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1. 发明授权

US12072304B2 Systems and methods for performing serial electron diffraction nanocrystallography 有权
$Systems and methods for performing serial electron diffraction nanocrystallography$
公开(公告)号：US12072304B2
公开(公告)日：2024-08-27
申请号：US17428737
申请日：2020-02-06
申请人： R. J. Dwayne Miller , Robert Bücker , Günther Kassier
发明人： R. J. Dwayne Miller , Robert Bücker , Günther Kassier
IPC分类号： G01N23/20058
CPC分类号： G01N23/20058 , G01N2223/401
摘要： Systems and methods are provided for serial, high-throughput acquisition of electron diffraction patterns from nanocrystals. Nanocrystals dispersed on a TEM grid are automatically identified from an overview image that is obtained, for example, using a dark field detector in scanning mode. Diffraction patterns are subsequently obtained from a plurality of crystals identified in the overview image by sequentially moving (e.g. scanning) the electron nanobeam relative to the crystals and collecting diffraction images using a fast electron camera. In some example embodiments, this sequence may be repeated for different tilt angles, where registration among overview images obtained at the different tilt angles is employed to position the electron nanobeam for the different tilt angles (e.g. before the sample stage is moved to interrogate a different sample region). The present methods may be automated, thereby facilitating unsupervised acquisition of arbitrarily large data sets.

2. 发明授权

US07630418B2 Laser system for generation of high-power sub-nanosecond pulses with controllable wavelength in 2-15 μm region 有权
标题翻译：用于产生2-15mum区域可控波长的大功率亚纳秒脉冲的激光系统
公开(公告)号：US07630418B2
公开(公告)日：2009-12-08
申请号：US11328462
申请日：2006-01-10
申请人： Kresimir Franjic , Darren Kraemer , Michael L. Cowan , Renzhong Hua , R. J. Dwayne Miller
发明人： Kresimir Franjic , Darren Kraemer , Michael L. Cowan , Renzhong Hua , R. J. Dwayne Miller
IPC分类号： H01S3/10
CPC分类号： G02F1/39 , A61B18/20 , A61C1/0046 , A61N2005/0659 , B23K26/0624 , B23K26/38 , B23K2103/32 , B23K2103/50 , G02F1/3534 , G02F2201/16 , G02F2203/11 , H01S3/0092 , H01S3/2383
摘要： A laser system capable of efficient production of high energy sub-nanosecond pulses in the 2-15 μm spectral region is disclosed. Diode pumped solid state lasers are used as pump sources. The system design is simple, reliable and compact allowing for easy integration. The laser system includes a combination of compact solid-state ˜1 micron laser sources, producing high power picosecond pulses, with optical parametric amplification and a quasi-continuous wave laser for seeding the amplification process that enables the efficient conversion of the high power ˜1 micron laser radiation to tuneable mid-infrared sub-ns pulses. New parametric processes are presented for achieving high gains in bulk nonlinear crystals. Furthermore, a method of exceeding the fundamental conversion efficiency limit of direct three wave mixing is presented. The compact and robust nature of this novel laser system opens up the use of high power and high peak power mid-infrared laser pulses to a wide variety of important medical and dental applications.
摘要翻译：公开了能够有效地生产2-15mum光谱区中的高能亚纳秒脉冲的激光系统。二极管泵浦固体激光器用作泵浦源。系统设计简单，可靠，紧凑，易于集成。激光系统包括紧凑型固态〜1微米激光源的组合，产生高功率皮秒脉冲，具有光学参数放大和准连续波激光器，用于播种放大过程，使得能够有效地转换高功率〜1 微米激光辐射可调谐中红外sub-ns脉冲。提出了新的参数化过程，以获得大量非线性晶体的高增益。此外，提出了一种超过直接三波混频的基本转换效率极限的方法。这种新颖的激光系统的紧凑和坚固的性质开启了大功率和高峰值功率的中红外激光脉冲对各种重要医疗和牙科应用的使用。

3. 发明授权

US5075795A Electro-optic device for optical signal processing at high repetition rates 失效
标题翻译：用于以高重复率进行光信号处理的电光装置
公开(公告)号：US5075795A
公开(公告)日：1991-12-24
申请号：US513525
申请日：1990-04-19
申请人： R. J. Dwayne Miller , Pierre Basseras
发明人： R. J. Dwayne Miller , Pierre Basseras
IPC分类号： G02F1/03 , G02F1/11
CPC分类号： G02F1/0305 , G02F1/11 , G02F2201/505
摘要： An electro-optic device, which processes by modulating, switching or gating, a light beam in response to an electrical signal utilizes an electro-optic crystal through which the beam to be processed passes. An electric field is generated by pulses which modulate the crystal's index of refraction and also causes piezoelectric ringing in the crystal. Acoustic energy absorbing material is coupled to the crystal for absorbing the piezoelectrically generated acoustic waves propagating perpendicularly to the applied electric field direction which has been found to be the dominant acoustic mode affecting the birefringence of the crystal and causing the ringing. The field is applied in short pulses (of the order of 10 nsec or less) thereby reducing lower frequencies in the acoustic energy spectrum thereby facilitating the absorption of the ringing energy. The modulation or gating of the optical beam may be carried out at high repetition rates which have heretofore limited the use of electro-optic devices to repetition rates of approximately 1 KHz or less.
摘要翻译：通过响应于电信号调制，切换或选通光束进行处理的电光装置利用电光晶体，待处理的光束穿过该光电晶体。通过调制晶体折射率的脉冲产生电场，并在晶体中产生压电振荡。声能吸收材料耦合到晶体，用于吸收垂直于所施加的电场方向传播的压电产生的声波，已经被发现是影响晶体的双折射并引起振铃的主要声学模式。该场以短脉冲（约为10nsec或更小）施加，从而降低声能谱中的较低频率，从而便于吸收能量。光束的调制或门控可以以高重复率进行，其以前限制了电光器件对大约1KHz或更小的重复率的使用。

4. 发明授权

US07852886B2 Reduction of surface heating effects in nonlinear crystals for high power frequency conversion of laser light 有权
标题翻译：降低非线性晶体的表面加热效应，实现激光的高功率变频
公开(公告)号：US07852886B2
公开(公告)日：2010-12-14
申请号：US12437502
申请日：2009-05-07
申请人： R. J. Dwayne Miller , Shujie Lin , Kresimir Franjic
发明人： R. J. Dwayne Miller , Shujie Lin , Kresimir Franjic
IPC分类号： H01S3/00
CPC分类号： G02F1/353 , G02F1/3525 , G02F1/3534 , G02F1/3551 , G02F2001/3503 , G02F2001/3509 , H01S3/0092
摘要： A device for generating a high power frequency converted laser beam includes a nonlinear optical crystal having an entrance surface and a curved surface. The nonlinear optical crystal is configured to receive at least one laser beam at the entrance surface and provide a frequency converted beam through a frequency conversion process. The device also includes an optical coating coupled to the curved surface. The reflectance of the optical coating is greater than 50% at a wavelength of the frequency converted beam. Additionally, the far field divergence angle of the frequency converted beam increases after reflection off the curved surface. The device further includes a heat sink in thermal contact with the optical coating.
摘要翻译：用于产生高功率频率转换的激光束的装置包括具有入射面和曲面的非线性光学晶体。非线性光学晶体被配置为在入射面处接收至少一个激光束，并通过频率转换处理提供频率转换的光束。该装置还包括耦合到弯曲表面的光学涂层。在频率转换光束的波长处，光学涂层的反射率大于50％。此外，频率转换光束的远场发散角在从曲面反射之后增加。该装置还包括与光学涂层热接触的散热器。

5. 发明授权

US07542490B2 Reduction of surface heating effects in nonlinear crystals for high power frequency conversion of laser light 有权
标题翻译：降低非线性晶体的表面加热效应，实现激光的高功率变频
公开(公告)号：US07542490B2
公开(公告)日：2009-06-02
申请号：US11739652
申请日：2007-04-24
申请人： R. J. Dwayne Miller , Shujie Lin , Kresimir Franjic
发明人： R. J. Dwayne Miller , Shujie Lin , Kresimir Franjic
IPC分类号： H01S3/10
CPC分类号： G02F1/353 , G02F1/3525 , G02F1/3534 , G02F1/3551 , G02F2001/3503 , G02F2001/3509 , H01S3/0092
摘要： A device for generating a frequency converted laser beam includes a nonlinear crystal having a first end face and a second end face opposed to the first end face. The nonlinear crystal is configured to receive at least one input laser beam at the first end face and output a frequency converted beam at the second face. A beam waist of the at least one input laser beam is positioned between the first end face and the second end face during a frequency conversion process. The device also includes a second crystal having a first end face bonded to the second end face of the nonlinear crystal and a second end face opposed to the first end face. A beam diameter of the frequency converted beam at the first end face of the second crystal is less than a beam diameter of the frequency converted beam at the second end face of the second crystal.
摘要翻译：用于产生变频激光束的装置包括具有与第一端面相对的第一端面和第二端面的非线性晶体。非线性晶体被配置为在第一端面处接收至少一个输入激光束并且在第二面处输出频率转换的光束。在频率转换过程中，至少一个输入激光束的束腰定位在第一端面和第二端面之间。该装置还包括具有接合到非线性晶体的第二端面的第一端面和与第一端面相对的第二端面的第二晶体。在第二晶体的第一端面处的频率转换光束的光束直径小于第二晶体的第二端面处的频率转换光束的光束直径。

6. 发明授权

US08110794B2 Soft ablative desorption method and system 有权
标题翻译：软烧蚀解吸方法和系统
公开(公告)号：US08110794B2
公开(公告)日：2012-02-07
申请号：US12656536
申请日：2010-02-02
申请人： R. J. Dwayne Miller
发明人： R. J. Dwayne Miller
IPC分类号： H01J49/04 , H01J49/16 , G01N1/28
CPC分类号： G01N1/405 , H01J49/0463 , Y10T436/25 , Y10T436/25125
摘要： Methods and systems are provided for the soft desorption of analyte from a sample, in which an optical beam absorbed within an irradiate zone of the sample causes vibrational excitations of a component within the sample. The optical beam, providing sufficient energy to superheat the component, is provided for a time interval that is less than the time duration required for the loss of energy out of the irradiated zone due to thermal diffusion and acoustic expansion. The superheated component thus drives ablation within the irradiated zone, resulting in the soft desorption of analyte without ionization and fragmentation. The ejected ablation plume may be directed towards the inlet of a mass analysis device for detection of the desorbed analyte, which is preferably ionized by a linear resonant photo-ionization step.
摘要翻译：提供了用于从样品软分解分析物的方法和系统，其中吸收在样品的照射区域内的光束引起样品内部件的振动激发。提供足够的能量以使部件过热的光束的时间间隔小于由于热扩散和声扩展而导致辐射区域的能量损失所需的持续时间。因此，过热部件驱动辐射区域内的烧蚀，导致分析物的软解吸附物质不会电离和破碎。喷射的消融羽流可以被引导到质量分析装置的入口，用于检测解吸附的分析物，其优选通过线性共振光电离步骤离子化。

7. 发明授权

US08029501B2 Laser selective cutting by impulsive heat deposition in the IR wavelength range for direct-drive ablation 有权
标题翻译：激光选择性切割通过脉冲热沉积在红外波长范围进行直接驱动消融
公开(公告)号：US08029501B2
公开(公告)日：2011-10-04
申请号：US11321057
申请日：2005-12-30
申请人： R. J. Dwayne Miller
发明人： R. J. Dwayne Miller
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61C1/0046 , B23K26/0624 , B23K26/36
摘要： The present invention provides a method of laser processing of materials, specifically laser induced ablation processes for laser removal of material particularly important in medical and dental applications in which the laser removal of material should be done in such a way as to not damage any of the surrounding soft or hard biomaterial. The ablation process is achieved by impulsive heat deposition (IHD) by direct and specific excitation of short lived vibrations or phonons of the material in such a way as to not generate highly reactive and damaging ions through multiphoton absorption. The heat deposition and ensuing ablation process under prescribed time and wavelength conditions for laser irradiation is achieved faster than heat transfer to surrounding tissue by either acoustic or thermal expansion or thermal diffusion that otherwise would lead to excess heat related damage. The result is that all the deposited laser energy is optimally channelled into the ablation process in which the inertially confined stresses from both photomechanical expansion forces and thermally driven phase transitions and associated volume changes constructively interfere to drive the most efficient ablation process possible with minimal damage to surrounding areas by either ionizing radiation or heat effects. By choosing a specific range of wavelengths, spatial and temporal shaping of infrared laser pulses, the energy can be optimally deposited in a manner that further increases the efficiency of the ablation process with respect to minimizing collateral damage.
摘要翻译：本发明提供一种激光处理材料的方法，特别是用于激光去除在医疗和牙科应用中特别重要的材料的激光去除技术的方法，其中激光去除材料应以不损坏任何材料的方式进行周围的软或硬生物材料。通过冲击热沉积（IHD）通过直接和特异性激发材料的短暂振动或声子来实现消融过程，以便通过多光子吸收不产生高反应性和有害的离子。在规定的时间和波长条件下，用于激光照射的热沉积和随后的消融过程比通过声学或热膨胀或热扩散的热传递到周围组织的速度快，否则将导致过度的热相关损伤。结果是，所有沉积的激光能量被最佳地引导到消融过程中，其中来自光机械膨胀力和热驱动相变和相关联体积变化的惯性约束应力构造地干涉以驱动最有效的消融过程，同时以最小的损伤通过电离辐射或热效应的周围区域。通过选择特定范围的波长，红外激光脉冲的空间和时间成形，可以以进一步提高消融过程效率以减少附带损伤的方式来最佳地沉积能量。

8. 发明申请

US20090296199A1 Laser amplifiers with high gain and small thermal aberrations 审中-公开
公开(公告)号：US20090296199A1
公开(公告)日：2009-12-03
申请号：US12453625
申请日：2009-05-15
申请人： Kresimir Franjic , Renzhong Hua , R. J. Dwayne Miller
发明人： Kresimir Franjic , Renzhong Hua , R. J. Dwayne Miller
IPC分类号： H01S5/00 , H01S3/042 , H01S3/0941
CPC分类号： H01S3/0941 , H01S3/005 , H01S3/025 , H01S3/0407 , H01S3/042 , H01S3/0604 , H01S3/0606 , H01S3/0612 , H01S3/0615 , H01S3/0632 , H01S3/094053 , H01S3/094057 , H01S3/094084 , H01S3/1611 , H01S3/1673 , H01S3/2333 , H01S3/2341 , H01S2301/02
摘要： The present invention discloses a laser amplifier with high gain and low thermally induced optical aberrations on the amplified laser beam. The amplifier designs allow simple multipass configurations to optimally extract the gain and reduce thermally induced index of refraction aberrations, making it possible to obtain an amplified laser beam of high quality combined with very high overall gains comparable to those achievable with expensive regenerative amplifiers. The amplifier includes a thin active laser solid to create the population inversion and associated heat generation within the thin laser active solid possible for the desired gain value. The system includes a cooling device in thermal contact with the thin active laser solid to provide good heat transport and high reflectivity coatings at the wavelengths of the pump and laser wavelengths. The pump light sources are laser diodes tuned to the maximum absorption of the laser active material. The amplifier also includes an optical system to transport the pump light to the laser active solid in such a way as to further confine the absorption of light along the two orthogonal directions in the plane of the laser active solid in order to get high population inversion and consequently high gains possible.

9. 发明授权

US06297894B1 Optical scheme for holographic imaging of complex diffractive elements in materials 有权
$Optical scheme for holographic imaging of complex diffractive elements in materials$
标题翻译：材料中复杂衍射元素的全息成像光学方案
公开(公告)号：US06297894B1
公开(公告)日：2001-10-02
申请号：US09385999
申请日：1999-08-30
申请人： R. J. Dwayne Miller , Gregory D. Goodno
发明人： R. J. Dwayne Miller , Gregory D. Goodno
IPC分类号： G03H104
CPC分类号： G03H1/0248 , G02B5/1857 , G02B5/32 , G02B6/02133 , G02B6/124 , G02B2006/12107 , G03H2210/12 , G03H2210/20
摘要： This invention discloses optical system and method for writing a refractive index pattern in a light transmissive or light absorbing sample. A light source for providing a short pulse laser beam in the femtosecond range having a low power per unit area is coupled to provide the short pulse beam to a diffractive optical element. A curved mirror collects light transmitted through or reflected from the diffractive optical element preserves an image relating to characteristics of the diffractive optical element encoded within the collected light, and directs the collected light in wavelength independent manner while preserving the image of the diffractive optical element encoded within the collected light. A rod lens demagnifies the image within the light received from the curved mirror so as to increase its power per unit area when directed to the light transmissive or absorbing sample to be permanently impressed therein.
摘要翻译：本发明公开了一种在透光或光吸收样品中写入折射率图案的光学系统和方法。用于在具有每单位面积的低功率的飞秒范围内提供短脉冲激光束的光源被耦合以向衍射光学元件提供短脉冲光束。收集透射通过衍射光学元件或从衍射光学元件反射的光的曲面镜保留与所收集的光中编码的衍射光学元件的特性有关的图像，并且以波长独立的方式引导收集的光，同时保持被编码的衍射光学元件的图像在收集的光下。棒状透镜在从弯曲镜接收的光中对图像进行缩小，以便当指向透光或吸收样品以在其中永久地印刷时增加其每单位面积的功率。

10. 发明申请

US20120041428A1 LASER SELECTIVE CUTTING BY IMPULSIVE HEAT DEPOSITION IN THE IR WAVELENGTH RANGE FOR DIRECT-DRIVE ABLATION 审中-公开
标题翻译：激光选择性切割在IR波长范围内用于直接驱动吸收的热沉积
公开(公告)号：US20120041428A1
公开(公告)日：2012-02-16
申请号：US13240531
申请日：2011-09-22
申请人： R. J. Dwayne Miller
发明人： R. J. Dwayne Miller
IPC分类号： A61B18/20 , A61B18/22
CPC分类号： A61B18/20 , A61C1/0046 , B23K26/0624 , B23K26/36
摘要： A method of laser processing of materials and specifically laser induced ablation processes for laser removal of material by impulsive heat deposition (IHD) by direct and specific excitation of short lived vibrations or phonons of the material in such a way as to not generate highly reactive and damaging ions through multiphoton absorption. The heat deposition and ensuing ablation is achieved faster than heat transfer to surrounding tissue by either acoustic or thermal expansion or thermal diffusion. The deposited laser energy is channeled into the ablation process to drive the most efficient ablation process possible with minimal damage to surrounding areas by either ionizing radiation or heat effects.
摘要翻译：激光处理材料的方法，特别是通过冲击热沉积（IHD）激光去除材料的激光诱导消融方法，通过直接和特异性地激发材料的短暂的振动或声子，使得不产生高反应性和通过多光子吸收损伤离子。通过声学或热膨胀或热扩散，热沉积和随后的消融实现得比传递到周围组织的热量快。将沉积的激光能量引入消融过程中，以通过电离辐射或热效应以最小的对周围区域的损伤来驱动最有效的消融过程。

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