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1. 发明授权

US5157133A Dihydropyran derivatives, processes for preparation and use 失效
标题翻译：二氢衍生物，制备和使用方法
公开(公告)号：US5157133A
公开(公告)日：1992-10-20
申请号：US620609
申请日：1990-12-03
申请人： Pierre F. Chabardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
发明人： Pierre F. Chabardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
IPC分类号： C07C45/60 , C07C403/14 , C07D309/30 , C07D311/72 , C07D403/14
CPC分类号： C07C403/14 , C07C45/60 , C07D309/30
摘要： The present invention relates to dihydropyran derivatives, processes for preparing, and processes of using the derivatives. The derivatives are prepared by condensation of lithium dienolate of prenal with an aldehyde or a ketone.The pyran derivative prepared from .beta.-ionylideneacetaldehyde when treated in the presence of a catalyst directly forms retinal.
摘要翻译：本发明涉及二氢吡喃衍生物，制备方法和使用衍生物的方法。衍生物通过将prenal的二烯酸锂与醛或酮的缩合来制备。由β-亚酰基乙醛制备的吡喃衍生物在催化剂存在下处理直接形成视网膜。

2. 发明授权

US5250710A Dihydropyran derivatives, processes for preparation and use 失效
标题翻译：二氢吡喃衍生物，制备和使用方法
公开(公告)号：US5250710A
公开(公告)日：1993-10-05
申请号：US879335
申请日：1992-05-07
申请人： Pierre F. Chabardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
发明人： Pierre F. Chabardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
IPC分类号： C07C45/60 , C07D309/30 , C07D315/00
CPC分类号： C07C403/14 , C07C45/60 , C07D309/30
摘要： The present invention relates to dihydropyran derivatives, processes for preparing, and processes of using the derivatives. The derivatives are prepared by condensation of lithium dienolate of prenal with an aldehyde or a ketone.The pyran derivative prepared from .beta.-ionylideneacetaldehyde when treated in the presence of a catalyst directly forms retinal.
摘要翻译：本发明涉及二氢吡喃衍生物，制备方法和使用衍生物的方法。衍生物通过将prenal的二烯酸锂与醛或酮的缩合来制备。由β-亚酰基乙醛制备的吡喃衍生物在催化剂存在下处理直接形成视网膜。

3. 发明授权

US5266708A New intermediates, process for their preparation, and their use for the synthesis of vitamins A and E 失效
标题翻译：新中间体，其制备方法及其用于合成维生素A和E的用途
公开(公告)号：US5266708A
公开(公告)日：1993-11-30
申请号：US858621
申请日：1992-03-27
申请人： Pierre F. Charbardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
发明人： Pierre F. Charbardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
IPC分类号： C07C45/59 , C07C47/24 , C07D317/20 , C07D319/06 , C07F9/655 , C07D317/18
CPC分类号： C07C403/14 , C07C45/59 , C07C47/24 , C07D317/20 , C07D319/06 , C07F9/65515
摘要： New intermediates and processes for the preparation of vitamins A and E, which are the acetals of 5,6-dihalo-3-methyl-3-hydroxyhexanal or of 6-halo-3-hydroxy-3-methyl-5-hexenal or 3-methyl-3-hydroxy-5-hexenal, as well as processes for making the intermediates. After dehydrohalogenation and dehydration these intermediates are condensed directly with .beta.-ionone or with 2-methyl-2-heptene-6-one to synthesize vitamins A and E respectively.
摘要翻译：用于制备维生素A和E的新中间体和方法，其为5,6-二卤代-3-甲基-3-羟基己醛或6-卤代-3-羟基-3-甲基-5-己烯醛或3 3-甲基-3-羟基-5-己烯醛，以及制备中间体的方法。在脱卤化氢和脱水后，这些中间体直接与β-戊酮或2-甲基-2-庚烯-6-酮缩合以分别合成维生素A和E。

4. 发明授权

US5120864A Intermediates, process for their preparation, and their use for the synthesis of vitamins A and E 失效
标题翻译：中间体，其制备方法及其合成维生素A和E的用途
公开(公告)号：US5120864A
公开(公告)日：1992-06-09
申请号：US620854
申请日：1990-12-03
申请人： Pierre F. Charbardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
发明人： Pierre F. Charbardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
IPC分类号： C07D317/12 , B01J27/08 , B01J31/02 , C07B61/00 , C07C45/59 , C07C47/24 , C07C403/14 , C07C403/22 , C07D317/16 , C07D317/20 , C07D319/06 , C07D325/00 , C07F9/655
CPC分类号： C07C403/14 , C07C45/59 , C07C47/24 , C07D317/20 , C07D319/06 , C07F9/65515 , C07C2101/16
摘要： New intermediates and processes for the preparation of vitamins A and E, which are the acetals of 5,6-dihalo-3-methyl-3-hydroxyhexanal or of 6-halo-3-hydroxy-3-methyl-5-hexenal or 3-methyl-3-hydroxy-5-hexenal, as well as processes for making the intermediates. After dehydrohalogenation and dehydration these intermediates are condensed directly with .beta.-ionone or with 2-methyl-2-heptene-6-one to synthesize vitamins A and E respectively.
摘要翻译：用于制备维生素A和E的新中间体和方法，其为5,6-二卤代-3-甲基-3-羟基己醛或6-卤代-3-羟基-3-甲基-5-己烯醛或3 3-甲基-3-羟基-5-己烯醛，以及制备中间体的方法。在脱卤化氢和脱水后，这些中间体直接与β-戊酮或2-甲基-2-庚烯-6-酮缩合以分别合成维生素A和E。

5. 发明授权

US5292897A Process for preparing halo acetals from enamines 失效
标题翻译：从烯胺制备卤代缩醛的方法
公开(公告)号：US5292897A
公开(公告)日：1994-03-08
申请号：US858406
申请日：1992-03-27
申请人： Pierre Chabardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
发明人： Pierre Chabardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
IPC分类号： C07D295/02 , B01J27/02 , B01J27/06 , B01J31/02 , C07B61/00 , C07C41/50 , C07C43/313 , C07C45/56 , C07C251/12 , C07C251/30 , C07D295/06 , C07D295/067 , C07D317/16 , C07F9/06 , C07F9/40 , C07F9/655
CPC分类号： C07D295/067 , C07C403/14 , C07C43/313 , C07C45/56 , C07D317/16 , C07F9/65515 , C07C2101/16
摘要： The present invention relates to a process for preparing halo acetals of ethylenic aldehydes by reaction of a halogen cation with enamine followed by a hydrolysis and reaction with an alcohol, a glycol or an orthoformate. These halo acetals are used as intermediate for the synthesis of vitamins A and E.It also relates to a new compound of formula (IV), ##STR1## to a process for preparing it from halo acetals of ethylenic aldehydes by reaction with triethyl phosphate, and to its use for the preparation of retinal by reaction with .beta.-ionylideneacetaldehyde.
摘要翻译：本发明涉及通过卤素阳离子与烯胺的反应，然后与醇，二醇或原甲酸酯进行水解和反应来制备烯属醛的卤代缩醛的方法。这些卤代乙醛用作合成维生素A和E的中间体。它还涉及一种新的式（IV）化合物，（*化学结构*）（Ⅳ），其由乙烯醛的卤代缩醛制备的方法通过与磷酸三乙酯反应，以及其用于通过与（β） - 亚氨基乙醛反应来制备视网膜的用途。

6. 发明授权

US5145972A Process for preparing halo acetals from enamines 失效
标题翻译：从制定HALO ACET的方法
公开(公告)号：US5145972A
公开(公告)日：1992-09-08
申请号：US620610
申请日：1990-12-03
申请人： Pierre Chabardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
发明人： Pierre Chabardes , Lucette Duhamel , Pierre Duhamel , Jerome Guillemont , Jean-Marie Poirier
IPC分类号： C07D295/02 , B01J27/02 , B01J27/06 , B01J31/02 , C07B61/00 , C07C41/50 , C07C43/313 , C07C45/56 , C07C251/12 , C07C251/30 , C07D295/06 , C07D295/067 , C07D317/16 , C07F9/06 , C07F9/40 , C07F9/655
CPC分类号： C07D295/067 , C07C403/14 , C07C43/313 , C07C45/56 , C07D317/16 , C07F9/65515 , C07C2101/16
摘要： The present invention relates to a process for preparing halo acetals of ethylenic aldehydes by reaction of a halogen cation with enamine followed by a hydrolysis and reaction with an alcohol, a glycol or an orthoformate. These halo acetals are used as intermediate for the synthesis of vitamins A and E.It also relates to a new compound of formula (IV), ##STR1## to a process for preparing it from halo acetals of ethylenic aldehydes by reaction with triethyl phosphate, and to its use for the preparation of retinal by reaction with .beta.-ionylideneacetaldehyde.
摘要翻译：本发明涉及通过卤素阳离子与烯胺的反应，然后与醇，二醇或原甲酸酯进行水解和反应来制备烯属醛的卤代缩醛的方法。这些卤代乙醛用作合成维生素A和E的中间体。它还涉及一种新的式（IV）化合物，其作用是通过与乙烯醛的卤代缩醛反应制备该化合物，磷酸三乙酯，以及其用于通过与β-亚硫酰基乙醛反应制备视网膜的用途。

7. 发明授权

US5424460A Synthesis intermediates containing a hexane ring and processes for their preparation 失效
标题翻译：含有己烷环的合成中间体及其制备方法
公开(公告)号：US5424460A
公开(公告)日：1995-06-13
申请号：US139049
申请日：1993-10-21
申请人： Lucette Duhamel , Pierre Duhamel , Bertrand Leblond , Jean-Marie Poirier
发明人： Lucette Duhamel , Pierre Duhamel , Bertrand Leblond , Jean-Marie Poirier
IPC分类号： C07D301/26 , C07C29/10 , C07C29/124 , C07C29/64 , C07C35/48 , C07C37/06 , C07C39/24 , C07C39/26 , C07C39/28 , C07C39/373 , C07C45/51 , C07C45/58 , C07C49/463 , C07C49/687 , C07D303/08
CPC分类号： C07C45/512 , C07C35/48 , C07C45/58 , C07C49/463 , C07C49/687 , C07D303/08
摘要： The present invention relates to new fluorinated hexane compounds corresponding to the following general formula (II): ##STR1## in which X'.sub.2, X'.sub.3 and X'.sub.4 are the same or different, and denote a halogen or a pseudohalogen, preferably a halogen, more preferably chlorine and fluorine, with the condition that, when R.sub.1 is hydroxyl, cyano, amido, imido, ethoxy, benzyloxy, cyclohexyloxy and tert-butoxy, not all the halogens can simultaneously be chlorine and R.sub.4, R.sub.3 and R.sub.5 are simultaneously equal to H;R.sub.1 denotes a hydrogen, a hydrocarbon chain such as an alkyl chain, alkoxy, cycloalkyl ether, an aromatic group, aromatic ether or an alkoxy, carbonyl, carboxyl or acyloxy, cyano, amido, imido or hydroxyl group;R.sub.4 denotes a hydrogen, a fluorine atom, a hydrocarbon chain such as, for example, an alkyl chain, an aromatic group or a carbonyl, carboxyl or carboxamide group or else a radical joined to the hexane ring by a chalcogen or by an element of Group V, preferably of the first Period, such as an amido, alkoxy or acyloxy group;in which the radicals R.sub.3 and R.sub.5, which are different or preferably the same, denote a fluorine, or preferably hydrogen, atom or also a hydrocarbon chain as defined above in the case of R.sub.4.
摘要翻译：本发明涉及对应于以下通式（II）的新的氟化己烷化合物：其中X'2，X'3和X'4相同或不同，并且表示卤素或假卤素，优选卤素，更优选氯和氟，条件是当R1是羟基，氰基，酰胺基，亚氨基，乙氧基，苄氧基，环己氧基和叔丁氧基时，不是所有的卤素都可以同时是氯，R4，R3和R5是同时等于H; R 1表示氢，烃链如烷基链，烷氧基，环烷基醚，芳族基团，芳族醚或烷氧基，羰基，羧基或酰氧基，氰基，酰胺基，亚氨基或羟基; R4表示氢，氟原子，烃链，例如烷基链，芳族基团或羰基，羧基或羧酰胺基团，或者由硫属化合物连接到己烷环上的基团，或者由优选第一阶段的V族如酰氨基，烷氧基或酰氧基; 其中不同或优选相同的基团R3和R5表示在R4的情况下如上所定义的氟或优选氢原子或烃链。

8. 发明授权

US5817890A Process for preparation of halogenated or pseudohalogenated cyclic organic compounds 失效
标题翻译：制备卤化或假卤代环状有机化合物的方法
公开(公告)号：US5817890A
公开(公告)日：1998-10-06
申请号：US401254
申请日：1995-03-09
申请人： Lucette Duhamel , Pierre Duhamel , Bertrand Leblond , Jean-Marie Poirier
发明人： Lucette Duhamel , Pierre Duhamel , Bertrand Leblond , Jean-Marie Poirier
IPC分类号： C07D301/26 , C07C29/10 , C07C29/124 , C07C29/64 , C07C35/48 , C07C37/06 , C07C39/24 , C07C39/26 , C07C39/28 , C07C39/373 , C07C45/51 , C07C45/58 , C07C49/463 , C07C49/687 , C07D303/08
CPC分类号： C07C45/512 , C07C35/48 , C07C45/58 , C07C49/463 , C07C49/687 , C07D303/08
摘要： The present invention relates to new fluorinated hexane compounds corresponding to the following general formula (II): ##STR1## in which X'.sub.2, X'.sub.3, and X'.sub.4 are the same or different, and denote a halogen or a pseudohalogen, preferably a halogen, more preferably chlorine and fluorine, with the condition that, when R.sub.1 is hydroxyl, cyano, amido, imido, ethoxy, benzyloxy, cyclohexyloxy and tert-butoxy, not all the halogens can simultaneously be chlorine and R.sub.4, R.sub.3 and R.sub.5 are simultaneously equal to H; R.sub.1 denotes a hydrogen, a hydrocarbon chain such as an alkyl chain, alkoxy, cycloalkyl ether, an aromatic group, aromatic ether or an alkoxy, carbonyl, carboxyl or acyloxy, cyano, amido, imido or hydroxyl group; R.sub.4 denotes a hydrogen, a fluorine atom, a hydrocarbon chain such as, for example, an alkyl chain, an aromatic group or a carbonyl, carboxyl or carboxamide group or else a radical joined to the hexane ring by a chalcogen or by an element of Group V, preferably of the first Period, such as an amido, alkoxy or acyloxy group; in which the radicals R.sub.3 and R.sub.5, which are different or preferably the same, denote a fluorine, or preferably hydrogen, atom or also a hydrocarbon chain as defined above in the case of R.sub.4.
摘要翻译：本发明涉及对应于以下通式（II）的新的氟化己烷化合物：其中X'2，X'3和X'4相同或不同，表示卤素或假卤素，优选卤素，更优选氯和氟，条件是当R1是羟基，氰基，酰氨基，亚氨基，乙氧基，苄氧基，环己氧基和叔丁氧基时，不是所有的卤素都可以同时为氯，R4，R3和R5 同时等于H; R 1表示氢，烃链如烷基链，烷氧基，环烷基醚，芳族基团，芳族醚或烷氧基，羰基，羧基或酰氧基，氰基，酰胺基，亚氨基或羟基; R4表示氢，氟原子，烃链，例如烷基链，芳族基团或羰基，羧基或羧酰胺基团，或者由硫属化合物连接到己烷环上的基团，或者由优选第一阶段的V族如酰氨基，烷氧基或酰氧基; 其中不同或优选相同的基团R3和R5表示在R4的情况下如上所定义的氟或优选氢原子或烃链。

9. 发明授权

US06436973B1 LTA4 hydrolase inhibitors 失效
标题翻译： LTA4水解酶抑制剂
公开(公告)号：US06436973B1
公开(公告)日：2002-08-20
申请号：US09787708
申请日：2001-06-11
申请人： Denis Danvy , Thierry Monteil , Jean-Christophe Plaquevent , Pierre Duhamel , Lucette Duhamel , Nadine Noel , Claude Gros , Olivier Chamard , Jean-Charles Schwartz , Jeanne-Marie Lecomte
发明人： Denis Danvy , Thierry Monteil , Jean-Christophe Plaquevent , Pierre Duhamel , Lucette Duhamel , Nadine Noel , Claude Gros , Olivier Chamard , Jean-Charles Schwartz , Jeanne-Marie Lecomte
IPC分类号： C07D21364
CPC分类号： C07C323/25 , C07C327/30 , C07D213/64 , C07D317/64
摘要： The invention concerns LTA4 hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications.
摘要翻译：本发明涉及如下所述的式（1）的LTA4水解酶抑制组合物。它还涉及其治疗，特别是抗炎的应用。

10. 发明授权

US5449844A Intermediates for preparing vitamins A and E and carotenoids 失效
标题翻译：制备维生素A和E以及类胡萝卜素的中间体
公开(公告)号：US5449844A
公开(公告)日：1995-09-12
申请号：US982675
申请日：1992-11-27
申请人： Jean-Erick Ancel , Bienayme, Hugues , Lucette Duhamel , Pierre Duhamel
发明人： Jean-Erick Ancel , Bienayme, Hugues , Lucette Duhamel , Pierre Duhamel
IPC分类号： C07C29/44 , C07C33/44 , C07C45/51 , C07C45/65 , C07C47/21 , C07C47/24 , C07C47/267 , C07C49/203 , C07C49/227 , C07C49/242 , C07C49/255 , C07C323/15 , C07C391/02 , C07C403/06 , C07C403/08 , C07C403/10 , C07C403/12 , C07C403/14 , H01R13/639 , C07C43/00
CPC分类号： C07C403/22 , C07C391/02 , C07C403/08 , C07C403/12 , C07C403/14 , C07C403/16 , C07C45/511 , C07C45/513 , C07C45/65 , C07C47/21 , C07C47/24 , C07C49/203 , C07C2101/16
摘要： The present invention relates to a new method of condensing polyenic compounds wherein a compound having the formula III ##STR1## is condensed with a compound having the formula IV ##STR2## under the influence of a Lewis acid or a protic acid. R.sub.1 through R.sub.7 represent alkyl or alkenyl groups, A' is preferably chlorine, B is preferably a hydroxyl group, and n' is 0 to 10. The invention also relates to novel intermediates for use in the preparation of Vitamins A and E produced by means of the new method.
摘要翻译：本发明涉及一种缩合多元化合物的新方法，其中具有式III的化合物（III）在路易斯酸或质子的影响下与具有式IV的化合物（IV）缩合酸。 R1至R7表示烷基或烯基，A'优选为氯，B优选为羟基，n'为0至10.本发明还涉及用于制备维生素A和E的新型中间体的新方法。

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