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1. 发明授权

US06586402B1 LH-RH peptide analogues, their uses and pharmaceutical compositions containing them 失效
标题翻译： LH-RH肽类似物，其用途和含有它们的药物组合物
公开(公告)号：US06586402B1
公开(公告)日：2003-07-01
申请号：US09450443
申请日：1999-11-30
申请人： Rémi Delansorne , Jacques Paris
发明人： Rémi Delansorne , Jacques Paris
IPC分类号： A61K3809
CPC分类号： C07K7/23 , A61K38/00
摘要： The invention relates to LH-RH peptide analogues with excellent affinity for LH-RH receptors, of the formula: A1-A2-A3-A4-A5-A6-HAA-A7-Pro-Z (I) The invention also relates to the uses of said peptide analogues and to the pharmaceutical compositions containing them.
摘要翻译：本发明涉及对LH-RH受体具有优异亲和力的LH-RH肽类似物，具有下式：本发明还涉及所述肽类似物和含有它们的药物组合物的用途。

2. 发明申请

US20130172300A1 NEW HORMONAL COMPOSITION AND ITS USE 审中-公开
标题翻译：新型HORMONAL组合物及其用途
公开(公告)号：US20130172300A1
公开(公告)日：2013-07-04
申请号：US13448953
申请日：2012-04-17
申请人： Jacques Paris , Jean-Louis Thomas
发明人： Jacques Paris , Jean-Louis Thomas
IPC分类号： A61K31/57 , A61K31/567 , A61K31/565
CPC分类号： A61K31/57 , A61K31/565 , A61K31/567 , A61K45/06 , A61K2300/00
摘要： A method of preventing estrogen deficiencies and osteoporosis in menopausal women by continuously orally administering without interruption to menopausal women in need thereof an amount of 0.3 to 3 mg of 17β-estradiol or esters thereof and 0.3 to 1.25 mg of nomegestrol or esters thereof in an amount sufficient to prevent said problems.
摘要翻译：一种通过不间断地口服给予需要的绝经妇女不断口服绝经期女性的雌激素缺乏和骨质疏松症的方法，其量为0.3至3mg，17β-雌二醇或其酯，和0.3至1.25mg的炔雌醇或其酯，足以防止所述问题。

3. 发明授权

US3994819A Method for the preparation of acicular particles containing iron and other divalent metals 失效
标题翻译：制备含铁和其他二价金属的针状颗粒的方法
公开(公告)号：US3994819A
公开(公告)日：1976-11-30
申请号：US610720
申请日：1975-09-05
申请人： Paul Mollard , Jacques Paris , Abel Rousset
发明人： Paul Mollard , Jacques Paris , Abel Rousset
IPC分类号： C01G49/06 , G11B5/706 , C04B35/26
CPC分类号： G11B5/70642 , C01G49/06 , C01P2002/52 , C01P2004/03 , C01P2004/10 , C01P2004/61 , C01P2004/62
摘要： The invention concerns the preparation of acicular particles of mixed oxalates of iron and of one or more metals of the group consisting of cobalt, nickel, copper, manganese, zinc, magnesium and cadmium. The method consists in preparing a first solution containing cations of iron and of the divalent metal or metals, and a second solution containing oxalic acid, one of the said solutions further containing Cl.sup.- and SO.sub.4.sup.2.sup.- anions and at least the second solution containing alcohol with preferably a light hydrocarbon. The first solution is poured very slowly (1 drop every 10 seconds) into the second one, conveniently at temperature below 0.degree. C, while the latter is strongly stirred. The concentration in alcohol is preferably maintained at at least 50% in the second solution during the whole pouring process which should be effected with at least a slight excess of oxalic acid. The particles obtained may be treated for the preparation of solid solutions of oxides of iron and of the divalent metal or metals for the manufacture of magnetic tapes and the like.
摘要翻译：本发明涉及制备铁和由钴，镍，铜，锰，锌，镁和镉组成的组中的一种或多种金属的混合草酸铁的针状颗粒。该方法包括制备含有铁阳离子和二价金属或金属的第一溶液和含有草酸的第二溶液，所述溶液中的一种还含有Cl - 和SO42-阴离子，并且至少第二溶液含有优选轻质烃的醇的溶液。将第一溶液非常缓慢地（在每10秒滴1次）倒入第二溶液中，方便地在低于0℃的温度下，同时将其强烈搅拌。在整个浇注过程中，醇中的浓度优选在第二溶液中保持至少50％，这应该至少少量过量的草酸进行。所获得的颗粒可以用于制备铁氧化物和二价金属或金属的固溶体以制造磁带等。

4. 发明授权

US09084796B2 Hormonal composition and its use 有权
标题翻译：激素成分及其用途
公开(公告)号：US09084796B2
公开(公告)日：2015-07-21
申请号：US13448953
申请日：2012-04-17
申请人： Jacques Paris , Jean-Louis Thomas
发明人： Jacques Paris , Jean-Louis Thomas
IPC分类号： A61K31/56 , A61K31/57 , A61K31/565 , A61K45/06 , A61K31/567
CPC分类号： A61K31/57 , A61K31/565 , A61K31/567 , A61K45/06 , A61K2300/00
摘要： A method of preventing estrogen deficiencies and osteoporosis in menopausal women by continuously orally administering without interruption to menopausal women in need thereof an amount of 0.3 to 3 mg of 17β-estradiol or esters thereof and 0.3 to 1.25 mg of nomegestrol or esters thereof in an amount sufficient to prevent said problems.
摘要翻译：一种通过持续口服给予需要的绝经妇女不断口服绝经期妇女的雌激素缺乏和骨质疏松症的方法，其量为0.3至3mg的17-雌二醇或其酯和0.3至1.25mg的孕烯雌酚或其酯足以防止所述问题。

5. 发明申请

US20050124842A1 Method for destroying a nuclear graphite by gasification in aqueous medium 失效
标题翻译：在水性介质中通过气化破坏核石墨的方法
公开(公告)号：US20050124842A1
公开(公告)日：2005-06-09
申请号：US10498700
申请日：2002-12-10
申请人： Jacques Paris , Jean-Raymond Costes
发明人： Jacques Paris , Jean-Raymond Costes
IPC分类号： B01J19/08 , B02C19/18 , B09B5/00 , C10J3/18 , G21F9/30 , G21F9/00
CPC分类号： C10J3/723 , B02C19/18 , B02C2019/183 , C10J3/18 , C10J2200/12 , C10J2200/33 , C10J2300/09 , G21F9/30 , G21Y2004/60
摘要： A process for the treatment of a nuclear graphite contaminated with radioelements includes subjecting the graphite, immersed in a medium containing water, to high-voltage pulses. The pulses have sufficient energy for electric arcs to be initiated and to break the constituent bonds of the water molecules and the carbon-carbon bonds of the graphite. The number of high-voltage pulses is determined so as to convert the graphite into gas.
摘要翻译：用于处理被放射性元素污染的核石墨的方法包括将浸入含水介质的石墨进行高压脉冲。脉冲具有足够的能量来启动电弧并破坏水分子的组成键和石墨的碳 - 碳键。确定高压脉冲的数量以将石墨转化为气体。

6. 发明授权

US4096080A Solid solutions of magnetic oxides and method of preparation 失效
标题翻译：磁性氧化物的固体溶液及其制备方法
公开(公告)号：US4096080A
公开(公告)日：1978-06-20
申请号：US622573
申请日：1975-10-15
申请人： Paul Mollard , Jacques Paris , Abel Rousset
发明人： Paul Mollard , Jacques Paris , Abel Rousset
IPC分类号： C04B35/26
CPC分类号： C04B35/265 , C04B35/2625 , C04B35/2658 , C04B35/2666 , C04B35/2683
摘要： The invention concerns solid solutions of oxides of iron and of a divalent metal other than cobalt Co.sup.2+ or, alternatively, of iron and of more than one divalent metal, including cobalt. Besides Co, the divalent metals may be Ni, Cu, Mn, Zn, Mg and Cd. Such solutions are prepared by precipitating a mixed oxalate containing iron and the other divalent metal or metals desired. This mixed oxalate is decomposed by heating it in open air at a progressively increasing temperature until carbon is eliminated but without forming rhomboedric oxide .alpha.-Fe.sub.2 O.sub.3. The pyrolyzed product is treated by hydrogen and steam at an elevated temperature to obtain a substituted magnetite, and this magnetite is oxidized in air at such a temperature as to avoid formation of .alpha.-Fe.sub.2 O.sub.3.
摘要翻译：本发明涉及铁的氧化物和钴Co 2+以外的二价金属，或者铁和多于一种二价金属（包括钴）的固溶体。除Co之外，二价金属可以是Ni，Cu，Mn，Zn，Mg和Cd。通过沉淀含铁的混合草酸盐和所需的其它二价金属或金属来制备这些溶液。这种混合的草酸盐在逐渐增加的温度下在露天加热直到碳被除去但不形成氧化锆的α-Fe 2 O 3来分解。热解产物在高温下用氢气和蒸汽处理以获得取代的磁铁矿，并且该磁铁矿在空气中被氧化以避免形成α-Fe 2 O 3。

7. 发明授权

US08168619B1 Hormonal composition based on a progestational agent and an oestrogen and use thereof 有权
标题翻译：基于促孕剂和雌激素的激素组合物及其用途
公开(公告)号：US08168619B1
公开(公告)日：2012-05-01
申请号：US09423109
申请日：1999-10-29
申请人： Jacques Paris , Jean-Louis Thomas
发明人： Jacques Paris , Jean-Louis Thomas
IPC分类号： A61K31/56 , A61K9/00 , A61K9/14
CPC分类号： A61K31/57 , A61K31/565 , A61K31/567 , A61K45/06 , A61K2300/00
摘要： A method of preventing estrogen deficiencies and osteoporosis in menopausal women by continuously orally administering without interruption to menopausal women in need thereof an amount of 0.3 to 3 mg of 17β-estradiol or esters thereof and 0.3 to 1.25 mg of nomegestrol or esters thereof in an amount sufficient to prevent said problems.
摘要翻译：一种通过持续口服给予需要的绝经妇女不断口服绝经期妇女的雌激素缺乏和骨质疏松症的方法，其量为0.3至3mg的17-雌二醇或其酯和0.3至1.25mg的孕烯雌酚或其酯足以防止所述问题。

8. 发明授权

US07465377B2 Method for destroying a nuclear graphite by gasification in aqueous medium 失效
标题翻译：在水性介质中通过气化破坏核石墨的方法
公开(公告)号：US07465377B2
公开(公告)日：2008-12-16
申请号：US10498700
申请日：2002-12-10
申请人： Jacques Paris , Jean-Raymond Costes
发明人： Jacques Paris , Jean-Raymond Costes
IPC分类号： B01J19/08
CPC分类号： C10J3/723 , B02C19/18 , B02C2019/183 , C10J3/18 , C10J2200/12 , C10J2200/33 , C10J2300/09 , G21F9/30 , G21Y2004/60
摘要： A process for the treatment of a nuclear graphite contaminated with radioelements includes subjecting the graphite, immersed in a medium containing water, to high-voltage pulses. The pulses have sufficient energy for electric arcs to be initiated and to break the constituent bonds of the water molecules and the carbon-carbon bonds of the graphite. The number of high-voltage pulses is determined so as to convert the graphite into gas.
摘要翻译：用于处理被放射性元素污染的核石墨的方法包括将浸入含水介质的石墨进行高压脉冲。脉冲具有足够的能量来启动电弧并破坏水分子的组成键和石墨的碳 - 碳键。确定高压脉冲的数量以将石墨转化为气体。

9. 发明授权

US07030104B2 Topical oestroprogestational compositions with a systemic effect 失效
标题翻译：具有全身作用的局部使用雌二醇组合物
公开(公告)号：US07030104B2
公开(公告)日：2006-04-18
申请号：US10129040
申请日：2001-09-14
申请人： Georges Gray , Bertrand Villet , Jacques Paris , Jean-Louis Thomas
发明人： Georges Gray , Bertrand Villet , Jacques Paris , Jean-Louis Thomas
IPC分类号： A61K31/56 , A61K9/14 , A61K9/00
CPC分类号： A61K9/0014 , A61K9/06 , A61K9/7015 , A61K31/57 , A61K31/565 , A61K2300/00
摘要： The present invention relates to the field of therapeutic chemistry and more especially to the realization of new galenic forms intended to be applied on the skin.More particularly it relates to a topical hormonal composition with a systemic effect for the hormonal treatment of the perimenopause and of the menopause as well as for the treatment of the ovarian hormonal deficiencies in women with amenorrhea, characterized in that it comprises, as active ingredients, a progestogen derived from 19-nor progesterone and estradiol or one of its derivatives, a vehicle which allows the systemic passage of said active ingredients, chosen from the group constituted by a solubilizing agent, an absorption promoting agent, a film-forming agent, a gelling agent and their mixtures, in combination or in a mixture with suitable excipients for the realization of a gelled and/or film-forming pharmaceutical form.
摘要翻译：本发明涉及治疗化学领域，更具体地涉及旨在应用于皮肤的新的盖仑型形式的实现。更具体地说，本发明涉及一种局部激素组合物，具有用于激素治疗围绝经期和绝经期以及用于治疗闭经妇女的卵巢激素缺乏的全身效应，其特征在于，其包含作为活性成分的，衍生自19-没有孕酮和雌二醇或其衍生物之一的孕激素，其允许所述活性成分的全身通过，所述载体选自由增溶剂，吸收促进剂，成膜剂，胶凝剂及其混合物，组合或与合适的赋形剂的混合物，以实现胶凝和/或成膜药物形式。

10. 发明授权

US4857519A Novel pharmaceutical compositions endowed with anti-progesteronic properties and a process for making the same 失效
标题翻译：赋予抗孕酮性质的新型药物组合物及其制备方法
公开(公告)号：US4857519A
公开(公告)日：1989-08-15
申请号：US046936
申请日：1987-05-05
申请人： Jacques Paris
发明人： Jacques Paris
IPC分类号： A61K31/565 , C07J11/00
CPC分类号： A61K31/565
摘要： This invention relates to pharmaceutical compositions endowed with anti-progesteronic properties. This invention provides pharmaceutical compositions containing a pharmacologically effective amount of a 17.beta.-OR 17.alpha.-ethynyl-5.alpha.-androst-2-ene in admixture or conjunction with an innocuous pharmaceutical carrier or vehicle. The pharmaceutical compositions according to this invention are useful to prevent nidation or gestation.
摘要翻译：本发明涉及赋予抗孕酮性质的药物组合物。本发明提供药物组合物，其含有药理学有效量的17β-OR17α-乙炔基-5α-雄甾-2-烯与混合物或与无害的药物载体或载体结合。根据本发明的药物组合物可用于预防结痂或妊娠。

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