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    • 4. 发明申请
    • SHARED SIGNALING CHANNEL
    • 共享信道
    • WO2007051159A2
    • 2007-05-03
    • PCT/US2006/060292
    • 2006-10-27
    • QUALCOMM IncorporatedKHANDEKAR, AamodGOROKHOV, AlexeiGORE, Dhananjay, AshokTEAGUE, Edward, HarrisonDONG, Min
    • KHANDEKAR, AamodGOROKHOV, AlexeiGORE, Dhananjay, AshokTEAGUE, Edward, HarrisonDONG, Min
    • H04Q7/38H04L27/26H04B7/005
    • H04L5/0044H04L5/0007H04L5/0048H04L5/0053
    • A shared signaling channel can be used in an Orthogonal Frequency Division Multiple Access (OFDMA) communication system to provide signaling, acknowledgement, and power control messages to access terminals within the system. The shared signaling channel can be assigned to a predetermined number of sub-carriers within any frame. The assignment of a predetermined number of sub-carriers to the shared signaling channel establishes a fixed bandwidth overhead for the channel. The actual sub-carriers assigned to the channel can be varied periodically, and can vary according to a predetermined frequency hopping schedule. The amount of signal power allocated to the signaling channel can vary on a per symbol basis depending on the power requirements of the communication link. The shared signaling channel can direct each message carried on the channel to one or more access terminals. Unicast messages allow the channel power to be controlled per the needs of individual communication links.
    • 可以在正交频分多址(OFDMA)通信系统中使用共享信令信道,以向系统内的接入终端提供信令,确认和功率控制消息。 共享信令信道可以被分配给任何帧内的预定数量的子载波。 将预定数量的子载波分配给共享信令信道为信道建立固定的带宽开销。 分配给信道的实际子载波可以周期性地变化,并且可以根据预定的跳频调度而变化。 分配给信令信道的信号功率的量可以根据通信链路的功率要求在每个符号的基础上变化。 共享信令信道可以将信道上承载的每个消息引导到一个或多个接入终端。 单播消息允许根据各个通信链路的需要来控制信道功率。
    • 5. 发明申请
    • ORTHOGONAL RESOURCE REUSE WITH SDMA BEAMS
    • 正常资源重新使用SDMA BEAMS
    • WO2007124460A1
    • 2007-11-01
    • PCT/US2007/067149
    • 2007-04-20
    • QUALCOMM INCORPORATEDDONG, MinGOROKHOV, AlexeiJI, Tingfang
    • DONG, MinGOROKHOV, AlexeiJI, Tingfang
    • H04Q7/36
    • H04W16/00H04B7/0408H04W16/28
    • A wireless communication system can implement beamforming across multiple omni-directional antennas to create beams at different spatial directions. The communication system can arrange the beams in sets, with each set arranged to provide substantially complete coverage over a predetermined coverage area. The communication system can arrange the multiple SDMA beam sets to support substantially complementary coverage areas, such that a main beam from a first set provides coverage to a weak coverage area of the second beam set. The wireless communication system assigns or otherwise allocates substantially orthogonal resources to each of the beam sets. The wireless communication system allocates resources to a communication link using a combination of beam sets and substantially orthogonal resources in order to provide improved coverage without a corresponding increase in interference.
    • 无线通信系统可以实现跨多个全向天线的波束成形,以在不同的空间方向上创建波束。 通信系统可以将波束排列成一组,其中每个组被布置成在预定覆盖区域上提供基本上完整的覆盖。 通信系统可以布置多个SDMA波束组以支持基本互补的覆盖区域,使得来自第一组的主波束向第二波束组的弱覆盖区域提供覆盖。 无线通信系统分配或以其他方式分配基本上正交的资源到每个波束组。 无线通信系统使用波束组和基本上正交的资源的组合向通信链路分配资源,以便提供改进的覆盖而不会相应地增加干扰。
    • 7. 发明申请
    • ESTIMATION OF DATA-TO-PILOT RATIO IN A WIRELESS COMMUNICATION SYSTEM
    • 无线通信系统中数据对比率的估计
    • WO2009142654A1
    • 2009-11-26
    • PCT/US2008/077194
    • 2008-09-22
    • QUALCOMM INCORPORATEDAKKARAKARAN, Sony, JohnDONG, Min
    • AKKARAKARAN, Sony, JohnDONG, Min
    • H04B17/00H04L25/02
    • H04B7/0848H04B7/0857H04B17/309H04B17/336H04L5/0007H04L5/005H04L25/0228
    • Techniques for estimating data-to-pilot ratio are described. A terminal may receive pilot sent to multiple terminals and may receive data sent specifically to the terminal. The terminal may estimate channel gain and noise variance based on the received pilot. The terminal may then estimate a data-to-pilot ratio based on the received data y and the estimated channel gain h and noise variance σ 2 . In one design, the terminal may determine a metric I y I 2 −σ 2 / |h| 2 and may average the metric across multiple received data symbols to obtain the data-to-pilot ratio. The terminal may receive pilot and data via multiple antennas and may combine the received data across these antennas to obtain combined data. The terminal may estimate signal-to-noise-and-interference ratio (SINR) based on the received pilot from the multiple antennas and may then estimate the data-to-pilot ratio based on the combined data and the estimated SINR.
    • 描述了用于估计数据导频比的技术。 终端可以接收发送到多个终端的导频,并且可以接收专门发送到终端的数据。 终端可以基于接收到的导频来估计信道增益和噪声方差。 然后,终端可以基于接收到的数据y和估计的信道增益h和噪声方差s2来估计数据导频比。 在一种设计中,终端可以确定度量Iy I 2 -s 2 / | h | 2,并且可以在多个接收的数据符号之间平均度量以获得数据到导频比。 终端可以通过多个天线接收导频和数据,并且可以在这些天线之间组合接收的数据以获得组合数据。 终端可以基于来自多个天线的接收导频来估计信噪比干扰比(SINR),然后可以基于组合数据和估计的SINR来估计数据导频比。
    • 8. 发明申请
    • RESONANCE ENERGY TRANSFER ASSAY WITH CLEAVAGE SEQUENCE AND SPACER
    • 谐振能量传递测量与清除序列和间隔
    • WO2009035476A1
    • 2009-03-19
    • PCT/US2008/004252
    • 2008-03-31
    • BIOSENTINEL, LLCFISH, Robert D.DONG, Min
    • FISH, Robert D.DONG, Min
    • G01N33/53
    • C12Q1/37C07K14/00C07K14/47C07K19/00C07K2319/50C07K2319/60G01N21/6428G01N33/542G01N33/9406G01N2021/6432G01N2333/952
    • A molecular construct comprises a donor label, an acceptor label, a linker peptide disposed between the donor and the acceptor, the linker having a cleavage site sequence, and a spacer between at least one of (a) the donor and the cleavage site sequence and (b) the acceptor and the cleavage site sequence. Preferably, the construct is selected from the group consisting of CFP-(SGLRSRA)-SNAP-25-(SNS)-YFP, and CFP-(SGLRSRA)-synaptobrevin-(SNS)-YFP. In preferred embodiments, the linker peptide is a substrate of a botulinum neurotoxin selected from the group consisting of synaptobrevin (VAMP), syntaxin and SNAP-25, or a fragment thereof that can be recognized and cleaved by the botulinum neurotoxin. Advantageously, the spacer increases the electronic coupling between the donor label and the acceptor label relative to a corresponding construct without the spacer.
    • 分子构建体包括供体标记,受体标记,置于供体和受体之间的接头肽,接头具有切割位点序列,以及(a)供体和切割位点序列之间的间隔基和 (b)受体和切割位点序列。 优选地,构建体选自CFP-(SGLRSRA)-SNAP-25-(SNS)-YFP和CFP-(SGLRSRA)-Synaptobrevin-(SNS)-YFP。 在优选的实施方案中,接头肽是肉毒杆菌神经毒素的底物,其选自由肉毒杆菌神经毒素可识别和切割的突触连锁蛋白(VAP),突触蛋白(S)或SNAP-25,或其片段。 有利地,间隔物相对于没有间隔物的相应构建体增加了供体标签和受体标记之间的电子偶联。
    • 10. 发明申请
    • BOTULINUM NEUROTOXIN E RECEPTORS AND USES THEREOF
    • BURULIN神经毒素E受体及其用途
    • WO2010039748A2
    • 2010-04-08
    • PCT/US2009/058906
    • 2009-09-30
    • WISCONSIN ALUMNI RESEARCH FOUNDATIONCHAPMAN, EdwinDONG, Min
    • CHAPMAN, EdwinDONG, Min
    • C07K14/195
    • C07K14/473C07K14/705C07K16/18G01N33/5058G01N2500/02
    • An isolated polypeptide comprising an amino acid sequence selected from amino acids 506-582 of SV2A, wherein position 573 is N and is glycosylated, or amino acids 449-525 of SV2B, wherein position 516 is N and is glycosylated. The present invention also provides an antibody that binds specifically to the polypeptide, an isolated nucleic acid comprising a polynucleotide that encodes the polypeptide; a method for reducing BoNT/E toxicity in an animal; a method for identifying an agent that blocks or inhibits binding between BoNT/E and an SV2A or SV2B protein; a method for monitoring synaptic vesicle endo- or exocytosis, a method for specifically delivering a chemical entity to a cell which has a specific receptor to a BoNT toxin. Also provided are a chimeric toxin for targeting a proteolytic domain of a toxin to a cell, the chimeric toxin comprising a catalytic or proteolytic domain of the BoNT toxin, and a ligand or a fragment thereof for a non-BoNT receptor on the cell; a method for targeting a proteolytic domain of a BoNT toxin to a cell, an isolated non-neuronal cell comprising a BoNT toxin receptor; and a method for screening for an inhibitor of a BoNT toxin.
    • 分离的多肽,其包含选自SV2A的氨基酸506-582的氨基酸序列,其中位置573是N并被糖基化,或SV2B的氨基酸449-525,其中位置516是N并被糖基化。 本发明还提供了与多肽特异性结合的抗体,分离的核酸,其包含编码该多肽的多核苷酸; 一种降低动物体内BoNT / E毒性的方法; 用于鉴定阻断或抑制BoNT / E与SV2A或SV2B蛋白之间结合的试剂的方法; 用于监测突触小泡内吞或胞吐的方法,用于将化学实体特异性递送至具有BoNT毒素特异性受体的细胞的方法。 还提供了用于将毒素的蛋白水解结构域靶向细胞的嵌合毒素,所述嵌合毒素包含BoNT毒素的催化或蛋白水解结构域,以及用于细胞上非BoNT受体的配体或其片段; 将BoNT毒素的蛋白水解结构域靶向细胞的方法,包含BoNT毒素受体的分离的非神经元细胞; 以及筛选BoNT毒素抑制剂的方法。