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1. 发明授权

US5593492A Weld through primer 失效
标题翻译：通过底漆焊接
公开(公告)号：US5593492A
公开(公告)日：1997-01-14
申请号：US521552
申请日：1995-08-30
申请人： Peter Schaffer , Scott Armstrong
发明人： Peter Schaffer , Scott Armstrong
IPC分类号： B23K35/22 , C09D5/10 , C09D1/04 , C09D5/00
CPC分类号： B23K35/226 , C09D5/10
摘要： A corrosion inhibiting primer for metal pieces which need not be removed prior to welding the pieces includes an alkali metal silicate binder having a silicone wetting agent incorporated therewith, a powder metal and an oxygen scavenger. The primer can be sprayed onto the metal. Zero porosity welds can be achieved up to speeds of about 750 mms/sec. by welding through the primer.
摘要翻译：用于金属片的腐蚀抑制底漆在焊接前不需要去除，包括具有与其结合的硅氧烷润湿剂的碱金属硅酸盐粘合剂，粉末金属和除氧剂。底漆可以喷在金属上。零孔隙度焊缝可以达到约750mms / sec的速度。通过底漆焊接。

2. 发明申请

US20070091687A1 Implantable medical device with reconfigurable non-volatile program 有权
标题翻译：具有可重构非易失性程序的可植入医疗器械
公开(公告)号：US20070091687A1
公开(公告)日：2007-04-26
申请号：US11257267
申请日：2005-10-24
申请人： Randolph Armstrong , Scott Armstrong
发明人： Randolph Armstrong , Scott Armstrong
IPC分类号： G11C16/04
CPC分类号： A61N1/37264
摘要： A device comprises a stimulus generator comprising an instruction processor. The stimulus generator is configured to deliver stimuli to a biological tissue. The device also comprises a non-volatile memory for storing instructions directly executable by the instruction processor, the instructions controlling, at least in part, the operation of the device. The instruction processor generates an erase control signal to erase at least a segment of the non-volatile memory and a write control signal to write one or more new instructions to at least a segment of the non-volatile memory, thereby modifying the operation of the device.
摘要翻译：一种装置包括一个包括指令处理器的刺激发生器。刺激发生器被配置为将刺激递送到生物组织。该设备还包括用于存储可由指令处理器直接执行的指令的非易失性存储器，该指令至少部分地控制该设备的操作。指令处理器产生擦除控制信号以擦除非易失性存储器的至少一个段和写入控制信号，以将一个或多个新指令写入非易失性存储器的至少一个段，由此修改设备。

3. 发明申请

US20060057630A1 MLL translocations specify a distinct gene expression profile, distinguishing a unique leukemia 审中-公开
公开(公告)号：US20060057630A1
公开(公告)日：2006-03-16
申请号：US11256381
申请日：2005-10-20
申请人： Todd Golub , Scott Armstrong , Stanley Korsmeyer
发明人： Todd Golub , Scott Armstrong , Stanley Korsmeyer
IPC分类号： C12Q1/68
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N2333/475 , G01N2800/52
摘要： The present invention relates to the diagnosis of mixed lineage leukemia (MLL), acute lymphoblastic leukemia (ALL), and acute myelogenous leukemia (AML) according to the gene expression profile of a sample from an individual, as well as to methods of therapy and screening that utilize the genes identified herein as targets.

4. 发明申请

US20110106207A1 PARASTHESIA USING SHORT-PULSE NEURAL STIMULATION SYSTEMS, DEVICES AND METHODS 审中-公开
标题翻译：使用短脉冲神经刺激系统的PARASTHESIA，设备和方法
公开(公告)号：US20110106207A1
公开(公告)日：2011-05-05
申请号：US12611110
申请日：2009-11-02
申请人： Lawrence J Cauller , Scott Armstrong
发明人： Lawrence J Cauller , Scott Armstrong
IPC分类号： A61N1/34
CPC分类号： A61N1/36082 , A61N1/36071 , A61N1/361
摘要： Methods, devices and systems for neural stimulation using a short-pulse stimulation are described. Using a waveform that generates a sufficiently large capacitive current density in the tissue surrounding a nerve allows neural stimulation at one hundredth the power of a charge injection stimulation. A capacitive discharge may be used to generate the short-pulse stimulation waveform. Short pulse stimulation may be used to generate parasthesia, particularly for treatment of chronic pain.
摘要翻译：描述了使用短脉冲刺激的神经刺激的方法，装置和系统。使用在神经周围的组织中产生足够大的电容电流密度的波形允许神经刺激是电荷注入刺激的功率的百分之一。可以使用电容放电来产生短脉冲刺激波形。可以使用短脉冲刺激来产生麻痹症，特别是用于治疗慢性疼痛。

5. 发明申请

US20070021785A1 Safe-mode implantable medical devices 有权
标题翻译：安全模式植入医疗器械
公开(公告)号：US20070021785A1
公开(公告)日：2007-01-25
申请号：US11186261
申请日：2005-07-21
申请人： Dana Michael Inman , Randolph Armstrong , Scott Armstrong
发明人： Dana Michael Inman , Randolph Armstrong , Scott Armstrong
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/36114 , A61N1/36142 , A61N1/36146 , A61N1/3718
摘要： A method, system, and apparatus for implementing a safe mode operation of an implantable medical system using impedance adjustment(s) are provided. A first impedance is provided to a lead. An indication of a possibility of a coupled energy is received. Based upon said indication, a second impedance associated with the lead to reduce the coupled energy is provided.
摘要翻译：提供了一种用于实现使用阻抗调节的可植入医疗系统的安全模式操作的方法，系统和装置。向引线提供第一阻抗。接收到耦合能量的可能性的指示。基于所述指示，提供与引线相关联的用于降低耦合能量的第二阻抗。

6. 发明申请

US20060247719A1 Weight loss method and advice 有权
标题翻译：减肥方法和建议
公开(公告)号：US20060247719A1
公开(公告)日：2006-11-02
申请号：US11118452
申请日：2005-04-29
申请人： Steven Maschino , Steven Parnis , Scott Armstrong
发明人： Steven Maschino , Steven Parnis , Scott Armstrong
IPC分类号： A61N1/18
CPC分类号： A61N1/36007 , A61F5/0003
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入迷走神经的动作电位。该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

7. 发明授权

US06479498B1 Sodium channel drugs and uses 有权
标题翻译：钠通道药物及用途
公开(公告)号：US06479498B1
公开(公告)日：2002-11-12
申请号：US10039699
申请日：2001-11-09
申请人： Daniel Marquess , Seok-Ki Choi , David T. Beattie , John H. Griffin , Scott Armstrong , Timothy J. Church , Thomas E. Jenkins , David C. Green
发明人： Daniel Marquess , Seok-Ki Choi , David T. Beattie , John H. Griffin , Scott Armstrong , Timothy J. Church , Thomas E. Jenkins , David C. Green
IPC分类号： C07D23942
CPC分类号： C07D239/48 , A61K47/55
摘要： The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.
摘要翻译：本发明的化合物包含共价连接的2-10个配体，每个配体能够结合Na +通道中的配体结合位点，由此调节其生物学活性。

8. 发明申请

US20070179547A1 Power supply monitoring for an implantable device 有权
标题翻译：可植入设备的电源监控
公开(公告)号：US20070179547A1
公开(公告)日：2007-08-02
申请号：US11341978
申请日：2006-01-27
申请人： Randolph Armstrong , Scott Armstrong , Dana Inman , Timothy Scott
发明人： Randolph Armstrong , Scott Armstrong , Dana Inman , Timothy Scott
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/3708 , A61N1/378
摘要： A method and an apparatus for projecting an end of service (EOS) and/or an elective replacement indication (ERI) of a component in an implantable device is provided. The method comprises measuring the measured voltage of the energy storage device, and determining whether the measured voltage is less than a transition voltage. When the measured voltage is less than the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the measured voltage. When the measured voltage is greater than or equal to the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the total charge depleted. The transition voltage is a voltage associated with the transition point of non-linearity in the battery voltage depletion curve.
摘要翻译：提供了一种用于在可植入装置中投射组件的服务结束（EOS）和/或选择性替换指示（ERI）的方法和装置。该方法包括测量能量存储装置的测量电压，以及确定测得的电压是否小于转换电压。当测量的电压小于转换电压时，确定剩余的能量储存装置的使用时间是基于所测量的电压的函数。当测量的电压大于或等于转换电压时，确定能量存储装置的使用结束之前剩余的时间是基于耗尽的总电荷的函数。转换电压是与电池电压耗尽曲线中的非线性转变点相关的电压。

9. 发明申请

US20060247722A1 Noninvasively adjustable gastric band 有权
标题翻译：非侵入性可调节胃带
公开(公告)号：US20060247722A1
公开(公告)日：2006-11-02
申请号：US11118980
申请日：2005-04-29
申请人： Steven Maschino , Steven Parnis , Scott Armstrong
发明人： Steven Maschino , Steven Parnis , Scott Armstrong
IPC分类号： A61N1/18
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入迷走神经的动作电位。该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

10. 发明申请

US20060247721A1 Identification of electrodes for nerve stimulation in the treatment of eating disorders 有权
标题翻译：鉴别用于治疗进食障碍的神经刺激电极
公开(公告)号：US20060247721A1
公开(公告)日：2006-11-02
申请号：US11118861
申请日：2005-04-29
申请人： Steven Maschino , Steven Parnis , Scott Armstrong
发明人： Steven Maschino , Steven Parnis , Scott Armstrong
IPC分类号： A61N1/18
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007 , A61N1/36082 , A61N1/36185 , A61N1/3686
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入迷走神经的动作电位。该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

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