专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06245330B1 Recombinant adenoviruses coding for glial-derived neurotrophic factor (GDNF) 失效
标题翻译：编码胶质神经营养因子（GDNF）的重组腺病毒
公开(公告)号：US06245330B1
公开(公告)日：2001-06-12
申请号：US08716326
申请日：1996-10-04
申请人： Philippe Horellou , Jacques Mallet , Michel Perricaudet , Frédéric Revah , Emmanuelle Vigne
发明人： Philippe Horellou , Jacques Mallet , Michel Perricaudet , Frédéric Revah , Emmanuelle Vigne
IPC分类号： A61K4800
CPC分类号： A61K48/00 , A61K38/00 , C07K14/475 , C12N15/86 , C12N2710/10343
摘要： Recombinant adenoviruses comprising a heterologous DNA sequence coding for glial-derived neurotrophic growth factor (GDNF) are provided. The recombinant adenoviruses are useful in a method of expressing GDNF in a cell, wherein the cell is present in a mammal suffering from Parkinson's disease, comprising infecting said cell with a replication-defective recombinant adenovirus comprising a DNA sequence encoding GDNF operably linked to a promoter by administering the adenovirus into cells of the central nervous system. The recombinant adenoviruses of the invention are also useful in a method of treating Parkinson's disease comprising administering into cells of the central nervous system of a mammal suffering therefrom a replication defective recombinant adenovirus comprising ITRs, an encapsidation sequence and a DNA sequence encoding GDNF operably linked to a promoter, wherein the adenovirus E1 gene is non-functional and GDNF is expressed at a level that provides a therapeutic effect.
摘要翻译：提供了包含编码神经胶质来源的神经营养生长因子（GDNF）的异源DNA序列的重组腺病毒。所述重组腺病毒可用于在细胞中表达GDNF的方法，其中所述细胞存在于患有帕金森病的哺乳动物中，所述方法包括用复制缺陷型重组腺病毒感染所述细胞，所述复制缺陷型重组腺病毒包含与启动子可操作地连接的编码GDNF的DNA序列通过将腺病毒施用于中枢神经系统的细胞。本发明的重组腺病毒也可用于治疗帕金森病的方法，包括向患有其的哺乳动物的中枢神经系统的细胞施用包含ITR的复制缺陷型重组腺病毒，包封序列和编码GDNF的DNA序列，其可操作地连接到启动子，其中腺病毒E1基因是非功能性的，并且GDNF以提供治疗效果的水平表达。

IPRDB

热门服务

关于我们

友情链接

联系方式