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1. 发明授权

US5216023A Polyunsaturated fatty acid derivatives, pharmaceutical compositions containing the same, method for the preparation thereof, and their use as medicament 失效
标题翻译：聚氨酯脂肪酸衍生物，含有它们的药物组合物，其制备方法及其作为药物的用途
公开(公告)号：US5216023A
公开(公告)日：1993-06-01
申请号：US576393
申请日：1990-09-12
申请人： Peter N. Literati , Gyorgy Keri , Maria Boross , Gabor Nemeth , Jeno Szilbereky , Ildiko Szilagyi
发明人： Peter N. Literati , Gyorgy Keri , Maria Boross , Gabor Nemeth , Jeno Szilbereky , Ildiko Szilagyi
IPC分类号： C07C219/08 , C07C233/38 , C07C233/49 , C07C279/14
CPC分类号： C07C219/08 , C07C233/38 , C07C233/49 , C07C279/14
摘要： The compounds of the Formula (I) ##STR1## wherein R.sub.1 is a C.sub.18-24 alkenyl containing at least two double bonds, or --(CH2)n --CH(NH2)m --COOHX is 0, NH or C.sub.1-4 alkyl-N,Y is CONH.sub.2, COOH or COOMe, wherein Me is hydrogen metal, andR.sub.2 is a side chain of a any amino acid except L-GLU or L-ASP at .alpha.-position or a group of Formula--(CH.sub.2).sub.k --C.sub.6 H.sub.3 --(A).sub.2 (II),--(CH.sub.2).sub.n --X--(CH.sub.2).sub.m --X--M (III) whereink is zero or an integer of 1,n is zero or an integer of 1 to 3,m is zero or an integer of 1 to 4,A is hydroxyl or one A is hydroxyl and the other A is hydrogen.M is H or R.sub.1 --CO andX and R.sub.1 are as defined aboveand their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.
摘要翻译： PCT No.PCT / HU90 / 00004 Sec。 371 1990年9月12日第 102（e）1990年9月12日PCT PCT 1990年1月16日PCT PCT。出版物WO90 / 08130 （I）化合物其中R 1是含有至少两个双键的C 18-24链烯基，或 - （CH 2）n -CH（NH 2）m -COOH X 是0，NH或C 1-4烷基-N，Y是CONH 2，COOH或COOMe，其中Me是氢金属，R 2是在α-位上除了L-GLU或L-ASP之外的任何氨基酸的侧链，或式（ - ） - （CH2）k-C6H3-（A）2（Ⅱ）， - （CH2）nX-（CH2）mXM（Ⅲ）其中k为零或整数为1，n为0或1 至3，m为0或1〜4的整数，A为羟基或A为羟基，A为氢。 M是H或R1-CO，X和R1如上定义，并且其具有酪氨酸激酶抑制剂活性的盐可用作抗肿瘤剂。

2. 发明授权

US4647552A Process for obtaining ready for fertilization sexual products from sexually mature fish 失效
标题翻译：从性成熟鱼获得受精性产品的准备过程
公开(公告)号：US4647552A
公开(公告)日：1987-03-03
申请号：US684066
申请日：1984-12-20
申请人： Tamas Gulyas , Aniko Horvath , Gyorgy Keri , Karoly Nikolics , Balazs Szoke , Istvan Teplan
发明人： Tamas Gulyas , Aniko Horvath , Gyorgy Keri , Karoly Nikolics , Balazs Szoke , Istvan Teplan
IPC分类号： A01K61/00 , A61K38/00 , C07K7/06 , C07K7/23 , C07K14/575 , A61K37/24
CPC分类号： C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13
摘要： The invention relates to a process for obtaining ready-for-fertilization sexual products from sexually mature fish in a period independent of their natural spawning season, in which actual stage of ripening is determined by probing of sexual products [sperm or eggs], fish not yet ripe for ovulation are separated from ripe fish, compounds of hormonal effect are administered to fish, and after the ovulation sexual products are obtained from the fish or from their environment.In the process according to the invention a nonapeptide-C.sub.1-4 -alkyl-amide or a decapeptide amide of the general formula (I),Glp-His-Trp-Ser-Tyr-X.sub.1 -X.sub.2 -X.sub.3 -Pro-X.sub.4 (I)whereinX.sub.1 is a glycyl group or a D-isomer of any natural or synthetic amino acid group,X.sub.2 represents an L-amino acid group having 1 to 4 carbon atoms in the side chain, L-phenyl-alanyl or L-tryptophyl group,X.sub.3 represents an L-amino acid group having a C.sub.1-4 alkyl or C.sub.2-4 alkyl-amide side chain,X.sub.4 is a glycine-amide or a C.sub.1-4 alkyl-amide group,as well as salts or metal-complexes of these compounds are administered to fish in a dose of 0.1 .mu.g to 5 mg, and to fish not yet ripe for ovulation the above quantities are administered in at least 2 but at most 12 portions, wherein the last dose used is at least the same or advantageously at least 1.5 times higher than the previous one.The process according to the invention makes possible the obtaining of ripe sexual products ready for natural or artificial fertilization from any fish species in any period, independently of the natural spawning season of fish.
摘要翻译：本发明涉及一种独立于自然产卵季节从性成熟鱼获得即食受精性产品的方法，其中成熟的实际阶段是通过探查性产品[精子或卵]，鱼类成熟的排卵与成熟的鱼分离，激素作用的化合物被施用于鱼，并且在排卵之后，从鱼或其环境获得性产物。在根据本发明的方法中，通式（I）的Glc-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4（I）的非肽-C1-4-烷基酰胺或十肽酰胺）其中X1是任何天然或合成氨基酸基团的甘氨酰基或D-异构体，X2表示侧链中具有1至4个碳原子的L-氨基酸基团，L-苯丙氨酰基或L-色氨酸基团，X3表示具有C1-4烷基或C2-4烷基 - 酰胺侧链的L-氨基酸基，X4是甘氨酸 - 酰胺或C1-4烷基 - 酰胺基，以及盐或金属络合物这些化合物以0.1μg至5mg的剂量施用于鱼，并且为了排卵尚未成熟，上述量以至少2但最多12份施用，其中使用的最后剂量至少相同或有利地比前一个高至少1.5倍。根据本发明的方法使得可以在任何时间段内获得准备好从任何鱼类进行天然或人造受精的成熟性产品，而与鱼的天然产卵季节无关。

3. 发明申请

US20070275962A1 Heterobicyclic Compounds as Pharmaceutically Active Agents 审中-公开
标题翻译：异双环化合物作为药物活性剂
公开(公告)号：US20070275962A1
公开(公告)日：2007-11-29
申请号：US10597120
申请日：2004-09-10
申请人： Anil Koul , Bert Klebl , Gerhard Muller , Andrea Missio , Wilfried Schwab , Doris Hafenbradl , Lars Neumann , Marc-Nicola Sommer , Stefan Muller , Edmund Hoppe , Achim Freisleben , Alexander Backes , Christian Hartung , Beatrice Felber , Birgit Zech , Ola Engkvist , Gyorgy Keri , Laszlo Orfi , Peter Banhegyi , Zoltan Greff , Zoltan Horvath , Zoltan Varga , Peter Marko , Janos Pato , Istvan Szabadkai , Zsolt Szekelyhid , Frigyes Waczek
发明人： Anil Koul , Bert Klebl , Gerhard Muller , Andrea Missio , Wilfried Schwab , Doris Hafenbradl , Lars Neumann , Marc-Nicola Sommer , Stefan Muller , Edmund Hoppe , Achim Freisleben , Alexander Backes , Christian Hartung , Beatrice Felber , Birgit Zech , Ola Engkvist , Gyorgy Keri , Laszlo Orfi , Peter Banhegyi , Zoltan Greff , Zoltan Horvath , Zoltan Varga , Peter Marko , Janos Pato , Istvan Szabadkai , Zsolt Szekelyhid , Frigyes Waczek
IPC分类号： C07D495/04 , A61P31/04 , C07D209/42 , C07D333/66 , C07D333/68 , C07D495/10 , C07D409/12 , C07D413/14 , C07D491/04 , C07D493/04
CPC分类号： C07D409/12 , C07D209/42 , C07D333/66 , C07D333/68 , C07D491/04 , C07D493/04 , C07D495/04 , C07D495/10
摘要： Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.
摘要翻译：描述的是杂双环化合物，例如4,5,6,7-四氢苯并[b]噻吩-3-羧酸酰胺，4,7-二氢-5H-噻吩并[2,3-c]噻喃-3-羧酸酰胺，4 ，7-二氢-5H-噻吩并[2,3-c]吡喃-3-羧酸酰胺或苯并[b]噻吩-3-羧酸酰胺及其药学上可接受的盐，这些衍生物用于预防和 /或治疗诸如感染性疾病，包括分泌细菌感染和机会性疾病，朊病毒疾病，免疫疾病，自身免疫疾病，双相和临床病症，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有至少一种杂双环化合物和/或其药学上可接受的盐的组合物。此外，公开了用于合成杂双环化合物的反应程序。

4. 发明申请

US20050171176A1 Pharmaceutically active aromatic guanylhydrazones 审中-公开
标题翻译：药用活性芳香脒腙
公开(公告)号：US20050171176A1
公开(公告)日：2005-08-04
申请号：US11052325
申请日：2005-02-07
申请人： Dorian Bevec , Joachim Hauber , Sabine Obert , Gyorgy Keri , Laszlo Orfi , Istvan Szekely , Axel Choidas , Gerald Bacher
发明人： Dorian Bevec , Joachim Hauber , Sabine Obert , Gyorgy Keri , Laszlo Orfi , Istvan Szekely , Axel Choidas , Gerald Bacher
IPC分类号： A61K31/155 , A61K31/17 , A61K31/22 , A61K31/4164 , A61K45/06 , A61P31/04 , A61P31/18 , C07C281/18 , A61K31/4172 , A61K31/165
CPC分类号： A61K45/06 , A61K31/155 , A61K31/17 , A61K31/4164 , C07C281/18 , Y02A50/402 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/479 , Y02A50/481
摘要： The present invention relates to aromatic guanylhydrazone compounds and their use as pharmaceutically active agents, especially for prophylaxis and treatment of virally caused diseases and infections, including opportunistic infections. The inventive guanylhydrazone compounds are also useful as inhibitors of deoxyhypusine synthase and as inhibitors for nuclear export in infectious diseases and may be used to regulate bacterially induced TNF-α production. Furthermore, the aromatic guanylhydrazones exhibit antibacterial activity against Gram positive and Gram negative bacteria and can be regarded as a novel class of antibiotics. In addition, methods for prophylaxis and treatment of virally or bacterially induced infections and diseases are disclosed together with pharmaceutical compositions useful within said methods containing at least one aromatic guanylhydrazone of the present invention as active ingredient.
摘要翻译：本发明涉及芳香脒腙化合物及其作为药物活性剂的用途，特别是用于预防和治疗病毒引起的疾病和感染，包括机会性感染。本发明的脒腙化合物也可用作脱氧酪氨酸合成酶的抑制剂，并且可用作感染性疾病中核出口的抑制剂，并可用于调节细菌诱导的TNF-α产生。此外，芳香脒腙对革兰氏阳性和革兰氏阴性细菌具有抗菌活性，可被认为是一类新型抗生素。此外，还公开了用于预防和治疗病毒或细菌诱导的感染和疾病的方法以及在含有本发明的至少一种芳香脒腙作为活性成分的所述方法中有用的药物组合物。

5. 发明授权

US4647553A Gonadoliberin derivatives and process for the preparation thereof 失效
标题翻译： Gonadoliberin衍生物及其制备方法
公开(公告)号：US4647553A
公开(公告)日：1987-03-03
申请号：US684065
申请日：1984-12-20
申请人： Tamas Gulyas , Aniko Horvath , Gyorgy Keri , Karoly Nikolics , Balazs Szoke , Istvan Teplan
发明人： Tamas Gulyas , Aniko Horvath , Gyorgy Keri , Karoly Nikolics , Balazs Szoke , Istvan Teplan
IPC分类号： C07K14/575 , A61K38/00 , A61K38/08 , A61K38/24 , A61P5/00 , C07K7/06 , C07K7/23 , A61K37/43 , C07K7/20
CPC分类号： C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13
摘要： The invention relates to gonadoliberin derivatives of the general formula (I)Glp--His--Trp--Ser--Tyr--X.sub.1 --X.sub.2 --X.sub.3 --Pro--X.sub.4whereinX.sub.1 is a glycyl group or a D-isomer of any natural or synthetic amino acid group,X.sub.2 represents an L-amino acid group having 1 to 4 carbon atoms in the side chain, L-phenyl-alanyl or L-tryptophyl group,X.sub.3 represents an L-amino acid group having a C.sub.1-4 alkyl or C.sub.2-4 alkanoyl-amide side chain, andX.sub.4 is a glycine amide or a C.sub.1-4 alkyl amide group,with the proviso that if X.sub.1 stands for a group other than glycyl and X.sub.2 is a tryptophyl group then X.sub.3 may not be leucyl, and the addition salts formed with therapeutically useable acids and complexes thereof. Furthermore the invention relates to a process for preparing these compounds.The new gonadoliberin derivatives can be effectively used for the reproduction process of fish, birds and mammals.
摘要翻译：本发明涉及通式（I）Glp-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4的性腺蛋白衍生物，其中X1是任何天然或合成氨基酸的甘氨酰基或D-异构体基团，X2表示侧链具有1〜4个碳原子的L-氨基酸基，L-苯丙氨酰或L-色氨酰基，X3表示具有C1-4烷基或C2-4的L-氨基酸烷酰基酰胺侧链，X4为甘氨酸酰胺或C1-4烷基酰胺基，条件是如果X1表示除甘氨酰以外的基团，X2表示色氨酸基，则X3不可以是亮氨酰基，加成与治疗上可用的酸及其复合物形成的盐。此外，本发明涉及一种制备这些化合物的方法。新的促性腺激肽衍生物可以有效地用于鱼，鸟和哺乳动物的繁殖过程。

6. 发明申请

US20080214583A1 7H-Pyrrolo[2,3-D]Pyrimidine Derivatives, As Well As Their Therapeutically Acceptable Salts, Pharmaceutical Preparations Containing Them And Process For Production The Active Agent 审中-公开
标题翻译： 7H-吡咯并[2,3-D]嘧啶衍生物及其治疗上可接受的盐，含有它们的药物制剂及其制备方法活性剂
公开(公告)号：US20080214583A1
公开(公告)日：2008-09-04
申请号：US11587851
申请日：2005-04-25
申请人： Janos Szolcsanyi , Laszlo Orfi , Gyorgy Keri , Frigyes Waczek , Erika Pinter , Zsusanna Helyes , Tamas Szuts , Jozsef Nemeth
发明人： Janos Szolcsanyi , Laszlo Orfi , Gyorgy Keri , Frigyes Waczek , Erika Pinter , Zsusanna Helyes , Tamas Szuts , Jozsef Nemeth
IPC分类号： A61K31/519 , C07D487/04 , A61P19/08 , A61P19/02 , A61P25/00 , A61P29/00
CPC分类号： C07D487/04
摘要： The invention relates to new 7H-pyrrolo[2,3-d]pyrimidine derivatives, as well as their therapeutically acceptable salts, pharmaceutical preparations containing them and process for producing the active agent. The pharmaceutical preparation is adventageously antiphlogistic and analgetic one, a preparation reducing neuropathic hyperalgesia and rheumatic arthritis, a preparation for hindering destruction of bones chondrus, being applicable for treatment of other diseases, which may be connected with other inflammatory processes e.g. asthma, eczema or psoriasis.
摘要翻译：本发明涉及新的7H-吡咯并[2,3-d]嘧啶衍生物及其治疗上可接受的盐，含有它们的药物制剂和生产活性剂的方法。药物制剂是抗炎和止痛药物，减轻神经性痛觉过敏和风湿性关节炎的制剂，用于阻止骨骼软骨破坏的制剂，可用于治疗其它疾病，其可与其它炎症过程相关，例如与其它炎症过程相关。哮喘，湿疹或牛皮癣。

7. 发明申请

US20060105445A1 Medium and method for enriching, purifying or depleting atp binding proteins from a pool of proteins 审中-公开
标题翻译：用于从蛋白质池中富集，纯化或消耗atp结合蛋白的培养基和方法
公开(公告)号：US20060105445A1
公开(公告)日：2006-05-18
申请号：US10523577
申请日：2003-07-29
申请人： Klaus Godl , Andrea Missio , Henrik Daub , Matthias Stein-Gerlach , Zoltan Greff , Gyorgy Keri , Laszlo Orfi , Zoltan Varga , Bert Klebl
发明人： Klaus Godl , Andrea Missio , Henrik Daub , Matthias Stein-Gerlach , Zoltan Greff , Gyorgy Keri , Laszlo Orfi , Zoltan Varga , Bert Klebl
IPC分类号： C12N9/12 , C07K14/705
CPC分类号： G01N33/573 , A61K38/00 , C07D401/04 , C07D401/14 , C07K1/22 , G01N33/6803 , G01N2333/91205
摘要： The present invention relates to a medium and a method for enriching ATP binding proteins, e.g. proteinkinases, from a pool of proteins, like a proteome. The medium of the present invention comprises specific inhibitors, e.g. at least one of the compounds 4-[4-(4-fluoro-phenyl)-5-pyridine-4-yl-1H-imidazole-2-yl]-benzylamine, 2-[4-(2-Amino-ethoxy)-phenylamino]-6-(2,6-dichloro-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one, 2-[1-(3-aminopropyl)-1H-indole-3-yl)maleinmide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-3-(1H-indol 3-yl)-maleinmide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]4-(1-methyl-1H-indol-3-yl) maleinimide, 3-(8-Aminomethyl-6,7,8,9-tetrahydropyrido-[1,2-a]-indol-10-yl) (1-methyl-1H-indol -3-yl)-maleinmide, [6-(3-Amino-propoxy)-methoxy-quinazolin-4-yl]-(3-chloro-phenyl)-amine, 6-(3-Amino-propoxy)-7-methoxy-quinazolin-4-yl-(3-chloro-4-fluoro-phenyl)-amine, 6-(3Amino-propoxy)-7-methoxy-quinazolin-4-yl]-(3-bromo-phenyl)-amine and 4-[4-(4-Amino-butyl)-piperazin-1-yl-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide immobilized on a support material. According to the method of the present invention the above-mentioned immobilized compounds are used to selectively bind protein kinases from a pool of heterogeneous proteins.
摘要翻译：本发明涉及一种培养基和一种富含ATP结合蛋白的方法，蛋白质蛋白酶，来自蛋白质库，如蛋白质组。本发明的培养基包含特异性抑制剂，例如，至少一种化合物4- [4-（4-氟 - 苯基）-5-吡啶-4-基-1H-咪唑-2-基] - 苄胺，2- [4-（2-氨基 - 乙氧基） - 苯基氨基] -6-（2,6-二氯 - 苯基）-8-甲基-8H-吡啶并[2,3-d]嘧啶-7-酮，2- [1-（3-氨基丙基）-1H-吲哚 -3-（3-氨基丙基）-1H-吲哚-3-基] -3-（1H-吲哚-3-基） - 马来酰亚胺，3- [1-（3-氨基丙基） -1H-吲哚-3-基] 4-（1-甲基-1H-吲哚-3-基）马来酰亚胺，3-（8-氨基甲基-6,7,8,9-四氢吡啶并[1,2-a] - 吲哚-10-基）（1-甲基-1H-吲哚-3-基） - 马来酰亚胺，[6-（3-氨基 - 丙氧基） - 甲氧基 - 喹唑啉-4-基] - （3-氯 - 苯基） - 胺，6-（3-氨基 - 丙氧基）-7-甲氧基 - 喹唑啉-4-基 - （3-氯-4-氟 - 苯基） - 胺，6-（3Amin-丙氧基）-7-甲氧基 - 喹唑啉 -4-基] - （3-溴 - 苯基） - 胺和4- [4-（4-氨基 - 丁基） - 哌嗪-1-基 - 甲基] -N- [4-甲基-3-（4- 吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] - 苯甲酰胺固定在载体材料上。根据本发明的方法，上述固定化化合物用于选择性地结合来自异质蛋白库的蛋白激酶。

8. 发明申请

US20050203155A1 Imidazole compounds and human cellular proteins casein kinase I alpha, delta and epsilon as targets for medical intervention against Hepatitis C Virus infections 审中-公开
标题翻译：咪唑化合物和人细胞蛋白酪蛋白激酶Iα，δ和ε作为医疗干预丙型肝炎病毒感染的目标
公开(公告)号：US20050203155A1
公开(公告)日：2005-09-15
申请号：US11030538
申请日：2005-01-05
申请人： Konstadinos Salassidis , Alexander Kurtenbach , Henrik Daub , Sabine Obert , Zoltan Greff , Gyorgy Keri , Laszlo Orfi , Frigyes Waczek
发明人： Konstadinos Salassidis , Alexander Kurtenbach , Henrik Daub , Sabine Obert , Zoltan Greff , Gyorgy Keri , Laszlo Orfi , Frigyes Waczek
IPC分类号： A61K31/4178 , A61P31/20 , C07D233/54 , C07D233/64 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , A61K31/424 , A61K31/4184 , C07D413/02 , C07D43/02
CPC分类号： C07D233/64 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14
摘要： Novel imidazole compounds particularly useful against Hepatitis C Virus infections and diseases associated therewith are described. Applications of the human cellular proteins casein kinase I alpha (α), delta (δ), and epsilon (ε) as targets for medical intervention against Hepatitis C Virus (HCV) infections and diseases are also described. This invention further refers to a method for identifying compounds useful for the prophylaxis and/or treatment of Hepatitis C Virus infections and diseases, methods for treating Hepatitis C Virus infections and diseases, as well as pharmaceutical compositions useful for the prophylaxis and/or treatment of Hepatitis C Virus infections and diseases. Moreover, disclosed are antibodies, oligonucleotides and specific compounds which are effective for the detection, prophylaxis and/or treatment of Hepatitis C Virus infections and diseases. Solid supports useful for the identification of compounds suitable for preventing and/or treating Hepatitis C Virus infections and diseases are also disclosed.
摘要翻译：对丙型肝炎病毒感染和与之相关疾病特别有用的新型咪唑化合物进行了描述。还描述了人细胞蛋白质酪蛋白激酶Iα（α），δ（delta）和ε（ε）作为医疗干预对丙型肝炎病毒（HCV）感染和疾病的靶标的应用。本发明还涉及用于鉴定可用于预防和/或治疗丙型肝炎病毒感染和疾病的化合物的方法，用于治疗丙型肝炎病毒感染和疾病的方法，以及可用于预防和/或治疗丙型肝炎病毒感染和/ 丙型肝炎病毒感染和疾病。此外，公开了对丙型肝炎病毒感染和疾病的检测，预防和/或治疗有效的抗体，寡核苷酸和特异性化合物。用于鉴定适合于预防和/或治疗丙型肝炎病毒感染的化合物的固体支持物也被公开。

9. 发明授权

US4758552A Gonadoliberin derivatives containing an aromatic aminocarboxylic acid in the 6-position, pharmaceutical and veterinary compositions containing them and process for preparing same 失效
标题翻译：在6-位含有芳香族氨基羧酸的甘那球蛋白衍生物，含有它们的药物和兽医组合物及其制备方法
公开(公告)号：US4758552A
公开(公告)日：1988-07-19
申请号：US177
申请日：1987-01-02
申请人： Tamas Gulyas , Istvan Teplan , Aniko Horvath , Gyorgy Keri , Bokonyi Istvane , Sandor Vigh
发明人： Tamas Gulyas , Istvan Teplan , Aniko Horvath , Gyorgy Keri , Bokonyi Istvane , Sandor Vigh
IPC分类号： A61K38/04 , A61K38/00 , A61P15/00 , C07K1/02 , C07K1/04 , C07K7/06 , C07K7/23 , C07K14/575 , A61K37/43 , C07K7/20
CPC分类号： C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/11 , Y10S930/13
摘要： The invention relates to novel gonadoliberin nonapeptide ethylamide or decapeptide amide derivatives of the general formula (I),Glp-His-Trp-Ser-Tyr-X.sub.1 -X.sub.2 -X.sub.3 -Pro-X.sub.4 (I)whereinX.sub.1 stands for a 2-aminobenzoic or 3-aminobenzoic acid group;X.sub.2 stands for a leucyl, tryptophyl or phenylalanyl group;X.sub.3 means an arginyl, leucyl or glutaminyl group; andX.sub.4 represents a glycylamide or ethylamide group, as well as their acid addition salts and pharmaceutical presparations containing these compounds. Further on, the invention relates to a process for preparing these compounds and preparations.The gonadoliberin derivatives of the invention can more effectively be used for reproduction biological purposes as compared to the derivatives known so far.
摘要翻译：本发明涉及通式（I），Glp-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4（Ⅰ）的新颖性促性白列素壬肽乙酰胺或十肽酰胺衍生物，其中X1代表2-氨基苯甲酸或3-氨基苯甲酸基团; X2代表亮氨酰，色氨酸或苯丙氨酰基; X3表示精氨酰，亮氨酰或谷氨酰胺基; 并且X 4代表甘氨酰酰胺或乙酰胺基团，以及它们的酸加成盐和含有这些化合物的药物预制剂。此外，本发明涉及一种制备这些化合物和制剂的方法。与迄今已知的衍生物相比，本发明的性腺激肽衍生物可更有效地用于生殖生物学目的。

10. 发明申请

US20160113989A1 Anticancer and immunomodulating molecules and fractions containing said molecules, and process for preparing said fractions and said molecules from fermented vegetal material, and their uses 审中-公开
$Anticancer and immunomodulating molecules and fractions containing said molecules, and process for preparing said fractions and said molecules from fermented vegetal material, and their uses$
标题翻译：包含所述分子的抗癌和免疫调节分子和级分，以及从发酵植物材料制备所述级分和所述分子的方法及其用途
公开(公告)号：US20160113989A1
公开(公告)日：2016-04-28
申请号：US14121822
申请日：2014-10-22
申请人： Mate Hidvegi , Gyula Bencze , Gyorgy Keri , Laszlo Orfi , Darryl Pappin , Nicholas K. Tonks , James Watson
发明人： Mate Hidvegi , Gyula Bencze , Gyorgy Keri , Laszlo Orfi , Darryl Pappin , Nicholas K. Tonks , James Watson
IPC分类号： A61K36/899
CPC分类号： A61K36/899 , A61K2236/00
摘要： A method for formulating A250, a biologically active substance and fraction of wheat germ ferment/fermented wheat germ extract (FWGE), including formulation A250, the processes for their production, the pharmaceutical preparations containing them, and their uses.
摘要翻译：制备A250，一种生物活性物质和小麦芽发酵/发酵小麦胚芽提取物（FWGE）的分数，包括制剂A250，其生产方法，含有它们的药物制剂及其用途。

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