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1. 发明授权

US09266939B2 Compositions comprising natriuretic peptides and methods of use thereof 有权
标题翻译：包含利尿钠肽的组合物及其使用方法
公开(公告)号：US09266939B2
公开(公告)日：2016-02-23
申请号：US13336651
申请日：2011-12-23
申请人： Philippe Crine , Simon Joubert , Marie Parat
发明人： Philippe Crine , Simon Joubert , Marie Parat
IPC分类号： C07K1/00 , C07K16/00 , A61K38/12 , C07K14/58 , A61K31/7088 , A61K38/22
CPC分类号： C07K14/58 , A61K31/7088 , A61K38/2242 , C07K2319/22 , C07K2319/30 , C07K2319/31
摘要： The present invention provides methods, compositions, and kits for the treatment of disorders associated with overactivation of FGFR3, such as achondroplasia; bone or cartilage disorders; or vascular smooth muscle disorders, or for the elongation of bone. In some embodiments, the present invention provides polypeptides having a natriuretic peptide fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to subjects, e.g., subcutaneously, to treat a disorder associated with overactivation of FGFR3, a bone or cartilage disorder, or a vascular smooth muscle disorder, or to elongate bone. The invention also features nucleic acid molecules encoding such polypeptides and the use of the nucleic acid molecules for treating disorders associated with overactivation of FGFR3, bone or cartilage disorders, or vascular smooth muscle disorders, or for elongating bone.
摘要翻译：本发明提供了用于治疗与FGFR3的过度活化相关的疾病的方法，组合物和试剂盒，例如软骨发育不良; 骨或软骨疾病; 或血管平滑肌障碍，或用于骨的伸长。在一些实施方案中，本发明提供了具有与免疫球蛋白的Fc结构域融合的利尿钠肽的多肽。可以将这样的多肽施用于受试者，例如皮下，以治疗与FGFR3过度活化，骨骼或软骨疾病或血管平滑肌病症或细长骨骼相关的病症。本发明还具有编码这种多肽的核酸分子以及核酸分子用于治疗与FGFR3，骨或软骨障碍或血管平滑肌病或过度活化骨骼相关的疾病的用途。

2. 发明申请

US20120164142A1 COMPOSITIONS COMPRISING NATRIURETIC PEPTIDES AND METHODS OF USE THEREOF 有权
标题翻译：包含NATRIURETIC PEPTIDES的组合物及其使用方法
公开(公告)号：US20120164142A1
公开(公告)日：2012-06-28
申请号：US13336651
申请日：2011-12-23
申请人： Philippe Crine , Simon Joubert , Marie Parat
发明人： Philippe Crine , Simon Joubert , Marie Parat
IPC分类号： A61K39/395 , C12N15/62 , A61P19/08 , A61K31/7088 , A61P19/04 , C12N5/10 , A61P35/02 , A61P9/12 , A61P9/10 , A61P9/04 , A61K38/22 , C12P21/02 , C07K19/00 , A61P35/00
CPC分类号： C07K14/58 , A61K31/7088 , A61K38/2242 , C07K2319/22 , C07K2319/30 , C07K2319/31
摘要： The present invention provides methods, compositions, and kits for the treatment of disorders associated with overactivation of FGFR3, such as achondroplasia; bone or cartilage disorders; or vascular smooth muscle disorders, or for the elongation of bone. In some embodiments, the present invention provides polypeptides having a natriuretic peptide fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to subjects, e.g., subcutaneously, to treat a disorder associated with overactivation of FGFR3, a bone or cartilage disorder, or a vascular smooth muscle disorder, or to elongate bone. The invention also features nucleic acid molecules encoding such polypeptides and the use of the nucleic acid molecules for treating disorders associated with overactivation of FGFR3, bone or cartilage disorders, or vascular smooth muscle disorders, or for elongating bone.
摘要翻译：本发明提供了用于治疗与FGFR3的过度活化相关的疾病的方法，组合物和试剂盒，例如软骨发育不良; 骨或软骨疾病; 或血管平滑肌障碍，或用于骨的伸长。在一些实施方案中，本发明提供了具有与免疫球蛋白的Fc结构域融合的利尿钠肽的多肽。可以将这样的多肽施用于受试者，例如皮下，以治疗与FGFR3过度活化，骨骼或软骨疾病或血管平滑肌病症或细长骨骼相关的病症。本发明还具有编码这种多肽的核酸分子以及核酸分子用于治疗与FGFR3，骨或软骨障碍或血管平滑肌病或过度活化骨骼相关的疾病的用途。

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