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1. 发明申请

WO2012118910A3 COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY 审中-公开
公开(公告)号：WO2012118910A3
公开(公告)日：2012-09-07
申请号：PCT/US2012/027169
申请日：2012-03-01
申请人： QUARK PHARMACEUTICALS, INC. , WASHINGTON UNIVERSITY , GELMAN, Andrew E. , FEINSTEIN, Elena , ADAMSKY, Svetlana , METT, Igor , KALINSKI, Hagar , AVKIN-NACHUM, Sharon
发明人： GELMAN, Andrew E. , FEINSTEIN, Elena , ADAMSKY, Svetlana , METT, Igor , KALINSKI, Hagar , AVKIN-NACHUM, Sharon
IPC分类号： C12N15/113
摘要： Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising down-regulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.

2. 发明申请

WO2018201091A1 CHEMOKINE DECOY RECEPTORS OF RODENT GAMMAHERPESVIRUSES AND USES THEREOF 审中-公开
公开(公告)号：WO2018201091A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/030022
申请日：2018-04-27
申请人： WASHINGTON UNIVERSITY , FREMONT, Daved H. , LUBMAN, Olga Y. , GELMAN, Andrew E. , LU, Yun Hsuan
发明人： FREMONT, Daved H. , LUBMAN, Olga Y. , GELMAN, Andrew E. , LU, Yun Hsuan
IPC分类号： A61K38/17 , C07K14/03 , C07K14/715
摘要： The present disclosure generally provides compositions and methods related to the field of immunology. Specifically, disclosed herein are chemokine binding proteins and methods of use thereof.

3. 发明授权

EP2681314B1 COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY 有权
标题翻译：治疗肺部疾病和损伤的组合物和方法
公开(公告)号：EP2681314B1
公开(公告)日：2017-11-01
申请号：EP12708474.7
申请日：2012-03-01
申请人： Quark Pharmaceuticals, Inc. , Washington University
发明人： GELMAN, Andrew E. , FEINSTEIN, Elena , ADAMSKY, Svetlana , METT, Igor , KALINSKI, Hagar , AVKIN-NACHUM, Sharon
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/3521
摘要： Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.

4. 发明公开

EP2681314A2 COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY 有权
标题翻译：组合物和方法用于治疗肺疾病和损伤
公开(公告)号：EP2681314A2
公开(公告)日：2014-01-08
申请号：EP12708474.7
申请日：2012-03-01
申请人： Quark Pharmaceuticals, Inc. , Washington University
发明人： GELMAN, Andrew E. , FEINSTEIN, Elena , ADAMSKY, Svetlana , METT, Igor , KALINSKI, Hagar , AVKIN-NACHUM, Sharon
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/3521
摘要： Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.
摘要翻译：公开的是用于治疗哺乳动物中的肺部疾病，病症和损伤，包括治疗急性呼吸窘迫综合征（ARDS），急性肺损伤，肺纤维症（特发性），博来霉素诱导的肺纤维化，呼吸机诱导的肺损伤，慢性的治疗方法阻塞性肺病（COPD），慢性支气管炎，肺气肿，肺移植，肺移植引起的急性移植物功能障碍，包括治疗，预防或预防原发性移植失败，缺血 - 再灌注损伤，再灌注损伤，再灌注水肿的进展后闭塞性细支气管炎，同种异体移植物功能障碍，肺再植响应，肺移植和/或器官移植后的主要移植物功能障碍（PGD）后闭塞性细支气管炎，在肺移植particulare，包括下调的基因TLR2或两个基因TLR2和TLR4基因。在本发明提供的组合物，方法和试剂盒用于治疗肺部疾病，病症和损伤。

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