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1. 发明申请

US20110000645A1 HEAT DISSIPATING BOARD STRUCTURE AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：热消散板结构及其制造方法
公开(公告)号：US20110000645A1
公开(公告)日：2011-01-06
申请号：US12498091
申请日：2009-07-06
申请人： Ping Chen , Shu-Chun Yu
发明人： Ping Chen , Shu-Chun Yu
IPC分类号： F28D15/04 , F28F7/00 , B21D53/02
CPC分类号： B21D53/02 , B21D17/02 , B21D53/08 , F28D15/0275 , F28F1/22 , F28F2275/06 , F28F2275/065 , F28F2275/12 , H01L23/427 , H01L2924/0002 , Y10T29/4935 , H01L2924/00
摘要： A heat dissipating board structure includes a heat dissipating board body having a first face with at least one groove; and at least one heat pipe correspondingly received in the at least one groove to flush with the first face. To manufacture the heat dissipating board structure, first provide at least one heat pipe and a heat dissipating board body; then, form at least one groove on a first face of the board body, place the heat pipe in the groove, and press the board body with a press machine to associate the heat pipe with the groove while flatten a top of the heat pipe; and finally, flush the heat pipe with the first face by removing extra material of the heat pipe that is protruded from the first face. The completed heat dissipating board structure provides upgraded heat dissipation efficiency and eliminates the problem of thermal resistance.
摘要翻译：散热板结构包括具有至少一个凹槽的第一面的散热板本体; 以及相应地容纳在所述至少一个凹槽中以与所述第一面齐平的至少一个热管。为了制造散热板结构，首先提供至少一个热管和散热板体; 然后在板体的第一面上形成至少一个凹槽，将热管放置在槽中，并用压力机将板体按压以将热管与凹槽相连，同时使热管的顶部平坦化; 最后，通过除去从第一面突出的热管的多余材料与第一面冲洗热管。完成的散热板结构提供了升级的散热效率，并消除了热阻的问题。

2. 发明授权

US08756810B2 Board-shaped heat Dissipating method of manufacturing 有权
标题翻译：板状散热制造方法
公开(公告)号：US08756810B2
公开(公告)日：2014-06-24
申请号：US13355029
申请日：2012-01-20
申请人： Ping Chen , Shu-Chun Yu
发明人： Ping Chen , Shu-Chun Yu
IPC分类号： B21D53/02 , B23P19/02 , F28D15/02
CPC分类号： F28D15/0275 , F28F2275/02 , F28F2275/12 , Y10T29/4935 , Y10T29/49353 , Y10T29/49364 , Y10T29/49393 , Y10T29/49885 , Y10T29/49945
摘要： A board-shaped heat dissipating device includes a board body having a plane face with a recess formed thereon, a heat conducting element fitted in the recess, at least one groove formed on any one of the board body and the heat conducting element, and at least one heat pipe pressed into the groove to flush with an open side of the groove. After the heat pipe is pressed into the groove and the heat conducting element is firmly fitted in the recess, portions of the heat conducting element that are higher than the plane face are removed through a cut operation, so that the heat conducting element is flush with the plane face of the board body to reduce the space occupied by the heat dissipating device. With the above arrangements, the problem of thermal resistance can be avoided and upgraded overall heat dissipation efficiency can be achieved.
摘要翻译：一种板状散热装置，包括具有形成在其上的凹部的平面的板主体，嵌合在凹部中的导热元件，形成在板主体和导热元件中的任一个上的至少一个槽，至少一个热管被压入槽中以与槽的开放侧齐平。在热管被压入槽中并且导热元件牢固地装配在凹部中之后，通过切割操作去除导热元件高于平面的部分，使得导热元件与板体的平面减少了散热装置占用的空间。通过上述布置，可以避免热阻的问题，并且可以提高总的散热效率。

3. 发明授权

US08353333B2 Board-shaped heat dissipating device and method of manufacturing the same 有权
标题翻译：板状散热装置及其制造方法
公开(公告)号：US08353333B2
公开(公告)日：2013-01-15
申请号：US12535120
申请日：2009-08-04
申请人： Ping Chen , Shu-Chun Yu
发明人： Ping Chen , Shu-Chun Yu
IPC分类号： F28F7/00 , F28D15/00 , H05K7/20
CPC分类号： F28D15/0275 , F28F2275/02 , F28F2275/12 , Y10T29/4935 , Y10T29/49353 , Y10T29/49364 , Y10T29/49393 , Y10T29/49885 , Y10T29/49945
摘要： A board-shaped heat dissipating device includes a board body having a plane face with a recess formed thereon, a heat conducting element fitted in the recess, at least one groove formed on any one of the board body and the heat conducting element, and at least one heat pipe pressed into the groove to flush with an open side of the groove. After the heat pipe is pressed into the groove and the heat conducting element is firmly fitted in the recess, portions of the heat conducting element that are higher than the plane face are removed through a cut operation, so that the heat conducting element is flush with the plane face of the board body to reduce the space occupied by the heat dissipating device. With the above arrangements, the problem of thermal resistance can be avoided and upgraded overall heat dissipation efficiency can be achieved.
摘要翻译：一种板状散热装置，包括具有形成在其上的凹部的平面的板主体，嵌合在凹部中的导热元件，形成在板主体和导热元件中的任一个上的至少一个槽，至少一个热管被压入槽中以与槽的开放侧齐平。在热管被压入槽中并且导热元件牢固地装配在凹部中之后，通过切割操作去除导热元件高于平面的部分，使得导热元件与板体的平面减少了散热装置占用的空间。通过上述布置，可以避免热阻的问题，并且可以提高总的散热效率。

4. 发明申请

US20120117804A1 BOARD-SHAPED HEAT DISSIPATING METHOD OF MANUFACTURING 有权
标题翻译：板形热消散方法
公开(公告)号：US20120117804A1
公开(公告)日：2012-05-17
申请号：US13355029
申请日：2012-01-20
申请人： Ping Chen , Shu-Chun Yu
发明人： Ping Chen , Shu-Chun Yu
IPC分类号： B23P15/26
CPC分类号： F28D15/0275 , F28F2275/02 , F28F2275/12 , Y10T29/4935 , Y10T29/49353 , Y10T29/49364 , Y10T29/49393 , Y10T29/49885 , Y10T29/49945
摘要： A board-shaped heat dissipating device includes a board body having a plane face with a recess formed thereon, a heat conducting element fitted in the recess, at least one groove formed on any one of the board body and the heat conducting element, and at least one heat pipe pressed into the groove to flush with an open side of the groove. After the heat pipe is pressed into the groove and the heat conducting element is firmly fitted in the recess, portions of the heat conducting element that are higher than the plane face are removed through a cut operation, so that the heat conducting element is flush with the plane face of the board body to reduce the space occupied by the heat dissipating device. With the above arrangements, the problem of thermal resistance can be avoided and upgraded overall heat dissipation efficiency can be achieved.
摘要翻译：一种板状散热装置，包括具有形成在其上的凹部的平面的板主体，嵌合在凹部中的导热元件，形成在板主体和导热元件中的任一个上的至少一个槽，至少一个热管被压入槽中以与槽的开放侧齐平。在热管被压入槽中并且导热元件牢固地装配在凹部中之后，通过切割操作去除导热元件高于平面的部分，使得导热元件与板体的平面减少了散热装置占用的空间。通过上述布置，可以避免热阻的问题，并且可以提高总的散热效率。

5. 发明申请

US20110030922A1 BOARD-SHAPED HEAT DISSIPATING DEVICE AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：板形热灭火装置及其制造方法
公开(公告)号：US20110030922A1
公开(公告)日：2011-02-10
申请号：US12535120
申请日：2009-08-04
申请人： Ping Chen , Shu-Chun Yu
发明人： Ping Chen , Shu-Chun Yu
IPC分类号： F28D15/02 , B21D53/08
CPC分类号： F28D15/0275 , F28F2275/02 , F28F2275/12 , Y10T29/4935 , Y10T29/49353 , Y10T29/49364 , Y10T29/49393 , Y10T29/49885 , Y10T29/49945
摘要： A board-shaped heat dissipating device includes a board body having a plane face with a recess formed thereon, a heat conducting element fitted in the recess, at least one groove formed on any one of the board body and the heat conducting element, and at least one heat pipe pressed into the groove to flush with an open side of the groove. After the heat pipe is pressed into the groove and the heat conducting element is firmly fitted in the recess, portions of the heat conducting element that are higher than the plane face are removed through a cut operation, so that the heat conducting element is flush with the plane face of the board body to reduce the space occupied by the heat dissipating device. With the above arrangements, the problem of thermal resistance can be avoided and upgraded overall heat dissipation efficiency can be achieved.
摘要翻译：一种板状散热装置，包括具有形成在其上的凹部的平面的板主体，嵌合在凹部中的导热元件，形成在板主体和导热元件中的任一个上的至少一个槽，至少一个热管被压入槽中以与槽的开放侧齐平。在热管被压入槽中并且导热元件牢固地装配在凹部中之后，通过切割操作去除导热元件高于平面的部分，使得导热元件与板体的平面减少了散热装置占用的空间。通过上述布置，可以避免热阻的问题，并且可以提高总的散热效率。

6. 发明申请

US20180354957A1 SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20180354957A1
公开(公告)日：2018-12-13
申请号：US16058299
申请日：2018-08-08
申请人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.

7. 发明申请

US20180222919A1 N-ALKYL-2-PHENOXYETHANAMINES, THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20180222919A1
公开(公告)日：2018-08-09
申请号：US15944334
申请日：2018-04-03
申请人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号： C07D498/04 , C07D213/79 , C07D213/80 , C07D231/56 , C07D237/24 , C07C233/56 , C07D249/04 , C07D471/04 , C07D487/04 , C07D491/052 , C07D239/28
CPC分类号： C07D498/04 , C07C233/56 , C07D213/79 , C07D213/80 , C07D231/56 , C07D237/24 , C07D239/28 , C07D249/04 , C07D471/04 , C07D487/04 , C07D491/052
摘要： The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.

8. 发明授权

US08805025B2 Stain detection 有权
标题翻译：污渍检测
公开(公告)号：US08805025B2
公开(公告)日：2014-08-12
申请号：US13436078
申请日：2012-03-30
申请人： Ping Chen , Chao He , Gary Ross
发明人： Ping Chen , Chao He , Gary Ross
IPC分类号： G06T7/00 , G07D11/00
CPC分类号： G07D7/187
摘要： A method of detecting staining on a media item is described. An example method includes receiving an image of the media item, including a plurality of pixels having different intensity values within a range of intensity values, applying central weighting to the received image, applying a threshold to each pixel in the centrally-weighted image to transform each pixel to a binary value, comparing a pixel in the evaluation image with a pixel in a binary reference image to create a difference image including (i) a stain pixel at each spatial location in which a pixel in the evaluation image has a low intensity pixel and the corresponding pixel in the binary reference image has a high intensity pixel, and (ii) a non-stain pixel at all other spatial locations. The media item is identified as stained in the event that the difference image meets a staining criterion.
摘要翻译：描述了在媒体项目上检测染色的方法。一种示例性方法包括接收媒体项目的图像，包括在强度值范围内具有不同强度值的多个像素，对接收到的图像应用中央加权，向中央加权图像中的每个像素应用阈值以变换每个像素为二进制值，将评估图像中的像素与二进制参考图像中的像素进行比较，以产生差分图像，其包括（i）评估图像中的像素具有低强度的每个空间位置处的污点像素像素和二进制参考图像中的对应像素具有高强度像素，以及（ii）所有其它空间位置处的非污点像素。在差异图像满足染色标准的情况下，媒体项目被识别为染色。

9. 发明申请

US20140128339A1 2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译： 2'-甲基取代的核苷衍生物及其用于治疗病毒性疾病的方法
公开(公告)号：US20140128339A1
公开(公告)日：2014-05-08
申请号：US14054424
申请日：2013-10-15
申请人： Vinay Girijavallabhan , Stephane Bogen , Quang T. Truong , Ping Chen , Angela Kerekes , Frank Bennett , Sara Esposite , Qingmei Hong , Ian Davies
发明人： Vinay Girijavallabhan , Stephane Bogen , Quang T. Truong , Ping Chen , Angela Kerekes , Frank Bennett , Sara Esposite , Qingmei Hong , Ian Davies
IPC分类号： C07H19/06 , A61K45/06 , A61K31/7072 , C07H19/10 , A61K31/7068
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/067 , C07H19/073 , C07H19/10
摘要： The present invention relates to 2′-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R1, R2 and R3, are as defined herein. The present invention also relates to compositions comprising at least one 2′-Methyl Substituted Nucleoside Derivative, and methods of using the 2′-Methyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及式（I）的2'-甲基取代的核苷衍生物及其药学上可接受的盐，其中R，R 1，R 2和R 3如本文所定义。本发明还涉及包含至少一种2'-甲基取代的核苷衍生物的组合物，以及使用2'-甲基取代的核苷衍生物治疗或预防患者HCV感染的方法。

10. 发明申请

US20140080884A1 NOVEL CRYSTALLINE FORMS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR 有权
标题翻译：一种DIPEPTIDYL PEPTIDASE-IV抑制剂的新型结晶形式
公开(公告)号：US20140080884A1
公开(公告)日：2014-03-20
申请号：US14118998
申请日：2012-06-25
申请人： Itzia Arroyo , Davida Krueger , Ping Chen , Aaron Moment , Tesfaye Biftu , Faye Sheen , Yanfeng Zhang
发明人： Itzia Arroyo , Davida Krueger , Ping Chen , Aaron Moment , Tesfaye Biftu , Faye Sheen , Yanfeng Zhang
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/4439 , A61K31/4985 , A61K31/513 , C07B2200/13 , Y02P20/55
摘要： Novel crystalline forms of (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine are potent inhibitors of dipeptidyl peptidase-IV and are useful for the treatment of non-insulin dependent (Type 2) diabetes mellitus. The invention also relates to pharmaceutical compositions containing these novel forms, processes to prepare these forms and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes.
摘要翻译：（2R，3S，5R）-2-（2,5-二氟苯基）-5- [2-（甲基磺酰基）-2,6-二氢吡咯并[3,4-c]吡唑-5（4H） - 吡啶-3-基]四氢-2H-吡喃-3-胺是二肽基肽酶-IV的有效抑制剂，可用于治疗非胰岛素依赖型（2型）糖尿病。本发明还涉及含有这些新型形式的药物组合物，制备这些形式的方法及其药物组合物及其用于治疗2型糖尿病的用途。

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