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1. 发明授权

US07504509B2 Compounds and methods for development of Ret modulators 有权
标题翻译： Ret调制剂的开发化合物和方法
公开(公告)号：US07504509B2
公开(公告)日：2009-03-17
申请号：US11016350
申请日：2004-12-17
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译：描述了在Ret上活性的化合物，以及使用这些化合物的方法。还描述了使用X射线晶体学测定的Ret替代物的晶体结构。使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。

2. 发明申请

US20100324065A1 Compounds and methods for development of Ret Modulators 有权
标题翻译： Ret调制剂开发的化合物和方法
公开(公告)号：US20100324065A1
公开(公告)日：2010-12-23
申请号：US12082665
申请日：2008-04-11
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： A61K31/497 , A61K31/437
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译：描述了在Ret上活性的化合物，以及使用这些化合物的方法。还描述了使用X射线晶体学测定的Ret替代物的晶体结构。使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。

3. 发明申请

US20070049615A1 Compounds and methods for development of Ret modulators 有权
标题翻译： Ret调制剂的开发化合物和方法
公开(公告)号：US20070049615A1
公开(公告)日：2007-03-01
申请号：US11016350
申请日：2004-12-17
申请人： Prabha Ibrahim , Dean Artis , Ryan Bremer , Gaston Habets , Clarence Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Artis , Ryan Bremer , Gaston Habets , Clarence Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译：描述了在Ret上活性的化合物，以及使用这些化合物的方法。还描述了使用X射线晶体学测定的Ret替代物的晶体结构。使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。

4. 发明申请

US20150046885A1 Method and device for unlocking touch screen 有权
标题翻译：解锁触摸屏的方法和设备
公开(公告)号：US20150046885A1
公开(公告)日：2015-02-12
申请号：US14379393
申请日：2012-05-07
申请人： Shengge Zhang , Lina Wang , Yong Zhu
发明人： Shengge Zhang , Lina Wang , Yong Zhu
IPC分类号： G06F3/0484 , G06F3/0488 , G06F3/0481
CPC分类号： G06F3/04847 , G06F3/0481 , G06F3/0484 , G06F3/04842 , G06F3/0488 , G06F3/04883 , G06F2203/04802 , G06F2203/04803
摘要： Disclosed is a method for unlocking a touch screen, including that: an unlocking gesture and a screen transition in unlocking are preset, wherein the screen transition is as follows: a screen is turned along an axis on the screen to produce a visual effect similar to that of pushing open a revolving door, such that a lock screen is turned gradually from the front of the screen to the back of the screen, and an unlocked screen is turned gradually from the back of the screen to the front of the screen; the screen is divided into two or more zones each corresponding to a distinct application; when the screen is unlocked in such a zone, the unlocked screen is an interface of an application corresponding to the zone; and when the screen has to be unlocked, the unlocking gesture is performed on the screen to unlock the screen. With the technical solution, efficiency in unlocking a touch screen and user experience may be improved significantly. Also disclosed is a device for unlocking a touch screen including an unlocking gesture setting module, a screen transition setting module, a screen dividing module, and an unlocking module.
摘要翻译：公开了一种用于解锁触摸屏的方法，包括：解锁手势和解锁中的屏幕转换被预设，其中屏幕转换如下：屏幕沿着屏幕上的轴转动以产生类似于推开打开旋转门的方式，使得屏幕从屏幕的前部逐渐转到屏幕的后部，并且解锁的屏幕从屏幕的后部逐渐转向屏幕的前部; 屏幕被分成两个或更多个区域，每个区域对应于不同的应用; 当屏幕在这样的区域中解锁时，解锁的屏幕是对应于该区域的应用的接口; 并且当屏幕必须被解锁时，在屏幕上执行解锁手势来解锁屏幕。通过技术方案，可以显着提高触摸屏解锁效率和用户体验。还公开了一种用于解锁包括解锁手势设置模块，屏幕转变设置模块，屏幕分割模块和解锁模块的触摸屏的设备。

5. 发明授权

US08480996B2 High-purity tellurium dioxide single crystal and manufacturing method thereof 失效
标题翻译：高纯二氧化碲单晶及其制备方法
公开(公告)号：US08480996B2
公开(公告)日：2013-07-09
申请号：US13262209
申请日：2010-04-02
申请人： Zengwei Ge , Yong Zhu , Guoging Wu , Xueji Yin , Linyao Tang , Hanbin Zhao , Lizhen Gu
发明人： Zengwei Ge , Yong Zhu , Guoging Wu , Xueji Yin , Linyao Tang , Hanbin Zhao , Lizhen Gu
IPC分类号： C01B19/04 , C30B11/02 , C30B15/00
CPC分类号： C30B29/46 , C30B11/00 , C30B15/00 , C30B29/16
摘要： A high-purity tellurium dioxide (TeO2) single crystal and its manufacturing method are provided. The method comprises the following procedures: firstly performing a first single crystal growth, and then dissolving the resulting single crystal again, thereafter adding a precipitation agent to form powder, and finally performing a second single crystal growth of as-prepared powder to obtain the high purity single crystal. The TeO2 single crystal prepared according to present invention is of high purity, especially with a content of radioactive impurities such as U and Th decreased to a level of 10−13 g/g.
摘要翻译：提供了高纯二氧化碲（TeO2）单晶及其制造方法。该方法包括以下步骤：首先进行第一单晶生长，然后再次溶解所得单晶，然后加入沉淀剂形成粉末，最后进行制备的粉末的第二单晶生长以获得高纯度单晶。根据本发明制备的TeO 2单晶具有高纯度，特别是随着诸如U和Th的放射性杂质的含量降低到10-13g / g的水平。

6. 发明申请

US20130070969A1 METHOD AND SYSTEM FOR PEOPLE FLOW STATISTICS 有权
标题翻译：人流统计方法与系统
公开(公告)号：US20130070969A1
公开(公告)日：2013-03-21
申请号：US13578324
申请日：2010-02-10
申请人： Zhigang Hu , Yong Zhu , Ye Ren , Weiwei Cai , Yonghua Jia
发明人： Zhigang Hu , Yong Zhu , Ye Ren , Weiwei Cai , Yonghua Jia
IPC分类号： G06K9/00
CPC分类号： G06K9/00335 , G06K9/00248 , G06K9/00778 , G06K9/6282
摘要： A method and system for people flow statistics is disclosed in the invention, wherein said method comprises: multi-types of classifiers connected in parallel are used to perform the human head detection in the current image, the respective human heads in the current image are determined; the respective determined human heads are tracked to form the human head target movement tracks; and the people flow is counted at the direction of the human head target movement track. It can be seen, a plurality of classifiers connected in parallel are used in the invention, multi-types of human head targets, such as dark colored hair, light colored hair and caps of various colors, and the like, can be detected simultaneously.
摘要翻译：本发明公开了人流统计的方法和系统，其中所述方法包括：并行连接的多类分类器用于在当前图像中执行人头检测，确定当前图像中各个人头 ; 跟踪各自确定的人头以形成人头目标运动轨迹; 人流量按人头目标运动轨迹的方向计算。可以看出，在本发明中使用并联连接的多个分类器，可以同时检测多种类型的人头目标，例如深色头发，浅色头发和各种颜色的帽等。

7. 发明授权

US08349299B2 Conditioning agent and a method for making hair having a shape memory effect 有权
标题翻译：调理剂和具有形状记忆效果的头发的方法
公开(公告)号：US08349299B2
公开(公告)日：2013-01-08
申请号：US12430904
申请日：2009-04-28
申请人： Jinlian Hu , Yong Zhu , Shaojun Chen , Hongsheng Luo , Jing Lu
发明人： Jinlian Hu , Yong Zhu , Shaojun Chen , Hongsheng Luo , Jing Lu
IPC分类号： A61Q5/06 , A61Q5/12
CPC分类号： C08G18/4833 , A61K8/8147 , A61K8/817 , A61K8/8182 , A61K8/87 , A61Q5/04 , A61Q5/12 , C08G18/714 , C08G2280/00
摘要： A method of imparting a shape memory effect to hair may include administrating an effective amount of a hair-conditioning agent to hair. The hair-conditioning agent may include a shape memory polymer selected from the group consisting of a polyurethane, an acrylic acid copolymer, a pyridine-based copolymer, and a pyrrolidone copolymer.
摘要翻译：赋予毛发形状记忆效果的方法可以包括向毛发施用有效量的头发调理剂。护发剂可以包括选自聚氨酯，丙烯酸共聚物，吡啶类共聚物和吡咯烷酮共聚物的形状记忆聚合物。

8. 发明申请

US20120301446A1 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，不进行遗传修饰治疗神经病
公开(公告)号：US20120301446A1
公开(公告)日：2012-11-29
申请号：US13576394
申请日：2011-02-01
申请人： Yong Zhu , Shili Wu , Jun Bao
发明人： Yong Zhu , Shili Wu , Jun Bao
IPC分类号： A61K38/16 , C12N5/071 , G01N21/76 , A61K35/12 , A61P31/00 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/08 , A61P25/06 , C07K14/00 , A61P25/00
CPC分类号： C12N5/0636 , A61K38/00 , C07K14/08 , C12N5/0619 , C12N5/0676 , C12N5/0696 , C12N2501/065 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/99 , C12N2506/08 , C12N2506/11 , C12N2506/1307 , C12N2506/14 , C12N2770/30041 , C12N2770/30045
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as glial cells) into neurons without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the transducible compositions thereof.
摘要翻译：本发明涉及关于将其它细胞（例如神经胶质细胞）重编程成神经元而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

9. 发明申请

US20120108507A1 Methods for In Vivo Cell Reprogramming 审中-公开
标题翻译：体内细胞重编程方法
公开(公告)号：US20120108507A1
公开(公告)日：2012-05-03
申请号：US13288040
申请日：2011-11-03
申请人： Yong Zhu , Shili Wu , Jun Bao
发明人： Yong Zhu , Shili Wu , Jun Bao
IPC分类号： A61K38/02 , A61K31/7088 , A61P3/10 , A61P9/00 , G01N33/53 , A61P25/16 , A61P25/28 , C12Q1/02 , C12Q1/68 , C12N5/071 , A61P19/00
CPC分类号： G01N33/5073 , A61K31/7088 , G01N33/56966
摘要： The present disclosure provides a new technology platform that converts one type of cells (substrate cells) to another type of cells (product cells).
摘要翻译：本公开提供了将一种类型的细胞（底物细胞）转换成另一种细胞（产品细胞）的新技术平台。

10. 发明申请

US20120070366A1 High-Purity Tellurium Dioxide Single Crystal and Manufacturing Method Thereof 失效
标题翻译：高纯度碲化镉单晶及其制造方法
公开(公告)号：US20120070366A1
公开(公告)日：2012-03-22
申请号：US13262209
申请日：2010-04-02
申请人： Zengwei Ge , Yong Zhu , Guoging Wu , Xueji Yin , Linyao Tang , Hanbin Zhao , Lizhen Gu
发明人： Zengwei Ge , Yong Zhu , Guoging Wu , Xueji Yin , Linyao Tang , Hanbin Zhao , Lizhen Gu
IPC分类号： C01B19/04 , C30B11/02 , C30B15/00
CPC分类号： C30B29/46 , C30B11/00 , C30B15/00 , C30B29/16
摘要： A high-purity tellurium dioxide (TeO2) single crystal and its manufacturing method are provided. The method comprises the following procedures: firstly performing a first single crystal growth, and then dissolving the resulting single crystal again, thereafter adding a precipitation agent to form powder, and finally performing a second single crystal growth of as-prepared powder to obtain the high purity single crystal. The TeO2 single crystal prepared according to present invention is of high purity, especially with a content of radioactive impurities such as U and Th decreased to a level of 10−13 g/g.
摘要翻译：提供了高纯二氧化碲（TeO2）单晶及其制造方法。该方法包括以下步骤：首先进行第一单晶生长，然后再次溶解所得单晶，然后加入沉淀剂形成粉末，最后进行制备的粉末的第二单晶生长以获得高纯度单晶。根据本发明制备的TeO 2单晶具有高纯度，特别是随着诸如U和Th的放射性杂质的含量降低到10-13g / g的水平。

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