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1. 发明申请

US20110165083A1 Peptides that home to tumor lymphatic vasculature and methods of using same 有权
标题翻译：归巢于肿瘤淋巴管脉管的肽及其使用方法
公开(公告)号：US20110165083A1
公开(公告)日：2011-07-07
申请号：US12657529
申请日：2010-01-22
申请人： Pirjo Laakkonen , Kimmo Porkka , Jason A. Hoffman , Erkkil Ruoslahti
发明人： Pirjo Laakkonen , Kimmo Porkka , Jason A. Hoffman , Erkkil Ruoslahti
IPC分类号： A61K49/00 , C07K7/00 , C07K7/64 , A61P43/00
CPC分类号： A61K38/08 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering to the subject a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature.
摘要翻译：本发明提供了一种含有与归巢分子连接的部分的缀合物，其选择性地归巢于肿瘤淋巴管脉管。本发明还提供了通过向受试者施用包含选择性地置于肿瘤淋巴管脉管的归巢分子连接的部分的缀合物来引导受试者部分到肿瘤淋巴管脉管系统的方法。

2. 发明授权

US07671021B2 Peptides that home to tumor lymphatic vasculature and methods of using same 有权
标题翻译：归巢于肿瘤淋巴管脉管的肽及其使用方法
公开(公告)号：US07671021B2
公开(公告)日：2010-03-02
申请号：US11712043
申请日：2007-02-27
申请人： Pirjo Laakkonen , Kimmo Porkka , Jason A. Hoffman , Erkki Ruoslahti
发明人： Pirjo Laakkonen , Kimmo Porkka , Jason A. Hoffman , Erkki Ruoslahti
IPC分类号： A61K38/00
CPC分类号： A61K38/08 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering to the subject a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature.
摘要翻译：本发明提供了一种含有与归巢分子连接的部分的缀合物，其选择性地归巢于肿瘤淋巴管脉管。本发明还提供了通过向受试者施用包含选择性地置于肿瘤淋巴管脉管的归巢分子连接的部分的缀合物来引导受试者部分到肿瘤淋巴管脉管系统的方法。

3. 发明授权

US07192921B2 Peptides that home to tumor lymphatic vasculature and methods of using same 有权
标题翻译：归巢于肿瘤淋巴管脉管的肽及其使用方法
公开(公告)号：US07192921B2
公开(公告)日：2007-03-20
申请号：US10290385
申请日：2002-11-05
申请人： Pirjo Laakkonen , Kimmo Porkka , Jason A. Hoffman , Erkki Ruoslahti
发明人： Pirjo Laakkonen , Kimmo Porkka , Jason A. Hoffman , Erkki Ruoslahti
IPC分类号： C07K7/06 , C07K7/64
CPC分类号： A61K38/08 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering to the subject a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature.
摘要翻译：本发明提供了一种含有与归巢分子连接的部分的缀合物，其选择性地归巢于肿瘤淋巴管脉管。本发明还提供了通过向受试者施用包含选择性地置于肿瘤淋巴管脉管的归巢分子连接的部分的缀合物来引导受试者部分到肿瘤淋巴管脉管系统的方法。

4. 发明授权

US08329859B2 Peptides that home to tumor lymphatic vasculature and methods of using same 有权
标题翻译：归巢于肿瘤淋巴管脉管的肽及其使用方法
公开(公告)号：US08329859B2
公开(公告)日：2012-12-11
申请号：US12657529
申请日：2010-01-22
申请人： Pirjo Laakkonen , Kimmo Porkka , Jason A. Hoffman , Erkki I. Ruoslahti
发明人： Pirjo Laakkonen , Kimmo Porkka , Jason A. Hoffman , Erkki I. Ruoslahti
IPC分类号： C07K7/00 , C07K7/02 , A61K38/12 , A61K38/00 , A61P35/00
CPC分类号： A61K38/08 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering to the subject a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature.
摘要翻译：本发明提供了一种含有与归巢分子连接的部分的缀合物，其选择性地归巢于肿瘤淋巴管脉管。本发明还提供了通过向受试者施用包含选择性地置于肿瘤淋巴管脉管的归巢分子连接的部分的缀合物来引导受试者部分到肿瘤淋巴管脉管系统的方法。

5. 发明申请

US20110179162A1 Managing Workloads and Hardware Resources in a Cloud Resource 有权
标题翻译：管理云资源中的工作负载和硬件资源
公开(公告)号：US20110179162A1
公开(公告)日：2011-07-21
申请号：US12696334
申请日：2010-01-29
申请人： Mark G. Mayo , James Duncan , Pedro Palazón Candel , Jason A. Hoffman , David P. Young
发明人： Mark G. Mayo , James Duncan , Pedro Palazón Candel , Jason A. Hoffman , David P. Young
IPC分类号： G06F9/50 , G06F15/173 , G06F12/08
CPC分类号： G06F9/5077 , G06F9/45558 , H04L12/1822 , H04L29/06 , H04L29/08072 , H04L29/0809
摘要： Systems and methods to manage workloads and hardware resources in a data center or cloud. In one embodiment, a method includes a data center having a plurality of servers in a network. The data center provides a virtual machine for each of a plurality of users, each virtual machine to use a portion of hardware resources of the data center. The hardware resources include storage and processing resources distributed onto each of the plurality of servers. The method further includes sending messages amongst the servers, some of the messages being sent from a server including status information regarding a hardware resource utilization status of that server. The method further includes detecting a request from the virtual machine to handle a workload requiring increased use of the hardware resources, and provisioning the servers to temporarily allocate additional resources to the virtual machine, wherein the provisioning is based on status information provided by one or more of the messages.
摘要翻译：管理数据中心或云中的工作负载和硬件资源的系统和方法。在一个实施例中，一种方法包括具有网络中的多个服务器的数据中心。数据中心为多个用户中的每一个提供虚拟机，每个虚拟机使用数据中心的一部分硬件资源。硬件资源包括分布在多个服务器中的每一个上的存储和处理资源。该方法还包括在服务器之间发送消息，一些消息从服务器发送，包括关于该服务器的硬件资源利用状态的状态信息。该方法还包括检测来自虚拟机的请求以处理需要更多使用硬件资源的工作负载，以及提供服务器以临时分配额外的资源给虚拟机，其中所述供应基于由一个或多个的消息。

6. 发明申请

US20110179134A1 Managing Hardware Resources by Sending Messages Amongst Servers in a Data Center 有权
标题翻译：通过在数据中心中的服务器之间发送消息来管理硬件资源
公开(公告)号：US20110179134A1
公开(公告)日：2011-07-21
申请号：US12696802
申请日：2010-01-29
申请人： Mark G. Mayo , James Duncan , Pedro Palazón Candel , Jason A. Hoffman , David P. Young
发明人： Mark G. Mayo , James Duncan , Pedro Palazón Candel , Jason A. Hoffman , David P. Young
IPC分类号： G06F15/167 , G06F15/173
CPC分类号： G06F9/5077 , G06F9/45558 , H04L12/1822 , H04L29/06 , H04L29/08072 , H04L29/0809
摘要： Systems and methods to manage workloads and hardware resources in a data center or cloud. In one embodiment, a method includes a data center having a plurality of servers in a network. The data center provides a virtual machine for each of a plurality of users, each virtual machine to use a portion of hardware resources of the data center. The hardware resources include storage and processing resources distributed onto each of the plurality of servers. The method further includes sending messages amongst the servers, some of the messages being sent from a server including status information regarding a hardware resource utilization status of that server. The method further includes detecting a request from the virtual machine to handle a workload requiring increased use of the hardware resources, and provisioning the servers to temporarily allocate additional resources to the virtual machine, wherein the provisioning is based on status information provided by one or more of the messages.
摘要翻译：管理数据中心或云中的工作负载和硬件资源的系统和方法。在一个实施例中，一种方法包括具有网络中的多个服务器的数据中心。数据中心为多个用户中的每一个提供虚拟机，每个虚拟机使用数据中心的一部分硬件资源。硬件资源包括分布在多个服务器中的每一个上的存储和处理资源。该方法还包括在服务器之间发送消息，一些消息从服务器发送，包括关于该服务器的硬件资源利用状态的状态信息。该方法还包括检测来自虚拟机的请求以处理需要更多使用硬件资源的工作负载，以及提供服务器以临时分配额外的资源给虚拟机，其中所述供应基于由一个或多个的消息。

7. 发明授权

US08789050B2 Systems and methods for transparently optimizing workloads 有权
标题翻译：用于透明优化工作负载的系统和方法
公开(公告)号：US08789050B2
公开(公告)日：2014-07-22
申请号：US13963980
申请日：2013-08-09
申请人： Jason A. Hoffman , James Duncan , Mark G. Mayo , David P. Young
发明人： Jason A. Hoffman , James Duncan , Mark G. Mayo , David P. Young
IPC分类号： G06F9/45 , G06F9/455 , G06F15/16 , G06F15/173
CPC分类号： G06F9/455 , G06F9/5072 , G06F9/5083
摘要： Systems, methods, and media for transparently optimizing a workload of a containment abstraction are provided herein. Methods may include monitoring a workload of the containment abstraction, the containment abstraction being at least partially hardware bound, the workload corresponding to resource utilization of the containment abstraction, converting the containment abstraction from being at least partially hardware bound to being entirely central processing unit (CPU) bound by placing the containment abstraction in a memory store, based upon the workload, and allocating the workload of the containment abstraction across at least a portion of a data center to optimize the workload of the containment abstraction.
摘要翻译：这里提供了用于透明地优化容纳抽象的工作负载的系统，方法和媒体。方法可以包括监视容纳抽象的工作负载，至少部分硬件绑定的容纳抽象，与容纳抽象的资源利用相对应的工作负载，将包含抽象从至少部分硬件转换为完全中央处理单元（ CPU），通过基于工作负载将容纳抽象放置在存储器存储中，并且在数据中心的至少一部分上分配容纳抽象的工作负载以优化容纳抽象的工作负载。

8. 发明申请

US20120233315A1 SYSTEMS AND METHODS FOR SIZING RESOURCES IN A CLOUD-BASED ENVIRONMENT 审中-公开
标题翻译：用于在基于云的环境中量化资源的系统和方法
公开(公告)号：US20120233315A1
公开(公告)日：2012-09-13
申请号：US13046660
申请日：2011-03-11
申请人： Jason A. Hoffman , James Duncan , Mark G. Mayo , David P. Young
发明人： Jason A. Hoffman , James Duncan , Mark G. Mayo , David P. Young
IPC分类号： G06F15/173
CPC分类号： G06F9/5072
摘要： Systems and methods for sizing resources in a cloud-based environment are provided. In an exemplary embodiment, a method includes receiving quality of service requirements and a functional description of a cloud architecture associated with the application, including application resources and relations between the application resources, performing latency analysis of data packets in a compute layer of the cloud architecture, with the latency analysis including comparing size per time metrics of the data packets, determining minimal resources to guarantee the quality of service requirements based on the latency analysis and the quality of service requirements, and providing to the data center the minimal resources.
摘要翻译：提供了在基于云的环境中调整资源大小的系统和方法。在示例性实施例中，一种方法包括接收服务质量要求和与应用相关联的云架构的功能描述，包括应用资源和应用资源之间的关系，在云架构的计算层中执行数据分组的等待时间分析延迟分析包括比较数据分组的每个时间度量的大小，基于延迟分析和服务质量要求确定最小资源以保证服务质量要求，并向数据中心提供最少的资源。

9. 发明申请

US20120233626A1 SYSTEMS AND METHODS FOR TRANSPARENTLY OPTIMIZING WORKLOADS 有权
标题翻译：用于透明优化工作负载的系统和方法
公开(公告)号：US20120233626A1
公开(公告)日：2012-09-13
申请号：US13046647
申请日：2011-03-11
申请人： Jason A. Hoffman , James Duncan , Mark G. Mayo , David P. Young
发明人： Jason A. Hoffman , James Duncan , Mark G. Mayo , David P. Young
IPC分类号： G06F9/46
CPC分类号： G06F9/455 , G06F9/5072 , G06F9/5083
摘要： Systems, methods, and media for transparently optimizing a workload of a containment abstraction are provided herein. Methods may include monitoring a workload of the containment abstraction, the containment abstraction being at least partially hardware bound, the workload corresponding to resource utilization of the containment abstraction, converting the containment abstraction from being at least partially hardware bound to being entirely central processing unit (CPU) bound by placing the containment abstraction in a memory store, based upon the workload, and allocating the workload of the containment abstraction across at least a portion of a data center to optimize the workload of the containment abstraction.
摘要翻译：这里提供了用于透明地优化容纳抽象的工作负载的系统，方法和媒体。方法可以包括监视容纳抽象的工作负载，至少部分硬件绑定的容纳抽象，与容纳抽象的资源利用相对应的工作负载，将包含抽象从至少部分硬件转换为完全中央处理单元（ CPU），通过基于工作负载将容纳抽象放置在存储器存储中，并且在数据中心的至少一部分上分配容纳抽象的工作负载以优化容纳抽象的工作负载。

10. 发明申请

US20090191223A1 Peptides that selectively home to heart vasculature and related conjugates and methods 有权
标题翻译：选择性地置于心脏血管和相关共轭物和方法的肽
公开(公告)号：US20090191223A1
公开(公告)日：2009-07-30
申请号：US12322371
申请日：2009-01-29
申请人： Lianglin Zhang , Jason A. Hoffman , Erkki Ruoslahti
发明人： Lianglin Zhang , Jason A. Hoffman , Erkki Ruoslahti
IPC分类号： A61K39/395 , C07K7/06 , A61K38/08 , A61P7/02
CPC分类号： A61K47/48246 , A61K38/00 , A61K38/04 , A61K38/08 , A61K47/6849 , C07K7/06 , C07K7/08 , C07K14/001
摘要： The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a variety of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimetic thereof.
摘要翻译：本发明提供了多种分离的肽和肽模拟物，其可用于构建本发明的缀合物，或其中肽本身具有生物学活性的非共轭形式作为治疗各种各样的心血管疾病如下所述。因此，本发明提供长度小于60个残基的分离的肽或肽模拟物，并且包括氨基酸序列CRPPR（SEQ ID NO：1）或其肽模拟物。本发明还提供长度小于60个残基的分离的肽或肽模拟物，包括氨基酸序列CARPAR（SEQ ID NO：5）或其拟肽，或氨基酸序列CPKRPR（SEQ ID NO：6）或其拟肽。

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