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1. 发明申请

WO2012038944A1 MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：基质金属蛋白酶抑制剂
公开(公告)号：WO2012038944A1
公开(公告)日：2012-03-29
申请号：PCT/IB2011/054229
申请日：2011-09-26
申请人： RANBAXY LABORATORIES LIMITED , KHERA, Manoj Kumar , PALLE, Venkata P. , SATTIGERI, Viswajanani , SATTIGERI, Jitendra , SONI, Ajay , RAUF, Abdul Rehman Abdul , SIVAKUMAR, R. , REDDY, Ranadheer R. , MUSIB, Arpita , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
发明人： KHERA, Manoj Kumar , PALLE, Venkata P. , SATTIGERI, Viswajanani , SATTIGERI, Jitendra , SONI, Ajay , RAUF, Abdul Rehman Abdul , SIVAKUMAR, R. , REDDY, Ranadheer R. , MUSIB, Arpita , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
IPC分类号： C07D209/48 , C07D253/04 , C07D401/12 , C07C271/28 , A61K31/27 , A61K31/4035 , A61K31/53 , A61P11/00 , A61P19/02 , A61P35/00
CPC分类号： C07D253/04 , C07C271/28 , C07D209/48 , C07D401/12
摘要： The present invention relates to methyl sulfonamides and N-formamides derivatives of formula (I) and to processes for their syntheses. The invention also relates to pharmacological compositions containing these derivatives and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatie arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of an matrix metalloproteinase using the compounds.
摘要翻译：本发明涉及式（I）的甲基磺酰胺和N-甲酰胺衍生物及其合成方法。本发明还涉及含有这些衍生物的药物组合物和治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，银屑病关节炎，牛皮癣，肺纤维化，肺部炎症，急性呼吸窘迫综合征，牙周炎，多发性硬化，牙龈炎，动脉粥样硬化，干眼症，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他以使用该化合物过度表达和过度活化基质金属蛋白酶为特征的炎症性疾病。

2. 发明申请

WO2012038942A1 MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：基质金属蛋白酶抑制剂
公开(公告)号：WO2012038942A1
公开(公告)日：2012-03-29
申请号：PCT/IB2011/054227
申请日：2011-09-26
申请人： RANBAXY LABORATORIES LIMITED , KHERA, Manoj Kumar , SONI, Ajay , SATTIGERI, Jitendra , SATTIGERI, Viswajanani , DAS, Biswajit , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAUF, Abdul Rehman Abdul , MUSIB, Arpita , SAHA, Subham , YADAV, Neeraj Kumar , AHAMMED, Sabir , REDDY, Ranadheer R. , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
发明人： KHERA, Manoj Kumar , SONI, Ajay , SATTIGERI, Jitendra , SATTIGERI, Viswajanani , DAS, Biswajit , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAUF, Abdul Rehman Abdul , MUSIB, Arpita , SAHA, Subham , YADAV, Neeraj Kumar , AHAMMED, Sabir , REDDY, Ranadheer R. , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
IPC分类号： C07D237/32 , C07D253/08 , C07D265/26 , C07D401/12 , C07D403/12 , C07D409/12 , A61K31/502 , A61K31/53 , A61K31/536 , A61P29/00
CPC分类号： C07D253/08 , A61K31/502 , A61K31/53 , A61K45/06 , C07D237/32 , C07D265/26 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart faliure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of matrix metalloproteinase using the compounds.
摘要翻译：本发明还涉及含有本发明化合物的药物组合物，以及治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，牛皮癣关节炎，牛皮癣，肺纤维化，肺部炎症，急性呼吸窘迫综合征，牙周炎，多发性硬化症牙龈炎，动脉粥样硬化，干眼症，新生内膜增生，其导致再狭窄和缺血性心脏肥大，中风，肾脏疾病，肿瘤转移和其他以基质金属蛋白酶过度表达和过度活化为特征的炎症性疾病。

3. 发明申请

WO2012014114A1 MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：基质金属蛋白酶抑制剂
公开(公告)号：WO2012014114A1
公开(公告)日：2012-02-02
申请号：PCT/IB2011/053155
申请日：2011-07-14
申请人： RANBAXY LABORATORIES LIMITED , KHERA, Manoj, Kumar , SATTIGERI, Jitendra , SATTIGERI, Viswajanani , YADAV, Neeraj, Kumar , KUMAR, Kewal , RAUF, Abdul, Rehman, Abdul , CLIFFE, Ian, A. , BHATNAGAR, Pradip, Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda, Ghosh
发明人： KHERA, Manoj, Kumar , SATTIGERI, Jitendra , SATTIGERI, Viswajanani , YADAV, Neeraj, Kumar , KUMAR, Kewal , RAUF, Abdul, Rehman, Abdul , CLIFFE, Ian, A. , BHATNAGAR, Pradip, Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda, Ghosh
IPC分类号： C07D253/08 , A61K31/536 , A61P37/02 , A61P37/08 , A61P29/00
CPC分类号： C07D253/08
摘要： The present invention relates to certain hydroxy propionic acid derivatives and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over activation of a matrix metalloproteinase using the compounds.
摘要翻译：本发明涉及某些羟基丙酸衍生物及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，牛皮癣关节炎，牛皮癣，肺纤维化，肺部炎症，急性呼吸窘迫综合征，牙周炎，多发性硬化症，牙龈炎，动脉粥样硬化，干眼症，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他以使用该化合物过度表达和过度活化基质金属蛋白酶为特征的炎症性疾病。

4. 发明申请

WO2012038943A1 MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：基质金属蛋白酶抑制剂
公开(公告)号：WO2012038943A1
公开(公告)日：2012-03-29
申请号：PCT/IB2011/054228
申请日：2011-09-26
申请人： RANBAXY LABORATORIES LIMITED , KHERA, Manoj Kumar , SATTIGERI, Jitendra , YADAV, Neeraj Kumar , RAUF, Abdul Rehman Abdul , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
发明人： KHERA, Manoj Kumar , SATTIGERI, Jitendra , YADAV, Neeraj Kumar , RAUF, Abdul Rehman Abdul , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
IPC分类号： C07C309/60 , C07C321/28 , C07C333/08 , A61K31/192 , A61K31/325 , A61P11/00 , A61P19/02 , A61P35/00
CPC分类号： C07C317/46 , C07C323/52 , C07C323/60
摘要： The present invention relates to certain sulfone acetic acid derivatives of formula I as MMP inhibitor and processes for its syntheses. The invention also relates to pharmacological compositions containing the compounds of the present invention and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple scleorisis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of a matrix metalloproteinase using the compounds.
摘要翻译：本发明涉及作为MMP抑制剂的某些式I的砜乙酸衍生物及其合成方法。本发明还涉及含有本发明化合物的药物组合物和治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，银屑病关节炎，银屑病，肺纤维化，肺部炎症，急性呼吸窘迫综合征，牙周炎，多发性硬化症，牙龈炎，动脉粥样硬化，干眼症，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移以及其他以使用该化合物过度表达和过度激活基质金属蛋白酶为特征的炎症性疾病。

5. 发明申请

WO2004005250A1 HMG-COA REDUCTASE INHIBITORS 审中-公开
标题翻译： HMG-COA还原抑制剂
公开(公告)号：WO2004005250A1
公开(公告)日：2004-01-15
申请号：PCT/IB2003/002696
申请日：2003-07-08
申请人： RANBAXY LABORATORIES LIMITED , KUMAR, Yatendra , ARYAN, Ram, Chander , SATTIGERI, Jitendra , SALMAN, Mohammad , SHANKAR, Gowri , BHUSHAN, Kumar, Hari , PANDYA, Bhargav R. , SHARMA, Ramnik
发明人： KUMAR, Yatendra , ARYAN, Ram, Chander , SATTIGERI, Jitendra , SALMAN, Mohammad , SHANKAR, Gowri , BHUSHAN, Kumar, Hari , PANDYA, Bhargav R. , SHARMA, Ramnik
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： The invention relates to particular hydroxyl and protected hydroxyl derivatives of compounds known to be useful as HMG CoA-reductase inhibitors. In particular, herein are provided hydroxyl and protected hydroxyl compounds of Formula I and their corresponding lactones.
摘要翻译：本发明涉及已知可用作HMG CoA还原酶抑制剂的化合物的特定羟基和被保护的羟基衍生物。特别地，本文提供式I的羟基和保护的羟基化合物及其相应的内酯。

6. 发明申请

WO2004106299A3 SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE AS HMG-CO INHIBITORS 审中-公开
公开(公告)号：WO2004106299A3
公开(公告)日：2004-12-09
申请号：PCT/IB2004/001761
申请日：2004-05-28
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , SATTIGERI, Jitendra , KUMAR, Yatendra , ARYAN, Ram, Chander , RAMANATHAN, Vikram, Krishna , CHUGH, Anita
发明人： SALMAN, Mohammad , SATTIGERI, Jitendra , KUMAR, Yatendra , ARYAN, Ram, Chander , RAMANATHAN, Vikram, Krishna , CHUGH, Anita
IPC分类号： C07D405/06
摘要： The present invention relates to substituted pyrrole derivatives of formula I, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms. Its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, metabolites, polymorphs, tautomers, racemates, pure enantiomers, diastereoisomers or N-oxides wherein Formula (II).

7. 发明申请

WO2003008391A1 AZOLE COMPOUNDS AS ANTI-FUNGAL AGENTS 审中-公开
标题翻译：化合物作为抗真菌剂
公开(公告)号：WO2003008391A1
公开(公告)日：2003-01-30
申请号：PCT/IB2002/002662
申请日：2002-07-08
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , KATOCH, Rita , VERMA, Ashwani, Kumar , SATTIGERI, Jitendra , RATTAN, Ashok
发明人： SALMAN, Mohammad , KATOCH, Rita , VERMA, Ashwani, Kumar , SATTIGERI, Jitendra , RATTAN, Ashok
IPC分类号： C07D249/12
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D249/12
摘要： The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared with presently available agents in this class and the processes for the preparation thereof. This invention also relates to pharmaceutical preparations containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.
摘要翻译：本发明涉及特定取代的唑类化合物的衍生物，其与本类目前可得的试剂相比具有改善的抗真菌活性及其制备方法。本发明还涉及含有本发明化合物的药物制剂及其用于治疗和/或预防哺乳动物，优选人类的真菌感染的用途。

8. 发明申请

WO2005100331A2 ANTIDIABETIC AGENTS 审中-公开
标题翻译：抗真菌剂
公开(公告)号：WO2005100331A2
公开(公告)日：2005-10-27
申请号：PCT/IB2005/000998
申请日：2005-04-14
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , SATTIGERI, Jitendra , VIR, Dharam , GANGAN, Vija Dattatraya
发明人： SALMAN, Mohammad , SATTIGERI, Jitendra , VIR, Dharam , GANGAN, Vija Dattatraya
IPC分类号： C07D277/34
CPC分类号： C07D277/20 , C07D277/34 , C07D417/10 , C07D417/12
摘要： The present invention relates to alkynyl derivatives, which have PPAR agonist activity and hence can be used as antidiabetic compounds. Compounds disclosed herein can be used for the treatment of diabetes and diabetes-associated complications, for the treatment of diseases and conditions in which insulin resistance is the central pathophysiological mechanism, for the treatment of diseases or conditions such as Type II diabetes, dyslipidaemia, hypertension, coronary heart disease, cardiovascular disease, atherosclerosis, diabetes nephropathy, glomerulonephritis, glomerularsclerosis, nephrotic syndorme, hypertensive nephrosclerosis, polycystic ovarian syndrome, eating disorders, psoriasis, obesity, for improving cognitive functions in dementia and as aldose reductase inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diabetes mellitus and the diseases and conditions mediated through insulin resistance are provided.
摘要翻译：本发明涉及具有PPAR激动剂活性的炔基衍生物，因此可用作抗糖尿病化合物。本文公开的化合物可用于治疗糖尿病和糖尿病相关并发症，用于治疗其中胰岛素抵抗是中枢病理机制的疾病和病症，用于治疗疾病或病症如II型糖尿病，血脂异常，高血压冠心病，心血管疾病，动脉粥样硬化，糖尿病肾病，肾小球肾炎，肾小球硬化症，肾病综合征，高血压性肾硬化，多囊卵巢综合征，进食障碍，牛皮癣，肥胖症，用于改善痴呆症中的认知功能和作为醛糖还原酶抑制剂。提供了制备所公开化合物的方法，含有所公开化合物的药物组合物，以及治疗糖尿病的方法以及通过胰岛素抵抗介导的疾病和病症。

9. 发明申请

WO2004105752A1 SUBSTITUTED PYRROLE DERIVATIVES AS HMG-COA REDUCTASE INHIBITORS 审中-公开
标题翻译：作为HMG-COA还原酶抑制剂的取代的吡咯烷酮衍生物
公开(公告)号：WO2004105752A1
公开(公告)日：2004-12-09
申请号：PCT/IB2004/001754
申请日：2004-05-28
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra , SALMAN, Mohammad , KUMAR, Yatendra
发明人： SATTIGERI, Jitendra , SALMAN, Mohammad , KUMAR, Yatendra
IPC分类号： A61K31/4025
CPC分类号： C07D401/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to substituted pyrrole derivatives of Formula (I), wherein (Y), with the proviso that one of R 2 , R 4 and R 5 is a heterocycle and with the further provision that if R 2 is not a heterocycle then either R 4 or R 5 alone is not unsubstituted pyridyl, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.
摘要翻译：本发明涉及式（I）的取代吡咯衍生物，其中（Y），条件是R 2，R 4和R 5中的一个是杂环，并且进一步规定如果R 2不是杂环，则R 4或R 5 单独不是未取代的吡啶基，其可以用作3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂。本文公开的化合物可用作胆固醇降低剂，并且可用于治疗胆固醇相关疾病和相关症状。提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物，以及治疗胆固醇相关疾病和相关症状的方法。

10. 发明申请

WO2003027103A1 SYNTHESIS OF KEY AZOLE-ANTIFUNGAL INTERMEDIATES 审中-公开
标题翻译：关键AZOLE反义中间体的合成
公开(公告)号：WO2003027103A1
公开(公告)日：2003-04-03
申请号：PCT/IB2002/003942
申请日：2002-09-24
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra , ARORA, Jasbir, Singh , MALHOTRA, Sanjay , VERMA, Ashwani, Kumar , SALMAN, Mohammad
发明人： SATTIGERI, Jitendra , ARORA, Jasbir, Singh , MALHOTRA, Sanjay , VERMA, Ashwani, Kumar , SALMAN, Mohammad
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , C07D405/14 , C07D471/04
摘要： Methods for producing azole compounds useful as intermediates for antifungal compounds and compositions including reaction of epoxy alcohols with reactants having active hydrogen attached to nitrogen, oxygen or sulfur in the presence of redox coupling agents. In some embodiments, a procedure known as a Mitsunobu reaction is utilized for the transformations.
摘要翻译：用于生产用作抗真菌化合物和组合物的中间体的唑化合物的方法，包括环氧醇与在氧化还原偶联剂存在下与氮，氧或硫连接的活性氢的反应物的反应。在一些实施方案中，将已知为Mitsunobu反应的方法用于转化。

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