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1. 发明申请

WO2005092907A2 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：WO2005092907A2
公开(公告)日：2005-10-06
申请号：PCT/IB2005000803
申请日：2005-03-29
申请人： RANBAXY LAB LTD , SATTIGERI VISWAJANANI JITENDRA , ARORA SUDERSHAN K , SALMAN MOHAMMAD , PALLE VENKATA P , YADAV GYAN CHAND , TANWAR MADAN PAL , MUKHERJEE ASHIS , NARAYANAN RAMAMURTHY , RAUF ABDUL REHAMAN ABDUL , NAIK KESHAV PRABHAKAR , SONI AJAY , RAY ABHIJIT , SHIRUMALLA RAJ KUMAR , MOOKHTIAR KASIM ABBAS
发明人： SATTIGERI VISWAJANANI JITENDRA , ARORA SUDERSHAN K , SALMAN MOHAMMAD , PALLE VENKATA P , YADAV GYAN CHAND , TANWAR MADAN PAL , MUKHERJEE ASHIS , NARAYANAN RAMAMURTHY , RAUF ABDUL REHAMAN ABDUL , NAIK KESHAV PRABHAKAR , SONI AJAY , RAY ABHIJIT , SHIRUMALLA RAJ KUMAR , MOOKHTIAR KASIM ABBAS
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7042 , C07H3/02 , C07H9/04 , C07H15/00 , C07H
CPC分类号： C07H9/04 , C07H3/02 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文中的化合物障碍可用于抑制和预防炎症和相关病症，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥或银屑病。还提供了含有本文公开的化合物的药理学组合物和使用该化合物治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植物排斥和其它炎性和/或自身免疫性疾病的方法。

2. 发明申请

WO2005092907B1 Monosaccharide derivatives as anti-cancer and anti-inflammatory agents 审中-公开
标题翻译：单糖衍生物作为抗癌和抗炎剂
公开(公告)号：WO2005092907B1
公开(公告)日：2006-06-01
申请号：PCT/IB2005000803
申请日：2005-03-29
申请人： RANBAXY LAB LTD , SATTIGERI VISWAJANANI JITENDRA , ARORA SUDERSHAN K , SALMAN MOHAMMAD , PALLE VENKATA P , YADAV GYAN CHAND , TANWAR MADAN PAL , MUKHERJEE ASHIS , NARAYANAN RAMAMURTHY , RAUF ABDUL REHAMAN ABDUL , NAIK KESHAV PRABHAKAR , SONI AJAY , RAY ABHIJIT , SHIRUMALLA RAJ KUMAR , MOOKHTIAR KASIM ABBAS
发明人： SATTIGERI VISWAJANANI JITENDRA , ARORA SUDERSHAN K , SALMAN MOHAMMAD , PALLE VENKATA , YADAV GYAN CHAND , TANWAR MADAN PAL , MUKHERJEE ASHIS , NARAYANAN RAMAMURTHY , RAUF ABDUL REHAMAN ABDUL , NAIK KESHAV PRABHAKAR , SONI AJAY , RAY ABHIJIT , SHIRUMALLA RAJ KUMAR , MOOKHTIAR KASIM ABBAS
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7042 , C07H3/02 , C07H9/04 , C07H15/00
CPC分类号： C07H9/04 , C07H3/02 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文中的化合物障碍可用于抑制和预防炎症和相关病症，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥或银屑病。还提供了含有本文公开的化合物的药理学组合物和使用该化合物治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植物排斥和其它炎性和/或自身免疫性疾病的方法。

3. 发明申请

WO2005100373A3 MONOSACCHARIDE DERIVATIVES AS ANTI-CANCER AND ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：单抗衍生物作为抗癌剂和抗炎剂
公开(公告)号：WO2005100373A3
公开(公告)日：2006-04-06
申请号：PCT/IB2005000974
申请日：2005-04-13
申请人： RANBAXY LAB LTD , SATTIGERI VISWAJANANI JITENDRA , ARORA SUDERSHAN K , SALMAN MOHAMMAD , PALLE VENKATA P , RAY ABHIJIT , SHIRUMALLA RAJ KUMAR
发明人： SATTIGERI VISWAJANANI JITENDRA , ARORA SUDERSHAN K , SALMAN MOHAMMAD , PALLE VENKATA P , RAY ABHIJIT , SHIRUMALLA RAJ KUMAR
IPC分类号： C07H9/04 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61P11/06 , A61P17/00 , A61P35/00 , A61P37/00 , C07H3/02 , C07H15/00
CPC分类号： C07H9/04 , C07H3/02 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，还提供了使用该化合物的瘙痒症或过敏性鼻炎和其它炎性和/或自身免疫性疾病。

4. 发明专利

CU20090025A7 INHIBIDORES DE LA METALOPROTEINASA MATRIZ 未知
公开(公告)号：CU20090025A7
公开(公告)日：2011-07-11
申请号：CU20090025
申请日：2009-02-20
申请人： RANBAXY LAB LTD
发明人： SRIVASTAVA PUNIT KUMAR , MUSIB ARPITA , JOSEPH SONY , RAUF ABDUL REHMAN ABDUL , SONI AJAY , TIWARI MANOJ KUMAR , REDDY RANADHEER , PALLE VEKATA P , DASTIDAR SUNANDA G , KHERA MANOJ KUMAR , SATTIGERI VISWAJANANI JITENDRA
IPC分类号： C07D209/48
摘要： El presente invento se rerlaciona con ácidos carboxílicos sustituidos mediante B-hidroxi y amino, que actúan como inhibidores de la metaloproteasa matriz, ácidos carboxílicos B-hidroxi diastereoméricamente puros, procesos correspondientes para la síntesis de composiciones farmacéuticas que contienen los compuestos del presente invento. Los compuestos del presente invento son útiles en el tratamiento de diversas enfermedades inflamatorias, de autoinmunidad y alérgicas , como ser los métodos para tratar el asma, la artritis reumatoidea, COPD, rinitis, osteoartritis, artritis soriásica, psoriasis, fibrosis pulmonar, desórdenes en la cura de heridas, inflamación pulmonar, síndrome de perturbación respiratoria agudo, periodontitis, esclerosis múltiple, gingivitis, ateroesclerosis, proliferación neoíntima, que lleva a la restenosis y a la insuficiencia cardíaca isquémica, ataque apopléjico, enfermedades renales, metástasis tumoral y otros desódenes inflamatorios caracterizados por la hiperexpresión e hiper-activación de una metaloproteinasa matriz utilizando los compuestos.

6. 发明专利

RS52232B 5-PHENYL-PENTANOIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS FOR THE TREATMENT OF ASTHMA AND OTHER DISEASES 未知
公开(公告)号：RS52232B
公开(公告)日：2012-10-31
申请号：RSP20120174
申请日：2006-02-21
申请人： RANBAXY LAB LTD
发明人： PALLE VENKATA P , SATTIGERI VISWAJANANI JITENDRA , KHERA MANOJ KUMAR , RAY ABHIJIT , DASTIDAR SUNANDA G , VOLETI SREEDHARA RAO
IPC分类号： C07D249/18 , A61P11/06 , C07D207/40 , C07D209/12 , C07D209/48 , C07D211/88 , C07D213/64 , C07D237/32 , C07D239/54 , C07D239/96 , C07D263/58 , C07D265/28 , C07D401/10 , C07D403/10 , C07D471/04
摘要： The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rχ, —NHC(═O)OR4, —NHSO2R4, C(═Y)NR4R5, C(═O)OR6 [wherein Y is oxygen or sulphur], OR5, —O(C═O)NR4R5, O-acyl, S(O)mR4, —SO2N(R4)2, cyano, amidino or guanidino [wherein R4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R5 is hydrogen or R4; Rx is R4 or —SO2N(R4)2 and R6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR4, —OC(═O)NR4R5, O-acyl, NH2, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rx, —NHC(═O)OR4, —NHSO2R4, and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of an matrix metalloproteinase, using the compounds.

7. 发明专利

EA013539B1 ПРОИЗВОДНЫЕ 5-ФЕНИЛПЕНТАНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ МАТРИЧНОЙ МЕТАЛЛОПРОТЕИНАЗЫ ДЛЯ ЛЕЧЕНИЯ АСТМЫ И ДРУГИХ ЗАБОЛЕВАНИЙ 未知
公开(公告)号：EA013539B1
公开(公告)日：2010-06-30
申请号：EA200701768
申请日：2006-02-21
申请人： RANBAXY LAB LTD
发明人： PALLE VENKATA P , SATTIGERI VISWAJANANI JITENDRA , KHERA MANOJ KUMAR , VOLETI SREEDHARA RAO , RAY ABHIJIT , DASTIDAR SUNANDA G
IPC分类号： C07D249/18 , A61P11/06 , C07D207/40 , C07D209/12 , C07D209/48 , C07D211/88 , C07D213/64 , C07D237/32 , C07D239/54 , C07D239/96 , C07D263/58 , C07D265/28 , C07D401/10 , C07D403/10 , C07D471/04
摘要： Настоящееизобретениеотноситсяк соединениямструктурнойформулы (I), где n имеетзначениеот 1 до 5; Rпредставляетсобойнеобязательнозамещенныйалкил, алкенил, алкинил, циклоалкил, арил, гетероциклил, гетероарил, аралкил, алкокси, арилокси, алкенилоксиилиалкинилокси; Rпредставляетсобойалкенил, алкинил, арил, гетероциклил, гетероарил, циклоалкил, NRR, -NHC(=Y)R, -NHC(=Y)NRR, -NHC(=O)OR, -NHSOR, C(=Y)NRR, C(=O)OR(где Y представляетсобойатомкислородаилисеры), OR, -OC(=O)NRR, О-ацил, S(O)R, -SON(R), циано, амидиноилигуанидино (где Rпредставляетсобойалкил, алкенил, алкинил, циклоалкил, арил, гетероциклил, гетероарил, аралкил, гетероарилалкил, гетероциклилалкилилициклоалкилалкили m имеетзначение 0-2; Rпредставляетсобойводородили R; Rпредставляетсобой Rили -SON(R)и Rпредставляетсобойводород, алкил, циклоалкил, аралкил, гетероарилалкил, гетероциклилалкилилициклоалкилалкил); Rпредставляетсобойводород, фтор, алкил, циклоалкилалкилилиаралкил; АпредставляетсобойОН, OR, -OC(=O)NRR, О-ацил, NH, NRR, -NHC(=Y)R, -NHC(=Y)NRR, -NHC(=O)OR, -NHSOR, ик способамихполучения. Настоящееизобретениетакжеотноситсяк фармакологическимкомпозициям, содержащимсоединениянастоящегоизобретения, ик способамлеченияастмы, ревматоидногоартрита, COPD, ринита, остеоартрита, псориатическогоартрита, псориаза, легочногофиброза, воспалениялегких, острогореспираторногодистрессовогосиндрома, периодонтита, рассеянногосклероза, гингивита, атеросклероза, неоинтимальнойпролиферации, котораяприводитк рестенозуи ишемическойсердечнойнедостаточности, инсульта, почечныхзаболеваний, опухолевыхметастази другихвоспалительныхзаболеваний, характеризующихсясверхэкспрессиейи сверхактивациейматричнойметаллопротеиназы, спомощьюэтихсоединений.

8. 发明专利

AP200904783A0 Substituted pyrrole derivatives 未知
公开(公告)号：AP200904783A0
公开(公告)日：2009-02-28
申请号：AP200904783
申请日：2004-05-28
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANANI JITENDRA , KUMAR YATENDRA , ARYAN RAM CHANDER
IPC分类号： A61K31/366 , A61K31/40 , C07D207/00 , C07D207/34 , C07D401/12 , C07D405/06 , C07D405/14
CPC分类号： C07D207/34 , A61K31/40 , C07C69/716 , C07C69/738 , C07D401/12 , C07D403/04 , C07D405/06 , C07D405/14 , C07D413/04

9. 发明专利

AP2009004783A0 Substituted pyrrole derivatives 未知
公开(公告)号：AP2009004783A0
公开(公告)日：2009-02-28
申请号：AP2009004783
申请日：2004-05-28
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANANI JITENDRA , KUMAR YATENDRA , ARYAN RAM CHANDER
IPC分类号： A61K31/366 , A61K31/40 , C07D207/00 , C07D207/34 , C07D401/12 , C07D405/06 , C07D405/14
摘要： The present invention relates to substituted pyrrole derivatives, which can be used as 2-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.

10. 发明专利

AU2003202767A1 PREPARATION OF MONOSACCHARIDE DERIVATIVES 未知
公开(公告)号：AU2003202767A1
公开(公告)日：2004-09-06
申请号：AU2003202767
申请日：2003-02-12
申请人： RANBAXY LAB LTD
发明人： SALMAN MOHAMMAD , YADAV GYAN CHAND , SATTIGERI VISWAJANANI JITENDRA
IPC分类号： A61K31/70 , C07H13/12 , C07H15/00

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