专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08513266B2 Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K alpha 有权
标题翻译：使用PI3Kα的吡啶并嘧啶酮抑制剂治疗癌症的方法
公开(公告)号：US08513266B2
公开(公告)日：2013-08-20
申请号：US12595219
申请日：2008-04-09
申请人： Peter Lamb , David Matthews
发明人： Peter Lamb , David Matthews
IPC分类号： A61K31/519
CPC分类号： A61K31/4745 , A61K31/282 , A61K31/337 , A61K31/517 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments.(Formula I)
摘要翻译：本发明提供了通过与其它癌症治疗组合施用式I化合物，任选地作为其药学上可接受的盐，溶剂合物和/或水合物来治疗癌症的方法。（式I）

2. 发明申请

US20100209420A1 METHODS OF TREATING CANCER USING PYRIDOPYRIMIDINONE INHIBITORS OF P13K ALPHA 有权
标题翻译：使用P13K ALPHA的吡嗪二酮抑制剂治疗癌症的方法
公开(公告)号：US20100209420A1
公开(公告)日：2010-08-19
申请号：US12595219
申请日：2008-04-09
申请人： Peter Lamb , David Matthews
发明人： Peter Lamb , David Matthews
IPC分类号： A61K39/395 , A61K31/519 , A61P35/04
CPC分类号： A61K31/4745 , A61K31/282 , A61K31/337 , A61K31/517 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments.(Formula I)
摘要翻译：本发明提供了通过与其它癌症治疗组合施用式I化合物，任选地作为其药学上可接受的盐，溶剂合物和/或水合物来治疗癌症的方法。（式I）

3. 发明授权

US08802692B2 Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents 有权
标题翻译：鞘氨醇-1-磷酸受体拮抗剂和抗微管剂之间的协同作用
公开(公告)号：US08802692B2
公开(公告)日：2014-08-12
申请号：US13124586
申请日：2009-10-16
申请人： Geetha Shankar , Frauke Bentzien , Peter Lamb , David Matthews
发明人： Geetha Shankar , Frauke Bentzien , Peter Lamb , David Matthews
IPC分类号： A61K31/44 , A01N43/36 , A61K31/40
CPC分类号： A61K31/4196 , A61K31/16 , A61K31/337 , A61K31/34 , A61K31/4192 , A61K31/435 , A61K2300/00
摘要： This invention is based on the discovery that the administration of a sphingosine-1-phosphate receptor antagonist (S1P) and at least one chemotherapeutic agent selected from the the group of antimicrotubule agents provides an unexpectedly superior treatment for cancer. Antimicrobial agents such as the taxane compounds are known in the art, for example, paclitaxel (available as TAXOL® from Bristol-Myers Squibb, Princeton, N.J.), docetaxel (available as TAXOTERE® from Sanofi-aventis, Bridgewater, N.J.) and the like and other compounds that act as antimicrotubule agents, such as Vincristine (ONCOVIN®, VINCASAR PFS®, VCR), Vinblastin (VELBAN®, VELSAR®) and Vinorelbine, and similar compounds. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one sphingosine-1-phosphate 1 (S1P1R) receptor antagonists, and at least one antimicrotubule agent.
摘要翻译：本发明基于以下发现：施用鞘氨醇-1-磷酸受体拮抗剂（S1P）和选自抗微管剂组的至少一种化学治疗剂提供了对于癌症的意想不到的优异治疗。抗菌剂如紫杉烷化合物是本领域已知的，例如紫杉醇（可从Bristol-Myers Squibb，Princeton，NJ获得），多西紫杉醇（可从Sanofi-aventis，Bridgewater，NJ获得）和类似物和其它作为抗微管剂的化合物，如长春新碱（ONCVIN®，VINCASARPFS®，VCR），长春花碱（VELBAN®，VELSAR）和长春瑞滨等）和类似化合物。本发明还提供了通过施用治疗有效量的至少一种鞘氨醇-1-磷酸1（S1P1R）受体拮抗剂和至少一种抗微管剂来调节所选细胞群体如癌细胞的生长的方法。

4. 发明申请

US20110123434A1 COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF P13K-ALPHA FOR USE IN THE TREATMENT OF CANCER 有权
标题翻译：包含用于治疗癌症的P13K-ALPHA的喹诺酮抑制剂的组合治疗
公开(公告)号：US20110123434A1
公开(公告)日：2011-05-26
申请号：US12595236
申请日：2008-04-08
申请人： Peter Lamb , David Matthews
发明人： Peter Lamb , David Matthews
IPC分类号： A61K51/00 , A61K31/635 , A61K31/498 , A61K31/4985 , A61K31/5377 , A61K31/551 , A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： A61K31/337 , A61K31/436 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments.
摘要翻译：本发明提供了通过与其它癌症治疗组合施用式I化合物，任选地作为其药学上可接受的盐，溶剂合物和/或水合物来治疗癌症的方法。

5. 发明授权

US08481001B2 Combination therapies comprising quinoxaline inhibitors of P13K-alpha for use in the treatment of cancer 有权
标题翻译：组合疗法包括用于治疗癌症的P13K-α的喹喔啉抑制剂
公开(公告)号：US08481001B2
公开(公告)日：2013-07-09
申请号：US12595236
申请日：2008-04-08
申请人： Peter Lamb , David Matthews
发明人： Peter Lamb , David Matthews
IPC分类号： A61K31/5377 , A61K31/551 , A61K39/395
CPC分类号： A61K31/337 , A61K31/436 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments.
摘要翻译：本发明提供了通过与其它癌症治疗组合施用式I化合物，任选地作为其药学上可接受的盐，溶剂合物和/或水合物来治疗癌症的方法。

6. 发明申请

US20110301188A1 Synergistic Effects Between Sphingosine-1-Phosphate Receptor Antagonists and Antimicrotubule Agents 有权
标题翻译：鞘氨醇-1-磷酸受体拮抗剂与抗微管剂之间的协同作用
公开(公告)号：US20110301188A1
公开(公告)日：2011-12-08
申请号：US13124586
申请日：2009-10-16
申请人： Geetha Shankar , Frauke Bentzien , Peter Lamb , David Matthews
发明人： Geetha Shankar , Frauke Bentzien , Peter Lamb , David Matthews
IPC分类号： A61K31/475 , A61P35/00 , A61P35/02 , A61K31/4192
CPC分类号： A61K31/4196 , A61K31/16 , A61K31/337 , A61K31/34 , A61K31/4192 , A61K31/435 , A61K2300/00
摘要： This invention is based on the discovery that the administration of a sphingosine-1-phosphate receptor antagonist (S1P) and at least one chemotherapeutic agent selected from the the group of antimicrotubule agents provides an unexpectedly superior treatment for cancer. Antimicrobial agents such as the taxane compounds are known in the art, for example, paclitaxel (available as TAXOL® from Bristol-Myers Squibb, Princeton, N.J.), docetaxel (available as TAXOTERE® from Sanofi-aventis, Bridgewater, N.J.) and the like and other compounds that act as antimicrotubule agents, such as Vincristine (ONCOVIN®, VINCASAR PFS®, VCR), Vinblastin (VELBAN®, VELSAR®) and Vinorelbine, and similar compounds. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one sphingosine-1-phosphate 1 (S1P1R) receptor antagonists, and at least one antimicrotubule agent.
摘要翻译：本发明基于以下发现：施用鞘氨醇-1-磷酸受体拮抗剂（S1P）和选自抗微管剂组的至少一种化学治疗剂提供了对于癌症的意想不到的优异治疗。抗菌剂如紫杉烷化合物是本领域已知的，例如紫杉醇（可从Bristol-Myers Squibb，Princeton，NJ获得），多西紫杉醇（可从Sanofi-aventis，Bridgewater，NJ获得）和类似物和其它作为抗微管剂的化合物，如长春新碱（ONCVIN®，VINCASARPFS®，VCR），长春花碱（VELBAN®，VELSAR）和长春瑞滨等）和类似化合物。本发明还提供了通过施用治疗有效量的至少一种鞘氨醇-1-磷酸1（S1P1R）受体拮抗剂和至少一种抗微管剂来调节所选细胞群体如癌细胞的生长的方法。

7. 发明申请

US20120302586A1 ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE 有权
标题翻译：作为DIHYDROOROTETE DEHYDROGENASE的抑制剂的抗菌药物
公开(公告)号：US20120302586A1
公开(公告)日：2012-11-29
申请号：US13499031
申请日：2010-09-28
申请人： Pradipsinh K. Rathod , David Floyd , Jeremy Burrows , Alka Marwaha , Ramesh Gujjar , Jose Coteron-Lopez , Margaret Phillips , Susan A. Charman , David Matthews
发明人： Pradipsinh K. Rathod , David Floyd , Jeremy Burrows , Alka Marwaha , Ramesh Gujjar , Jose Coteron-Lopez , Margaret Phillips , Susan A. Charman , David Matthews
IPC分类号： A61K31/519 , C08B37/00 , A61P33/06 , C07D487/04 , A61P33/00
CPC分类号： C07D487/04
摘要： Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
摘要翻译：寄生二氢乳清酸脱氢酶（DHOD）的抑制剂是治疗疟疾的候选治疗剂。这样的治疗剂的实例包括化合物：和符合式IX的三唑并嘧啶类化合物及其溶剂合物，立体异构体，互变异构体和药学上可接受的盐。

8. 发明申请

US20070039326A1 Fuel injection method and apparatus for a combustor 失效
标题翻译：燃料喷射方法和燃烧器装置
公开(公告)号：US20070039326A1
公开(公告)日：2007-02-22
申请号：US11515959
申请日：2006-09-05
申请人： Kenneth Sprouse , Shahram Farhangi , Alan von Arx , David Matthews
发明人： Kenneth Sprouse , Shahram Farhangi , Alan von Arx , David Matthews
IPC分类号： F02C1/00
CPC分类号： F23R3/40 , F23C13/06 , F23D14/70 , F23R3/36
摘要： A combustor and injector system to inject a selected fuel into a combustor of a gas powered turbine. Generally, the injector is able to inject a selected fuel into a stream of an oxidizer to substantially mix the fuel with the oxidizer stream before any of the fuel in the fuel fan reaches an auto ignition temperature. Therefore the fuel may be substantially combusted at once and without any substantial hot spots.
摘要翻译：一种燃烧器和喷射器系统，用于将选定的燃料喷射到燃气轮机的燃烧器中。通常，在燃料风扇中的任何燃料达到自动点火温度之前，喷射器能够将所选择的燃料喷射到氧化剂流中，以将燃料与氧化剂流基本上混合。因此，燃料可以基本上一次燃烧并且没有任何实质的热点。

9. 发明申请

US20060282790A1 OPERATING SYSTEM PROGRAM LAUNCH MENU SEARCH 有权
标题翻译：操作系统程序启动菜单搜索
公开(公告)号：US20060282790A1
公开(公告)日：2006-12-14
申请号：US11465266
申请日：2006-08-17
申请人： David Matthews , Charles Stabb , Matthew Lerner
发明人： David Matthews , Charles Stabb , Matthew Lerner
IPC分类号： G06F17/00
CPC分类号： G06F3/0482 , G06F3/04845 , G06F3/04897 , G06F9/451 , G06F17/30106 , G06F17/30554
摘要： An operating system program launch menu, such as a Start menu, provides various mechanisms for a user to quickly and efficiently locate and launch desired data items such as programs, data files, storage locations, and the like. A search box within the program launch menu may be used to quickly locate programs, documents, communications, and other data items. An auto-complete feature may be used, e.g., when the user restricts the locations searched for the user-entered search text. A most commonly used program list may include programs based on various criteria including both frequency of use and recent use, thereby always including a most recently used item. An all programs view may display programs and documents in a hosted-tree view within the original confines of the program launch menu, thereby negating the need to open sub-menus on top of a large portion of the desktop displayed on the display device.
摘要翻译：诸如开始菜单的操作系统程序启动菜单提供了用于用户快速有效地定位和发射所需数据项（例如程序，数据文件，存储位置等）的各种机制。程序启动菜单中的搜索框可用于快速定位程序，文档，通信和其他数据项。可以使用自动完成功能，例如当用户限制搜索到用户输入的搜索文本的位置时。最常用的程序列表可以包括基于包括使用频率和最近使用的各种标准的程序，从而总是包括最近使用的项目。所有程序视图可以在程序启动菜单的原始范围内的托管树视图中显示程序和文档，从而不需要在显示设备上显示的桌面的大部分之上打开子菜单。

10. 发明申请

US20060242907A1 Gasifier injector 有权
标题翻译：气化器注射器
公开(公告)号：US20060242907A1
公开(公告)日：2006-11-02
申请号：US11117911
申请日：2005-04-29
申请人： Kenneth Sprouse , Shahram Farhangi , David Matthews
发明人： Kenneth Sprouse , Shahram Farhangi , David Matthews
IPC分类号： C10J3/00
CPC分类号： C10J3/50 , B05B7/066 , B05B7/0861 , C10J2200/152
摘要： A gasifier injection module includes a two-stage slurry splitter and an injector face plate with a coolant system incorporated therein. The two-stage slurry splitter includes a main cavity into which a main slurry flow is provided. The main cavity includes a plurality of first stage flow dividers that divide the main slurry flow into a plurality of secondary slurry flows that flow into a plurality of secondary cavities that extend from the main cavity. Each secondary cavity includes a plurality of second stage flow dividers that divide each secondary slurry flow into a plurality of tertiary slurry flows that flow into a plurality of slurry injection tubes extending from the secondary cavities. The tertiary flows are injected as high pressure slurry streams into the gasification chamber via the slurry injection tubes. A reactant is impinged at high pressure, as an annular shaped spray, on each high pressure slurry stream via a plurality of annular impinging orifices incorporated into the injector face plate. The coolant system incorporated within the injector face plate maintains the injector face plate at a temperature sufficient to substantially reduce or prevent damage to the injector face plate by high temperatures and/or abrasive matter created by the resulting gasification reaction.
摘要翻译：气化器注射模块包括两级浆料分离器和其中结合有冷却剂系统的注射器面板。两级浆料分离器包括主空腔，主浆液流被提供到主腔中。主空腔包括多个第一级分流器，其将主浆料流分成多个次级浆料流，其流入从主腔延伸的多个次级空腔。每个次级腔包括多个第二级分流器，其将每个次级浆料流分成多个第三浆料流，其流入从次级腔延伸的多个浆料注入管中。通过浆料注入管将三次流作为高压浆料流注入气化室。反应物通过并入注射器面板中的多个环形冲击孔在每个高压浆料流上以高压作为环形喷雾冲击。结合在注射器面板内的冷却剂系统将注射器面板保持在足以基本上减少或防止由所产生的气化反应产生的高温和/或研磨物质损害注射器面板的温度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式