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1. 发明授权

US12053532B2 Synthesis and composition of non-amino acid linking groups conjugated to compounds used for the targeted imaging of tumors 有权
公开(公告)号：US12053532B2
公开(公告)日：2024-08-06
申请号：US17114195
申请日：2020-12-07
申请人： Purdue Research Foundation
发明人： Sumith A. Kularatne , Sakkarapalayam M. Mahalingam , Philip S. Low , Mohammad Noshi
IPC分类号： A61K51/00 , A61B5/00 , A61K49/00 , A61M36/14 , G01N33/574 , G01N33/58
CPC分类号： A61K49/0052 , A61B5/0071 , A61K49/0032 , G01N33/57411 , G01N33/57415 , G01N33/57423 , G01N33/57426 , G01N33/57449 , G01N33/582
摘要： The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

2. 发明申请

US20220016630A1 Micro-Fluidic System Using Micro-Apertures for High Throughput Detection of Cells 有权
公开(公告)号：US20220016630A1
公开(公告)日：2022-01-20
申请号：US17390404
申请日：2021-07-30
申请人： Purdue Research Foundation
发明人： Cagri A. Savran , Philip S. Low , Chun-Li Chang , Wanfeng Huang
IPC分类号： B01L3/00 , G01N33/574 , G01N33/543 , G01N27/74
摘要： A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

3. 发明申请

US20200155696A1 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING 审中-公开
公开(公告)号：US20200155696A1
公开(公告)日：2020-05-21
申请号：US16749827
申请日：2020-01-22
申请人： Purdue Research Foundation
发明人： Philip S. Low , Sumith A. Kularatne
IPC分类号： A61K47/64 , A61K47/54 , A61K51/08 , A61K49/00 , A61K31/475 , A61K31/4745 , A61K31/426 , C07K5/08 , A61K51/04 , C07D207/416 , C07C323/52
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

4. 发明申请

US20180303950A1 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING 审中-公开
公开(公告)号：US20180303950A1
公开(公告)日：2018-10-25
申请号：US15997451
申请日：2018-06-04
申请人： Purdue Research Foundation
发明人： Philip S. Low , Sumith A. Kularatne
IPC分类号： A61K47/64 , C07C323/52 , A61K51/04 , A61K47/54 , A61K49/00 , A61K31/475 , A61K51/08 , C07K5/08 , A61K31/426 , A61K31/4745 , C07D207/416
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

5. 发明授权

US10046054B2 PSMA binding ligand-linker conjugates and methods for using 有权
公开(公告)号：US10046054B2
公开(公告)日：2018-08-14
申请号：US14794482
申请日：2015-11-23
申请人： Purdue Research Foundation
发明人： Philip S. Low , Sumith A. Kularatne
IPC分类号： A61K47/54 , A61K31/426 , C07C323/52 , A61K47/48 , C07D207/416 , A61K49/00 , A61K51/04 , C07K5/08 , A61K31/4745 , A61K31/475 , A61K51/08
CPC分类号： A61K47/64 , A61K31/426 , A61K31/4745 , A61K31/475 , A61K47/54 , A61K47/542 , A61K47/547 , A61K47/548 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K51/088 , C07C323/52 , C07D207/416 , C07K5/08
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

6. 发明申请

US20180147286A1 BONE FRACTURE REPAIR BY TARGETING OF AGENTS THAT PROMOTE BONE HEALING 审中-公开
公开(公告)号：US20180147286A1
公开(公告)日：2018-05-31
申请号：US15578226
申请日：2016-05-29
申请人： Jindrich Kopecek , Jiyan Yang , Purdue Research Foundation Office of Technology Commercialization , University of Utah Research Foundation
发明人： Stewart Andrew Low , Philip S. Low , Christopher Galliford , Jindrich Kopecek , Jiyan Yang
IPC分类号： A61K47/42 , A61M5/00 , A61P19/00 , A61K9/107 , A61K31/404
CPC分类号： A61K47/42 , A61K9/1075 , A61K31/404 , A61L27/22 , A61L27/227 , A61L27/54 , A61L2400/06 , A61L2430/02 , A61M5/002 , A61P19/00 , C07K7/06 , C07K7/08
摘要： Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

7. 发明申请

US20170136462A1 Micro-Fluidic System Using Micro-Apertures for High Throughput Detection of Cells 审中-公开
公开(公告)号：US20170136462A1
公开(公告)日：2017-05-18
申请号：US15343908
申请日：2016-11-04
申请人： Purdue Research Foundation
发明人： Cagri Abdullah Savran , Philip S. Low , Chun-Li Chang
IPC分类号： B01L3/00 , G01N33/574 , G01N27/74 , G01N33/543
CPC分类号： B01L3/502761 , B01L3/50273 , B01L2200/0652 , B01L2200/0668 , B01L2300/0877 , B01L2400/043 , G01N27/745 , G01N33/54326 , G01N33/574 , G01N33/57434 , G01N33/57492 , G01N2001/4016
摘要： A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells.

8. 发明申请

US20140271482A1 SYNTHESIS AND COMPOSITION OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR THE TARGETED IMAGING OF TUMORS 有权
公开(公告)号：US20140271482A1
公开(公告)日：2014-09-18
申请号：US14010098
申请日：2013-08-26
申请人： Purdue Research Foundation
发明人： Philip S. Low , Sumith A. Kularatne , Sakkarapalayam M. Mahalingam
IPC分类号： A61K49/00 , G01N33/50
CPC分类号： A61K49/0052 , A61K49/001 , A61K49/0021 , A61K49/0032 , A61K49/0034 , C07D475/04 , G01N21/6428 , G01N33/5091 , G01N33/566 , G01N33/56966 , G01N33/57492 , G01N33/582 , G01N33/6893 , G01N2021/6432 , G01N2021/6439 , G01N2201/061 , G01N2333/705 , G01N2800/24
摘要： The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

9. 发明授权

US08808998B2 Diagnostic method for atherosclerosis 有权
标题翻译：动脉粥样硬化的诊断方法
公开(公告)号：US08808998B2
公开(公告)日：2014-08-19
申请号：US13714659
申请日：2012-12-14
申请人： Purdue Research Foundation
发明人： Philip S. Low
IPC分类号： G01N33/53
CPC分类号： A61K49/0043 , A61K49/0041 , A61K49/0052 , A61K49/006 , A61K51/0474 , A61K51/0497 , G01N33/5061 , G01N33/92 , G01N2800/323
摘要： The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device or by using an external imaging technique. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand.
摘要翻译：本发明涉及鉴定/监测与血管壁相关的活动性动脉粥样硬化斑块的方法，其中斑块包含具有可配位结合位点的活化巨噬细胞。该方法包括以下步骤：向被评估动脉粥样硬化的患者施用有效量的包含配体和能够在预定条件下发光的发色团的缀合物的组合物，允许配体缀合物足够的时间结合活化的巨噬细胞使用基于导管的装置对血管进行预定条件，并且使用基于导管的装置或通过使用外部成像技术检测由发色团发出的光来识别活性斑块。本发明还涉及一种类似的方法，其中能够发射辐射的化学部分与配体缀合。

10. 发明授权

US11504357B2 PSMA binding ligand-linker conjugates and methods for using 有权
公开(公告)号：US11504357B2
公开(公告)日：2022-11-22
申请号：US16869268
申请日：2020-05-07
申请人： Purdue Research Foundation
发明人： Philip S. Low , Sumith A. Kularatne
IPC分类号： C07D207/416 , A61K47/54 , A61K49/00 , C07K5/08 , A61K31/4745 , A61K31/475 , A61K51/08 , A61K47/64 , A61K31/426 , C07C323/52 , A61K51/04
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

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