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1. 发明公开

EP2231188A2 USE OF 5-AMINOLEVULINIC ACID AND DERIVATIVES IN A SOLID FORM FOR PHOTODYNAMIC TREATMENT AND DIAGNOSIS 审中-公开
标题翻译：使用5-氨基乙酰丙酸与以固体形式衍生物对照片动态治疗和诊断
公开(公告)号：EP2231188A2
公开(公告)日：2010-09-29
申请号：EP08860052.3
申请日：2008-12-12
申请人： Photocure ASA , Golding, Louise Ann
发明人： KLAVENESS, Jo , STENSRUD, Gry , GODAL, Aslak , BRAENDEN, Jon, Erik , KLEM, Bjørn
IPC分类号： A61K41/00 , A61P35/00 , A61K49/00 , A61K9/02 , A61K9/28 , A61K9/48 , A61K31/197
CPC分类号： A61K9/02 , A61K9/0031 , A61K9/0034 , A61K9/0075 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K9/20 , A61K9/2013 , A61K9/205 , A61K9/2054 , A61K9/2077 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/48 , A61K9/4858 , A61K9/4891 , A61K9/5042 , A61K9/5073 , A61K31/197 , A61K31/221 , A61K41/0057 , A61K41/0061 , A61K49/00 , A61K49/0021
摘要： The present invention relates to the use of a photosensitiser which is 5-ALA or a precursor or derivative thereof (e.g. an ALA ester), in the manufacture of a pharmaceutical product for use in the photodynamic treatment or diagnosis of cancer, an infection associated with cancer, or in the treatment or diagnosis of a non-cancerous condition, wherein said pharmaceutical product is in the form of a solid. The invention also relates to solid pharmaceutical products for use in such methods, e.g. suppositories, pessaries, tablets, pellets and capsules which comprise 5-ALA or a precursor or derivative thereof (e.g. an ALA ester) and at least one pharmaceutically acceptable carrier or excipient. Such products are particularly suitable for use in the photodynamic treatment or diagnosis of cancerous or non- cancerous conditions in the lower part of the gastrointestinal system or in the female reproductive system, e.g. in the treatment or diagnosis of colorectal cancer or cervical cancer.

2. 发明申请

WO2009074811A2 USE 审中-公开
标题翻译：使用
公开(公告)号：WO2009074811A2
公开(公告)日：2009-06-18
申请号：PCT/GB2008/004113
申请日：2008-12-12
申请人： PHOTOCURE ASA , GOLDING, Louise , KLAVENESS, Jo , STENSRUD, Gry , GODAL, Aslak , BRAENDEN, Jon, Erik , KLEM, Bjørn
发明人： KLAVENESS, Jo , STENSRUD, Gry , GODAL, Aslak , BRAENDEN, Jon, Erik , KLEM, Bjørn
IPC分类号： A61K41/00 , A61P35/00 , A61K49/00 , A61K9/02 , A61K9/28 , A61K9/48 , A61K31/197
CPC分类号： A61K9/02 , A61K9/0031 , A61K9/0034 , A61K9/0075 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K9/20 , A61K9/2013 , A61K9/205 , A61K9/2054 , A61K9/2077 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/48 , A61K9/4858 , A61K9/4891 , A61K9/5042 , A61K9/5073 , A61K31/197 , A61K31/221 , A61K41/0057 , A61K41/0061 , A61K49/00 , A61K49/0021
摘要： The present invention relates to the use of a photosensitiser which is 5-ALA or a precursor or derivative thereof (e.g. an ALA ester), in the manufacture of a pharmaceutical product for use in the photodynamic treatment or diagnosis of cancer, an infection associated with cancer, or in the treatment or diagnosis of a non-cancerous condition, wherein said pharmaceutical product is in the form of a solid. The invention also relates to solid pharmaceutical products for use in such methods, e.g. suppositories, pessaries, tablets, pellets and capsules which comprise 5-ALA or a precursor or derivative thereof (e.g. an ALA ester) and at least one pharmaceutically acceptable carrier or excipient. Such products are particularly suitable for use in the photodynamic treatment or diagnosis of cancerous or non¬ cancerous conditions in the lower part of the gastrointestinal system or in the female reproductive system, e.g. in the treatment or diagnosis of colorectal cancer or cervical cancer.
摘要翻译：本发明涉及使用5-ALA或其前体或衍生物（例如ALA酯）的光敏剂在制造用于癌症的光动力学治疗或诊断的药物产品中，与癌症或治疗或诊断非癌症状况，其中所述药物产品为固体形式。本发明还涉及用于这些方法的固体药物产品，例如。栓剂，阴道栓剂，片剂，丸剂和胶囊，其包含5-ALA或其前体或衍生物（例如ALA酯）和至少一种药学上可接受的载体或赋形剂。这些产品特别适用于光动力学治疗或诊断胃肠系统下部或女性生殖系统中的癌性或非癌性病症，例如，在结直肠癌或宫颈癌的治疗或诊断中。

3. 发明申请

WO2010142456A1 SOLID COMPOSITIONS COMPRISING 5-AMINOLEVULINIC ACID 审中-公开
标题翻译：包含5-氨基酸的固体组合物
公开(公告)号：WO2010142456A1
公开(公告)日：2010-12-16
申请号：PCT/EP2010/003531
申请日：2010-06-11
申请人： PHOTOCURE ASA , HELLAND, Oddveig Sellaeg , STENSRUD, Gry , KLEM, Bjorn , BRAENDEN, Jon Erik , GODAL, Aslak , KLAVENESS, Jo
发明人： HELLAND, Oddveig Sellaeg , STENSRUD, Gry , KLEM, Bjorn , BRAENDEN, Jon Erik , GODAL, Aslak , KLAVENESS, Jo
IPC分类号： A61K9/20 , A61K9/48 , A61K9/02 , A61K47/14 , A61K31/197
CPC分类号： A61K31/197 , A61K9/0009 , A61K9/4858 , A61K41/0061 , A61K49/0036
摘要： This invention relates to solid compositions and solid pharmaceutical products for use in methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions in the lower part of the gastrointestinal system. The solid pharmaceutical compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions of the lower gastrointestinal tract, wherein the solid pharmaceutical compositions and pharmaceutical products are used.
摘要翻译：本发明涉及用于癌症的光动力学诊断方法，胃肠系统下部癌前和非癌症病症的固体组合物和固体药物产品。固体药物组合物和药物产品包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐。本发明还涉及癌症的光动力学诊断方法，下胃肠道的癌前和非癌症状况，其中使用固体药物组合物和药物产品。

4. 发明申请

WO2010142457A1 SEMI-SOLID COMPOSITIONS AND PHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：半固体组合物和药物产品
公开(公告)号：WO2010142457A1
公开(公告)日：2010-12-16
申请号：PCT/EP2010/003532
申请日：2010-06-11
申请人： PHOTOCURE ASA , STENSRUD, Gry
发明人： STENSRUD, Gry
IPC分类号： A61K31/195 , A61K9/06 , A61K47/10 , A61K47/14 , A61K47/44
CPC分类号： A61K31/221 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/195 , A61K41/0061 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/26
摘要： This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.
摘要翻译：本发明涉及用于癌症的光动力学治疗（PDT），女性生殖系统，肛门和阴茎中的癌前病症和非癌症状态的半固体组合物和半固体药物产品，优选使用在子宫内膜，子宫颈，外阴，阴道，肛门和阴茎发育异常和子宫，子宫颈，外阴，阴道，肛门和阴茎的HPV感染的PDT中。半固体组合物和药物产品包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐。本发明还涉及在雌性生殖系统，肛门和阴茎中的癌症的PDT，癌前病症和非癌症病症的方法，其中使用所述半固体组合物和药物产品。

5. 发明公开

EP2440199A1 SEMI-SOLID COMPOSITIONS AND PHARMACEUTICAL PRODUCTS 失效
标题翻译：半固体药物组合物
公开(公告)号：EP2440199A1
公开(公告)日：2012-04-18
申请号：EP10724715.7
申请日：2010-06-11
申请人： Photocure ASA
发明人： STENSRUD, Gry
IPC分类号： A61K31/195 , A61K9/06 , A61K47/10 , A61K47/14 , A61K47/44
CPC分类号： A61K31/221 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/195 , A61K41/0061 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/26
摘要： This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.

6. 发明授权

EP2440199B1 SEMI-SOLID COMPOSITIONS AND PHARMACEUTICAL PRODUCTS 失效
标题翻译：半固体药物组合物
公开(公告)号：EP2440199B1
公开(公告)日：2016-04-13
申请号：EP10724715.7
申请日：2010-06-11
申请人： Photocure ASA
发明人： STENSRUD, Gry
IPC分类号： A61K31/195 , A61K9/06 , A61K41/00 , A61K47/10 , A61K47/14 , A61K47/44 , A61K47/12 , A61K47/24 , A61K47/26 , A61K31/221
CPC分类号： A61K31/221 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/195 , A61K41/0061 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/26

7. 发明授权

EP3042647B1 SEMI-SOLID COMPOSITIONS AND PHARMACEUTICAL PRODUCTS COMPRISING 5-AMINOLEVULINIC ACID ESTERS 有权
公开(公告)号：EP3042647B1
公开(公告)日：2020-08-26
申请号：EP16156371.3
申请日：2010-06-11
申请人： Photocure ASA
发明人： STENSRUD, Gry
IPC分类号： A61K9/00 , A61K31/195 , A61K9/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/26 , A61K47/14 , A61K31/221

8. 发明公开

EP3042647A1 SEMI-SOLID COMPOSITIONS AND PHARMACEUTICAL PRODUCTS COMPRISING 5-AMINOLEVULINIC ACID ESTERS 有权
标题翻译：哈伯斯特ZUSAMMENSETZUNGEN ARZNEIPRODUKTE ENTHALTEND ESTER DER 5-AMINOLÄVULINSÄURE
公开(公告)号：EP3042647A1
公开(公告)日：2016-07-13
申请号：EP16156371.3
申请日：2010-06-11
申请人： Photocure ASA
发明人： STENSRUD, Gry
IPC分类号： A61K9/00 , A61K31/195 , A61K9/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/26 , A61K47/14 , A61K31/221
摘要： This invention relates to water-free, semi-solid pharmaceutical products which comprise an active ingredient selected from a 5-ALA ester and pharmaceutically acceptable salts thereof; one or more triglycerides; and optionally one or more viscosity enhancers; wherein the concentration of the active ingredient is 0.5 to 30% by weight of the total weight of the product, and the concentration of the one or more triglycerides is in the range of 60 to 96% by weight of the total weight of the product if the one or more viscosity enhancers are present, or in the range of 70 to 99.5% by weight of the total weight of the product if the one or more viscosity enhancers are not present. The invention further relates to the use of such products in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis.
摘要翻译：本发明涉及无水半固体药物产品，其包含选自5-ALA酯和其药学上可接受的盐的活性成分; 一种或多种甘油三酯; 和任选的一种或多种粘度增强剂; 其中所述活性成分的浓度为所述产品总重量的0.5至30重量％，并且所述一种或多种甘油三酯的浓度在产物总重量的60至96重量％的范围内，如果如果不存在一种或多种粘度增强剂，则存在一种或多种粘度增强剂，或者在产品总重量的70-99.5重量％的范围内。本发明还涉及这种产品在女性生殖系统，肛门和阴茎中的癌症，癌前病症和非癌症状态的光动力学治疗（PDT）中的应用，优选在子宫内膜，宫颈，外阴的PDT中阴道，肛门和阴茎发育不良以及子宫，子宫颈，外阴，阴道，肛门和阴茎的HPV感染。

9. 发明公开

EP2440188A1 SOLID COMPOSITIONS COMPRISING 5-AMINOLEVULINIC ACID 审中-公开
标题翻译：固体组合物含有5-氨基乙酰丙酸
公开(公告)号：EP2440188A1
公开(公告)日：2012-04-18
申请号：EP10725043.3
申请日：2010-06-11
申请人： Photocure ASA
发明人： HELLAND, Oddveig Sellaeg , STENSRUD, Gry , KLEM, Bjorn , BRAENDEN, Jon Erik , GODAL, Aslak , KLAVENESS, Jo
IPC分类号： A61K9/20 , A61K9/48 , A61K9/02 , A61K47/14 , A61K31/197
CPC分类号： A61K31/197 , A61K9/0009 , A61K9/4858 , A61K41/0061 , A61K49/0036
摘要： This invention relates to solid compositions and solid pharmaceutical products for use in methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions in the lower part of the gastrointestinal system. The solid pharmaceutical compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions of the lower gastrointestinal tract, wherein the solid pharmaceutical compositions and pharmaceutical products are used.

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