专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08431565B2 Substituted imidazoheterocycles 有权
标题翻译：取代的咪唑杂环
公开(公告)号：US08431565B2
公开(公告)日：2013-04-30
申请号：US12337683
申请日：2008-12-18
申请人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
发明人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
IPC分类号： A61K31/519 , C07D487/04 , A61P25/02
CPC分类号： C07D487/04
摘要： The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要翻译：本发明提供了具有式I结构的取代的咪唑并杂环化合物。还提供式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂和预防和治疗的大麻素受体相关疾病和病症，如疼痛，炎症和瘙痒。

2. 发明申请

US20090149450A1 SUBSTITUTED IMIDAZOHETEROCYCLES 有权
标题翻译：取代的咪唑啉酮
公开(公告)号：US20090149450A1
公开(公告)日：2009-06-11
申请号：US12337683
申请日：2008-12-18
申请人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
发明人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/5377 , A61P25/00 , A61K31/551
CPC分类号： C07D487/04
摘要： The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要翻译：本发明提供了具有式I结构的取代的咪唑并杂环化合物。还提供式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂和预防和治疗的大麻素受体相关疾病和病症，如疼痛，炎症和瘙痒。

3. 发明申请

US20110034443A1 USES OF SUBSTITUTED IMIDAZOHETEROCYCLES 有权
标题翻译：替代的咪唑啉酮的使用
公开(公告)号：US20110034443A1
公开(公告)日：2011-02-10
申请号：US12868815
申请日：2010-08-26
申请人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary G. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
发明人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary G. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
IPC分类号： A61K31/551 , A61K31/4985 , A61K31/5377 , A61P29/00 , A61P37/08 , A61P17/06 , A61P17/00 , A61P37/02 , A61P19/02 , A61P19/08 , A61P31/00 , A61P3/10 , A61P3/04 , A61P5/50 , A61P1/00 , A61P25/06
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides methods of prevention and treatment of cannabinoid receptor-associated diseases and conditions, wherein the method includes administering a substituted imidazoheterocyclic compounds having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate, solvate or stereoisomer of a compound having the structure of formula I. The cannabinoid receptor-associated diseases and conditions preventable or treatable by the methods of the present invention include pain, inflammation and pruritis.
摘要翻译：本发明提供了预防和治疗大麻素受体相关疾病和病症的方法，其中所述方法包括给予具有式I结构的取代的咪唑并杂环化合物或化合物的药学上可接受的盐，酸盐，水合物，溶剂合物或立体异构体具有式I的结构。通过本发明的方法可预防或可治疗的大麻素受体相关疾病和病症包括疼痛，炎症和瘙痒。

4. 发明申请

US20080318935A1 SUBSTITUTED IMIDAZOHETEROCYCLES 有权
标题翻译：取代的咪唑啉酮
公开(公告)号：US20080318935A1
公开(公告)日：2008-12-25
申请号：US12142846
申请日：2008-06-20
申请人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin
发明人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin
IPC分类号： A61K31/5517 , C07D487/04 , C07D471/04 , A61K31/4985 , A61K31/5377 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要翻译：本发明提供了具有式I结构的取代的咪唑并杂环化合物。还提供式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂和预防和治疗的大麻素受体相关疾病和病症，如疼痛，炎症和瘙痒。

5. 发明授权

US07517874B2 Substituted imidazo[1,5-a][1,4]diazepines and imidazo[1,5-a]pyrazines as cannabinoid receptor agonists for the treatment of pain 有权
标题翻译：取代的咪唑并[1,5-a] [1,4]二氮杂和咪唑并[1,5-a]吡嗪作为大麻素受体激动剂治疗疼痛
公开(公告)号：US07517874B2
公开(公告)日：2009-04-14
申请号：US12142846
申请日：2008-06-20
申请人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary G. Gustafson , Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin
发明人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary G. Gustafson , Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin
IPC分类号： A61K31/519 , C07D487/04 , A61P25/02
CPC分类号： C07D487/04
摘要： The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要翻译：本发明提供了具有式I结构的取代的咪唑并杂环化合物。还提供式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂和预防和治疗的大麻素受体相关疾病和病症，如疼痛，炎症和瘙痒。

6. 发明授权

US08859538B2 Uses of substituted imidazoheterocycles 有权
标题翻译：取代的咪唑并杂环的用途
公开(公告)号：US08859538B2
公开(公告)日：2014-10-14
申请号：US12868815
申请日：2010-08-26
申请人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary G. Gustafson , Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin
发明人： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary G. Gustafson , Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin
IPC分类号： A61P29/00 , A61P25/04 , A61K31/519 , C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides a method of prophylaxis, treatment or inhibition of a cannabinoid receptor-associated disease, disorder or condition in a mammalian subject, the method comprising administering to the subject a compound having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate or stereoisomer thereof, wherein the cannabinoid receptor-associated disease, disorder or condition is pain or an inflammatory disease, disorder or condition, and wherein formula I is as follows: wherein Rb, Rc, Z, Y and m are defined in the specification.
摘要翻译：本发明提供了在哺乳动物受试者中预防，治疗或抑制大麻素受体相关疾病，病症或病症的方法，所述方法包括向受试者施用具有结构式I的化合物或其药学上可接受的盐，酸盐，水合物或立体异构体，其中大麻素受体相关疾病，病症或病症是疼痛或炎性疾病，病症或病症，其中式I如下：其中Rb，Rc，Z，Y和m定义于规格。

7. 发明授权

US06660752B2 2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效
标题翻译：用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物
公开(公告)号：US06660752B2
公开(公告)日：2003-12-09
申请号：US10131448
申请日：2002-04-22
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K3144
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译：本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。

8. 发明授权

US06919371B2 2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效
标题翻译：用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物
公开(公告)号：US06919371B2
公开(公告)日：2005-07-19
申请号：US10666903
申请日：2003-09-17
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译：本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。

9. 发明授权

US06469065B1 Nitrosated and nitrosylated &agr;-adrenergic receptor antagonist, compositions and methods of use 失效
标题翻译：亚硝化和亚硝酰化α-肾上腺素能受体拮抗剂，组合物和使用方法
公开(公告)号：US06469065B1
公开(公告)日：2002-10-22
申请号：US09387724
申请日：1999-09-01
申请人： David S. Garvey , Joseph D. Schroeder , Inigo Saenez de Tejada , Ricky D. Gaston , Tatiana E. Shelekhin , Tiansheng Wang
发明人： David S. Garvey , Joseph D. Schroeder , Inigo Saenez de Tejada , Ricky D. Gaston , Tatiana E. Shelekhin , Tiansheng Wang
IPC分类号： A61K31135
CPC分类号： A61K45/06 , C07C381/00 , C07D211/62 , C07D233/24 , C07D239/95 , C07D401/04 , C07D405/12 , C07D459/00
摘要： The present invention describes novel nitrosated and/or nitrosylated &agr;-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated &agr;-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one &agr;-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.
摘要翻译：本发明描述了新的亚硝化和/或亚硝基化的α-肾上腺素能受体拮抗剂，以及含有至少一种亚硝化和/或亚硝基化的α-肾上腺素能受体拮抗剂的新组合物，以及任选的一种或多种捐赠，转移或释放一氧化氮的化合物提高内源性舒张因子的内源水平，刺激一氧化氮的内源性合成，或是一氧化氮合酶的底物和/或一种或多种血管活性剂。本发明还提供含有至少一种α-肾上腺素能受体拮抗剂和一种或多种捐赠，转移或释放一氧化氮的化合物的新型组合物，提高内源性内皮水平的内源性松弛因子，刺激一氧化氮的内源性合成，或是一种一氧化氮合酶的底物和/或一种或多种血管活性剂。本发明还提供了用于治疗或预防男性和女性性功能障碍的方法，用于增强男性和女性的性反应，以及用于治疗或预防良性前列腺增生，高血压，充血性心力衰竭，变体（印刷金属）心绞痛，青光眼，神经变性疾病，血管痉挛性疾病，认知障碍，急迫性尿失禁或膀胱过度活动，以及扭转麻醉状态。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式