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1. 发明申请

WO2006085212A3 CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV 审中-公开
标题翻译：作为磷酸二酯酶类型IV的抑制剂的稠合的异构衍生物
公开(公告)号：WO2006085212A3
公开(公告)日：2006-10-19
申请号：PCT/IB2006000285
申请日：2006-02-13
申请人： RANBAXY LAB LTD , PALLE VENKATA P , BALACHANDRAN SARALA , GUPTA NIDHI , MUTHUKAMAL NAGARAJAN , RAMAIAH MANDADAPU RAGHU , KHERA MANOJ KUMAR , BAREGAMA LAILT KUMAR , KAHIRNAR VINAYAK VASANTRAO , RAY ABHIJIT , DASTIDAR SUNANDA G
发明人： PALLE VENKATA P , BALACHANDRAN SARALA , GUPTA NIDHI , MUTHUKAMAL NAGARAJAN , RAMAIAH MANDADAPU RAGHU , KHERA MANOJ KUMAR , BAREGAMA LAILT KUMAR , KAHIRNAR VINAYAK VASANTRAO , RAY ABHIJIT , DASTIDAR SUNANDA G
IPC分类号： C07D498/10 , A61K31/423 , A61K31/424 , A61P11/00 , A61P31/18 , C07D261/20 , C07D498/04
CPC分类号： C07D261/20
摘要： The present invention relates to isoxazoline derivatives of fprmula (I), which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
摘要翻译：本发明涉及fprmula（I）的异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。特别地，本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS）嗜酸粒细胞肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是在人类中。本发明还涉及制备所公开的化合物及其药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途的方法。

2. 发明申请

WO2008035315A3 INHIBITORS OF PHOSPHODIESTERASE TYPE-IV 审中-公开
标题翻译：磷酸酯酶类型IV的抑制剂
公开(公告)号：WO2008035315A3
公开(公告)日：2008-12-04
申请号：PCT/IB2007053854
申请日：2007-09-22
申请人： RANBAXY LAB LTD , RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , CHAKLADAR SASWATI , RAMAIAH MANDADAPU RAGHU , MUTHUKAMAL NAGARAJAN , BALACHANDRAN SARLA , RAMNANI SARIKA , PALLE VENKATA P , DASTIDAR SUNANDA G , RAY ABHIJIT , VIJAYKRISHNAN LALITHA , SATTIGERI JITENDRA
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , CHAKLADAR SASWATI , RAMAIAH MANDADAPU RAGHU , MUTHUKAMAL NAGARAJAN , BALACHANDRAN SARLA , RAMNANI SARIKA , PALLE VENKATA P , DASTIDAR SUNANDA G , RAY ABHIJIT , VIJAYKRISHNAN LALITHA , SATTIGERI JITENDRA
IPC分类号： C07D261/04 , A61K31/41 , A61P29/00 , C07D261/20 , C07D498/10
CPC分类号： C07D498/10 , C07D261/04 , C07D261/20
摘要： The present invention relates to catechol derivatives of formula (I), which can be used as inhibitors of phosphodiesterase (PDPI) type 4 or type 7, Compounds disclosed herein can be useful in the treatment of CNS disorders, inflammatory diseases such as, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type 4 or type 7 inhibitors.
摘要翻译：本发明涉及式（I）的儿茶酚衍生物，其可用作4型或7型磷酸二酯酶（PDPI）的抑制剂。本文公开的化合物可用于治疗CNS疾病，炎性疾病如AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），嗜酸性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎等炎症性疾病在人类提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为4型或7型抑制剂的磷酸二酯酶（PDE）的用途。

3. 发明申请

WO2008035315A9 INHIBITORS OF PHOSPHODIESTERASE TYPE-IV 审中-公开
标题翻译：磷酸酯酶类型IV的抑制剂
公开(公告)号：WO2008035315A9
公开(公告)日：2008-10-23
申请号：PCT/IB2007053854
申请日：2007-09-22
申请人： RANBAXY LAB LTD , RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , CHAKLADAR SASWATI , RAMAIAH MANDADAPU RAGHU , MUTHUKAMAL NAGARAJAN , BALACHANDRAN SARLA , RAMNANI SARIKA , PALLE VENKATA P , DASTIDAR SUNANDA G , RAY ABHIJIT , VIJAYKRISHNAN LALITHA , SATTIGERI JITENDRA
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , CHAKLADAR SASWATI , RAMAIAH MANDADAPU RAGHU , MUTHUKAMAL NAGARAJAN , BALACHANDRAN SARLA , RAMNANI SARIKA , PALLE VENKATA P , DASTIDAR SUNANDA G , RAY ABHIJIT , VIJAYKRISHNAN LALITHA , SATTIGERI JITENDRA
IPC分类号： C07D261/04 , A61K31/41 , A61P29/00 , C07D261/20 , C07D498/10
CPC分类号： C07D498/10 , C07D261/04 , C07D261/20
摘要： The present invention relates to catechol derivatives of formula I, which can be used as inhibitors of phosphodiesterase (PDPI) type 4 or type 7, Compounds disclosed herein can be useful in the treatment of CNS disorders, inflammatory diseases such as, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type 4 or type 7 inhibitors. (I).
摘要翻译：本发明涉及式I的儿茶酚衍生物，其可用作4型或7型磷酸二酯酶（PDPI）的抑制剂。本文公开的化合物可用于治疗CNS疾病，炎性疾病如AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎症性疾病。提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为4型或7型抑制剂的磷酸二酯酶（PDE）的用途。（一世）。

6. 发明专利

CA2680625C PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 未知
公开(公告)号：CA2680625C
公开(公告)日：2016-02-23
申请号：CA2680625
申请日：2008-03-14
申请人： RANBAXY LAB LTD
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , RAMAIAH MANDADAPU RAGHU , PALLE VENKATA P , BALACHANDRAN SARALA , KONDASKAR ATUL , SALLA MANOHAR , RAY ABHIJIT , DASTIDAR SUNANDA G , VIJAYKRISHNAN LALITHA
IPC分类号： C07D471/04 , A61K31/437 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4 /PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formura 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4 /PDE type 7 inhibitors are provided.

7. 发明专利

EA018670B9 ПРОИЗВОДНЫЕ ПИРАЗОЛО[3,4-В]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗЫ 未知
公开(公告)号：EA018670B9
公开(公告)日：2014-01-30
申请号：EA200970852
申请日：2008-03-14
申请人： RANBAXY LAB LTD
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , RAMAIAH MANDADAPU RAGHU , PALLE VENKATA P , BALACHANDRAN SARALA , KONDASKAR ATUL , SALLA MANOHAR , RAY ABHIJIT , DASTIDAR SUNANDA G , VIJAYKRISHNAN LALITHA
IPC分类号： A61K31/437 , A61P11/00 , A61P17/00 , A61P19/00 , A61P35/00 , C07D471/04 , C07D519/00
摘要： Изобретениеотноситсяк ингибиторамфосфодиэстеразы (PDE) типа 4, фосфодиэстеразы (PDE) типа 7 идвойнымингибиторам PDE типа 4/PDE типа 7. Соединения, описанныев изобретении, имеющиеструктуруформулы I, могутбытьполезныв лечении, предупреждении, ингибированииилиподавленииболезнейЦНС (центральнойнервнойсистемы), напримермножественногосклероза; различныхпатологическихсостояний, как, например, заболеваний, поражающихиммуннуюсистему, включаяСПИД (синдромприобретенногоиммунодефицита), отторжениетрансплантата, аутоиммунныерасстройства, такиекакассоциированныес Т-клеткамизаболевания, напримерревматоидныйартрит; воспалительныхзаболеваний, такихкакреспираторныевоспалительныезаболевания, включаяхроническуюобструктивнуюболезньлегких (COPD), астму, бронхит, аллергическийринит, респираторныйдистресс-синдромвзрослых (ARDS) идругиевоспалительныезаболевания, включая, ноэтимнеограничиваясь, псориаз, шок, атопическийдерматит, эозинофильнуюгранулёму, аллергическийконъюнктивит, остеоартрит; желудочно-кишечныхвоспалительныхзаболеваний, такихкакболезньКрона, колит, панкреатит, атакжеразличныхтиповрака, включаялейкоз; особенноу людей. Предложеныспособполученияописанныхсоединений, фармацевтическиекомпозиции, содержащиеописанныесоединения, иихприменениев качествеингибиторов PDE типа 4, PDE типа 7 идвойныхингибиторов PDE типа 4/PDE типа 7.

8. 发明专利

NZ579645A PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 未知
公开(公告)号：NZ579645A
公开(公告)日：2012-01-12
申请号：NZ57964508
申请日：2008-03-14
申请人： RANBAXY LAB LTD
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , RAMAIAH MANDADAPU RAGHU , PALLE VENKATA P , BALACHANDRAN SARALA , KONDASKAR ATUL , SALLA MANOHAR , RAY ABHIJIT , DASTIDAR SUNANDA G , VIJAYKRISHNAN LALITHA
IPC分类号： C07D519/00 , A61K31/437 , A61P11/00 , A61P17/00 , A61P19/00 , A61P35/00 , C07D471/04
摘要： Disclosed are compounds of general Formula I where M and R1-R3 are as defined in the claims. The compounds are phosphodiesterase (PDE) type 4 PDE type 7 and dual PDE type 4/PDE type 7 inhibitors. Examples of the disclosed compounds include: N-cyclohexyl-1-ethyl-5-(1-oxa-2-azaspiro[4,4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine; and 4-{ [1-Ethyl-5-(5-oxa-6-azaspiro[3,4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl] amino} cyclohexanol. Further disclosed is a method for the preparation of compounds of Formula I, a pharmaceutical composition comprising a therapeutically effective amount of the compounds, and the use of the compounds in the manufacture of a medicament for the treatment or prevention of multiple sclerosis, AIDS, transplant rejection, rheumatoid arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), asthma, psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophillic granuloma, allergic conjunctivitis, osteoarthritis, colitis, pancreatitis and cancer in a mammal.

9. 发明专利

MX2009003100A INHIBIDORES DE FOSFODIESTERASA TIPO IV. 未知
公开(公告)号：MX2009003100A
公开(公告)日：2009-05-11
申请号：MX2009003100
申请日：2007-09-22
申请人： RANBAXY LAB LTD
发明人： PALLE VENKATA P , RAY ABHIJIT , DASTIDAR SUNANDA G , RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , CHAKLADAR SASWATI , RAMAIAH MANDADAPU RAGHU , MUTHUKAMAL NAGARAJAN , BALACHANDRAN SARLA , RAMNANI SARIKA , VIJAYKRISHNAN LALITHA , SATTIGERI JLTENDRA
IPC分类号： C07D261/04 , A61K31/00 , A61P29/00 , C07D261/20 , C07D498/10
摘要： La presente invención se relaciona a derivados de catecol de la fórmula (I), que pueden ser utilizados como inhibidores de fosfodiesterasa (PDPI) tipo 4 o tipo 7. Los compuestos divulgados en la presente pueden ser útiles en el tratamiento de desórdenes del CNS, enfermedades inflamatorias tales como, SIDA, asma, artritis, bronquitis, enfermedad pulmonar obstructiva crónica (COPD), psoriasis, rinitis alérgica, shock, dermatitis atópica, enfermedad de Crohn, síndrome de aflicción respiratoria en adultos (ARDS), granuloma eosinofílico, conjuntivitis alérgica, osteoartritis, colitis ulcerativa y otras enfermedades inflamatorias especialmente en humanos. Se proporcionan procesos para la preparación de los compuestos divulgados, así como composiciones farmacéuticas que contienen los compuestos divulgados, y su uso como inhibidores de fosfodiesterasa (PDE) tipo 4 o tipo 7.

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