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1. 发明申请

WO2007016582A3 AMORPHOUS APREPITANT COPRECIPITATES 审中-公开
标题翻译：不寻常的合作伙伴
公开(公告)号：WO2007016582A3
公开(公告)日：2009-04-30
申请号：PCT/US2006029973
申请日：2006-07-31
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , MATHAD VIJAYAVITTHAL THIPPANNA , JAYANTILAL PRAVINCHANDRA VANKA , ELATI CHANDRASEKHAR RAVI RAM , CHLAMALA SUBRAHMANYESWARA RAO , KOLLA NAVEEN KUMAR , GANGULA SRINIVAS , KIKKURU SRIRAMI REDDY , NETI SRINIVASAN , CHINTA RAVEENDRA REDDY
发明人： MATHAD VIJAYAVITTHAL THIPPANNACHAR , JAYANTILAL PRAVINCHANDRA VANKAWALA , ELATI CHANDRASEKHAR RAVI RAM , CHLAMALA SUBRAHMANYESWARA RAO , KOLLA NAVEEN KUMAR , GANGULA SRINIVAS , KIKKURU SRIRAMI REDDY , NETI SRINIVASAN , CHINTA RAVEENDRA REDDY
IPC分类号： A61K31/5377 , A61K47/00 , A61K47/32
CPC分类号： A61K31/496 , A61K9/146 , A61K47/32
摘要： A coprecipitate comprising amorphous aprepitant and a pharmaceutically accceptable carrier is prepared by rapidly removing solvent from a solution containing aprepitant and the carrier.
摘要翻译：通过从含有阿维地丁和载体的溶液中快速除去溶剂来制备包含无定形阿拉曲珠和药学上可接受的载体的共沉淀物。

2. 发明申请

WO2006044754A3 PROCESS FOR PREPARING TELMISARTAN 审中-公开
标题翻译：制备TELMISARTAN的过程
公开(公告)号：WO2006044754A3
公开(公告)日：2006-12-14
申请号：PCT/US2005037185
申请日：2005-10-18
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , VENKATARAMAN SUNDARAM , MATHAD VIJAYAVITTHAL THIPPANNA , KIKKURU SRIRAMI REDDY , NETI SRINIVASAN , CHINTA RAVEENDRA REDDY , ARUNAGIRI MUTHULINGAM , ROUTHU LALITHA KUMARI
发明人： VENKATARAMAN SUNDARAM , MATHAD VIJAYAVITTHAL THIPPANNA , KIKKURU SRIRAMI REDDY , NETI SRINIVASAN , CHINTA RAVEENDRA REDDY , ARUNAGIRI MUTHULINGAM , ROUTHU LALITHA KUMARI
IPC分类号： C07D235/04 , C07D403/02
CPC分类号： C07D403/04 , C07C233/54 , C07C237/42 , C07D235/08 , C07D235/20
摘要： A process for preparing telmisartan and intermediates formed in the process.
摘要翻译：一种制备替米沙坦及其制备中间体的方法。

3. 发明申请

WO2008011462A2 PROCESS FOR PREPARING SOLIFENACIN AND ITS SALTS 审中-公开
标题翻译：制备SOL烯酸及其盐的方法
公开(公告)号：WO2008011462A2
公开(公告)日：2008-01-24
申请号：PCT/US2007073782
申请日：2007-07-18
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , MATHAD VIJAYAVITTHAL THIPPANNA , LILAKAR JAYDEEPKUMAR DAHYABHAI , GILLA GOVERDHAN , KIKKURU SRIRAMIREDDY , CHINTA RAVEENDRA REDDY , DUDIPALA SWAROOPA
发明人： MATHAD VIJAYAVITTHAL THIPPANNA , LILAKAR JAYDEEPKUMAR DAHYABHAI , GILLA GOVERDHAN , KIKKURU SRIRAMIREDDY , CHINTA RAVEENDRA REDDY , DUDIPALA SWAROOPA
IPC分类号： A61K31/4745
CPC分类号： C07D453/02
摘要： The present invention relates to solifenacin in solid form and a process for its preparation and to a process for the preparation of (1S)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline, a key intermediate in the synthesis of solifenacin and its salts.
摘要翻译：本发明涉及固体形式的索非那新及其制备方法和用于制备（1S）-1-苯基-1,2,3,4-四氢 - 异喹啉的合成方法中的关键中间体索非那新及其盐。

4. 发明公开

EP2046751A4 PROCESS FOR PREPARING SOLIFENACIN AND ITS SALTS 审中-公开
标题翻译：塞维利亚萨尔辛VERFAHREN ZUR HERSTELLUNG VON SOLIFENACIN
公开(公告)号：EP2046751A4
公开(公告)日：2010-12-29
申请号：EP07813058
申请日：2007-07-18
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR
发明人： MATHAD VIJAYAVITTHAL THIPPANNACHAR , LILAKAR JAYDEEPKUMAR DAHYABHAI , GILLA GOVERDHAN , KIKKURU SRIRAMIREDDY , CHINTA RAVEENDRA REDDY , DUDIPALA SWAROOPA
IPC分类号： C07D453/02
CPC分类号： C07D453/02

5. 发明公开

EP1912651A4 AMORPHOUS APREPITANT COPRECIPITATES 审中-公开
标题翻译：非晶阿瑞吡坦，COPRÄZIPITATE
公开(公告)号：EP1912651A4
公开(公告)日：2010-12-22
申请号：EP06800625
申请日：2006-07-31
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR
发明人： MATHAD VIJAYAVITTHAL THIPPANNACHAR , JAYANTILAL PRAVINCHANDRA VANKAWALA , ELATI CHANDRASEKHAR RAVI RAM , CHLAMALA SUBRAHMANYESWARA RAO , KOLLA NAVEEN KUMAR , GANGULA SRINIVAS , KIKKURU SRIRAMI REDDY , NETI SRINIVASAN , CHINTA RAVEENDRA REDDY
IPC分类号： A61K31/5377 , A61K47/00 , A61K47/32
CPC分类号： A61K31/496 , A61K9/146 , A61K47/32

6. 发明公开

EP1805146A4 PROCESS FOR PREPARING TELMISARTAN 审中-公开
标题翻译：用于生产替米沙坦
公开(公告)号：EP1805146A4
公开(公告)日：2009-01-14
申请号：EP05812410
申请日：2005-10-18
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR
发明人： VENKATARAMAN SUNDARAM , MATHAD VIJAYAVITTHAL T , KIKKURU SRIRAMI REDDY , NETI SRINIVASAN , CHINTA RAVEENDRA REDDY , ARUNAGIRI MUTHULINGAM , ROUTHU LALITHA KUMARI
IPC分类号： C07D235/04 , C07D403/02
CPC分类号： C07D403/04 , C07C233/54 , C07C237/42 , C07D235/08 , C07D235/20
摘要： A process for preparing telmisartan and intermediates formed in the process.

7. 发明专利

CA2617211A1 AMORPHOUS APREPITANT COPRECIPITATES 未知
公开(公告)号：CA2617211A1
公开(公告)日：2007-02-08
申请号：CA2617211
申请日：2006-07-31
申请人： REDDYS LAB INC DR , REDDYS LAB LTD DR
发明人： CHINTA RAVEENDRA REDDY , NETI SRINIVASAN , MATHAD VIJAYAVITTHAL THIPPANNA , JAYANTILAL PRAVINCHANDRA VANKA , CHLAMALA SUBRAHMANYESWARA RAO , ELATI CHANDRASEKHAR RAVI RAM , GANGULA SRINIVAS , KIKKURU SRIRAMI REDDY , KOLLA NAVEEN KUMAR
IPC分类号： A61K31/496
摘要： A coprecipitate comprising amorphous aprepitant and a pharmaceutically accceptable carrier is prepared by rapidly removing solvent from a solution containing aprepitant and the carrier.

8. 发明申请

WO2012001484A3 AN IMPROVED PROCESS FOR THE PREPARATION OF VALSARTAN 审中-公开
标题翻译：改进VALSARTAN的制备方法
公开(公告)号：WO2012001484A3
公开(公告)日：2012-04-26
申请号：PCT/IB2011001483
申请日：2011-06-24
申请人： AUROBINDO PHARMA LTD , CHINTA RAVEENDRA REDDY , NANGI GANGADHARA BHIMA SHANKAR , NAYINI MAHENDAR REDDY , YALLAPPA SOMAPPA SOMANNAVAR , BUDIDET SHANKAR REDDY , AMINUL ISLAM , MEENAKSHISUNDERAM SIVAKUMARAN
发明人： CHINTA RAVEENDRA REDDY , NANGI GANGADHARA BHIMA SHANKAR , NAYINI MAHENDAR REDDY , YALLAPPA SOMAPPA SOMANNAVAR , BUDIDET SHANKAR REDDY , AMINUL ISLAM , MEENAKSHISUNDERAM SIVAKUMARAN
IPC分类号： C07D257/04
CPC分类号： C07D257/04
摘要： The present invention relates to a process for the preparation of pure Valsartan (I) substantially free from impurities of formulae (la), (lb), and (Ic), which comprises: (i) condensing 2-(4'-bromomethylphenyl)benzonitrile of formula (II) with L-valine methyl ester hydrochloride of formula (V) in the presence of a base in a solvent to produce N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester of formula (VI); (ii) treating the compound VI of step (i) with acid followed by treating with base to produce pure compound VI substantially free from dimeric impurity of formula (Via); (iii) reacting the pure compound of formula (VI) with n-valeryl chloride in the presence of a base to produce pure N-valeryl-N-[(2'-cyanobiphenyl-4-yl)methyl]- (L)-valine methyl ester (VII) substantially free from alkene impurity of formula (Vila); (iv) reacting the compound of formula (VII) with trialkyltin chloride and a metal azide in a solvent at a reflux temperature to produce N-(l-oxopentyl)-N-[[2'-(2- tributyltintetrazol-5-yl)-(l, l '-biphenyl)-4-yl]methyl]-(L)-valine methyl ester of formula (VHIb) free from thermal degradation impurity (Villa); (v) hydrolyzing the compound of formula (VHIb) in the presence of alkaline conditions to produce Valsartan (I).
摘要翻译：本发明涉及一种制备基本上不含式（Ia），（Ib）和（Ic）杂质的纯缬沙坦（I）的方法，其包括：（i）将2-（4'-溴甲基苯基）（II）的苄腈与式（V）的L-缬氨酸甲酯盐酸盐在碱的存在下在溶剂中反应，得到N - [（2'-氰基联苯-4-基）甲基] - （L） - 缬氨酸（VI）的甲酯; （ii）用酸处理步骤（i）的化合物VI，然后用碱处理以产生基本上不含式（VIa）的二聚杂质的纯化合物VI; （ⅲ）在碱的存在下使式（Ⅵ）的纯的化合物与正戊酰氯反应，得到纯的N-戊酰基-N - [（2'-氰基联苯-4-基）甲基] - （L） - 缬氨酸甲酯（Ⅶ）基本上不含式（Ⅵa）的烯烃杂质; （ⅳ）使式（Ⅶ）化合物与氯化三烷基锡和金属叠氮化物在溶剂中在回流温度下反应，得到N-（1-氧代戊基）-N - [[2' - （2-三丁基四唑-5-基） - 不含热降解杂质的式（VHIb）的（1）联苯-4-基]甲基] - （L） - 缬氨酸甲酯（Villa）; （v）在碱性条件下水解式（VHIb）化合物以制备缬沙坦（I）。

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