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1. 发明专利

JP2012180383A Polymeric gel system for controlled delivery codrug 审中-公开
标题翻译：用于控制输送机的聚合凝胶系统
公开(公告)号：JP2012180383A
公开(公告)日：2012-09-20
申请号：JP2012145841
申请日：2012-06-28
申请人： Psivida Inc , シヴィダ・インコーポレイテッド
发明人： ASHTON PAUL , CHEN JIANBING
IPC分类号： A61K9/20 , A61K45/06 , A61K9/00 , A61K9/06 , A61K9/16 , A61K9/48 , A61K31/196 , A61K31/407 , A61K31/485 , A61K45/00 , A61K45/08 , A61K47/08 , A61K47/12 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61P9/00 , A61P19/02 , A61P25/02 , A61P25/04 , A61P25/06 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/06 , A61P43/00
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/205 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/55
摘要： PROBLEM TO BE SOLVED: To provide an improved injectable, implantable, insertable, or administrable drug delivery composition for releasing a pharmaceutically active compound to a biological tissue.SOLUTION: A pharmaceutical composition comprising a codrug, or a pharmaceutically acceptable salt or prodrug thereof, in admixture with a hydrogel-forming compound, wherein the codrug comprises: (a) at least two constituent moieties, each moiety being a residue of a biologically active compound or a prodrug thereof, including a first constituent moiety and a second constituent moiety; and (b) a linkage covalently linking the at least two constituent moieties to form the codrug, wherein the linkage is cleaved under physiological conditions to regenerate the constituent moieties.
摘要翻译：要解决的问题：提供改进的可注射，可植入，可插入或可施用的药物递送组合物，用于将药学活性化合物释放到生物组织中。解决方案：一种药物组合物，其包含与水凝胶形成化合物混合的一种或多种药学上可接受的盐或前体药物，其中所述代码包含：（a）至少两个构成部分，每个部分是包括第一组成部分和第二组成部分的生物活性化合物或其前药; 和（b）共价连接所述至少两个构成部分以形成所述共药物的连接，其中所述连接在生理条件下切割以再生所述组成部分。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2010168388A Sustained release drug delivery system 审中-公开
标题翻译：持续发放药物递送系统
公开(公告)号：JP2010168388A
公开(公告)日：2010-08-05
申请号：JP2010044187
申请日：2010-03-01
申请人： Psivida Inc , シヴィダ・インコーポレイテッド
发明人： CHEN JIANBING , ASHTON PAUL
IPC分类号： A61K9/00 , A61K9/22 , A61K9/32 , A61K9/52 , A61K31/4422 , A61K31/455 , A61K31/52 , A61K31/522 , A61K31/58 , A61K47/04 , A61K47/32 , A61L27/00 , A61P3/10 , A61P19/02 , A61P25/04 , A61P27/02 , A61P29/00 , A61P31/22 , A61P35/00 , A61P37/06
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/0051
摘要： PROBLEM TO BE SOLVED: To provide a drug delivery system that can be released in a controlled, sustained manner to an area wherein release of an effective drug is desired in a mammalian organism in need of treatment etc. SOLUTION: The drug delivery system comprises: an inner core or a reservoir containing the effective drug; a first coating layer which is permeable to the passage of the effective drug; a second coating layer which is essentially impermeable to the passage of the effective drug; and a third coating layer which is permeable to the passage of the effective drug. The first coating layer covers at least a portion of the inner core. The second coating layer covers at least a portion of the first coating layer and the inner core; however, at least a portion of the first coating layer or the inner core is not covered by the second coating layer. The second coating layer comprises an impermeable film and at least one impermeable disc. The third coating layer essentially covers the second coating layer and the uncovered portion of the first coating layer or the inner core. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可以以受控的，持续的方式释放到需要在需要治疗的哺乳动物生物体中有效药物释放的区域的药物递送系统。解决方案：药物递送系统包括：含有有效药物的内核或储存器; 第一涂层，其可渗透有效药物的通过; 第二涂层，其对于有效药物的通过基本上是不可渗透的; 以及可渗透有效药物通过的第三涂层。第一涂层覆盖内芯的至少一部分。第二涂层覆盖第一涂层和内芯的至少一部分; 然而，第一涂层或内芯的至少一部分未被第二涂层覆盖。第二涂层包括不渗透膜和至少一个不渗透盘。第三涂层基本上覆盖第二涂层和第一涂层或内芯的未覆盖部分。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2011052015A Sustained release drug delivery system containing codrug 审中-公开
标题翻译：持续发放包含CODRUG的药物递送系统
公开(公告)号：JP2011052015A
公开(公告)日：2011-03-17
申请号：JP2010270741
申请日：2010-12-03
申请人： Psivida Inc , シヴィダ・インコーポレイテッド
发明人： CHEN JIANBING , ASHTON PAUL , SMITH THOMAS J
IPC分类号： A61K47/48 , A61F2/84 , A61K9/00 , A61K9/10 , A61K9/22 , A61K9/52 , A61K9/70 , A61K31/192 , A61K31/196 , A61K31/496 , A61K31/513 , A61K45/00 , A61K47/30 , A61K47/32 , A61K47/34 , A61L17/00 , A61L29/00 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/10 , A61P35/00 , A61P37/00 , A61P43/00 , C08K5/00 , C08L101/00
CPC分类号： A61K9/0024 , A61K9/7007 , A61K31/513 , A61K47/32 , A61K47/34 , A61K47/55 , A61K47/554 , A61L17/005 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61L2300/602
摘要： PROBLEM TO BE SOLVED: To provide an improved drug delivery system which has a release speed sustained for a long time at a portion adjacent to an object portion in a body without requiring a complicated manufacturing process.
SOLUTION: A sustained release compound contains a polymer matrix and a prodrug having formula A-L-B dispersed in the polymer (A represents a pharmacological active ingredient, L represents a linker to form the prodrug by being bound to A and B, the linker forms A shape showing a therapeutic effect by being cleaved under a physiological condition, and B is bound to A to represent an ingredient to form the prodrug having a lower solubility than the A shape showing the therapeutic effect). The compound has the solubility in water of the A shape showing the therapeutic effect which exceeds 1 mg/ml, and, on the other hand, has the solubility in water of the prodrug which is less than 1 mg/ml.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种改进的药物递送系统，其具有在与身体中的对象部分相邻的部分处长时间保持的释放速度，而不需要复杂的制造过程。解决方案：持续释放化合物包含聚合物基质和分散在聚合物中的式ALB的前药（A代表药物活性成分，L表示通过与A和B结合形成前药的连接体，连接体形式通过在生理条件下被切割而显示治疗效果的形状，B与A结合以表示形成具有比具有治疗效果的A形状更低的溶解度的前药的成分）。化合物在A型水中的溶解度显示出超过1mg / ml的治疗效果，另一方面在前药的水溶解度小于1mg / ml。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2011093944A Biodegradable sustained release drug delivery system 审中-公开
标题翻译：可生物可追溯释放药物递送系统
公开(公告)号：JP2011093944A
公开(公告)日：2011-05-12
申请号：JP2011031239
申请日：2011-02-16
申请人： Psivida Inc , シヴィダ・インコーポレイテッド
发明人： ASHTON PAUL , CHEN JIANBING , GUO HONG , SU DONGLING
IPC分类号： A61K9/48 , A61K9/00 , A61K9/50 , A61K31/382 , A61K31/485 , A61K31/542 , A61K47/34 , A61K47/44 , A61K47/48
CPC分类号： A61K38/385 , A61K9/0019 , A61K9/0024 , A61K9/0051 , A61K9/0092 , A61K9/5031 , A61K31/382 , A61K31/485 , A61K31/542
摘要： PROBLEM TO BE SOLVED: To attain a sustained release drug delivery system comprising biocompatible solid and biocompatible fluid compositions. SOLUTION: There is disclosed the sustained release drug delivery system, a medical device incorporating the system, use and method for manufacturing the same. The system is composed of a biodegradable drug delivery device including the biocompatible solid and the biocompatible liquid compositions, consequently the sustained release drug delivery is attained. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：获得包含生物相容性固体和生物相容性流体组合物的缓释药物递送系统。解决方案：公开了缓释药物递送系统，结合该系统的医疗装置，其制造方法及其制造方法。该系统由包括生物相容性固体和生物相容性液体组合物的可生物降解的药物递送装置组成，从而达到缓释药物递送。版权所有（C）2011，JPO＆INPIT

5. 发明申请

WO2010129545A3 POROUS SILICON DRUG-ELUTING PARTICLES 审中-公开
标题翻译：多孔硅胶药物颗粒
公开(公告)号：WO2010129545A3
公开(公告)日：2011-03-24
申请号：PCT/US2010033541
申请日：2010-05-04
申请人： PSIVIDA INC , ASHTON PAUL , GUO HONG , CHEN JIANBING , CANHAM LEIGH
发明人： ASHTON PAUL , GUO HONG , CHEN JIANBING , CANHAM LEIGH
IPC分类号： A61K9/22 , A61K9/20 , A61K9/32 , A61K47/30
CPC分类号： A61K31/58 , A61K9/0048 , A61K9/0097
摘要： The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent- permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention. The invention also provides methods of fabricating a drug- eluting particle for releasing therapeutic agents.
摘要翻译：本发明提供了可用于递送诊断或治疗剂的可生物降解的药物洗脱颗粒。在某些实施方案中，本发明的药物洗脱颗粒包括可生物降解的多孔硅体，形成在多孔硅体内的储存器，其具有至少一个开口到本体的外部，其中储存器包含治疗剂或诊断剂，以及设置在所述至少一个开口上方的渗透剂的密封件。本发明进一步提供了一种治疗患者以获得所需局部或全身生理或药理作用的方法，包括施用本发明的缓释药物递送颗粒。本发明还提供了制备用于释放治疗剂的药物洗脱颗粒的方法。

6. 发明公开

EP2427179A4 POROUS SILICON DRUG-ELUTING PARTICLES 审中-公开
标题翻译：多孔颗粒透露有关硅产品
公开(公告)号：EP2427179A4
公开(公告)日：2013-09-11
申请号：EP10772695
申请日：2010-05-04
申请人： PSIVIDA INC
发明人： ASHTON PAUL , GUO HONG , CHEN JIANBING , CANHAM LEIGH
IPC分类号： A61K9/22 , A61K9/20 , A61K9/32 , A61K47/30
CPC分类号： A61K31/58 , A61K9/0048 , A61K9/0097
摘要： The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent-permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention. The invention also provides methods of fabricating a drug-eluting particle for releasing therapeutic agents

7. 发明专利

AU2016203393A1 Porous silicon drug-eluting particles 未知
公开(公告)号：AU2016203393A1
公开(公告)日：2016-06-16
申请号：AU2016203393
申请日：2016-05-24
申请人： PSIVIDA INC
发明人： ASHTON PAUL , GUO HONG , CHEN JIANBING , CANHAM LEIGH
IPC分类号： A61K9/20 , A61K9/22 , A61K9/32 , A61K47/30
摘要： POROUS SILICON DRUG-ELUTING PARTICLES Abstract The present invention provides biodegradable drug-eluting particles for sustained release of a therapeutic or diagnostic agent ("the agent"). The particles are designed to release the agent in a controlled fashion and then biodegrade in the body, thereby avoiding the need for surgical resection of the particles.

8. 发明专利

ES2379466T3 Sistema de suministro de fármacos de liberación sostenida bioerosionables 未知
公开(公告)号：ES2379466T3
公开(公告)日：2012-04-26
申请号：ES04777134
申请日：2004-06-25
申请人： CONTROL DELIVERY SYS INC , PSIVIDA INC
发明人： ASHTON PAUL , CHEN JIANBING , GUO HONG , SU DONGLING
IPC分类号： A61K9/10 , A61K9/00 , A61K9/50 , A61K31/382 , A61K31/485 , A61K31/542
摘要： Un sistema de suministro de fármacos, que comprende: un núcleo interno, que comprende (i) un componente de fluido biocompatible, (ii) un componente de sólido biocompatible disperso, suspendido, o disuelto en el componente de fluido biocompatible, en el que el componente de sólido biocompatible es un polímero bioerosionable y es más soluble en el componente de fluido biocompatible que en fluido fisiológico, y en el que el componente de polímero bioerosionable precipita o gelifica al entrar en contacto con un fluido fisiológico, y (iii) al menos un agente dispersado, suspendido o disuelto en el núcleo interno, y una primera capa de polímero que cubre al menos parte de pero menos de 100% de dicho núcleo interno.

9. 发明专利

PL1635875T3 System dostarczania leków poprzez żelowanie w warunkach in-situ 未知
公开(公告)号：PL1635875T3
公开(公告)日：2009-03-31
申请号：PL04756068
申请日：2004-06-25
申请人： PSIVIDA INC
发明人： ASHTON PAUL , CHEN JIANBING , SU DONGLING
IPC分类号： A61K47/34 , A61K9/00 , A61K31/382 , A61K31/485 , A61K31/542 , A61K47/48

10. 发明专利

SI1635787T1 Bioeredibilni sistemi za oddajanje zdravil z zadrĹľevanim sproĹˇÄŤanjem 未知
公开(公告)号：SI1635787T1
公开(公告)日：2012-04-30
申请号：SI200431836
申请日：2004-06-25
申请人： PSIVIDA INC
发明人： ASHTON PAUL , CHEN JIANBING , GUO HONG , SU DONGLING
IPC分类号： A61K9/00

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