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1. 发明授权

US5328906A 0-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same 失效
标题翻译： O-（3-氨基-2-羟丙基） - 羟基酰卤，及其制备方法
公开(公告)号：US5328906A
公开(公告)日：1994-07-12
申请号：US72765
申请日：1993-06-07
申请人： Peter L. Nagy , Bela Balazs , Maria Boross , Jeno Szilbereky , Gizella Zsila , Lajos Abraham , Gyorgy Blasko , Bela Gachalyi , Attila Almasi , Gabor Nemet
发明人： Peter L. Nagy , Bela Balazs , Maria Boross , Jeno Szilbereky , Gizella Zsila , Lajos Abraham , Gyorgy Blasko , Bela Gachalyi , Attila Almasi , Gabor Nemet
IPC分类号： A61K31/13 , A61K31/135 , A61K31/15 , A61K31/44 , A61K31/4406 , A61K31/445 , A61P3/00 , A61P3/08 , A61P3/10 , C07C249/12 , C07C251/58 , C07C259/02 , C07C259/08 , C07D213/54 , C07D213/78 , C07D295/08 , C07D295/088 , C07D295/12 , A61K31/47 , C07D401/12 , C07D413/12 , C07D471/06
CPC分类号： C07D213/78 , C07C259/08 , C07D295/088
摘要： Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.
摘要翻译：这些化合物可用于治疗糖尿病血管病。

2. 发明授权

US5147879A O-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same 失效
标题翻译： O-（3-氨基-2-羟基丙酸） - 羟基酸类抗坏血酸及其制备方法
公开(公告)号：US5147879A
公开(公告)日：1992-09-15
申请号：US499318
申请日：1990-06-28
申请人： Peter L. Nagy , Bela Balazs , Maria Boross , Jeno Szilbereky , Gizella Zsila , Lajos braham , Gyorgy Blasko , Bela Gachalyi , Attila Almasi , Gabor Nemet
发明人： Peter L. Nagy , Bela Balazs , Maria Boross , Jeno Szilbereky , Gizella Zsila , Lajos braham , Gyorgy Blasko , Bela Gachalyi , Attila Almasi , Gabor Nemet
IPC分类号： A61K31/13 , A61K31/135 , A61K31/15 , A61K31/44 , A61K31/4406 , A61K31/445 , A61P3/00 , A61P3/08 , A61P3/10 , C07C249/12 , C07C251/58 , C07C259/02 , C07C259/08 , C07D213/54 , C07D213/78 , C07D295/08 , C07D295/088 , C07D295/12
CPC分类号： C07D213/78 , C07C259/08 , C07D295/088
摘要： Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.
摘要翻译： PCT No.PCT / HU89 / 00048 Sec。 371日期1990年6月28日第 102（e）日期1990年6月28日PCT提交1989年10月19日PCT公布。第WO90 / 04584号公报日期：1990年5月3日。式（Ⅰ）所示的盐酸衍生物这些化合物可用于治疗糖尿病血管病。

3. 发明授权

US5296606A O-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same 失效
标题翻译： O-（3-氨基-2-羟丙基） - 羟基酰卤化物及其制备方法
公开(公告)号：US5296606A
公开(公告)日：1994-03-22
申请号：US906402
申请日：1992-07-01
申请人： Peter L. Nagy , Bela Balazs , Maria Boross , Jeno Szilbereky , Gizella Zsila , Lajos braham , Gyorgy Blasko , Bela Gachalyi , Attila Almasi , Gabor Nemet
发明人： Peter L. Nagy , Bela Balazs , Maria Boross , Jeno Szilbereky , Gizella Zsila , Lajos braham , Gyorgy Blasko , Bela Gachalyi , Attila Almasi , Gabor Nemet
IPC分类号： A61K31/13 , A61K31/135 , A61K31/15 , A61K31/44 , A61K31/4406 , A61K31/445 , A61P3/00 , A61P3/08 , A61P3/10 , C07C249/12 , C07C251/58 , C07C259/02 , C07C259/08 , C07D213/54 , C07D213/78 , C07D295/08 , C07D295/088 , C07D295/12 , C07D211/04 , C07C219/06
CPC分类号： C07D213/78 , C07C259/08 , C07D295/088
摘要： Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.
摘要翻译：式（1）的羟基亚氨酸衍生物（1）这些化合物可用于治疗糖尿病血管病。

4. 发明申请

US20090134793A1 IR REFLECTING GRATING FOR HALOGEN LAMPS 审中-公开
标题翻译：红外反射红光激光
公开(公告)号：US20090134793A1
公开(公告)日：2009-05-28
申请号：US11946223
申请日：2007-11-28
申请人： Geza Z. Cseh , Peter L. Nagy , Ferenc Fazekas
发明人： Geza Z. Cseh , Peter L. Nagy , Ferenc Fazekas
IPC分类号： H01K1/26 , H01J9/00
CPC分类号： H01J61/35 , H01J61/025 , H01J61/34 , H01J65/00
摘要： A lamp, such as a halogen lamp, includes a bulb which is sealed to define an interior chamber. An emitter, such as a filament, is disposed within the interior chamber which, during operation of the lamp, emits radiation in the visible and infrared regions of the spectrum. An optical grating, generally spaced from the emitter, is positioned to intercept radiation from the emitter. The optical grating reflects infrared radiation and transmits visible radiation therethrough. In this way, the output of the lamp in the visible range can be increased as compared with an otherwise identical lamp formed without the grating.
摘要翻译：诸如卤素灯的灯包括密封以限定内部室的灯泡。诸如灯丝的发射器设置在内部室内，在灯的操作期间，在光谱的可见光和红外区域中发射辐射。通常与发射器间隔开的光栅被定位成拦截来自发射器的辐射。光栅反射红外辐射并透射可见光。以这种方式，与不用光栅形成的其它相同的灯相比，灯的输出在可见光范围内可以增加。

5. 发明授权

US4373104A Sulfur-containing isoquinoline derivatives, process for the preparation thereof and pharmaceutical compositions containing them 失效
标题翻译：含硫异喹啉衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US4373104A
公开(公告)日：1983-02-08
申请号：US164939
申请日：1980-07-01
申请人： Kalman Takacs , Maria H. Papp , Gabor Kovacs , Ilona K. Ajzert , Antal Simay , Peter L. Nagy , Marian E. Puskas , Gyula Sebestyen , Istvan Stadler , Zoltan Sumeghy
发明人： Kalman Takacs , Maria H. Papp , Gabor Kovacs , Ilona K. Ajzert , Antal Simay , Peter L. Nagy , Marian E. Puskas , Gyula Sebestyen , Istvan Stadler , Zoltan Sumeghy
IPC分类号： C07D217/00 , A61K31/47 , A61K31/472 , A61P7/08 , A61P7/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P29/00 , A61P43/00 , C07D217/14 , C07D217/16 , C07D513/04
CPC分类号： C07D513/04 , C07D217/14 , Y10S514/869
摘要： Isoquinolines are disclosed of the formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms,R.sup.1 is hydrogen, alkyl having 1 to 4 carbon atoms and optionally substituted with phenyl, phenyl optionally substituted with one or more halogen or alkoxy group, cyano or carbomoyl,R.sup.2 is phenyl optionally substituted with one or more halogen, alkoxy or carboxyl, or a group of the general formula A ##STR2## wherein R.sup.3 is hydrogen, a straight or branched chained alkyl having 1 to 4 carbon atoms or phenyl,m and n independently represent 0, 1 or 2, with the proviso that m+n is at least 1,R.sup.4 is hydrogen, phenyl, hydroxyl, acyloxy, carboxyl, alkoxycarbonyl having 1 to 6 carbon atoms, carbamoyl, carbazoyl or dialkylamino containing 1 to 6 carbon atoms in the alkyl moiety, orR.sup.2 is a straight or branched chained alkylene group having 1 to 6 carbon atoms, andthe dotted line stands for a further carbon-carbon bond or hydrogen atoms in the 3- and 4-positions of the ring,or salts thereof. The new compounds are potent diuretic agents.
摘要翻译：公开了式（I）的异喹啉（I）其中R独立地表示氢，羟基或具有1至4个碳原子的烷氧基，R 1是氢，具有1至4个碳原子的烷基，任选被苯基取代，苯基任选地被一个或多个卤素或烷氧基取代，氰基或甲酰甲酰基，R 2是任选被一个或多个卤素，烷氧基或羧基取代的苯基或通式A的基团，其中R 3是氢，直链或支链具有1至4个碳原子的烷基或苯基，m和n独立地表示0,1或2，条件是m + n至少为1，R4为氢，苯基，羟基，酰氧基，羧基，具有1至6个碳原子的烷氧基羰基碳原子，氨基甲酰基，咔唑基或在烷基部分含有1至6个碳原子的二烷基氨基，或者R2是具有1至6个碳原子的直链或支链链烯基，虚线代表另外的碳 - 碳键或氢原子在3-和环的4-位，或其盐。新化合物是有效的利尿剂。

6. 再颁专利

USRE32519E Sulfur-containing isoquinoline derivatives, process for the preparation thereof and pharmaceutical compositions containing them 失效
标题翻译：含硫异喹啉衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：USRE32519E
公开(公告)日：1987-10-13
申请号：US524023
申请日：1983-08-17
申请人： Kalman Takacs , Maria H. Papp , Gabor Kovaacs , Ilona K. Ajzert , Antal Simay , Peter L. Nagy , Marian E. Puskas , Gyula Sebestyen , Istvan Stadler , Zoltan Sumeghy
发明人： Kalman Takacs , Maria H. Papp , Gabor Kovaacs , Ilona K. Ajzert , Antal Simay , Peter L. Nagy , Marian E. Puskas , Gyula Sebestyen , Istvan Stadler , Zoltan Sumeghy
IPC分类号： C07D217/14 , C07D513/04
CPC分类号： C07D513/04 , C07D217/14
摘要： Isoquinolines are disclosed of the formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms,R.sup.1 is hydrogen, alkyl having 1 to 4 carbon atoms and optionally substituted with phenyl, phenyl optionally substituted with one or more halogen or alkoxy group, cyano or carbomoyl,R.sup.2 is phenyl optionally substituted with one or more halogen, alkoxy or carboxyl, or a group of the general formula A ##STR2## wherein R.sup.3 is hydrogen, a straight or branched chained alkyl having 1 to 4 carbon atoms or phenyl,m and n independently represent 0, 1 or 2, with the proviso that m+n is at least 1,R.sup.4 is hydrogen, phenyl, hydroxyl, acyloxy, carboxyl, alkoxycarbonyl having 1 to 6 carbon atoms, carbamoyl, carbazoyl or dialkylamino containing 1 to 6 carbon atoms in the alkyl moiety, orR.sup.2 is a straight or branched chained alkylene group having 1 to 6 carbon atoms, andthe dotted line stands for a further carbon-carbon bond or hydrogen atoms in the 3- and 4-positions of the ring,or salts thereof. The new compounds are potent diuretic agents.

7. 发明授权

US4308270A 1,2,4-Oxadiazine derivatives, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译： 1,2,4-恶二嗪衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US4308270A
公开(公告)日：1981-12-29
申请号：US196034
申请日：1980-10-10
申请人： Kalman Takacs , Antal Simay , Ilona Kiss nee Ajzert , Peter L. Nagy , Maria Hetyey nee Papp , Marian Escery nee Puskas , Jozsef Szegy , Sandor Virag , Sandor J. Nagy
发明人： Kalman Takacs , Antal Simay , Ilona Kiss nee Ajzert , Peter L. Nagy , Maria Hetyey nee Papp , Marian Escery nee Puskas , Jozsef Szegy , Sandor Virag , Sandor J. Nagy
IPC分类号： A61K31/535 , A61P7/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P29/00 , C07D273/04 , C07D413/06
CPC分类号： C07D273/04 , Y10S514/821 , Y10S514/869
摘要： The invention concerns new compounds of the general formula (I) ##STR1## wherein R.sup.1 is hydrogen or phenyl optionally substituted by one or more of the following substituents: alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro;R.sup.2 is alkyl having 1 to 4 carbon atoms, cycloalkyl having 5 to 7 carbon atoms or phenyl, optionally substituted with one or more of the following groups: alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro; or R.sup.2 is a naphthyl group;R.sup.3 is alkyl having 1 to 4 carbon atoms, acyl or hydrogen;R.sup.4 hydrogen or alkyl having 1 to 4 carbon atoms;R.sup.5 is cycloalkyl having 5 to 7 carbon atoms, alkyl having 1 to 6 carbon atoms, phenyl-(C.sub.1-4 -alkyl) in which the phenyl moiety may optionally be substituted with alkoxy having 1 to 4 carbon atoms, halogen or nitro;or R.sup.4 and R.sup.5 together represent a group of the general formula (V) ##STR2## wherein R.sup.6 is hydrogen or alkoxy having 1 to 4 carbon atoms, m and n stand for 0, 1 or 2and acid addition and quaternary salts thereof.The compounds of the general formula (I) are potent peripheral vasodilators and hypotensive agents. They increase the coronary blood flow and in addition to their slight antiinflammatory and diuretic acidivity possess strong antiarrhythmic properties.A process for the preparation of these compounds and pharmaceutical compositions containing them are also within the scope of the invention.
摘要翻译：本发明涉及通式（I）的新化合物其中R 1为氢或任选被一个或多个下述取代基取代的苯基：具有1-4个碳原子的烷基，卤素，具有1-4个碳原子的烷氧基碳原子或硝基; R 2是具有1至4个碳原子的烷基，具有5至7个碳原子的环烷基或苯基，任选被一个或多个下列基团取代：具有1至4个碳原子的烷基，卤素，具有1至4个碳原子的烷氧基或硝基 ; 或R 2为萘基; R3是具有1-4个碳原子的烷基，酰基或氢; R4是氢或具有1-4个碳原子的烷基; R5是具有5至7个碳原子的环烷基，具有1至6个碳原子的烷基，苯基部分可任选地被具有1至4个碳原子的烷氧基取代的苯基 - （C 1-4 - 烷基），卤素或硝基; 或者R 4和R 5一起表示通式（V）的基团，其中R 6是氢或具有1至4个碳原子的烷氧基，m和n代表0,1或2，酸加成和季盐其中。通式（I）的化合物是有效的外周血管扩张剂和降压药。它们增加冠状动脉血流量，除了其轻微的抗炎和利尿酸性之外，具有强烈的抗心律失常性质。制备这些化合物的方法和含有它们的药物组合物也在本发明的范围内。

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