9/4808 , A61K9/5084 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/225 , A61K31/366 , A61K31/401 , A61K31/549 , A61K31/616 , A61K2300/00

6. 发明申请

WO2006085335A3 PHARMACEUTICAL COMPOSITION OF ACID LABILE SUBSTANCES 审中-公开
标题翻译：酸性可溶性物质的药物组成
公开(公告)号：WO2006085335A3
公开(公告)日：2006-10-05
申请号：PCT/IN2006000004
申请日：2006-01-03
申请人： LUPIN LTD , GUNUPATI JYOTHI LAKSHMI , JAYANTHI SURYAKUMAR , SEN HIMADRI
发明人： GUNUPATI JYOTHI LAKSHMI , JAYANTHI SURYAKUMAR , SEN HIMADRI
IPC分类号： A61K9/32 , A61K9/36 , A61K9/48 , A61K31/4439 , A61K47/18
CPC分类号： A61K31/133 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/4439 , A61K2300/00
摘要： A pharmaceutical composition for oral use comprising a) a core comprising an effective amount of benzimidazole and an organic stabilizing agent which is present in an amount effective to stabilize the composition, b) an intermediate layer comprising of a water insoluble polymer and an organic stabilizer, and c) an outer enteric coating layer. The organic stabilizing agent is present in the core from about 1% to about 10% by weight of the core and in the intermediate layer from about 5% to about 35% by weight of intermediate layer.
摘要翻译：一种用于口服的药物组合物，其包含：a）包含有效量的苯并咪唑和有机稳定剂的核心，所述有机稳定剂以有效稳定组合物的量存在，b）包含水不溶性聚合物和有机稳定剂的中间层，和c）外部肠溶包衣层。有机稳定剂在核心中的含量为核心的约1重量％至约10重量％，中间层为约5重量％至约35重量％的中间层。

7. 发明申请

WO2005048978A3 A CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION AND A PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：控制释放药物组合物及其制备方法
公开(公告)号：WO2005048978A3
公开(公告)日：2006-02-23
申请号：PCT/IN2004000306
申请日：2004-09-29
申请人： LUPIN LTD , SEN HIMADRI , JAYANTHI SURYAKUMAR , RAGHAVAN VINEETH , ARRA GANGA SRINIVAS
发明人： SEN HIMADRI , JAYANTHI SURYAKUMAR , RAGHAVAN VINEETH , ARRA GANGA SRINIVAS
IPC分类号： A61K9/00 , A61K9/24 , A61K9/20
CPC分类号： A61K9/209
摘要： A three-drug antiretrovial pharmaceutical composition having a selective combination of a controlled release active formulation and an immediate release active formulation for once daily administration. The composition provides desired dosages of the actives lamivudine, zidovudine or pharmaceutically acceptable derivatives thereof, and the immediate release formulation including at least one selective Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI), preferably nevirapine or a pharmaceutically acceptable derivative thereof along with pharmaceutically acceptable excipients. The once daily composition would favour patient compliance and effective treatment. A method of reducing the pill burden in a patient suffering from HIV infection and /or Acquired Immunodeffieciency Syndrome by administering a once daily dose of the three-drug antiretroviral pharmaceutical composition.
摘要翻译：一种三药抗逆转录药物组合物，其具有一次每日一次给药的控释活性制剂和立即释放活性制剂的选择性组合。所述组合物提供所需剂量的拉米夫定，齐多夫定或其药学上可接受的衍生物，以及即时释放制剂，其包含至少一种选择性非核苷逆转录酶抑制剂（NNRTI），优选奈韦拉平或其药学上可接受的衍生物以及药学上可接受的赋形剂。每天一次的组合将有利于患者的顺应性和有效的治疗。通过施用一日剂量的三药抗逆转录病毒药物组合物，减少患有HIV感染和/或获得性免疫缺陷综合征的患者的药丸负担的方法。

8. 发明申请

WO2007015270A3 NOVEL CONTROLLED RELEASE COMPOSITIONS OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS 审中-公开
标题翻译：选择性硒激酶抑制剂的新型控制释放组合物
公开(公告)号：WO2007015270A3
公开(公告)日：2007-04-19
申请号：PCT/IN2006000274
申请日：2006-08-01
申请人： LUPIN LTD , VELHAL AVINASH K , RAGHAVAN VINEETH , JAYANTHI SURYAKUMAR , SEN HIMADRI
发明人： VELHAL AVINASH K , RAGHAVAN VINEETH , JAYANTHI SURYAKUMAR , SEN HIMADRI
IPC分类号： A61K9/14 , A61K9/20 , A61K31/343 , A61K47/48
CPC分类号： A61K9/2866 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K31/343
摘要： A controlled release pharmaceutical composition of a selective serotonin reuptake inhibitor. The composition essentially comprises of a core comprising the active ingredient, one or more controlled release polymer(s) and one or more pharmaceutically acceptable excipients. The composition optionally will have a coating comprising one or more controlled release polymers. The composition is prepared by mixing the active ingredient with one or more controlled release polymers and one or more pharmaceutically acceptable excipients. Thereafter the mixture is granulated, dried, lubricated and compressed into tablets. The composition is used in the manufacture of a medicament, for treating and/or preventing the disorders. The active is released between about 2-8 hours with about 10-25% of active is released in vitro in 2 hours in 0.1N HCl, 750 ml dissolution medium using USP Dissolution tester, paddle method at 150 rpm. About 20-55%, 50-75% and 70-95% of active is released in vitro in 4,6 and 8 hours respectively in pH 7.5 Tris buffer, 1000 ml dissolution medium using USP Dissolution tester, paddle method at 150 rpm.
摘要翻译：选择性5-羟色胺再摄取抑制剂的控释药物组合物。组合物基本上由包含活性成分，一种或多种控释聚合物和一种或多种药学上可接受的赋形剂的核心组成。组合物任选地具有包含一种或多种控释聚合物的涂层。通过将活性成分与一种或多种控释聚合物和一种或多种药学上可接受的赋形剂混合来制备组合物。然后将混合物造粒，干燥，润滑并压制成片剂。该组合物用于制备用于治疗和/或预防疾病的药物。活性物质在约2-8小时之间释放，约10-25％的活性物质在2小时内在0.1N HCl，750ml溶出介质中使用USP溶出度测定仪以桨叶方式在150rpm下释放。在pH 7.5的Tris缓冲液，1000ml溶解介质中，使用USP溶出度试验仪，桨叶法以150rpm分别在体外释放约20-55％，50-75％和70-95％的活性物质。

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