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1. 发明申请

WO1992019961A1 TWO-TERMINAL VOLTAMMETRIC MICROSENSORS 审中-公开
标题翻译：两端电压显微镜
公开(公告)号：WO1992019961A1
公开(公告)日：1992-11-12
申请号：PCT/US1992003664
申请日：1992-04-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WRIGHTON, Mark, S. , HICKMAN, James, J. , LAIBINIS, Paul, E. , OFER, David , MIRKIN, Chad, A. , VALENTINE, James, R. , WHITESIDES, George, M.
IPC分类号： G01N27/28
CPC分类号： B82Y30/00 , B82Y15/00 , G01N27/3277
摘要： Self-assembly of a chemically insensitive redox material, such as ferrocenyl thiol, and a chemically sensitive redox material, such as a quinone thiol, onto microelectrodes forms the basis for a two-terminal, voltammetric microsensor having reference and sensor functions on the same electrode. Detection is based on measuring the potential difference of current peaks for oxidation and reduction of the reference (ferrocene) and indicator (quinone) in aqueous electrolyte in a two-terminal, linear sweep voltammogram using a counterelectrode of relatively large surface area. Use of microelectrodes modified with monolayer coverages of reference and indicator molecules minimizes the size of the counterelectrode and the perturbation of the solution interrogated. Key advantages are that the sensor requires no separate reference electrode and the sensor functions as long as current peaks can be located for reference and indicator molecules.

2. 发明申请

WO2015127446A1 PAPER-BASED IMMUNOASSAY WITH POLYMERIZATION-BASED SIGNAL AMPLIFICATION 审中-公开
标题翻译：基于纸张的基于聚合信号放大的免疫测定
公开(公告)号：WO2015127446A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/017312
申请日：2015-02-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： BADU-TAWIAH, Abraham, Kwame , AL-SAYAH, Mohammad, Hussein , KAASTRUP, Kaja , LATHWAL, Shefali , CHRISTODOULEAS, Dionysios , SIKES, Hadley , WHITESIDES, George, M.
IPC分类号： G01N33/549
CPC分类号： G01N33/542 , G01N33/54353 , G01N33/54393 , G01N33/548 , G01N33/56905 , G01N33/56911 , G01N2333/23 , G01N2333/445 , Y02A50/58
摘要： Disclosed herein are paper-based immunoassays useful for the detection of analytes, kits for the same and methods of using the same.
摘要翻译：本文公开了可用于检测分析物的纸基免疫测定法，用于其的试剂盒及其使用方法。

3. 发明申请

WO2006086551A3 MICROFLUIDIC LASERS 审中-公开
公开(公告)号：WO2006086551A3
公开(公告)日：2006-08-17
申请号：PCT/US2006/004577
申请日：2006-02-08
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MAYERS, Brian, T. , CONROY, Richard, S. , VEZENOV, Dmitri, V. , SNEE, Preston , CHAN, Yinthai , BAWENDI, Moungi, G. , WHITESIDES, George, M.
发明人： MAYERS, Brian, T. , CONROY, Richard, S. , VEZENOV, Dmitri, V. , SNEE, Preston , CHAN, Yinthai , BAWENDI, Moungi, G. , WHITESIDES, George, M.
IPC分类号： H01S3/05 , H01S3/20 , H01S3/213
摘要： The present invention generally relates to lasers comprising fluidic channels, such as microfluidic channels. In some instances, the channel contains two or more fluids. The fluids may remain non-mixed within the channel, for example, due to immiscibility and/or laminar flow within the channel. The fluids may be arranged in the channel such that light propagating in a first fluid is prevented by the second fluid from exiting the first fluid, for example, due to differences in the indexes of refraction (e.g., causing internal reflection of the fluid to occur). Thus, in one embodiment, a first fluid may be at least partially surrounded by a second fluid having a second index of refraction lower than the index of refraction of the first fluid. In some embodiments, the fluidic channel is used as a laser, for instance, a dye laser, i.e., a laser created by directing light at a dye to produce coherent light. The dye may be present in one or more fluids within the fluidic channel. The incident light (for example, created by another laser) may be directed at the channel from any angle. In some cases, laser light may be produced in a direction substantially aligned with the longitudinal axis of the channel. In some embodiments, the laser is free of mirrors, prisms, or gratings, or the laser may produce coherent light using a non-resonant photonic pathway. However, in other cases, mirrors, prisms, or gratings may be used to reflect light along the channel to enhance stimulated emission of coherent light. Another aspect of the invention includes optical diffractors, such as prisms or gratings, which can contain a fluid. The optical diffractors, in certain embodiments, are positioned to diffract light, such as coherent light, emanating from the fluidic channel. Still other aspects of the invention provide devices, kits, and methods of making and using such lasers.

4. 发明公开

EP1080394A1 ELASTOMERIC MASK AND USE IN FABRICATION OF DEVICES, INLCUDING PIXELATED ELECTROLUMINESCENT DISPLAYS 审中-公开
标题翻译：弹性体材料的MASK，利用生产设备的掩码，包括电致发光光栅化SCREENS
公开(公告)号：EP1080394A1
公开(公告)日：2001-03-07
申请号：EP99918698.4
申请日：1999-04-20
申请人： President And Fellows of Harvard College , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： JACKMAN, Rebecca, J. , DUFFY, David, C. , WHITESIDES, George, M. , VAETH, Kathleen, M. , JENSEN, Klavs, F.
IPC分类号： G03F7/00 , G03F1/00 , G03F7/12 , B41C1/14
CPC分类号： C23C14/042 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F1/00 , G03F7/0002 , G03F7/0007 , G03F7/12 , H01L27/32 , H01L27/3211 , H01L51/0011 , H01L51/56
摘要： An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain unshielded, while other openings of the lower mask are shielded. A first deposition step, followed by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.

5. 发明申请

WO2021081070A1 EXPANDING FOAM-FABRIC ORTHOPEDIC LIMB STABILIZATION DEVICE 审中-公开
公开(公告)号：WO2021081070A1
公开(公告)日：2021-04-29
申请号：PCT/US2020/056625
申请日：2020-10-21
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： ROOT, Samuel, E. , FAZZINI, Jovanna, A. , SANCHEZ, Vanessa , PRESTON, Daniel, J. , WHITESIDES, George, M.
IPC分类号： A61F5/04 , A61F5/01 , A61F5/05 , A61F5/058 , A61F13/00 , A61F13/04 , A61L15/07
摘要： In one aspect, a kit includes a sleeve including an outer lining and an inner lining; a pouch arranged within the sleeve and including one or more polymer sheets, a plurality of channels, and a plurality of vents; and a foam precursor capable of forming a foam within the pouch. In one aspect, a method of stabilizing a body part includes providing a sleeve including an outer lining and an inner lining around a body part; providing a pouch arranged within the sleeve and including one or more polymer sheets, a plurality of channels, and a plurality of vents; providing a foam precursor in the pouch; and forming a foam within the pouch.

6. 发明申请

WO2021041667A1 MODIFYING MESSAGES STORED IN MIXTURES OF MOLECULES USING THIN-LAYER CHROMATOGRAPHY 审中-公开
公开(公告)号：WO2021041667A1
公开(公告)日：2021-03-04
申请号：PCT/US2020/048190
申请日：2020-08-27
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： WHITESIDES, George, M. , WONG, Albert, Siangyoong , FINK, Michael, Johannes , MOHAMED, Khaled, Abdelazim
IPC分类号： G01N30/90 , B01J19/00 , C12Q1/68 , G06K19/00 , G09C1/00 , G11B7/241
摘要： Storage media and methods of reading data from and writing data to said storage media are provided. Information is stored as a mixture of small molecules (MolBits), arranged in an array of addressable locations on a substrate. The mixture comprises at least two subsets of molecules being identifiable by different properties thereof. In one embodiment, the information stored in the mixture (1-16) is decoded by a first step of separating subsets of Molbits having different retardation factors (Rf, I - VIII) on a thin layer chromatography plate. In a second step the separated subsets (4, 15; 10, 16) can be readout differently using various visualization methods adapted to the different properties. Each MolBit is uniquely associated with a predetermined position in a numerical value, wherein the presence of the Molbit in the mixture indicates a predetermined digit at the associated position and the absence of said molecule in the mixture indicates a zero at said associated position.

7. 发明申请

WO2020112233A2 STORAGE OF INFORMATION USING MIXTURES OF MOLECULES 审中-公开
公开(公告)号：WO2020112233A2
公开(公告)日：2020-06-04
申请号：PCT/US2019/053521
申请日：2019-09-27
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , NORTHWESTERN UNIVERSITY
发明人： WHITESIDES, George, M. , CAFFERTY, Brian, J. , TEN, Alexei, S. , FINK, Michael, J. , PRESTON, Daniel, J. , MRKSICH, Milan, M. , NAGARKAR, Amit Arun
摘要： A machine-readable medium and methods of reading and writing same are disclosed. The machine-readable medium comprises a substrate having an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of non-polymeric molecules. The molecules in each collection are selected from a set of unambiguously identifiable molecules, each molecule uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position.

8. 发明申请

WO2020069081A1 MAGNETIC LEVITATION 审中-公开
公开(公告)号：WO2020069081A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/053094
申请日：2019-09-26
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： GE, Shencheng , WHITESIDES, George, M.
IPC分类号： H01F7/02
摘要： A magnetic levitation system is described, including a first cylinder-shaped magnet; a second cylinder-shaped magnet coaxially aligned with the first cylinder-shaped magnet; and a first cavity coaxially aligned with the first cylinder-shaped magnet; wherein the surfaces of the like-poles of the first and second cylinder-shaped magnets are parallel to each other and face each other to result in a linear magnetic field between the first and the second magnets. Methods of using a magnetic levitation system for analyzing a diamagnetic or paramagnetic sample are also described.

9. 发明申请

WO2017083350A1 ACTUATORS 审中-公开
标题翻译：动器
公开(公告)号：WO2017083350A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061078
申请日：2016-11-09
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： YANG, Dian , WHITESIDES, George, M.
IPC分类号： B25J9/10 , B25J9/14 , B25J11/00 , C12M3/06
CPC分类号： B25J9/144 , B25J9/1075 , B25J9/142 , C12M35/04
摘要： A shear force actuator is described, including: two substantially parallel first structural components disposed along a first axis; a plurality of substantially parallel second structural components disposed between and bridging the two first structural components; a plurality of joint sections each joining the second structural component with the first structural components at an oblique angle of between 0 and 90 degrees to define a plurality of cells, each capable of being connected with a fluid inflation or deflation source; an elastic surface covering the remaining surfaces of the cells in a fluid-tight manner, wherein at least one of the joint section, the first structural components, and the second structural components is elastic so that cell collapses upon removal of fluid from the cell to generate a linear force along the first axis.
摘要翻译：描述了剪切力致动器，其包括：沿第一轴设置的两个基本上平行的第一结构部件; 多个基本上平行的第二结构部件，其设置在两个第一结构部件之间并桥接两个第一结构部件; 多个接合部分，每个接合部分将第二结构部件与第一结构部件以0和90度之间的倾斜角度接合以限定多个单元，每个单元能够与流体膨胀或放气源连接; 弹性表面以流体密封的方式覆盖单元的其余表面，其中接合部分，第一结构部件和第二结构部件中的至少一个是弹性的，从而在将流体从单元去除到沿着第一轴产生线性力。

10. 发明申请

WO2016040762A1 SEPARATION OF EMULSIFIED AND DISSOLVED ORGANIC COMPOUNDS FROM WATER 审中-公开
标题翻译：水分解和分解有机化合物
公开(公告)号：WO2016040762A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/049616
申请日：2015-09-11
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： BADU-TAWIAH, Abraham, Kwame , THUO, Martin, Mwangi , WHITESIDES, George, M.
IPC分类号： C08B11/00 , A61K8/89 , C09D101/26
CPC分类号： C08B15/05 , C08B11/06
摘要： Cellulose materials allow selective absorption of emulsified and dissolved hydrocarbons from water. Hydrophobic cellulosic surfaces are prepared in a gas-phase silanization process. The process of using 3,3,3-trifluoropropyl coated paper, cotton fabric and wool in separating hydrocarbon from water is described in details. A functional pillow is provided from encapsulation of untreated cotton wool into 3,3,3-trifluoropropyl functionalized cotton fabric container. The pillow repels water with 100% efficiency, and can absorb large volumes of hydrocarbon depending on its size. The purity of the treated water is >99% for emulsified oils. Additionally, hydrophobic paper can extract dissolved benzene from contaminated water.
摘要翻译：纤维素材料允许从水中选择性吸收乳化和溶解的碳氢化合物。在气相硅烷化方法中制备疏水纤维素表面。详细描述了使用3,3,3-三氟丙基涂布纸，棉织物和羊毛从水中分离烃的过程。通过将未处理的棉絮包封到3,3,3-三氟丙基官能化棉织物容器中来提供功能性枕头。枕头以100％的效率排斥水，并且可以根据其尺寸吸收大量的碳氢化合物。乳化油的处理水的纯度> 99％。另外，疏水性纸可以从污染的水中提取溶解的苯。

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