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    • 10. 发明授权
    • 8.alpha.-Substituted ergoline-I derivatives
    • 8α-取代的麦角灵-I衍生物
    • US4348392A
    • 1982-09-07
    • US189295
    • 1980-09-22
    • Theodor FehrPaul StadlerPeter Stutz
    • Theodor FehrPaul StadlerPeter Stutz
    • C07D457/02C07D457/04C07D457/12A61K31/48
    • C07D457/04C07D457/02C07D457/12
    • This invention provides new compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine,R.sub.1 is methyl or ethyl, andR.sub.2 is CH.sub.2 --CN, or a group NR.sub.3 R.sub.4, whereinR.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.4 is SO.sub.2 R.sub.5, wherein R.sub.5 is alkyl of 1 to 4 carbon atoms, mono- to tri-halogenalkyl of 1 to 4 carbon atoms, phenyl, pyridyl, phenyl monosubstituted by halogen or alkoxy of 1 to 4 carbon atoms, or a group NR.sub.6 R.sub.7, wherein each ofR.sub.6 and R.sub.7 is independently hydrogen or alkyl of 1 to 4 carbon atoms, orR.sub.6 and R.sub.7 together are one of the groups (CH.sub.2).sub.n or (CH.sub.2).sub.2 --A--(CH.sub.2).sub.2, whereinn is a number from 3 to 7, andA is oxygen, sulphur or nitrogen substituted by alkyl of 1 to 4 carbon atoms or phenyl,useful as prolactin secretion agents and antiparkinson agents.
    • 本发明提供了新的式I化合物,其中X是氢,氯或溴,R1是甲基或乙基,R2是CH2-CN,或NR3R4基团,其中R3是氢或1-4个碳原子的烷基 碳原子,R 4为SO 2 R 5,其中R 5为1至4个碳原子的烷基,1至4个碳原子的一至三卤代烷基,苯基,吡啶基,被卤素或1-4个碳原子的烷氧基取代的苯基,或 基团NR 6 R 7,其中R 6和R 7各自独立地为氢或1至4个碳原子的烷基,或者R 6和R 7一起为(CH 2)n或(CH 2)2 -A-(CH 2)2基团之一,其中 n为3至7的数,A为氧,硫或被1至4个碳原子的烷基取代的氮或苯基,可用作催乳激素分泌剂和抗帕金森药剂。