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1. 发明授权

US4348392A 8.alpha.-Substituted ergoline-I derivatives 失效
标题翻译： 8α-取代的麦角灵-I衍生物
公开(公告)号：US4348392A
公开(公告)日：1982-09-07
申请号：US189295
申请日：1980-09-22
申请人： Theodor Fehr , Paul Stadler , Peter Stutz
发明人： Theodor Fehr , Paul Stadler , Peter Stutz
IPC分类号： C07D457/02 , C07D457/04 , C07D457/12 , A61K31/48
CPC分类号： C07D457/04 , C07D457/02 , C07D457/12
摘要： This invention provides new compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine,R.sub.1 is methyl or ethyl, andR.sub.2 is CH.sub.2 --CN, or a group NR.sub.3 R.sub.4, whereinR.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.4 is SO.sub.2 R.sub.5, wherein R.sub.5 is alkyl of 1 to 4 carbon atoms, mono- to tri-halogenalkyl of 1 to 4 carbon atoms, phenyl, pyridyl, phenyl monosubstituted by halogen or alkoxy of 1 to 4 carbon atoms, or a group NR.sub.6 R.sub.7, wherein each ofR.sub.6 and R.sub.7 is independently hydrogen or alkyl of 1 to 4 carbon atoms, orR.sub.6 and R.sub.7 together are one of the groups (CH.sub.2).sub.n or (CH.sub.2).sub.2 --A--(CH.sub.2).sub.2, whereinn is a number from 3 to 7, andA is oxygen, sulphur or nitrogen substituted by alkyl of 1 to 4 carbon atoms or phenyl,useful as prolactin secretion agents and antiparkinson agents.
摘要翻译：本发明提供了新的式I化合物，其中X是氢，氯或溴，R1是甲基或乙基，R2是CH2-CN，或NR3R4基团，其中R3是氢或1-4个碳原子的烷基碳原子，R 4为SO 2 R 5，其中R 5为1至4个碳原子的烷基，1至4个碳原子的一至三卤代烷基，苯基，吡啶基，被卤素或1-4个碳原子的烷氧基取代的苯基，或基团NR 6 R 7，其中R 6和R 7各自独立地为氢或1至4个碳原子的烷基，或者R 6和R 7一起为（CH 2）n或（CH 2）2 -A-（CH 2）2基团之一，其中 n为3至7的数，A为氧，硫或被1至4个碳原子的烷基取代的氮或苯基，可用作催乳激素分泌剂和抗帕金森药剂。

2. 发明授权

US4348391A Sulfonamido and sulfamoylamino-ergoline-I derivatives 失效
标题翻译：磺酰胺氨基和氨磺酰氨基 - 麦角林-I衍生物
公开(公告)号：US4348391A
公开(公告)日：1982-09-07
申请号：US189068
申请日：1980-09-22
申请人： Peter Stutz , Theodor Fehr , Paul Stadler
发明人： Peter Stutz , Theodor Fehr , Paul Stadler
IPC分类号： C07D457/02 , A61K31/48 , A61K31/535 , A61P25/00 , A61P25/24 , A61P25/26 , C07D457/04 , C07D457/06 , C07D457/12
CPC分类号： C07D457/04 , C07D457/06 , C07D457/12
摘要： The present invention provides compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine,R.sub.1 is methyl or ethyl,R.sub.2 is alkyl of 1 to 4 carbon atoms or allyl,R.sub.3 is CH.sub.2 CN or a group --NR.sub.4 R.sub.5, wherein R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, and R.sub.5 is alkanoyl of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms in the aggregate thereof, or mono-, di- or tri-haloalkoxycarbonyl of 3 to 5 carbon atoms, wherein the alkoxy group is substituted by halogen other than in the .alpha. position to the oxygen atom, or R.sub.5 is SO.sub.2 R.sub.6, wherein R.sub.6 is alkyl of 1 to 4 carbon atoms, mono-, di- or tri-haloalkyl of 1 to 4 carbon atoms, phenyl, phenyl mono-substituted by halogen or alkoxy of 1 to 4 carbon atoms, or pyridyl, or R.sub.6 is a group NR.sub.7 R.sub.8, wherein R.sub.7 and R.sub.8 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, or R.sub.7 and R.sub.8 together form --[CH.sub.2 ].sub.n -- or --[CH.sub.2 ].sub.2 --A--[CH.sub.2 ].sub.2 --, wherein n is a whole number from 3 to 7, and A is oxygen, sulphur, or nitrogen substituted by alkyl of 1 to 4 carbon atoms or phenylwhich are useful as prolactin inhibitors, anti-parkinson agents, and anti-depressants.
摘要翻译：本发明提供式I化合物，其中X是氢，氯或溴，R1是甲基或乙基，R2是1-4个碳原子的烷基或烯丙基，R3是CH2CN或基团-NR4R5，其中 R4是氢或1〜4个碳原子的烷基，R5是1〜5个碳原子的烷酰基，2〜5个碳原子的烷氧基羰基，3〜5个碳原子的一，二 - 或三 - 卤代烷氧基羰基原子，其中烷氧基被除了在氧原子的α位置以外的卤素取代，或R 5是SO 2 R 6，其中R 6是1至4个碳原子的烷基，1至4的一，二或三卤代烷基碳原子，苯基，被卤素或1-4个碳原子的烷氧基取代的苯基，或吡啶基，或R6是NR7R8基团，其中R7和R8独立地是氢或1-4个碳原子的烷基或R7 和R8一起形成 - [CH 2] n - 或 - [CH 2] 2 -A- [CH 2] 2 - ，其中n是3至7的整数，A是氧，硫或被烷基取代的氮 1个1-4个碳原子的苯基或可用作催乳激素抑制剂的苯基，抗帕金森试剂和抗抑郁剂。

3. 发明授权

US4147789A 6-Methyl-8-thiomethyl-ergolene derivatives 失效
标题翻译： 6-甲基-8-硫代甲基 - 麦角烯衍生物
公开(公告)号：US4147789A
公开(公告)日：1979-04-03
申请号：US726981
申请日：1976-09-27
申请人： Peter Stutz , Paul Stadler
发明人： Peter Stutz , Paul Stadler
IPC分类号： C07D457/02
CPC分类号： C07D457/02
摘要： This invention provides new compounds of formula I, ##STR1## wherein X Y IS THE GROUP ##STR2## and R is hydrogen, cyano, a 5- or 6-membered unsaturated heterocyclic radical attached through a ring carbon atom and having 1, 2 or 3 hetero ring atoms, the first hetero atom being nitrogen, oxygen or sulphur, and the second and third hetero atoms, if present, being nitrogen, or 2- or 4-pyridyl monosubstituted by lower alkyl, lower alkoxy or halogen,Useful as anti-Parkinson agents.
摘要翻译：本发明提供了新的式I化合物，其中XY是基团，R是氢，氰基，通过环碳原子连接的5或6元不饱和杂环基，并具有1,2或 3个杂环原子，第一个杂原子是氮，氧或硫，第二和第三个杂原子（如果存在）是氮，或被低级烷基，低级烷氧基或卤素单取代的2-或4-吡啶基，有用的抗原帕金森药剂。

4. 发明授权

US4146626A 8-Adamantylaminomethyl ergolene derivatives 失效
标题翻译： 8-氨基亚氨基乙酸衍生物
公开(公告)号：US4146626A
公开(公告)日：1979-03-27
申请号：US860308
申请日：1977-12-14
申请人： Peter Stutz , Paul Stadler
发明人： Peter Stutz , Paul Stadler
IPC分类号： A61K31/48 , A61P25/20 , C07D457/02
CPC分类号： C07D457/02
摘要： The present invention provides compounds of the formula, ##STR1## wherein R.sub.1 is alkyl (C.sub.1-5),R.sub.2 is alkyl (C.sub.1-5),R.sub.3 is hydrogen or halogen, and either each of R.sub.4 and R.sub.5 is hydrogen, orR.sub.4 and R.sub.5, together, are a bond,Which are useful as sleep-inducing and sleep-prolonging agents.

5. 发明授权

US4124712A Ergot peptide alkaloid derivatives 失效
标题翻译： got肽生物碱衍生物
公开(公告)号：US4124712A
公开(公告)日：1978-11-07
申请号：US829206
申请日：1977-08-30
申请人： Peter Stutz , Paul Stadler
发明人： Peter Stutz , Paul Stadler
IPC分类号： C07D519/02 , A61K31/495 , C07D413/14
CPC分类号： C07D519/02
摘要： Compounds of formula I, ##STR1## wherein R.sub.1 is alkyl of 1 to 4 carbon atoms,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl,R.sub.3 and R.sub.5 are, independently, hydrogen or methyl,R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.6 and R.sub.7 together form a single bond, orR.sub.6 and R.sub.7 are each hydrogen,R.sub.6 is methoxy, andR.sub.7 is hydrogen,Are useful in the treatment of hypertension, angina pectoris, depressions, neuroses and psychoses.
摘要翻译：式I化合物，其中R 1是1至4个碳原子的烷基，R 2是氢，1至4个碳原子的烷基或苄基，R 3和R 5独立地是氢或甲基，R 4是氢或烷基 1至4个碳原子，R6和R7一起形成单键，或R6和R7各自为氢，R6为甲氧基，R7为氢，有用于治疗高血压，血管紧张素转移酶，神经元和神经元。

6. 发明授权

US4000139A Organic compounds 失效
公开(公告)号：US4000139A
公开(公告)日：1976-12-28
申请号：US485275
申请日：1974-07-02
申请人： Peter Stutz , Paul Stadler
发明人： Peter Stutz , Paul Stadler
IPC分类号： C07D263/52 , A61K31/424 , A61K31/4985 , C07D207/16 , C07D241/36 , C07D498/14 , C07D519/02 , C07K5/065 , C07D295/04
CPC分类号： C07D207/16 , C07K5/06078
摘要： The invention concerns a novel process for the production of a compound of formula I, ##STR1## wherein R.sub.1 is the cyano group, or -COX, wherein X is the amino group or an -O-(lower)alkyl radical, andR.sub.2 to R.sub.5 are substituents inert to internal cyclization conditions,Comprising subjecting a compound of formula II, ##STR2## wherein the variables R.sub.1 to R.sub.5 are as defined above, and R.sub.6 is a radical capable of leaving under the reaction conditions, to an intramolecular condensation in the presence of a base, the compounds of formula I being useful intermediates in the preparation of ergot alkaloids.

7. 发明授权

US6139509A Graduated bone graft harvester 失效
标题翻译：毕业骨移植收割机
公开(公告)号：US6139509A
公开(公告)日：2000-10-31
申请号：US157634
申请日：1998-09-21
申请人： Hansen Yuan , Peter Stutz , John Dowdle , Serafin Samson
发明人： Hansen Yuan , Peter Stutz , John Dowdle , Serafin Samson
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/16 , A61B19/00
CPC分类号： A61B10/025 , A61B17/1635 , A61B17/1664 , A61B2017/00473 , A61B2090/063
摘要： A disposable, bone graft harvester having a clear, graduated plastic tube tipped with a bone cutting head at one end and a handle or other torque supplying connection at the other end.
摘要翻译：一次性骨移植物收割机，其具有在一端具有骨切割头的透明的刻度塑料管，另一端具有手柄或其它扭矩供应连接。

8. 发明授权

US5665727A Use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them 失效
标题翻译：使用11,28-二氧杂-4-氮杂三环[22.3.1.04,9]二十八烷-18-烯衍生物和含有它们的药物组合物
公开(公告)号：US5665727A
公开(公告)日：1997-09-09
申请号：US291010
申请日：1994-08-15
申请人： Maximilian Grassberger , Josef Gottfried Meingassner , Anton Stutz , Peter Stutz
发明人： Maximilian Grassberger , Josef Gottfried Meingassner , Anton Stutz , Peter Stutz
IPC分类号： A61K31/40 , A61K31/407 , A61K31/436 , A61K31/445 , A61K31/44
CPC分类号： A61K31/436 , A61K31/40 , A61K31/407 , A61K31/445
摘要： The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.
摘要翻译：已发现式I化合物具有优异的局部活性。因此，它们被指示用于局部治疗炎性和超增殖皮肤疾病以及免疫学诱导的疾病如牛皮癣的皮肤表现。

9. 发明授权

US5366971A Use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them 失效
标题翻译：使用11,28-二氧杂-4-氮杂三环[22.3.1.04,9]二十八烷-18-烯衍生物和含有它们的药物组合物
公开(公告)号：US5366971A
公开(公告)日：1994-11-22
申请号：US982925
申请日：1992-11-30
申请人： Maximilian Grassberger , Josef G. Meingassner , Anton Stutz , Peter Stutz
发明人： Maximilian Grassberger , Josef G. Meingassner , Anton Stutz , Peter Stutz
IPC分类号： A61K31/40 , A61K31/407 , A61K31/436 , A61K31/445 , A61K31/44
CPC分类号： A61K31/436 , A61K31/40 , A61K31/407 , A61K31/445
摘要： New use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing themThe compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.
摘要翻译：新使用11,28-二氧杂-4-氮杂三环[22.3.1.04,9]二十八烷-18-烯衍生物和含有它们的药物组合物已经发现式I化合物 I具有优异的局部活性。因此，它们被指示用于局部治疗炎性和超增殖皮肤疾病以及免疫学诱导的疾病如牛皮癣的皮肤表现。

10. 发明授权

US07853537B2 Letter flow control 有权
标题翻译：信流控制
公开(公告)号：US07853537B2
公开(公告)日：2010-12-14
申请号：US11672711
申请日：2007-02-08
申请人： Christian Moy , Peter Stutz , Hans Jaeger
发明人： Christian Moy , Peter Stutz , Hans Jaeger
IPC分类号： G07B17/02
CPC分类号： B65H3/042 , B41J2/16547 , B41J2/1752 , B65H1/08 , B65H5/00 , B65H29/18 , B65H31/06 , B65H2301/321 , B65H2301/4214 , B65H2402/441 , B65H2405/35 , B65H2511/13 , B65H2511/51 , B65H2513/40 , B65H2555/13 , B65H2601/321 , B65H2701/1916 , G06K15/102 , G07B17/00661 , G07B2017/00241 , G07B2017/00322 , G07B2017/00677 , B65H2220/01 , B65H2220/02 , B65H2220/11
摘要： A modular franking system including at least one module and a module sensor adapted to sense objects fed to the module. The module can include information on the distance between a position of the sensor and at least one edge of the module, and a location of at least one other module. The modular system can also include a communication system adapted to allow the module to sense objects being transported and communicate information concerning events such as velocity and distance to another module.
摘要翻译：包括至少一个模块和适于感测馈送到模块的物体的模块传感器的模块化封印系统。模块可以包括关于传感器的位置与模块的至少一个边缘之间的距离以及至少一个其他模块的位置的信息。模块化系统还可以包括适于允许模块感测被传送对象的通信系统，并将关于诸如速度和距离的事件的信息传送到另一个模块。

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