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1. 发明申请

WO03030656A2 METHODS AND COMPOSITIONS FOR PROMOTING GROWTH AND INNATE IMMUNITY IN YOUNG ANIMALS 审中-公开
标题翻译：促进幼年生长和免疫免疫的方法和组合
公开(公告)号：WO03030656A2
公开(公告)日：2003-04-17
申请号：PCT/EP0211212
申请日：2002-10-07
申请人： QIAGEN GMBH , UNIV SASKATCHEWAN , BABIUK LORNE ALAN , HECKER ROLF , GRIEBEL PHILIP J , POTTER ANDREW ALLAN , GOMIS SUSANTHA
发明人： BABIUK LORNE ALAN , HECKER ROLF , GRIEBEL PHILIP J , POTTER ANDREW ALLAN , GOMIS SUSANTHA
IPC分类号： A23K1/16 , A23K1/18 , A61P37/04
CPC分类号： A23K50/60 , A23K20/153 , A23K50/75
摘要： The invention provides novel methods and compositions for promoting weight gain in non-human animals comprising immunostimulatory nucleic acids. The invention similarly provides methods and compositions for promoting innate immunity in young non-human animals.
摘要翻译：本发明提供用于促进包含免疫刺激性核酸的非人动物体重增加的新颖方法和组合物。本发明类似地提供用于促进年轻非人动物中先天免疫的方法和组合物。

2. 发明申请

WO2004108755A3 CHIMERIC ADENOVIRUS CAPSID PROTEINS 审中-公开
标题翻译： CHIMERIC ADENOVIRUS CAPSID蛋白
公开(公告)号：WO2004108755A3
公开(公告)日：2005-05-19
申请号：PCT/IB2004002532
申请日：2004-06-10
申请人： UNIV SASKATCHEWAN , TIKOO SURESH K , ZAKHARTCHOUK ALEXANDRE N , BABIUK LORNE A , KAUSHIK RADHEY S , GRIEBEL PHILIP J
发明人： TIKOO SURESH K , ZAKHARTCHOUK ALEXANDRE N , BABIUK LORNE A , KAUSHIK RADHEY S , GRIEBEL PHILIP J
IPC分类号： C07K14/075 , C12N15/861 , C12Q1/70
CPC分类号： C07K14/005 , C07K2319/33 , C12N2710/10322 , C12N2810/405 , C12N2810/859
摘要： The present invention relates to chimeric adenovirus capsid proteins comprising a part of or all of an adenovirus capsid protein and a binding partner of a cell-surface binding site on a cell present in gut associated lymphoid tissues (GALT) of a mammal, wherein the chimeric adenovirus capsid protein is capable of binding the cell present in gut associated lymphoid tissues (GALT). In some examples, the adenovirus capsid protein is located on the surface of the adenovirus capsid. The present invention provides adenovirus capsids comprising a chimeric capsid protein. The present invention also provides complexes comprising a chimeric adenovirus capsid protein bound to a cell in GALT. The present invention also provides encapsidation systems and vectors, in particular adenovirus vectors, capable of expressing a chimeric adenovirus capsid protein encompassed within the invention. The present invention also provides viral particles, host cells and compositions comprising such vectors, in particular for use in vaccines, methods of eliciting an immune response and methods for targeted delivery of heterologous proteins, such as antigens, to target cells.
摘要翻译：本发明涉及包含哺乳动物肠道相关淋巴组织（GALT）中存在的细胞上的一部分或全部腺病毒衣壳蛋白和细胞表面结合位点的结合配偶体的嵌合腺病毒衣壳蛋白，其中嵌合腺病毒衣壳蛋白能够结合存在于肠道相关淋巴组织（GALT）中的细胞。在一些实例中，腺病毒衣壳蛋白位于腺病毒衣壳的表面上。本发明提供了包含嵌合衣壳蛋白的腺病毒衣壳。本发明还提供了包含与GALT中的细胞结合的嵌合腺病毒衣壳蛋白的复合物。本发明还提供能够表达包含在本发明内的嵌合腺病毒衣壳蛋白的包衣系统和载体，特别是腺病毒载体。本发明还提供病毒颗粒，宿主细胞和包含这种载体的组合物，特别是用于疫苗，引发免疫应答的方法和用于将异源蛋白质例如抗原靶向递送至靶细胞的方法。

3. 发明专利

CA2527721A1 CHIMERIC ADENOVIRUS CAPSID PROTEINS 未知
公开(公告)号：CA2527721A1
公开(公告)日：2004-12-16
申请号：CA2527721
申请日：2004-06-10
申请人： UNIV SASKATCHEWAN
发明人： TIKOO SURESH KUMAR , ZAKHARTCHOUK ALEXANDRE N , KAUSHIK RADHEY S , GRIEBEL PHILIP J , BABIUK LORNE A
IPC分类号： C07K14/075 , C12N15/861 , C12Q1/70
摘要： The present invention relates to chimeric adenovirus capsid proteins comprising a part of or all of an adenovirus capsid protein and a binding partner of a cell-surface binding site on a cell present in gut associated lymphoid tissues (GALT) of a mammal, wherein the chimeric adenovirus capsid protein is capable of binding the cell present in gut associated lymphoid tissues (GALT). In some examples, the adenovirus capsid protein is located o n the surface of the adenovirus capsid. The present invention provides adenovirus capsids comprising a chimeric capsid protein. The present inventi on also provides complexes comprising a chimeric adenovirus capsid protein boun d to a cell in GALT. The present invention also provides encapsidation systems and vectors, in particular adenovirus vectors, capable of expressing a chimeric adenovirus capsid protein encompassed within the invention. The present invention also provides viral particles, host cells and compositions comprising such vectors, in particular for use in vaccines, methods of eliciting an immune response and methods for targeted delivery of heterologo us proteins, such as antigens, to target cells.

4. 发明专利

CA2527721C CHIMERIC ADENOVIRUS CAPSID PROTEINS 未知
公开(公告)号：CA2527721C
公开(公告)日：2016-05-10
申请号：CA2527721
申请日：2004-06-10
申请人： UNIV SASKATCHEWAN
发明人： TIKOO SURESH KUMAR , ZAKHARTCHOUK ALEXANDRE N , BABIUK LORNE A , KAUSHIK RADHEY S , GRIEBEL PHILIP J
IPC分类号： C07K14/075 , C12N15/861 , C12Q1/70
摘要： The present invention relates to chimeric adenovirus capsid proteins comprising a part of or all of an adenovirus capsid protein and a binding partner of a cell-surface binding site on a cell present in gut associated lymphoid tissues (GALT) of a mammal, wherein the chimeric adenovirus capsid protein is capable of binding the cell present in gut associated lymphoid tissues (GALT). In some examples, the adenovirus capsid protein is located on the surface of the adenovirus capsid. The present invention provides adenovirus capsids comprising a chimeric capsid protein. The present invention also provides complexes comprising a chimeric adenovirus capsid protein bound to a cell in GALT. The present invention also provides encapsidation systems and vectors, in particular adenovirus vectors, capable of expressing a chimeric adenovirus capsid protein encompassed within the invention. The present invention also provides viral particles, host cells and compositions comprising such vectors, in particular for use in vaccines, methods of eliciting an immune response and methods for targeted delivery of heterologous proteins, such as antigens, to target cells.

5. 发明专利

DK1455593T3 FREMGANGSMÅDER OG SAMMENSÆTNINGER TIL FREMME AF VÆKST OG MEDFØDT IMMUNITET HOS UNGE DYR 未知
公开(公告)号：DK1455593T3
公开(公告)日：2013-08-26
申请号：DK02782843
申请日：2002-10-07
申请人： MERIAL LTD , UNIV SASKATCHEWAN
发明人： GRIEBEL PHILIP J , POTTER ANDREW ALLAN , GOMIS SUSANTHA , BABIUK LORNE ALAN , HECKER ROLF
IPC分类号： A23K1/16 , A23K1/18 , A61P37/04

6. 发明专利

MXPA05013234A PROTEINAS DE CAPSIDE DE ADENOVIRUS QUIMERICAS. 未知
公开(公告)号：MXPA05013234A
公开(公告)日：2006-03-09
申请号：MXPA05013234
申请日：2004-06-10
申请人： UNIV SASKATCHEWAN
发明人： GRIEBEL PHILIP J
IPC分类号： C07K14/075 , C12N15/861 , C12Q1/70
摘要： La presente invencion se relaciona proteinas de capside de adenovirus quimerica que comprende una parte de o toda de una proteina de capside de adenovirus y una molecula de union de un sitio de union de la superficie celular sobre una celula presente en tejidos linfoides asociados con el intestino (GALT) de un mamifero, donde la proteina de la capside del adenovirus quimerica es capaz de unirse a la celula presente en los tejidos linfoides asociados con el intestino (GALT). En algunos ejemplos la proteina de la capside de adenovirus se localiza sobre la superficie de la capside del adenovirus La presente invencion proporciona capsides de adenovirus que comprenden una proteina de capside quimerica. La presente invencion tambien proporciona complejos que comprenden una proteina de capside de adenovirus quimerica unida a una celula en GALT. La presente invencion tambien proporciona sistemas y vectores de encapsulacion, en particulas vectores de adenovirus capaces de expresar una proteina de capside de adenovirus quimerica abarcada dentro dela invencion. La presente invencion tambien proporciona particulas virales, celulas anfitrionas y composiciones que comprenden esos vectores, en particular para usarse en vacunas, metodos para producir una respuesta inmune y metodos para la liberacion dirigida de proteinas heterologas, como antigenos, a celulas blanco.

7. 发明专利

AU2002346960A1 Methods and compositions for promoting growth and innate immunity in young animals 未知
公开(公告)号：AU2002346960A1
公开(公告)日：2003-04-22
申请号：AU2002346960
申请日：2002-10-07
申请人： UNIV SASKATCHEWAN , MERIAL LTD
发明人： GRIEBEL PHILIP J , BABIUK LORNE ALAN , GOMIS SUSANTHA , POTTER ANDREW ALLAN , HECKER ROLF
IPC分类号： A23K1/16 , A23K1/18 , A61P37/04 , A61K9/00 , A61K31/7088 , C12N15/11

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