专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4943589A Anthelmintic dysinins of marine origin 失效
标题翻译：海洋起源的驱虫虫排毒素
公开(公告)号：US4943589A
公开(公告)日：1990-07-24
申请号：US263261
申请日：1988-10-27
申请人： Phillip Crews , Thomas R. Matthews , Paul Horton
发明人： Phillip Crews , Thomas R. Matthews , Paul Horton
IPC分类号： A61K31/34 , C07D307/92
CPC分类号： C07D307/92 , A61K31/34
摘要： This invention is directed to a method for treating helminthiasis which comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of Formula (I): ##STR1## where R.sup.1 is hydrogen or --SR.sup.2, whereinR.sup.2 is hydrogen, --C(O)--CH.sub.3, or ##STR2## or a pharmaceutically acceptable salt thereof. This invention is also directed to a composition for treating helminthiasis in an animal which comprises a pharmaceutically acceptable excipient and an anthelmintically effective amount of a compound of Formula (I). This invention is also directed to novel compounds of Formula (I) wherein R.sup.2 is ##STR3##
摘要翻译：本发明涉及一种治疗蠕虫病的方法，其包括向有需要的动物施用驱肠成形有效量的式（I）化合物：其中R 1为氢或-SR 2，其中R 2为氢，-C（O）-CH 3或其药学上可接受的盐。本发明还涉及用于治疗动物中的蠕虫病的组合物，其包含药学上可接受的赋形剂和驱肠虫有效量的式（I）化合物。本发明还涉及式（I）的新化合物，其中R 2是

2. 发明授权

US4959370A Alkaloids of marine origin 失效
标题翻译：海洋来源的生物碱
公开(公告)号：US4959370A
公开(公告)日：1990-09-25
申请号：US330164
申请日：1989-03-29
申请人： Phillip Crews , Thomas R. Matthews , Wayne D. Inman
发明人： Phillip Crews , Thomas R. Matthews , Wayne D. Inman
IPC分类号： C07D471/16
CPC分类号： C07D471/16
摘要： This invention is directed to novel compounds of Formula (I): ##STR1## wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof and pharmaceutical compositions formulated therewith. This invention is also directed to a method for treating helminthiasis and for inhibiting reverse transcriptase activity in an animal by the administration of compounds of Formula (I).
摘要翻译：本发明涉及式（I）的新化合物：其中R是氢或甲基，或其药学上可接受的盐和与其配制的药物组合物。本发明还涉及通过给予式（I）化合物来治疗蠕虫病和用于抑制动物体内逆转录酶活性的方法。

3. 发明授权

US4785012A Oxazole anthelmintic agents of marine origin 失效
标题翻译：海洋起源的恶唑驱虫剂
公开(公告)号：US4785012A
公开(公告)日：1988-11-15
申请号：US36267
申请日：1987-04-09
申请人： Philip Crews , Thomas R. Matthews , Emilio Q. Cabana , Madeline Adamczeski
发明人： Philip Crews , Thomas R. Matthews , Emilio Q. Cabana , Madeline Adamczeski
IPC分类号： C07D263/32 , A61K31/42
CPC分类号： C07D263/32
摘要： New oxazole derivatives of formula 1 and their pharmacetically acceptable salts have anthelmintic activity: ##STR1## where R is H, OH, or acyloxy of 8 to 22 carbon atoms;R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each independently H or acyl of 1 to 6 carbon atoms.
摘要翻译：式1的新的恶唑衍生物及其药物可接受的盐具有驱虫活性：其中R是H，OH或8-22个碳原子的酰氧基; R 1，R 2，R 3和R 4各自独立地为H或1至6个碳原子的酰基。

4. 发明授权

US4522811A Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides 失效
标题翻译：连续注射胞壁酰二肽和脂质体可增强胞壁酰二肽的抗感染活性
公开(公告)号：US4522811A
公开(公告)日：1985-06-11
申请号：US396213
申请日：1982-07-08
申请人： Deborah A. Eppstein , Elizabeth B. Fraser-Smith , Thomas R. Matthews
发明人： Deborah A. Eppstein , Elizabeth B. Fraser-Smith , Thomas R. Matthews
IPC分类号： A61K9/127 , A61K31/00 , A61K38/00 , A61K38/14 , A61K37/02
CPC分类号： A61K31/00 , A61K38/14 , A61K9/127
摘要： Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides.
摘要翻译：连续注射胞壁酰二肽和脂质体可增强胞壁酰二肽的抗感染活性。

5. 发明授权

US4684625A Method for enhancing the anti-infective activity of muramyldipeptide derivatives 失效
标题翻译：增强胞壁酰二肽衍生物的抗感染活性的方法
公开(公告)号：US4684625A
公开(公告)日：1987-08-04
申请号：US725037
申请日：1985-04-19
申请人： Deborah A. Eppstein , Elizabeth Fraser-Smith , Thomas R. Matthews
发明人： Deborah A. Eppstein , Elizabeth Fraser-Smith , Thomas R. Matthews
IPC分类号： A61K31/00 , A61K38/00 , A61K38/14 , C07K5/06 , A61K9/42
CPC分类号： B82Y5/00 , A61K31/00 , A61K38/14
摘要： Co-administration of a muramyldipeptide derivative with liposomes enhances the anti-infective activity of the muramyldipeptide derivative.
摘要翻译：间质肽衍生物与脂质体的共同给药增强胞壁酰肽基衍生物的抗感染活性。

6. 发明授权

US4930824A Gutter cleaner 失效
标题翻译：沟槽清洁剂
公开(公告)号：US4930824A
公开(公告)日：1990-06-05
申请号：US345349
申请日：1989-04-28
申请人： Thomas R. Matthews , Garland B. Ricketts
发明人： Thomas R. Matthews , Garland B. Ricketts
IPC分类号： B25J1/04 , E04D13/076
CPC分类号： E04D13/0765 , B25J1/04
摘要： A gutter cleaner for remotely cleaning an overhead gutter or the like which includes an elongate handle, a pair of cooperating fork-like jaws mounted at the upper end of the handle, and a sleeve slidably mounted on the lower end of the handle for selectively opening and closing the fork-like jaws. The jaws include a stationary first jaw and a relatively pivotably movable second jaw which each have a greater width than height so that the jaws may be placed in a gutter extending in a direction lengthwise with the gutter. In this manner a substantial length of the gutter may be cleaned of collected debris with each application of the gutter cleaner thereto.
摘要翻译：一种用于远程清洁顶盖槽等的沟槽清洁器，其包括细长手柄，安装在手柄上端的一对配合的叉形夹爪以及可滑动地安装在手柄下端上的套筒，用于选择性地打开并关闭叉状夹爪。夹爪包括固定的第一颚和相对可枢转的第二颚，每个颚具有比高度更大的宽度，使得颚可以放置在沿沟槽纵向延伸的沟槽中。以这种方式，每个施加沟槽清洁器可以清除大量的沟槽，以收集收集的碎屑。

7. 发明授权

US4831135A Bengamide anthelmintics 失效
标题翻译：孟加拉胺驱虫药
公开(公告)号：US4831135A
公开(公告)日：1989-05-16
申请号：US875486
申请日：1986-06-18
申请人： Philip Crews , Thomas R. Matthews , Emilio Quinoa , Madeline Adamczeski
发明人： Philip Crews , Thomas R. Matthews , Emilio Quinoa , Madeline Adamczeski
IPC分类号： C07D223/12
CPC分类号： C07D223/12
摘要： Novel .delta.-caprolactam derivatives of formula I have anti-tumor, antibiotic and anthelmintic activity: ##STR1## wherein: R is H, lower alkyl, or lower acyl;R.sub.1, R.sub.2, and R.sub.3 are each independently H or lower acyl;R.sub.4 is H or acyl of 1 to 22 carbon atoms;R.sub.5 is H or lower acyl;R.sub.6 and R.sub.7 are each H or OH, or R.sub.6 and R.sub.7 together form an epoxide or a double bond;and the pharmaceutically acceptable salts thereof.
摘要翻译：式I的新型三 - 己内酰胺衍生物具有抗肿瘤，抗生素和驱肠虫活性：其中：R为H，低级烷基或低级酰基; R1，R2和R3各自独立地为H或低级酰基; R4是H或1〜22个碳原子的酰基; R5是H或低级酰基; R6和R7各自为H或OH，或R6和R7一起形成环氧化物或双键; 及其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式