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1. 发明申请

WO2006029075A8 FIBRATE COMPOUNDS HAVING PPAR AGONIST ACTIVITY 审中-公开
标题翻译：具有PPAR激动剂活性的纤维化合物
公开(公告)号：WO2006029075A8
公开(公告)日：2007-04-26
申请号：PCT/US2005031532
申请日：2005-09-06
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , DAS SAIBAL KUMAR , SINGH SUNIL KUMAR , MADHAVAN GURRAM RANGA , BHUNIYA DEBNATH , IQBAL JAVED , SHARMA SUDHIR KUMAR , CHAKRABARTI RANJAN
发明人： DAS SAIBAL KUMAR , SINGH SUNIL KUMAR , MADHAVAN GURRAM RANGA , BHUNIYA DEBNATH , IQBAL JAVED , SHARMA SUDHIR KUMAR , CHAKRABARTI RANJAN
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , C07D239/90
摘要： There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARa agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARa agonist activity and a PPARa agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.
摘要翻译：提供了具有PPAR激动剂活性的衍生物。衍生物包括化合物和/或其药学上可接受的盐; 其中A具有结构（II）或（III）的具有式（I）的化合物; X选自-CH 2 - ， - O - ， - NH-和-S-; Y选自-O - ， - NH-和-S-; 可以位于任何取代位置的Z是氢或卤素; R 1和R 2可以相同或不同，独立地选自氢和C 1 -C 8烷基，烷基或R 1和R 2一起形成具有4至6个碳原子的碳环; R 3选自氢和C 1 -C 8烷基; R 3选自氢和C 1 -C 8烷基; R 4，R 5和R 6可以相同或不同，独立地选自氢和C 1 -C 4烷基， -C 8烷基; 并且n是1至6.提供了各种实施例和变体。根据其它方面，本发明还提供了在哺乳动物中产生PPARα激动剂活性的方法，所述方法包括向哺乳动物施用有效量的本发明第一方面的某些衍生物，产生 PPARα激动剂活性和PPARα激动剂活性，所述方法包括给哺乳动物施用有效量的某些衍生物; 以及包含本发明第一方面的衍生物和一种或多种药学上可接受的赋形剂的药物组合物。提供了各种实施例和变体。

2. 发明申请

WO2006029075A2 FIBRATE COMPOUNDS HAVING PPAR AGONIST ACTIVITY 审中-公开
标题翻译：具有PPAR激动剂活性的纤维化合物
公开(公告)号：WO2006029075A2
公开(公告)日：2006-03-16
申请号：PCT/US2005031532
申请日：2005-09-06
申请人： REDDYS LAB LTD DR , REDDYS LAB LTD DR , DAS SAIBAL KUMAR , SINGH SUNIL KUMAR , MADHAVAN GURRAM RANGA , BHUNIYA DEBNATH , IQBAL JAVED , SHARMA SUDHIR KUMAR , CHAKRABARTI RANJAN
发明人： DAS SAIBAL KUMAR , SINGH SUNIL KUMAR , MADHAVAN GURRAM RANGA , BHUNIYA DEBNATH , IQBAL JAVED , SHARMA SUDHIR KUMAR , CHAKRABARTI RANJAN
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , C07D239/90
摘要： There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARa agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARa agonist activity and a PPARa agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.
摘要翻译：提供具有PPAR激动剂活性的衍生物。衍生物包括化合物和/或其药学上可接受的盐; 具有式（I）的化合物其中A具有结构（II）或（III）; X选自-CH 2 - ， - O - ， - N - 和-S-; Y选自-O - ， - NH-和-S-; 可以位于任何取代位置的Z是氢或卤素; R 1和R 2可以相同或不同，独立地选自氢和C 1 -C 8烷基，或者R 1和R 2一起形成具有4至6个碳原子的碳环; R 3选自氢和C 1 -C 8烷基; R 4，R 5，R 5和R 6可以相同或不同，独立地选自氢和C 1 C 8 -C 14烷基; 并且n为1至6.提供了各种实施方案和变体。根据其它方面，本发明还提供了在哺乳动物中产生PPARα激动剂活性的方法，所述方法包括向哺乳动物施用有效量的本发明第一方面的某些衍生物， PPARα激动剂活性和PPARα激动剂活性，所述方法包括向哺乳动物施用有效量的某些衍生物; 和包含本发明第一方面的衍生物和一种或多种药学上可接受的赋形剂的药物组合物。提供了各种实施例和变型。

3. 发明专利

AU2002351069A1 NEW COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：AU2002351069A1
公开(公告)日：2003-06-17
申请号：AU2002351069
申请日：2002-12-02
申请人： DAS SAIBAL KUMAR , MADHAVAN GURRAM RANGA , IQBAL JAVED , CHAKRABARTI RANJAN , VIKRAMADITHYAN REEBA KANNIMEL , REDDYS LAB LTD DR , BHUNIYA DEBNATH
发明人： DAS SAIBAL KUMAR , MADHAVAN GURRAM RANGA , IQBAL JAVED , CHAKRABARTI RANJAN , VIKRAMADITHYAN REEBA KANNIMEL , BHUNIYA DEBNATH
IPC分类号： A61K45/00 , A61K31/216 , A61K31/255 , A61K31/353 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P15/08 , A61P17/06 , A61P19/10 , A61P21/04 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , C07C279/14 , C07C303/30 , C07C309/66 , C07C309/73 , C07C311/53 , C07C309/00
摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

4. 发明公开

EP1793828A4 FIBRATE COMPOUNDS HAVING PPAR AGONIST ACTIVITY 审中-公开
标题翻译：与PRAR激动剂活性氯贝特
公开(公告)号：EP1793828A4
公开(公告)日：2009-09-02
申请号：EP05794037
申请日：2005-09-06
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR
发明人： DAS SAIBAL KUMAR , SINGH SUNIL KUMAR , MADHAVAN GURRAM R , BHUNIYA DEBNATH , IQBAL JAVED , SHARMA SUDHIR K , CHAKRABARTI RANJAN
IPC分类号： C07D487/04 , A61K31/517 , A61K31/519 , C07C43/205 , C07C59/01 , C07C59/48 , C07C69/003 , C07D231/14 , C07D231/18 , C07D239/90
CPC分类号： C07D487/04 , C07D239/90

5. 发明申请

WO2008036967A2 NOVEL HETEROCYCLIC COMPOUNDS AS LASY ACTIVATORS 审中-公开
标题翻译：新型杂环化合物作为激活剂
公开(公告)号：WO2008036967A2
公开(公告)日：2008-03-27
申请号：PCT/US2007079286
申请日：2007-09-24
申请人： REDDY US THERAPEUTICS INC , REDDY DUMBALA SRINIVAS , PADMALAYAM INDIRA , BHUNIYA DEBNATH , PILLARISETTI SIVARAM , CHAKRABARTI RANJAN
发明人： REDDY DUMBALA SRINIVAS , PADMALAYAM INDIRA , BHUNIYA DEBNATH , PILLARISETTI SIVARAM , CHAKRABARTI RANJAN
IPC分类号： A61K31/405
CPC分类号： C07D209/12 , C07D209/18 , C07D401/06
摘要： This invention provides a compound of formula (I), which is a free species and/or a pharmaceutically-acceptable salt or a stereoisomer of the compound of formula (I). Another aspect of the present invention provides the compound of the formula (I) as a Lipoic acid synthase (LASY) inducer
摘要翻译：本发明提供式（I）化合物，其是式（I）化合物的游离物质和/或药学上可接受的盐或立体异构体。本发明的另一方面提供了作为硫辛酸合酶（LASY）诱导剂的式（I）化合物

6. 发明专利

CA2579230A1 FIBRATE COMPOUNDS HAVING PPAR AGONIST ACTIVITY 未知
公开(公告)号：CA2579230A1
公开(公告)日：2006-03-16
申请号：CA2579230
申请日：2005-09-06
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR
发明人： IQBAL JAVED , BHUNIYA DEBNATH , MADHAVAN GURRAM RANGA , CHAKRABARTI RANJAN , SHARMA SUDHIR KUMAR , SINGH SUNIL KUMAR , DAS SAIBAL KUMAR
IPC分类号： A61K31/519 , C07D487/02
摘要： There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARalpha agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARalpha agonist activity and a PPARalpha agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.

7. 发明专利

IL297537A Novel compounds useful as poly(adp-ribose) polymerase (parp) inhibitors 未知
公开(公告)号：IL297537A
公开(公告)日：2022-12-01
申请号：IL29753722
申请日：2022-10-23
申请人： RHIZEN PHARMACEUTICALS AG , BHUNIYA DEBNATH , VISWANADHA SRIKANT , MERIKAPUDI GAYATRI SWAROOP , VAKKALANKA SWAROOP KUMAR VENKATA SATYA
发明人： BHUNIYA DEBNATH , VISWANADHA SRIKANT , MERIKAPUDI GAYATRI SWAROOP , VAKKALANKA SWAROOP KUMAR VENKATA SATYA
IPC分类号： A61P35/00
摘要： The present invention provides novel poly(ADP-ribose) polymerase (PARP) inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods for the treatment, prevention and/or amelioration of PARP mediated diseases or disorders using them. In particular, the compounds described herein are useful for the treatment of carcinoma of the breast, ovarian cancer, carcinoma of the liver, carcinoma of the lung, small cell lung cancer, esophageal cancer, gall bladder cancer, pancreatic cancer and stomach cancer.

8. 发明申请

WO2008104994A3 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION 审中-公开
标题翻译： 2,2,2-三取代的乙酰胺衍生物作为GLUCOKINASE激活剂，其过程和药物应用
公开(公告)号：WO2008104994A3
公开(公告)日：2009-04-02
申请号：PCT/IN2008000109
申请日：2008-02-25
申请人： ADVINUS THERAPEUTICS PRIVATE L , MOOKHTIAR KASIM A , BHUNIYA DEBNATH , DAVE BHAVESH , KAPKOTI GOBIND S , BASU SUJAY , CHUGH ANITA , DE SIDDARTHA , PALLE VENKATA P
发明人： MOOKHTIAR KASIM A , BHUNIYA DEBNATH , DAVE BHAVESH , KAPKOTI GOBIND S , BASU SUJAY , CHUGH ANITA , DE SIDDARTHA , PALLE VENKATA P
IPC分类号： C07D213/40 , A61K31/4168 , A61K31/44 , A61P3/10 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D277/46 , C07D277/82 , C07D285/135 , C07D417/12
CPC分类号： C07D277/46 , C07D213/40 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D239/42 , C07D257/06 , C07D261/14 , C07D277/82 , C07D285/135 , C07D417/12
摘要： Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. Processes of their preparation are also described in the disclosure. The disclosure also describes method to characterize partial glucokinase activators.
摘要翻译：本公开的化合物是可用作葡糖苷酶活化剂的式（I）的2,2,2-三取代乙酰胺衍生物，其多晶型物，立体异构体，前药，溶剂化物，药学上可接受的盐和制剂。本发明还描述了其制备方法。本公开还描述了表征部分葡糖激酶激活剂的方法。

9. 发明申请

WO2011048148A3 GLYCOSIDE DERIVATIVE AND USES THEREOF 审中-公开
标题翻译：糖苷衍生物及其用途
公开(公告)号：WO2011048148A3
公开(公告)日：2011-06-30
申请号：PCT/EP2010065802
申请日：2010-10-20
申请人： NOVARTIS AG , BEBERNITZ GREGORY RAYMOND , BOCK MARK G , BHUNIYA DEBNATH , DATRANGE LAXMIKANT , KURHADE SURESH EKNATH , PALLE P VENKATA , REDDY DUMBALA SRINIVAS
发明人： BEBERNITZ GREGORY RAYMOND , BOCK MARK G , BHUNIYA DEBNATH , DATRANGE LAXMIKANT , KURHADE SURESH EKNATH , PALLE P VENKATA , REDDY DUMBALA SRINIVAS
IPC分类号： C07H15/203 , A61K31/351 , A61K31/7034 , A61K31/7042 , A61K31/7056 , A61P3/10 , C07D309/10 , C07D309/30 , C07D405/10 , C07D407/10 , C07D407/12 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/10 , C07D491/107 , C07D493/10 , C07D498/04 , C07H15/26 , C07H17/00 , C07H19/04
CPC分类号： C07H17/00 , A61K31/351 , A61K31/7034 , A61K31/7042 , A61K31/7056 , A61K38/28 , A61K45/06 , C07D309/10 , C07D309/30 , C07D405/10 , C07D407/10 , C07D407/12 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/10 , C07D491/107 , C07D493/10 , C07D498/04 , C07H15/203 , C07H15/26 , C07H19/04 , A61K2300/00
摘要： This invention relates to compounds represented by formula (I) wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译：本发明涉及由式（I）表示的化合物，其中变量如上文所定义，其可用于治疗由D-葡萄糖共转运蛋白钠（SGLT）介导的疾病和病症，例如，糖尿病。本发明还提供了治疗这些疾病和病症的方法，以及用于治疗的组合物等。

10. 发明申请

WO2008036966A3 METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION, OBESITY AND RELATED METABOLIC DISORDERS 审中-公开
标题翻译：治疗炎症，肥胖和相关代谢疾病的方法和组合物
公开(公告)号：WO2008036966A3
公开(公告)日：2008-11-06
申请号：PCT/US2007079284
申请日：2007-09-24
申请人： REDDY US THERAPEUTICS INC , PADMALAYAM INDIRA , BHUNIYA DEBNATH , REDDY DUMBALA SRINIVAS , KHANNA ISH K , SAXENA UDAY , PILLARISETTI SIVARAM
发明人： PADMALAYAM INDIRA , BHUNIYA DEBNATH , REDDY DUMBALA SRINIVAS , KHANNA ISH K , SAXENA UDAY , PILLARISETTI SIVARAM
IPC分类号： A61K31/00 , A61K31/405
CPC分类号： A61K31/385 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： This invention provides a method of reducing inflammation in a living cell of a subject. This method increases the level of lipoic acid synthase within the living cell thereby causing the reduction of the inflammation. Various embodiments and variants are contemplated, some of which are set forth in claim format at the end of this document. The aspects, embodiments, and variants so exemplified in the claims format should not be understood as limiting the invention.
摘要翻译：本发明提供了减少受试者的活细胞中的炎症的方法。该方法增加了活细胞内硫辛酸合酶的水平，从而导致炎症的减轻。设想了各种实施例和变体，其中的一些在本文件结尾处以权利要求格式阐述。在权利要求格式中如此示例的方面，实施例和变体不应被理解为限制本发明。

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