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1. 发明授权

US07738953B2 Method and device for preventing plaque formation in coronary arteries 失效
标题翻译：用于预防冠状动脉斑块形成的方法和装置
公开(公告)号：US07738953B2
公开(公告)日：2010-06-15
申请号：US11203756
申请日：2005-08-15
申请人： Qingsheng Zhu , Avram Scheiner , Julio C. Spinelli
发明人： Qingsheng Zhu , Avram Scheiner , Julio C. Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/326 , A61N1/0587
摘要： A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.
摘要翻译：用于防止冠状动脉斑块积聚的方法和装置包括提供电场产生装置，并且在冠状动脉中产生电场以防止冠状动脉中的斑块积聚。该方法还包括感测心脏节律并在心脏中去极化波之后产生电场。电场由电路产生，在一个实施例中，植入电路连接到心外膜或心内置于心脏上的引线。

2. 发明申请

US20080221635A1 IMPLANTABLE CARDIAC RHYTHM MANAGEMENT SYSTEM HAVING MULTIPLE THERAPY MODALITIES 有权
标题翻译：具有多种治疗方式的可持续心脏健康管理系统
公开(公告)号：US20080221635A1
公开(公告)日：2008-09-11
申请号：US12048144
申请日：2008-03-13
申请人： Julio C. Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
发明人： Julio C. Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
IPC分类号： A61N1/365
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.
摘要翻译：一种用于提供多种治疗方式的心律管理系统。例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。可以使用各种手动和自动方法来选择操作模式。此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

3. 发明授权

US07177681B2 Cardiac rhythm management system for edema 有权
公开(公告)号：US07177681B2
公开(公告)日：2007-02-13
申请号：US10411795
申请日：2003-04-11
申请人： Qingsheng Zhu , Julio C. Spinelli
发明人： Qingsheng Zhu , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.

4. 发明授权

US06980851B2 Method and apparatus for determining changes in heart failure status 失效
标题翻译：用于确定心力衰竭状态变化的方法和装置
公开(公告)号：US06980851B2
公开(公告)日：2005-12-27
申请号：US10001223
申请日：2001-11-15
申请人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
发明人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
IPC分类号： A61N1/362 , A61N1/365 , A61B5/0402
CPC分类号： A61N1/3627 , A61N1/36585
摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.
摘要翻译：一种用于操作心律管理装置的方法，其中临床状态矢量被计算为与患者心力衰竭状态相关的多个参数的组合，并且与先前计算的临床状态向量进行比较，以确定指示变化的临床轨迹患者的心力衰竭状态。这种检测到的状态变化可以用作临床工具来评估治疗并自动调整装置的操作。

5. 发明授权

US06915163B2 Apparatus and method for testing and adjusting a bipolar stimulation configuration 有权
公开(公告)号：US06915163B2
公开(公告)日：2005-07-05
申请号：US10634202
申请日：2003-08-05
申请人： Julio C. Spinelli , Qingsheng Zhu
发明人： Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N1/362 , A61N1/37 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/371
摘要： A system and method for measuring the capture threshold of a bipolar lead in order to determine an appropriate value for the stimulus pulse energy to be used with the lead by a cardiac rhythm management device. An appropriate bipolar stimulating configuration can also be determined. The method is particularly useful in testing bipolar leads used to excite the left ventricle such as when delivering cardiac resynchronization therapy.

6. 发明授权

US06909916B2 Cardiac rhythm management system with arrhythmia classification and electrode selection 有权
公开(公告)号：US06909916B2
公开(公告)日：2005-06-21
申请号：US10027800
申请日：2001-12-20
申请人： Julio C. Spinelli , Qingsheng Zhu , Jeffrey E. Stahmann , Andrew P. Kramer
发明人： Julio C. Spinelli , Qingsheng Zhu , Jeffrey E. Stahmann , Andrew P. Kramer
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3684
摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

7. 发明授权

US09265950B2 Contractility modulation based on impedance signal 有权
标题翻译：基于阻抗信号的收缩调制
公开(公告)号：US09265950B2
公开(公告)日：2016-02-23
申请号：US12152099
申请日：2008-05-12
申请人： Qingsheng Zhu , Julio C. Spinelli
发明人： Qingsheng Zhu , Julio C. Spinelli
IPC分类号： A61N1/00 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.
摘要翻译：心律管理系统检测水肿。响应于检测到的水肿发作，其启动或调整心脏再同步治疗和/或心脏收缩调节（CCM）治疗。

8. 发明申请

US20080215108A1 Cardiac rhythm management system for edema 有权
标题翻译：水肿心律管理系统
公开(公告)号：US20080215108A1
公开(公告)日：2008-09-04
申请号：US12152099
申请日：2008-05-12
申请人： Qingsheng Zhu , Julio C. Spinelli
发明人： Qingsheng Zhu , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.
摘要翻译：心律管理系统检测水肿。响应于检测到的水肿发作，其启动或调整心脏再同步治疗和/或心脏收缩调节（CCM）治疗。

9. 发明授权

US07191000B2 Cardiac rhythm management system for edema 有权
标题翻译：水肿心律管理系统
公开(公告)号：US07191000B2
公开(公告)日：2007-03-13
申请号：US09919483
申请日：2001-07-31
申请人： Qingsheng Zhu , Julio C. Spinelli
发明人： Qingsheng Zhu , Julio C. Spinelli
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.
摘要翻译：心律管理系统检测水肿。响应于检测到的水肿发作，其启动或调整心脏再同步治疗和/或心脏收缩调节（CCM）治疗。

10. 发明授权

US07062323B2 Maximum atrial tracking rate for cardiac rhythm management system 失效
标题翻译：心律管理系统最大心房跟踪率
公开(公告)号：US07062323B2
公开(公告)日：2006-06-13
申请号：US10040287
申请日：2001-10-19
申请人： Gerrard M. Carlson , Julio C. Spinelli , Qingsheng Zhu
发明人： Gerrard M. Carlson , Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N1/18
CPC分类号： A61N1/36542 , A61N1/3622 , A61N1/36521
摘要： A cardiac rhythm management system includes an operational mode in which ventricular pacing pulses are delivered at a rate that tracks a sinoatrial rate up to an appropriate maximum atrial tracking rate (MATR) value determined by the system. In one example, the MATR value is based on a patient activity level and a hemodynamic maximum rate (HMR) determined from a QRS-to-S2 interval, where S2 is an accelerometer-generated fiducial correlative to aortic valve closure (AVC). In a further example, a correlation between the QRS-to-S2 interval and heart rate is established, and the MATR is based on the patient activity level and heart rate. In a further example, a lower rate threshold for providing antitachyarrhythmia therapy is modified based on the MATR. For example, when the MATR exceeds a default value of the antitachyarrhythmia therapy lower rate threshold, the threshold tracks the MATR. In another example, the MATR is based on an active time between a QRS complex and a heart impedance signal maximum slope during the same cardiac cycle.
摘要翻译：心律管理系统包括操作模式，其中心率起搏脉冲以跟踪窦房速率直到由系统确定的合适的最大心房跟踪率（MATR）值的速率递送。在一个示例中，MATR值基于患者活动水平和从QRS至S 2区间确定的血流动力学最大速率（HMR），其中S < 是与主动脉瓣闭合（AVC）相关的加速度计产生的基准。在另一个例子中，建立了QRS-S-SUB间隔和心率之间的相关性，并且MATR基于患者活动水平和心率。在另一个实例中，基于MATR修改用于提供抗心律不齐治疗的较低速率阈值。例如，当MATR超过抗心律不齐治疗较低速率阈值的默认值时，阈值跟踪MATR。在另一个例子中，MATR基于在相同心动周期期间QRS波形与心脏阻抗信号最大斜率之间的活动时间。

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