专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008020260A3 USE OF SIDEROPHORES IN PREVENTION OF VASCULAR DISEASES, PRODUCTION OF SIDEROPHORES AND QUALIFYING SIDEROPHORE CONTAINING MEAT-PRODUCTS 审中-公开
标题翻译：在预防血管疾病中的应用，生产外来食品和鉴定包含肉制品的食品
公开(公告)号：WO2008020260A3
公开(公告)日：2008-10-02
申请号：PCT/HU2007000076
申请日：2007-08-16
申请人： R KO N KFT , BALLA JOZSEF , BALLA GYOERGY , POCSI ISTVAN , FESUES LASZLO , JENEY VIKTORIA , POCSI IMRE , EMRI TAMAS , GYEMANT GYOENGYI , ROMAN GYULA , KOVACS ISTVAN
发明人： BALLA JOZSEF , BALLA GYOERGY , POCSI ISTVAN , FESUES LASZLO , JENEY VIKTORIA , POCSI IMRE , EMRI TAMAS , GYEMANT GYOENGYI , ROMAN GYULA , KOVACS ISTVAN
IPC分类号： A61K31/395 , A23L13/40 , A61K38/05 , A61K38/12 , A61P9/10 , C12P21/02 , C12P21/04 , G01N33/12
CPC分类号： A61K31/395 , A61K38/12 , C12P17/12 , C12P21/02
摘要： The invention relates to the use of fungal siderophores in the treatment of vascular diseases primarily caused by endothelial cell origin, which compounds are especially useful for oral application. Furthermore, the invention relates to a preferred route of production of fungal siderophores by using specifically isolated and selected species of fungi, foods, preferably meat products, especially sausage and salami, which contain siderophores in controlled and efficient amount. The invention also relates to a qualifying system to determine if different foods have preventive effect on the vasculature as described above.
摘要翻译：本发明涉及真菌载体在治疗主要由内皮细胞起源引起的血管疾病中的用途，该化合物特别适用于口服应用。此外，本发明涉及通过使用特定分离和选择的真菌，食品，优选肉制品，特别是香肠和萨拉米香肠的特定种类的真菌铁载体的生产的优选途径，其含有受控和有效量的铁载体。本发明还涉及一种鉴定系统，以确定不同的食物对上述血管系统具有预防作用。

2. 发明专利

HU0700535A2 SIDEROFOR USE FOR TREATMENT VASCULAR SYSTEM, PROCESS FOR PRODUCING SIDEROFOR, AND MEAT PRODUCT THAT CONTAIN SIDEROFOR AND QUALIFICATION THEREOF 未知
公开(公告)号：HU0700535A2
公开(公告)日：2008-05-28
申请号：HU0700535
申请日：2007-08-14
申请人： R KO N KFT
发明人： BALLA JOZSEF DR , BALLA GYOERGY DR , POCSI ISTVAN DR , FESUES LASZLO DR , JENEY VIKTORIA DR , POCSI IMRE , EMRI TAMAS DR , GYEMANT GYOENGYI DR , ROMAN GYULA , KOVACS ISTVAN
IPC分类号： A23L13/00 , C12N1/00
摘要： In the preparation of pharmaceutical composition for treatment of vascular diseases primarily with endothelial cell origin, fungal desferri-siderophores are used. Independent claims are included for the following: (1) preparing desferricoprogen group of formula (I), desferrichrome group of formula (II) and desferri-triacyl fuzarinine C involving culturing fungi on culture medium containing mineral salts, carbon and nitrogen source and purifying siderophores from the liquid medium. The fungi strains (S1) are selected from Penicillium chrysogenum, Penicillium roqueforti, Neurospora crassa, Penicillium roqueforti, Ustilago sphaerogena, Ustilago maydis, Neovossia indica, Aspergillus ochraceus or Aspergillus melleus; (2) introduction of siderophores into the siderophore containing meat-products involving mixing directly into the pasta isolated siderophores, or mixing directly into the pasta (S1), or introducing on the surface of the meat-products water solubilized (S1) during the curing step; and (3) qualification and quantification of siderophore content of meat-products involving comparing to the required siderophore amount of a healthy individual. R1H, 1-6C alkyl or 1-4C hydroxy-alkyl; R2R1 or 1-6C alkanoyl;and R3-R51-6C alkyl or 2-6C alkanoyl substituted by one or two hydroxy or carboxy. ACTIVITY : Vasotropic; Antiarteriosclerotic. The protective effects of desferricoprogen against human low density lipoprotein oxidation was determined as follows: Human low density lipoprotein (LDL) was isolated from plasma derived from ethylene diamine tetraacetic acid (EDTA) (1 mg/ml)-anticoagulated venous blood. Heme-mediated oxidation of LDL was obtained by reacting LDL (200 mg/l protein), heme (5 mu M), hydrogen peroxide (75 mu M), 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid (HEPES) buffer (10 mM), and desferricoprogen (10-250 mu M) for 2 hours at 37[deg] C. Results showed that desferricoprogen inhibited the conjugated diene generation by prolonging the initiation phase of the lipid peroxidation. MECHANISM OF ACTION : None given.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式