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1. 发明申请

US20120277741A1 TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION 有权
标题翻译：组织排除与不可逆电气
公开(公告)号：US20120277741A1
公开(公告)日：2012-11-01
申请号：US13546339
申请日：2012-07-11
申请人： RAFAEL DAVALOS , Boris Rubinsky
发明人： RAFAEL DAVALOS , Boris Rubinsky
IPC分类号： A61B18/14
CPC分类号： A61B18/12 , A61B18/1233 , A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/1425 , A61N1/0412 , A61N1/0472 , A61N1/05 , A61N1/327
摘要： A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
摘要翻译：公开了一种用于消除不想要的组织的新方法，例如癌性或非癌性肿瘤的细胞。它涉及通过施加电脉冲将电极放置在不期望的组织附近或附近，从而在不期望的组织的整个区域内引起细胞的不可逆电穿孔。电脉冲不可逆地渗透细胞膜，从而引起细胞死亡。不可逆透化的细胞留在原位，并通过身体免疫系统去除。通过使用不可逆电穿孔而不引起热损伤可实现的组织消融量是相当大的。

2. 发明授权

US08282631B2 Tissue ablation with irreversible electroporation 有权
标题翻译：组织消融与不可逆电穿孔
公开(公告)号：US08282631B2
公开(公告)日：2012-10-09
申请号：US13237199
申请日：2011-09-20
申请人： Rafael Davalos , Boris Rubinsky
发明人： Rafael Davalos , Boris Rubinsky
IPC分类号： A61B18/18
CPC分类号： A61B18/12 , A61B18/1233 , A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/1425 , A61N1/0412 , A61N1/0472 , A61N1/05 , A61N1/327
摘要： A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
摘要翻译：公开了一种用于消除不想要的组织的新方法，例如癌性或非癌性肿瘤的细胞。它涉及通过施加电脉冲将电极放置在不期望的组织附近或附近，从而在不期望的组织的整个区域内引起细胞的不可逆电穿孔。电脉冲不可逆地渗透细胞膜，从而引起细胞死亡。不可逆透化的细胞留在原位，并通过身体免疫系统去除。通过使用不可逆电穿孔而不引起热损伤可实现的组织消融量是相当大的。

3. 发明授权

US08048067B2 Tissue ablation with irreversible electroporation 有权
标题翻译：组织消融与不可逆电穿孔
公开(公告)号：US08048067B2
公开(公告)日：2011-11-01
申请号：US10571162
申请日：2004-12-21
申请人： Rafael Davalos , Boris Rubinsky
发明人： Rafael Davalos , Boris Rubinsky
IPC分类号： A61B18/18
CPC分类号： A61B18/12 , A61B18/1233 , A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/1425 , A61N1/0412 , A61N1/0472 , A61N1/05 , A61N1/327
摘要： A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
摘要翻译：公开了一种用于消除不想要的组织的新方法，例如癌性或非癌性肿瘤的细胞。它涉及通过施加电脉冲将电极放置在不期望的组织附近或附近，从而在不期望的组织的整个区域内引起细胞的不可逆电穿孔。电脉冲不可逆地渗透细胞膜，从而引起细胞死亡。不可逆透化的细胞留在原位，并通过身体免疫系统去除。通过使用不可逆电穿孔而不引起热损伤可实现的组织消融量是相当大的。

4. 发明授权

US09005189B2 Tissue ablation with irreversible electroporation 有权
标题翻译：组织消融与不可逆电穿孔
公开(公告)号：US09005189B2
公开(公告)日：2015-04-14
申请号：US13546339
申请日：2012-07-11
申请人： Rafael Davalos , Boris Rubinsky
发明人： Rafael Davalos , Boris Rubinsky
IPC分类号： A61B18/18 , A61B18/12 , A61N1/04 , A61B18/14 , A61N1/05 , A61N1/32
CPC分类号： A61B18/12 , A61B18/1233 , A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/1425 , A61N1/0412 , A61N1/0472 , A61N1/05 , A61N1/327
摘要： A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
摘要翻译：公开了一种用于消除不想要的组织的新方法，例如癌性或非癌性肿瘤的细胞。它涉及通过施加电脉冲将电极放置在不期望的组织附近或附近，从而在不期望的组织的整个区域内引起细胞的不可逆电穿孔。电脉冲不可逆地渗透细胞膜，从而引起细胞死亡。不可逆透化的细胞留在原位，并通过身体免疫系统去除。通过使用不可逆电穿孔而不引起热损伤可实现的组织消融量是相当大的。

5. 发明申请

US20120071874A1 TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION 有权
公开(公告)号：US20120071874A1
公开(公告)日：2012-03-22
申请号：US13237199
申请日：2011-09-20
申请人： Rafael Davalos , Boris Rubinsky
发明人： Rafael Davalos , Boris Rubinsky
IPC分类号： A61B18/14
CPC分类号： A61B18/12 , A61B18/1233 , A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/1425 , A61N1/0412 , A61N1/0472 , A61N1/05 , A61N1/327
摘要： A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.

6. 发明申请

US20070043345A1 Tissue ablation with irreversible electroporation 有权
标题翻译：组织消融与不可逆电穿孔
公开(公告)号：US20070043345A1
公开(公告)日：2007-02-22
申请号：US10571162
申请日：2004-12-21
申请人： Rafael Davalos , Boris Rubinsky
发明人： Rafael Davalos , Boris Rubinsky
IPC分类号： A61B18/14
CPC分类号： A61B18/12 , A61B18/1233 , A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/1425 , A61N1/0412 , A61N1/0472 , A61N1/05 , A61N1/327
摘要： A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
摘要翻译：公开了一种用于消除不想要的组织的新方法，例如癌性或非癌性肿瘤的细胞。它涉及通过施加电脉冲将电极放置在不期望的组织附近或附近，从而在不期望的组织的整个区域内引起细胞的不可逆电穿孔。电脉冲不可逆地渗透细胞膜，从而引起细胞死亡。不可逆透化的细胞留在原位，并通过身体免疫系统去除。通过使用不可逆电穿孔而不引起热损伤可实现的组织消融量是相当大的。

7. 发明授权

US08348921B2 Gels with predetermined conductivity used in electroporation of tissue 有权
标题翻译：具有预定电导率的凝胶用于组织电穿孔
公开(公告)号：US08348921B2
公开(公告)日：2013-01-08
申请号：US13427027
申请日：2012-03-22
申请人： Antoni Ivorra , Boris Rubinsky
发明人： Antoni Ivorra , Boris Rubinsky
IPC分类号： A61M31/00
CPC分类号： A61K9/0009 , A61K9/0024 , A61M5/329 , A61N1/042 , A61N1/327
摘要： Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
摘要翻译：公开了具有调节的电导率的凝胶组合物，其组合物用于引导细胞和组织的可逆电穿孔和不可逆电穿孔。凝胶组合物也以类似的方式使用，以对细胞和组织进行热疗。

8. 发明申请

US20120146621A1 VOLUMETRIC INDUCTION PHASE SHIFT DETECTION SYSTEM FOR DETERMINING TISSUE WATER CONTENT PROPERTIES 有权
标题翻译：用于确定组织水含量特性的体积感应相位移动检测系统
公开(公告)号：US20120146621A1
公开(公告)日：2012-06-14
申请号：US13329080
申请日：2011-12-16
申请人： Boris Rubinsky , Cesar A. Gonzalez
发明人： Boris Rubinsky , Cesar A. Gonzalez
IPC分类号： G01R25/00
CPC分类号： A61B5/0537 , A61B5/02042 , A61B5/0205 , A61B5/05 , A61B5/053 , A61B5/4064 , A61B5/413 , A61B5/4244 , A61B5/443 , A61B5/4519 , A61B5/4869 , A61B5/4878 , A61B5/7225 , A61B5/7228 , A61B5/725 , A61B2562/143 , G01N27/026 , G01R33/34 , G01R33/36 , G01R33/4828 , G01R33/483
摘要： A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample.
摘要翻译：通过以下步骤确定体组织样本的状况的方法和装置：将体组织样本定位在一对感应线圈（或天线）之间; 通过感应线圈（或天线）中的第一个通过交流（或电压）的频谱; 测量第二个感应线圈（或天线）中产生的交流（或电压）的频谱; 以及比较第一和第二感应线圈（或天线）中的交流电流（或电压）的频谱之间的相移，由此确定本体组织样本的状况。

9. 发明申请

US20110217730A1 SYSTEMS AND METHODS FOR ANALYZING AND MANIPULATING BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于分析和处理生物样品的系统和方法
公开(公告)号：US20110217730A1
公开(公告)日：2011-09-08
申请号：US13108038
申请日：2011-05-16
申请人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
发明人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
IPC分类号： C12Q1/04 , C12M1/42
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译：提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器细胞。

10. 发明授权

US07718409B2 Controlled electroporation and mass transfer across cell membranes 有权
标题翻译：受控的电穿孔和跨细胞膜的传质
公开(公告)号：US07718409B2
公开(公告)日：2010-05-18
申请号：US11340176
申请日：2006-01-25
申请人： Boris Rubinsky , Yong Huang
发明人： Boris Rubinsky , Yong Huang
IPC分类号： C12N13/00 , C12N15/01 , C12N15/87
CPC分类号： G01N33/48728 , C12M35/02 , C12N15/87
摘要： Electroporation is performed in a controlled manner in either individual or multiple biological cells or biological tissue by monitoring the electrical impedance, defined herein as the ratio of current to voltage in the electroporation cell. The impedance detects the onset of electroporation in the biological cell(s), and this information is used to control the intensity and duration of the voltage to assure that electroporation has occurred without destroying the cell(s). This is applicable to electroporation in general. In addition, a particular method and apparatus are disclosed in which electroporation and/or mass transfer across a cell membrane are accomplished by securing a cell across an opening in a barrier between two chambers such that the cell closes the opening. The barrier is either electrically insulating, impermeable to the solute, or both, depending on whether pore formation, diffusive transport of the solute across the membrane, or both are sought. Electroporation is achieved by applying a voltage between the two chambers, and diffusive transport is achieved either by a difference in solute concentration between the liquids surrounding the cell and the cell interior or by a differential in concentration between the two chambers themselves. Electric current and diffusive transport are restricted to a flow path that passes through the opening.
摘要翻译：通过监测电气阻抗（以本文定义为电穿孔细胞中的电流与电压之比），以受控的方式在单个或多个生物细胞或生物组织中进行电穿孔。阻抗检测生物细胞中电穿孔的发生，并且该信息用于控制电压的强度和持续时间，以确保电穿孔已经发生而不破坏细胞。这适用于一般的电穿孔。此外，公开了一种特定的方法和装置，其中穿过细胞膜的电穿孔和/或质量传递通过将细胞固定在两个室之间的屏障中的开口上而使细胞封闭开口来实现。屏障是电绝缘的，不溶于溶质的，或两者都是，这取决于是否需要孔形成，溶质在膜上的扩散传输或两者。通过在两个室之间施加电压来实现电穿孔，并且通过围绕电池和电池内部的液体之间的溶质浓度差或通过两个室本身之间的浓度差来实现扩散输送。电流和漫射传输限于通过开口的流路。

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