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1. 发明申请

US20070293932A1 Compliant blood vessel graft 有权
标题翻译：符合血管移植
公开(公告)号：US20070293932A1
公开(公告)日：2007-12-20
申请号：US11797648
申请日：2007-05-04
申请人： Peter Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael Wolf , Paul Human
发明人： Peter Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael Wolf , Paul Human
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
摘要： Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
摘要翻译：提供支架和使用支架的方法。本发明的支架为设置在其内的血管段提供外部支撑结构，其中支架能够以模仿动脉的顺应性的方式弹性径向扩张。支架可以由形成的针织或编织网形成，以便提供所需的顺应性。提供具有支架和设置在其内的静脉段的静脉移植物，其中移植物能够模拟动脉的顺应性。提供了选择小型化支架的方法和使用本发明的支架在缩小和平滑方面的方法。提供了用包括本发明的支架的静脉移植物代替动脉的一部分的方法。提供了使用本发明的支架在静脉移植物中减少植入静脉段内膜增生的方法。

2. 发明申请

US20110295157A1 Compliant Blood Vessel Graft 有权
标题翻译：符合血管移植
公开(公告)号：US20110295157A1
公开(公告)日：2011-12-01
申请号：US13209517
申请日：2011-08-15
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
IPC分类号： A61B5/103
CPC分类号： A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
摘要： Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
摘要翻译：提供支架和使用支架的方法。本发明的支架为设置在其内的血管段提供外部支撑结构，其中支架能够以模仿动脉的顺应性的方式弹性径向扩张。支架可以由形成的针织或编织网形成，以便提供所需的顺应性。提供具有支架和设置在其内的静脉段的静脉移植物，其中移植物能够模拟动脉的顺应性。提供了选择小型化支架的方法和使用本发明的支架在缩小和平滑方面的方法。提供了用包括本发明的支架的静脉移植物代替动脉的一部分的方法。提供了使用本发明的支架在静脉移植物中减少植入静脉段内膜增生的方法。

3. 发明授权

US07998188B2 Compliant blood vessel graft 有权
标题翻译：符合血管移植
公开(公告)号：US07998188B2
公开(公告)日：2011-08-16
申请号：US11797648
申请日：2007-05-04
申请人： Peter Paul Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
发明人： Peter Paul Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf , Paul Human
IPC分类号： A61F2/06
CPC分类号： A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
摘要： Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
摘要翻译：提供支架和使用支架的方法。本发明的支架为设置在其内的血管段提供外部支撑结构，其中支架能够以模仿动脉的顺应性的方式弹性径向扩张。支架可以由形成的针织或编织网形成，以便提供所需的顺应性。提供具有支架和设置在其内的静脉段的静脉移植物，其中移植物能够模拟动脉的顺应性。提供了选择小型化支架的方法和使用本发明的支架在缩小和平滑方面的方法。提供了用包括本发明的支架的静脉移植物代替动脉的一部分的方法。提供了使用本发明的支架在静脉移植物中减少植入静脉段内膜增生的方法。

4. 发明授权

US08382814B2 Compliant blood vessel graft 有权
标题翻译：符合血管移植
公开(公告)号：US08382814B2
公开(公告)日：2013-02-26
申请号：US13209517
申请日：2011-08-15
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F Wolf , Paul Human
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F Wolf , Paul Human
IPC分类号： A61F2/06
CPC分类号： A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
摘要： Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
摘要翻译：提供支架和使用支架的方法。本发明的支架为设置在其内的血管段提供外部支撑结构，其中支架能够以模仿动脉的顺应性的方式弹性径向扩张。支架可以由形成的针织或编织网形成，以便提供所需的顺应性。提供具有支架和设置在其内的静脉段的静脉移植物，其中移植物能够模拟动脉的顺应性。提供了选择小型化支架的方法和使用本发明的支架在缩小和平滑方面的方法。提供了用包括本发明的支架的静脉移植物代替动脉的一部分的方法。提供了使用本发明的支架在静脉移植物中减少植入静脉段内膜增生的方法。

5. 发明授权

US07955788B2 Bioprosthetic tissue preparation with synthetic hydrogels 有权
标题翻译：用合成水凝胶制备生物假体组织
公开(公告)号：US07955788B2
公开(公告)日：2011-06-07
申请号：US10967365
申请日：2004-10-18
申请人： Peter Zilla , Deon Bezuidenhout , Anel Oostheysen , Paul Human
发明人： Peter Zilla , Deon Bezuidenhout , Anel Oostheysen , Paul Human
IPC分类号： A01N1/00
CPC分类号： A61L27/52 , A61L27/3687 , A61L27/507
摘要： Methods for treating xenogenic tissue for implantation into a human body including in-situ polymerization of a hydrogel polymer in tissue, and tissue treated according to those methods, where the polymerization takes place in tissue that has not been fixed with glutaraldehyde. The polymerization may only fill the tissue, bind the polymer to the tissue, or cross-link the tissue through the polymer, depending on the embodiment. One method includes free radical polymerization of a first vinylic compound, and can include cross-linking through use of a second compound having at least two vinyl groups. Another method utilizes nucleophilic addition polymerization of two compounds, one of which can include PEG and can further include hydrolytically degradable regions. In one embodiment, applicants believe the in-situ polymerization inhibits calcification, and that the polymerization of tissue un-fixed by glutaraldehyde allows for improved penetration of the polymer. The methods find one use in the treatment of porcine heart valve tissue, intended to extend the useful life of the valves by inhibiting calcification. The incorporation of degradable hydrogel regions may initially fill the tissue and reduce any initial inflammatory response, but allow for later infiltration by cells to remodel the tissue.
摘要翻译：用于治疗异种组织用于植入人体的方法，包括组织中水凝胶聚合物的原位聚合，以及根据那些方法处理的组织，其中聚合发生在未用戊二醛固定的组织中。根据实施例，聚合可以仅填充组织，将聚合物结合到组织，或者通过聚合物交联组织。一种方法包括第一乙烯基化合物的自由基聚合，并且可以包括通过使用具有至少两个乙烯基的第二化合物的交联。另一种方法利用两种化合物的亲核加成聚合，其中一种可以包括PEG，并且还可以包括水解可降解区域。在一个实施方案中，申请人认为原位聚合抑制钙化，并且由戊二醛未固定的组织的聚合允许改善聚合物的渗透性。该方法可用于治疗猪心脏瓣膜组织，旨在通过抑制钙化来延长瓣膜的使用寿命。可降解水凝胶区域的引入可以初始地填充组织并减少任何初始炎症反应，但允许细胞稍后浸润以重塑组织。

6. 发明申请

US20050119736A1 Bioprosthetic tissue preparation with synthetic hydrogels 有权
标题翻译：用合成水凝胶制备生物假体组织
公开(公告)号：US20050119736A1
公开(公告)日：2005-06-02
申请号：US10967365
申请日：2004-10-18
申请人： Peter Zilla , Deon Bezuidenhout , Anel Oostheysen , Paul Human
发明人： Peter Zilla , Deon Bezuidenhout , Anel Oostheysen , Paul Human
IPC分类号： A61F2/24 , A61L27/26 , A61L27/52
CPC分类号： A61L27/52 , A61L27/3687 , A61L27/507
摘要： Methods for treating xenogenic tissue for implantation into a human body including in-situ polymerization of a hydrogel polymer in tissue, and tissue treated according to those methods, where the polymerization takes place in tissue that has not been fixed with glutaraldehyde. The polymerization may only fill the tissue, bind the polymer to the tissue, or cross-link the tissue through the polymer, depending on the embodiment. One method includes free radical polymerization of a first vinylic compound, and can include cross-linking through use of a second compound having at least two vinyl groups. Another method utilizes nucleophilic addition polymerization of two compounds, one of which can include PEG and can further include hydrolytically degradable regions. In one embodiment, applicants believe the in-situ polymerization inhibits calcification, and that the polymerization of tissue un-fixed by glutaraldehyde allows for improved penetration of the polymer. The methods find one use in the treatment of porcine heart valve tissue, intended to extend the useful life of the valves by inhibiting calcification. The incorporation of degradable hydrogel regions may initially fill the tissue and reduce any initial inflammatory response, but allow for later infiltration by cells to remodel the tissue.
摘要翻译：用于治疗异种组织用于植入人体的方法，包括组织中水凝胶聚合物的原位聚合，以及根据那些方法处理的组织，其中聚合发生在未用戊二醛固定的组织中。根据实施例，聚合可以仅填充组织，将聚合物结合到组织，或者通过聚合物交联组织。一种方法包括第一乙烯基化合物的自由基聚合，并且可以包括通过使用具有至少两个乙烯基的第二化合物的交联。另一种方法利用两种化合物的亲核加成聚合，其中一种可以包括PEG，并且还可以包括水解可降解区域。在一个实施方案中，申请人认为原位聚合抑制钙化，并且由戊二醛未固定的组织的聚合允许改善聚合物的渗透性。该方法可用于治疗猪心脏瓣膜组织，旨在通过抑制钙化来延长瓣膜的使用寿命。可降解水凝胶区域的引入可以初始地填充组织并减少任何初始炎症反应，但允许细胞稍后浸润以重塑组织。

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