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    • 6. 发明申请
    • PROCESS FOR PRODUCING COMPATIBILIZED POLYMER BLENDS
    • 生产混合聚合物共混物的方法
    • WO2008106631A1
    • 2008-09-04
    • PCT/US2008/055434
    • 2008-02-29
    • PRS MEDITERRANEAN LTD.HALAHMI, IzharEREZ, OdedEREZ, Adi
    • HALAHMI, IzharEREZ, OdedEREZ, Adi
    • C08L21/00B29B13/10
    • B29B7/005B29B7/186B29B7/244B29C47/64C08F255/02C08J3/005C08J2323/02C08L21/00C08L23/06C08L51/06C08L67/00C08L77/00C08L2666/18C08L2666/02C08L2666/14
    • A process is provided for producing a compatibilized polymeric blend. A first thermoplastic polymer and a reactive moiety are provided to a progressive melt kneading apparatus. The reactive moiety comprises a first reactive group capable of reacting with the first thermoplastic polymer but not a second polymer and a second reactive group capable of reacting with the second polymer but not the first polymer. The first thermoplastic polymer and the reactive moiety are then melt kneaded so that the first reactive group reacts with the first thermoplastic polymer and the second reactive group is grafted to the first thermoplastic polymer, forming a molten self-compatibilizer. A molten second polymer is then provided. The molten self- compatibilizer is melt kneaded with the molten second polymer so that the second reactive group reacts with the second polymer to form a compatibilized polymeric blend. Also provided are articles formed from the compatibilized polymer blend.
    • 提供了一种生产相容的聚合物共混物的方法。 将第一热塑性聚合物和反应性部分提供给渐进熔融捏合装置。 反应性部分包括能够与第一热塑性聚合物反应但不与第二聚合物反应的第一反应性基团和能够与第二聚合物但不与第一聚合物反应的第二反应性基团。 然后将第一热塑性聚合物和反应性部分熔融捏合,使得第一反应性基团与第一热塑性聚合物反应,第二反应基团接枝到第一热塑性聚合物上,形成熔融的自增容剂。 然后提供熔融的第二聚合物。 将熔融的自增容剂与熔融的第二聚合物熔融捏合,使得第二反应基团与第二聚合物反应形成相容的聚合共混物。 还提供由相容化的聚合物共混物形成的制品。
    • 9. 发明申请
    • INGESTIBLE DEVICE PLATFORM FOR THE COLON
    • 不可思议的设备平台
    • WO2005112895A2
    • 2005-12-01
    • PCT/IL2005/000517
    • 2005-05-19
    • V-TARGET TECHNOLOGIES LTD.ZILBERSTEIN, YoelNAGLER, MichaelROUSSO, BennyHALAHMI, Izhar
    • ZILBERSTEIN, YoelNAGLER, MichaelROUSSO, BennyHALAHMI, Izhar
    • A61K9/20
    • A61B1/00156A61B1/041A61B5/0077A61B5/073A61B5/14539A61B5/1459A61B5/205A61B5/415A61B5/4255A61B5/6861A61B6/425A61B6/4258A61B6/482A61B6/508A61B6/5247A61B8/12A61B8/4416
    • An ingestible pill platform for colon imaging is provided, designed to recognize its entry to the colon and expand in the colon, for improved imaging of the colon walls. On approaching the external anal sphincter muscle, the ingestible pill may contract or deform, for elimination. Colon recognition may be based on a structural image, based on the differences in diameters between the small intestine and the colon, and particularly, based on the semilunar fold structure, which is unique to the colon. Additionally or alternatively, colon recognition may be based on a functional image, based on the generally inflammatory state of the vermiform appendix. Additionally or alternatively, pH, flora, enzymes and (or) chemical analyses may be used to recognize the colon. The imaging of the colon walls may be functional, by nuclear-radiation imaging of radionuclide-labeled antibodies, or by optical-fluorescence-spectroscopy imaging of fluorescence-labeled antibodies. Additionally or alternatively, it may be structural, for example, by visual, ultrasound or MRI means. Due to the proximity to the colon walls, the imaging in accordance with the present invention is advantageous to colonoscopy or virtual colonoscopy, as it is designed to distinguish malignant from benign tumors and detect tumors even at their incipient stage, and overcome blood-pool background radioactivity.
    • 提供用于结肠成像的可摄取药丸平台,旨在识别其进入结肠并在结肠中扩张,以改善结肠壁的成像。 在接近外肛门括约肌时,可摄取的药丸可能收缩或变形,以消除。 结肠识别可以基于基于小肠和结肠之间的直径差异的结构图像,特别是基于结肠特有的半月形折叠结构。 另外或替代地,结肠识别可以基于功能图像,基于蠕形阑尾的通常炎症状态。 另外或替代地,可以使用pH,菌群,酶和(或)化学分析来识别结肠。 结肠壁的成像可以通过放射性核素标记的抗体的核辐射成像或荧光标记的抗体的光学 - 荧光光谱成像来实现。 另外或替代地,其可以是结构性的,例如通过视觉,超声或MRI手段。 由于靠近结肠壁,根据本发明的成像对于结肠镜检查或虚拟结肠镜检查是有利的,因为其被设计为将恶性肿瘤与良性肿瘤区分开,甚至在初期阶段检测肿瘤,并克服血池背景 放射性。