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1. 发明授权

US06500817B1 Thiazolyl urea derivatives and their utilization as antiviral agents 失效
标题翻译：噻唑脲衍生物及其作为抗病毒剂的利用
公开(公告)号：US06500817B1
公开(公告)日：2002-12-31
申请号：US09914554
申请日：2001-08-31
申请人： Rüdiger Fischer , Gerald Kleymann , Judith Baumeister , Wolfgang Bender , Ulrich Betz , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Udo Schneider , Olaf Weber , Kerstin Henninger , Axel Jensen , Jörg Keldenich
发明人： Rüdiger Fischer , Gerald Kleymann , Judith Baumeister , Wolfgang Bender , Ulrich Betz , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Udo Schneider , Olaf Weber , Kerstin Henninger , Axel Jensen , Jörg Keldenich
IPC分类号： A61K31426
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/54 , C07D417/12 , C07D487/04
摘要： The present invention relates to thiazolylurea derivatives, a process for their preparation, and their use as pharmaceuticals, in particular as antiviral pharmaceuticals.
摘要翻译：本发明涉及噻唑基脲衍生物，其制备方法及其作为药物，特别是作为抗病毒药物的用途。

2. 发明授权

US07105553B2 Thiazolyl amide derivatives 有权
标题翻译：噻唑基酰胺衍生物
公开(公告)号：US07105553B2
公开(公告)日：2006-09-12
申请号：US10168197
申请日：2000-12-12
申请人： Rüdiger Fischer , Gerald Kleymann , Ulrich Betz , Judith Baumeister , Wolfgang Bender , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Kerstin Henninger , Axel Jensen , Jörg Keldenich , Udo Schneider , Olaf Weber
发明人： Rüdiger Fischer , Gerald Kleymann , Ulrich Betz , Judith Baumeister , Wolfgang Bender , Peter Eckenberg , Gabriele Handke , Martin Hendrix , Kerstin Henninger , Axel Jensen , Jörg Keldenich , Udo Schneider , Olaf Weber
IPC分类号： A61K31/426 , C07D277/54
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/54 , C07D417/12 , C07F7/1804 , C07F9/6539
摘要： The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
摘要翻译：本发明涉及新化合物，其制备方法及其用作药物，特别是抗病毒药物。

3. 发明申请

US20070004735A1 Method for inhibiting the replication of herpes viruses 审中-公开
标题翻译：抑制疱疹病毒复制的方法
公开(公告)号：US20070004735A1
公开(公告)日：2007-01-04
申请号：US10541886
申请日：2003-12-24
申请人： Ulrich Betz , Guy Hewlett , Gerald Kleymann , Thomas Lampe , Tse-I Lin , Susanne Nikolic , Jurgen Reefshlager , Tobias Wunberg , Holger Zimmerman , Franz Zumpe , Wolfgang Bender , Kerstin Henninger , Axel Jensen , Jorg Keldenich , Rudolf Schohe-Loop
发明人： Ulrich Betz , Guy Hewlett , Gerald Kleymann , Thomas Lampe , Tse-I Lin , Susanne Nikolic , Jurgen Reefshlager , Tobias Wunberg , Holger Zimmerman , Franz Zumpe , Wolfgang Bender , Kerstin Henninger , Axel Jensen , Jorg Keldenich , Rudolf Schohe-Loop
IPC分类号： C12Q1/70 , A61K31/50 , A61K31/17 , C07C271/28
CPC分类号： C07C311/08 , C07C275/40 , C07D237/04 , G01N33/56994 , G01N2500/00
摘要： The invention relates to a method for inhibiting the replication of herpesviruses, to methods for identifying compounds which inhibit the replication of herpesviruses using this method, to compounds having activity against herpesviruses, to methods for their preparation and to their use for producing medicaments for the treatment of herpes infections.
摘要翻译：本发明涉及一种抑制疱疹病毒复制的方法，用于鉴定使用该方法抑制疱疹病毒复制的化合物的方法，具有抗疱疹病毒活性的化合物，其制备方法及其用于制备治疗药物的用途的疱疹感染。

4. 发明申请

US20050059658A1 Pyridazinone 审中-公开
标题翻译：哒嗪酮
公开(公告)号：US20050059658A1
公开(公告)日：2005-03-17
申请号：US10482520
申请日：2002-06-17
申请人： Tobias Wunberg , Ulrich Betz , Sabine Hallenberger , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Franz Zumpe , Marcus Bauser , Wolfgang Bender , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Axel Jensen , Jorg Keldenich , Holger Zimmermann
发明人： Tobias Wunberg , Ulrich Betz , Sabine Hallenberger , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Franz Zumpe , Marcus Bauser , Wolfgang Bender , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Axel Jensen , Jorg Keldenich , Holger Zimmermann
IPC分类号： A61K31/50 , A61K31/501 , A61P31/12 , C07D237/04 , C07D237/32 , C07D417/12
CPC分类号： C07D417/12 , C07D237/04 , C07D237/32
摘要： The invention relates to novel compounds, to a method for the production of said compounds and to the use thereof as medicaments, more particularly as antiviral agents, especially against cytomegalovirus.
摘要翻译：本发明涉及新化合物，所述化合物的制备方法及其作为药物的用途，更特别地涉及抗病毒剂，特别是抗巨细胞病毒。

5. 发明授权

US07125995B2 Substituted amidoalkyl uracils and their use as inhibitors of the poly(adp-ribose) synthetase (PARS) 失效
标题翻译：取代的酰氨基烷基尿嘧啶及其作为聚（adp-核糖）合成酶（PARS）的抑制剂的用途
公开(公告)号：US07125995B2
公开(公告)日：2006-10-24
申请号：US10416622
申请日：2001-11-02
申请人： Barbara Albrecht , Michael Gerisch , Gabriele Handke-Ergüden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人： Barbara Albrecht , Michael Gerisch , Gabriele Handke-Ergüden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号： C07D239/70 , C07D493/04 , C07D495/04 , A61K31/517 , A61P9/10
CPC分类号： C07D231/12 , C07D233/56 , C07D239/96 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D495/04
摘要： This application relates to compounds of formula (I) below in which the several variable groups are as defined in the specification and claims, to methods of preparing these materials, to pharmaceutical compositions containing these materials, and to methods of using these materials to treat ischaemia or reperfusion damage.
摘要翻译：本申请涉及以下式（I）的化合物，其中几个可变基团如说明书和权利要求中所定义，制备这些材料的方法，含有这些材料的药物组合物以及使用这些材料来治疗局部缺血的方法或再灌注损伤。

6. 发明授权

US06649618B2 Substituted amidoalkyl-uracils and their use 失效
标题翻译：取代的酰氨基烷基尿嘧啶及其用途
公开(公告)号：US06649618B2
公开(公告)日：2003-11-18
申请号：US09906296
申请日：2001-07-16
申请人： Michael Härter , Barbara Albrecht , Michael Gerisch , Gabriele Handke , Joachim Hütter , Axel Jensen , Thomas Krahn , Joachim Mittendorf , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人： Michael Härter , Barbara Albrecht , Michael Gerisch , Gabriele Handke , Joachim Hütter , Axel Jensen , Thomas Krahn , Joachim Mittendorf , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号： C07D491048
CPC分类号： C07D401/06 , C07D239/96 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Novel amidoalkyl-uracil derivatives of the formula (I) in which A represents 1-3 ring atoms and X represents optionally substituted (C2-C10)alkylene or (C3-C8)cycloalkylene as defined in claim 1, a process for their preparation, and their use as medicaments for the prophylaxis and/or treatment of disorders are described.
摘要翻译：式（I）的新型酰氨基烷基 - 尿嘧啶衍生物，其中A表示1-3个环原子，X表示如权利要求1所定义的任选取代的（C 2 -C 10）亚烷基或（C 3 -C 8）亚环烷基，其制备方法，并描述其用作预防和/或治疗病症的药物。

7. 发明申请

US20050075347A1 Substituted amidoalkyl uracils and their use as inhibitors of the poly(adp-ribose) synthetase (pars) 失效
标题翻译：取代的酰氨基烷基尿嘧啶及其作为聚（adp-核糖）合成酶（pars）抑制剂的用途
公开(公告)号：US20050075347A1
公开(公告)日：2005-04-07
申请号：US10416622
申请日：2001-11-02
申请人： Barbara Albrecht , Michael Gerisch , Gabriele Handke-Erguden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人： Barbara Albrecht , Michael Gerisch , Gabriele Handke-Erguden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号： C07D239/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D519/00 , C07D521/00 , A61K31/519
CPC分类号： C07D231/12 , C07D233/56 , C07D239/96 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The invention relates to novel amidoalkyl uracil derivatives of formula (I), to a method for the production thereof, and to their use as medicament active substances for the prophylaxis and/or treatment of medical disorders.
摘要翻译：本发明涉及式（I）的新型酰氨基烷基尿嘧啶衍生物，其制备方法及其作为用于预防和/或治疗医学病症的药物活性物质的用途。

8. 发明申请

US20050027456A1 Method and arrangement for signal loop test 有权
公开(公告)号：US20050027456A1
公开(公告)日：2005-02-03
申请号：US10840820
申请日：2004-05-07
申请人： Jonas Rosenberg , Fredrik Lindqvist , Adam Wia , Antoni Fertner , Axel Jensen , Per Borjesson , Per Odling
发明人： Jonas Rosenberg , Fredrik Lindqvist , Adam Wia , Antoni Fertner , Axel Jensen , Per Borjesson , Per Odling
IPC分类号： G01R27/28 , G01V1/00 , H04M3/30
CPC分类号： G01R27/04 , H04B3/46 , H04M1/24 , H04M3/305 , H04M3/306
摘要： The invention refers to single-ended test of a loop with the aid of a transceiver, wherein an input impedance (Zm(ƒ)) of the loop is generated. The transceiver has a digital part, a codec and an analog part and is connected to the loop. With the aid of a transmitted and a reflected broadband signal (vin, vout) an echo transfer function Hecho(ƒ)=V(f)out/Vin(f) is generated, which also can be expressed as H echo ⁡ ( f ) = H ∞ ⁡ ( f ) ⁢ Z in ⁡ ( f ) + Z h0 ⁡ ( f ) Z in ⁡ ( f ) + Z hyb ⁡ ( f ) Here Zh0(ƒ), Zhyb(ƒ) and H∞(ƒ) are model values for the transceiver. In a calibration process a test transceiver, with the same type of hardware as the transceiver, is connected to known impedances, replacing the loop. Hecho(ƒ)=V(f)out/Vin(f) is generated for the known impedances and the model values are generated and are stored in a memory in the transceiver. The stored model values are then used when the input impedance (Zin(ƒ)) for the loop is generated after a measurement of the broadband signal (Vin, vout) is performed.

9. 发明授权

US4035701A Method of stepwise speed control and three-phase squirrel-cage motor 失效
标题翻译：逐步调速和三相鼠笼式电动机的方法
公开(公告)号：US4035701A
公开(公告)日：1977-07-12
申请号：US562456
申请日：1975-03-27
申请人： Axel Jensen
发明人： Axel Jensen
IPC分类号： H02P1/32
摘要： A method of stepwise speed control, and three-phase squirrel-cage motor, that comprises main windings connected either in a delta or in a star circuit, the main windings being connected to at least one set of additional windings that are also connected either in delta or in star. The method permits at least five different speeds of rotation without the use of a transformer.
摘要翻译：一种逐步速度控制的方法和三相鼠笼式电动机，其包括以三角形或星形电路连接的主绕组，主绕组连接至至少一组额外的绕组，其还连接在三角洲或星形。该方法允许至少五个不同的旋转速度，而不使用变压器。

10. 发明申请

US20070043511A1 Method for generating a hierarchical topological tree of 2D or 3D-structural formulas of chemical compounds for property optimisation of chemical compounds 审中-公开
标题翻译：用于生成用于化学化合物性质优化的化合物的2D或3D结构式的分层拓扑树的方法
公开(公告)号：US20070043511A1
公开(公告)日：2007-02-22
申请号：US11588894
申请日：2006-10-27
申请人： Axel Jensen , Stefan Seidler
发明人： Axel Jensen , Stefan Seidler
IPC分类号： G06F19/00
CPC分类号： G16C20/80
摘要： The invention concerns a new method for automatically and dynamically generating hierarchical topological trees of 2D- or 3D-structural formulas for structurally characterized chemical compounds, especially drug-like molecules, wherein the molecular graph of each 2D- or 3D-structure for a chemical compound is analyzed in terms of topological key features, the Largest Topological Substructure (LTS) and the proper Topological Cluster Centre (TCC) are created for each molecular graph, the ranking of the classes of topological key features and/or the ranking within each class of topological key features present in the TCC is used to generate a connected hierarchical Topological Sequence Path (TSP) of sentinel molecules from each molecular graph, and different molecular graphs and their Topological Sequence Paths (TSPs) share common vertices for common topological key features thus growing a Topological Structure Tree (TST), each chemical compound from the input stream is attached as a leaf node to the appropriate Largest Topological Substructure (LTS) node in the tree.
摘要翻译：本发明涉及用于自动和动态地生成用于结构特征化学化合物，特别是药物样分子的2D或3D结构式的分层拓扑树的新方法，其中化学化合物的每个2D或3D结构的分子图根据拓扑关键特征进行分析，为每个分子图创建最大拓扑结构（LTS）和适当的拓扑聚类中心（TCC），拓扑关键特征类别和/或每类分类中的排名 TCC中存在的拓扑关键特征用于从每个分子图生成前哨分子的连接分层拓扑序列路径（TSP），并且不同的分子图及其拓扑序列路径（TSP）共享常见的拓扑关键特征的常见顶点，从而增长拓扑结构树（TST），来自输入流的每种化合物作为叶子附着节点到树中适当的最大拓扑子结构（LTS）节点。

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