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1. 发明专利

DK3286177T3 QUINOLINDERIVATER SOM TAM RTK-INHIBITORER 未知
公开(公告)号：DK3286177T3
公开(公告)日：2020-06-08
申请号：DK16716247
申请日：2016-04-14
申请人： QURIENT CO LTD , LEAD DISCOVERY CENTER GMBH
发明人： SCHULTZ-FADEMRECHT CARSTEN , KIM HANA , NAM KIYEAN , KIM JAESEUNG , AHN SEOHYUN , JEON YEEJIN , LEE DOOHYUNG , PARK DONGSIK , LEE SAEYEON , KIM JEONGJUN , AHN JIYE , JUNG CHUN-WON , YANG YEONG-IN
IPC分类号： C07D401/14 , A61K31/4709 , A61P35/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14

2. 发明专利

SG11201707638UA QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS 未知
公开(公告)号：SG11201707638UA
公开(公告)日：2017-10-30
申请号：SG11201707638U
申请日：2016-04-14
申请人： QURIENT CO LTD , LEAD DISCOVERY CENTER GMBH
发明人： NAM KIYEAN , KIM JAESEUNG , AHN SEOHYUN , JEON YEEJIN , LEE DOOHYUNG , PARK DONGSIK , YANG YOUNG-IN , LEE SAEYEON , KIM JEONGJUN , AHN JIYE , KIM HANA , JUNG CHUN-WON , SCHULTZ-FADEMRECHT CARSTEN
IPC分类号： C07D401/14 , A61K31/4709 , A61P35/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel compounds which are inhibitors of TAM (Axl, Mer and Tyro 3) and/or Met family receptor tyrosine kinases (RTKs). These compounds are suitable for the treatment of disorders associated with, accompanied by, caused by or induced by a receptor of the TAM family, in particular a hyperfunction thereof. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly immune-suppressive cancer, refractory cancer and cancer metastases.

3. 发明专利

PH12017501822A1 QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS 未知
公开(公告)号：PH12017501822A1
公开(公告)日：2018-04-23
申请号：PH12017501822
申请日：2017-10-04
申请人： LEAD DISCOVERY CENTER GMBH , QURIENT CO LTD
发明人： NAM KIYEAN , KIM JAESEUNG , AHN SEOHYUN , JEON YEEJIN , LEE DOOHYUNG , PARK DONGSIK , YANG YOUNG-IN , LEE SAEYEON , KIM JEONGJUN , AHN JIYE , KIM HANA , JUNG CHUN-WON , SCHULTZ-FADEMRECHT CARSTEN
IPC分类号： A61K31/4709 , A61P35/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel compounds which are inhibitors of TAM (Axl, Mer and Tyro 3) and/or Met family receptor tyrosine kinases (RTKs). These compounds are suitable for the treatment of disorders associated with, accompanied by, caused by or induced by a receptor of the TAM family, in particular a hyperfunction thereof. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly immune-suppressive cancer, refractory cancer and cancer metastases.

4. 发明专利

HUE049856T2 Kinolin-származékok mint TAM RTK inhibitorok 未知
公开(公告)号：HUE049856T2
公开(公告)日：2020-10-28
申请号：HUE16716247
申请日：2016-04-14
申请人： QURIENT CO LTD , LEAD DISCOVERY CENTER GMBH
发明人： NAM KIYEAN , KIM JAESEUNG , AHN SEOHYUN , JEON YEEJIN , LEE DOOHYUNG , PARK DONGSIK , YANG YEONG-IN , LEE SAEYEON , KIM JEONGJUN , AHN JIYE , KIM HANA , JUNG CHUN-WON , SCHULTZ-FADEMRECHT CARSTEN
IPC分类号： A61P35/00

5. 发明专利

AU2016249860B2 Quinoline derivatives as TAM RTK inhibitors 未知
公开(公告)号：AU2016249860B2
公开(公告)日：2019-10-10
申请号：AU2016249860
申请日：2016-04-14
申请人： LEAD DISCOVERY CENTER GMBH , QURIENT CO LTD
发明人： NAM KIYEAN , KIM JAESEUNG , AHN SEOHYUN , JEON YEEJIN , LEE DOOHYUNG , PARK DONGSIK , YANG YOUNG-IN , LEE SAEYEON , KIM JEONGJUN , AHN JIYE , KIM HANA , JUNG CHUN-WON , SCHULTZ-FADEMRECHT CARSTEN
IPC分类号： C07D401/14 , A61K31/4709 , A61P35/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel compounds which are inhibitors of TAM (Axl, Mer and Tyro 3) and/or Met family receptor tyrosine kinases (RTKs). These compounds are suitable for the treatment of disorders associated with, accompanied by, caused by or induced by a receptor of the TAM family, in particular a hyperfunction thereof. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly immune-suppressive cancer, refractory cancer and cancer metastases.

6. 发明专利

ZA201706380B QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS 未知
公开(公告)号：ZA201706380B
公开(公告)日：2022-03-30
申请号：ZA201706380
申请日：2017-09-21
申请人： QURIENT CO LTD , LEAD DISCOVERY CENTER GMBH
发明人： NAM KIYEAN , KIM JAESEUNG , AHN SEOHYUN , JEON YEEJIN , LEE DOOHYUNG , PARK DONGSIK , YANG YOUNG-IN , LEE SAEYEON , KIM JEONGJUN , AHN JIYE , KIM HANA , JUNG CHUN-WON , SCHULTZ-FADEMRECHT CARSTEN
摘要： The present invention relates to novel compounds which are inhibitors of TAM (Axl, Mer and Tyro 3) and/or Met family receptor tyrosine kinases (RTKs). These compounds are suitable for the treatment of disorders associated with, accompanied by, caused by or induced by a receptor of the TAM family, in particular a hyperfunction thereof. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly immune-suppressive cancer, refractory cancer and cancer metastases.

7. 发明专利

CA2980652C QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS 未知
公开(公告)号：CA2980652C
公开(公告)日：2021-04-27
申请号：CA2980652
申请日：2016-04-14
申请人： QURIENT CO LTD , LEAD DISCOVERY CENTER GMBH
发明人： NAM KIYEAN , KIM JAESEUNG , AHN SEOHYUN , JEON YEEJIN , LEE DOOHYUNG , PARK DONGSIK , YANG YOUNG-IN , LEE SAEYEON , KIM JEONGJUN , AHN JIYE , KIM HANA , JUNG CHUN-WON , SCHULTZ-FADEMRECHT CARSTEN
IPC分类号： C07D401/14 , A61K31/4709 , A61P35/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel compounds having TAM family and Met receptor tyrosine kinase-inhibiting activity and having the general formula l: (see formula I). The compounds are suitable for the treatment of infectious, diseases and hyperproliferative disorders, such as cancer, particularly immune-suppressive cancer, refractory cancer and cancer metastases.

8. 发明专利

ES2807851T3 Derivados de quinolina como inhibidores de RTK de TAM 未知
公开(公告)号：ES2807851T3
公开(公告)日：2021-02-24
申请号：ES16716247
申请日：2016-04-14
申请人： QURIENT CO LTD , LEAD DISCOVERY CENTER GMBH
发明人： NAM KIYEAN , KIM JAESEUNG , AHN SEOHYUN , JEON YEEJIN , LEE DOOHYUNG , PARK DONGSIK , YANG YEONG-IN , LEE SAEYEON , KIM JEONGJUN , AHN JIYE , KIM HANA , JUNG CHUN-WON , SCHULTZ-FADEMRECHT CARSTEN
IPC分类号： C07D401/14 , A61K31/4709 , A61P35/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Un compuesto que tiene actividad inhibidora del receptor tirosina quinasa Met y de la familia TAM, de fórmula general I: **(Ver fórmula)** en la que X1 es, independientemente en cada presencia, seleccionado de CH y N; X2 es, independientemente en cada presencia, seleccionado de CH y N; Y1 es, independientemente en cada presencia, seleccionado de CH2, CH(CH3)CH2, C(CH3)2, C(CH3)2CH2 y CH2CH2; n es, independientemente en cada presencia, seleccionado de 0 y 1; R1 es, en cada presencia, independientemente seleccionado del grupo que consiste en alquilo C1-C6 y haloalquilo C1-C3; R2 es, en cada presencia, independientemente seleccionado del grupo que consiste en alquilo C1-C6 y haloalquilo C1-C3, cualquiera de los cuales está opcionalmente sustituido; R3 es, en cada presencia, independientemente seleccionado del grupo que consiste en hidrógeno, halógeno, por ejemplo Cl o F, alquilo C1-C3, el cual está opcionalmente sustituido, y NHCH(CH3)CH3; R4 es, en cada presencia, independientemente seleccionado del grupo que consiste en hidrógeno, halógeno, por ejemplo Cl o F, NHCH(CH3)2, -CH2OH, alquilo C1-C3, el cual está opcionalmente sustituido, alcoxi, en particular alcoxi C1-C3, por ejemplo metoxi, y -CF3; R5 es, en cada presencia, independientemente seleccionado del grupo que consiste en alquilo C1-C6, alquilo C1-C6 sustituido con cicloalquilo C1-C6, con heterociclilo o con O-(alquilo C1-C6); haloalquilo C1-C3, por ejemplo CH2F, CHF2, CF3, CH2CF3, N,N-dimetiletan-amino, N,N-dimetilpropan-1-amino; R6 es, en cada presencia, independientemente seleccionado del grupo que consiste en hidrógeno y CH3; Z1 es, en cada presencia, independientemente seleccionado del grupo que consiste en hidrógeno, hidroxilo, alquilo C1-C6, C(O)R7, C(O)NHR7, C(O)OR7, CN, C(O)R8, C(O)OR8, N(R7)2, OR8, OCH3, OCH2F, OCHF2, OCF3 y cualquier estructura del siguiente grupo A, cualesquiera estructura de las cuales está opcionalmente sustituida;

9. 发明专利

BR112017021929A2 derivados de quinolina como inibidores tam rtk, composição farmacêutica compreendendo os referidos derivados e uso destes 未知
公开(公告)号：BR112017021929A2
公开(公告)日：2018-07-03
申请号：BR112017021929
申请日：2016-04-14
申请人： LEAD DISCOVERY CENTER GMBH , QURIENT CO LTD
发明人： AHN JIYE , AHN SEOHYUN , CARSTEN SCHULTZ-FADEMRECHT , JEON YEEJIN , JUNG CHUN-WON , KIM HANA , KIM JAESEUNG , KIM JEONGJUN , LEE DOOHYUNG , LEE SAEYEON , NAM KIYEAN , PARK DONGSIK , YANG YOUNG-IN
IPC分类号： C07D401/12 , A61K31/4709 , A61P35/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： a presente invenção refere-se aos novos compostos que são inibidores de tam (axl, mer e tyro3) e/ou receptor de família de tirosina quinases (rtks). estes compostos são adequados para o tratamento de distúrbios associados, acompanhados de, causados por ou induzidos por um receptor da família tam, em particular a sua hiperfunção. os compostos são adequados para o tratamento de distúrbios hiperproliferativos, tais como câncer, particularmente câncer imunossurpresivo, câncer refratário e metástases de câncer.

10. 发明公开

EP3286177A1 QUINOLINE DERIVATIVES AS TAM RTK INHIBITORS 有权
公开(公告)号：EP3286177A1
公开(公告)日：2018-02-28
申请号：EP16716247
申请日：2016-04-14
申请人： QURIENT CO LTD , LEAD DISCOVERY CENTER GMBH
发明人： NAM KIYEAN , KIM JAESEUNG , AHN SEOHYUN , JEON YEEJIN , LEE DOOHYUNG , PARK DONGSIK , YANG YOUNG-IN , LEE SAEYEON , KIM JEONGJUN , AHN JIYE , KIM HANA , JUNG CHUNG-WON , SCHULTZ-FADEMRECHT CARSTEN
IPC分类号： C07D401/14 , A61K31/4709 , A61P35/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to novel compounds which are inhibitors of TAM (Axl, Mer and Tyro 3) and/or Met family receptor tyrosine kinases (RTKs). These compounds are suitable for the treatment of disorders associated with, accompanied by, caused by or induced by a receptor of the TAM family, in particular a hyperfunction thereof. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly immune-suppressive cancer, refractory cancer and cancer metastases.

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