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1. 发明授权

US07451649B2 Differentiation and identification of analogous chemical or biological substances with biosensors 有权
标题翻译：用生物传感器分化和鉴定类似的化学或生物物质
公开(公告)号：US07451649B2
公开(公告)日：2008-11-18
申请号：US11088809
申请日：2005-03-25
申请人： Peter J. Edmonson , William D. Hunt , Desmond D. Stubbs , Sang Hun Lee
发明人： Peter J. Edmonson , William D. Hunt , Desmond D. Stubbs , Sang Hun Lee
IPC分类号： H01L41/00 , G01N9/24 , G01N29/00
CPC分类号： G01N33/54373 , G01N29/022 , G01N29/036 , G01N29/4481 , G01N2291/0255 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2291/045
摘要： A biosensor detection system for detecting a particular substance has at least two biosensor devices. Each biosensor device includes a piezoelectric material, an input transducer mounted on the piezoelectric material to receive an input radio frequency signal and propagate a corresponding acoustic wave within the piezoelectric material and an output transducer mounted on the piezoelectric material to receive the acoustic wave and transmit a corresponding output radio frequency signal. A biolayer is mounted on the piezoelectric material to receive a substance to be tested and cause a corresponding change in the acoustic wave. An oscillator circuit is connected to the input transducer and to the output transducer, the oscillator circuit including an amplifier and providing an output signal indicative of a change in the acoustic wave. The biosensor devices having two different biolayers, whereby the output signals can be utilized to detect receipt of a particular substance by the biolayers of the biosensor devices.
摘要翻译：用于检测特定物质的生物传感器检测系统具有至少两个生物传感器装置。每个生物传感器装置包括压电材料，安装在压电材料上的输入传感器，用于接收输入射频信号并传播压电材料内相应的声波，以及安装在压电材料上的输出变换器，以接收声波并传输相应的输出射频信号。生物层安装在压电材料上以接收待测物质并引起声波的相应变化。振荡器电路连接到输入变换器和输出变换器，振荡器电路包括放大器，并提供表示声波变化的输出信号。具有两个不同生物层的生物传感器装置，由此输出信号可用于检测生物传感器装置的生物层的特定物质的接收。

2. 发明申请

US20100178688A1 ACOUSTIC WAVE BIOSENSOR FOR THE DETECTION AND IDENTIFICATION OF CHARACTERISTIC SIGNALING MOLECULES IN A BIOLOGICAL MEDIUM 有权
标题翻译：用于检测和鉴定生物介质中特征信号分子的声波生物传感器
公开(公告)号：US20100178688A1
公开(公告)日：2010-07-15
申请号：US12636252
申请日：2009-12-11
申请人： Peter J. Edmonson , William D. Hunt , Desmond D. Stubbs
发明人： Peter J. Edmonson , William D. Hunt , Desmond D. Stubbs
IPC分类号： C12M1/34
CPC分类号： G01N33/54373
摘要： An acoustic wave biosensor comprises a plurality of spaced apart electrodes disposed on a substrate of piezoelectric material and having a biolayer matched to a specific type of autoinducer signaling molecule to be detected. The biolayer comprises a layer of heterobifunctional molecules disposed on the electrodes and on the piezoelectric material between the electrodes, and a plurality of bioreceptor molecules which bind exclusively with the specific type of autoinducer signaling molecule to be detected. The bioreceptor molecules are supported by the layer of heterobifunctional molecules, and a hydrogel layer surrounds the bioreceptor molecules to support a three-dimensional structure thereof. The bioreceptor molecules can bind with the specific type of autoinducer signaling molecule to be detected, and the biolayer is reactive thereto such that corresponding autoinducer signaling molecules bind to the biolayer and detectably vary acoustic characteristics of the acoustic wave biosensor.
摘要翻译：声波生物传感器包括设置在压电材料的衬底上的多个间隔开的电极，并且具有与要检测的特定类型的自动感染信号分子匹配的生物层。生物层包括设置在电极和电极之间的压电材料上的异双功能分子层，以及仅与特定类型的待检测的自身诱导剂信号分子结合的多个生物受体分子。生物受体分子由异双功能分子层支撑，水凝胶层围绕生物受体分子以支持其三维结构。生物受体分子可以与要检测的特异性类型的自身诱导剂信号分子结合，并且生物层与其反应，使得相应的自体感染信号分子与生物层结合并可检测地改变声波生物传感器的声学特性。

3. 发明申请

US20080145890A1 Detection of signaling molecules in a biological environment 有权
标题翻译：检测生物环境中的信号分子
公开(公告)号：US20080145890A1
公开(公告)日：2008-06-19
申请号：US11226261
申请日：2005-09-15
申请人： Desmond D. Stubbs , Peter J. Edmonson , William D. Hunt
发明人： Desmond D. Stubbs , Peter J. Edmonson , William D. Hunt
IPC分类号： C12Q1/04
CPC分类号： G01N33/54373
摘要： A method of detecting and identifying bacteria, micro-organisms or plants in a liquid or gaseous medium, the bacteria, micro-organisms or plants being of the kind which produce signaling molecules in intercellular space. The method includes positioning a biosensor in the liquid or gaseous medium, the biosensor having a biolayer matched to specific signaling molecules to be detected whereby the biolayer is reactive thereto in a manner which varies operation of the sensor. Such variation of the operation of the biosensor is detected to thereby determine the presence and purpose of the bacteria, micro-organisms or plants in the liquid or gaseous medium.
摘要翻译：在液体或气体介质中检测和鉴定细菌，微生物或植物的方法，细菌，微生物或植物是在细胞间隙中产生信号分子的那种。该方法包括将生物传感器定位在液体或气体介质中，生物传感器具有与要检测的特定信号分子匹配的生物层，由此生物层以改变传感器操作的方式与其反应。检测生物传感器的操作的这种变化，从而确定液体或气体介质中的细菌，微生物或植物的存在和目的。

4. 发明授权

US08420382B2 Acoustic wave biosensor for the detection and identification of characteristic signaling molecules in a biological medium 有权
标题翻译：用于检测和鉴定生物介质中特征信号分子的声波生物传感器
公开(公告)号：US08420382B2
公开(公告)日：2013-04-16
申请号：US12636252
申请日：2009-12-11
申请人： Peter J. Edmonson , William D. Hunt , Desmond D. Stubbs
发明人： Peter J. Edmonson , William D. Hunt , Desmond D. Stubbs
IPC分类号： C12M1/34
CPC分类号： G01N33/54373
摘要： An acoustic wave biosensor comprises a plurality of spaced apart electrodes disposed on a substrate of piezoelectric material and having a biolayer matched to a specific type of autoinducer signaling molecule to be detected. The biolayer comprises a layer of heterobifunctional molecules disposed on the electrodes and on the piezoelectric material between the electrodes, and a plurality of bioreceptor molecules which bind exclusively with the specific type of autoinducer signaling molecule to be detected. The bioreceptor molecules are supported by the layer of heterobifunctional molecules, and a hydrogel layer surrounds the bioreceptor molecules to support a three-dimensional structure thereof. The bioreceptor molecules can bind with the specific type of autoinducer signaling molecule to be detected, and the biolayer is reactive thereto such that corresponding autoinducer signaling molecules bind to the biolayer and detectably vary acoustic characteristics of the acoustic wave biosensor.
摘要翻译：声波生物传感器包括设置在压电材料的衬底上的多个间隔开的电极，并且具有与要检测的特定类型的自动感染信号分子匹配的生物层。生物层包括设置在电极上和电极之间的压电材料上的异双功能分子层，以及仅与要检测的特异性类型的自身感染信号分子结合的多个生物受体分子。生物受体分子由异双功能分子层支撑，水凝胶层围绕生物受体分子以支持其三维结构。生物受体分子可以与要检测的特异性类型的自身诱导剂信号分子结合，并且生物层与其反应，使得相应的自体感染信号分子与生物层结合并可检测地改变声波生物传感器的声学特性。

5. 发明授权

US07651843B2 Acoustic wave biosensor for the detection and identification of characteristic signaling molecules in a biological medium 有权
标题翻译：用于检测和鉴定生物介质中特征信号分子的声波生物传感器
公开(公告)号：US07651843B2
公开(公告)日：2010-01-26
申请号：US11226261
申请日：2005-09-15
申请人： Desmond D. Stubbs , William D. Hunt , Peter J. Edmonson
发明人： Desmond D. Stubbs , William D. Hunt , Peter J. Edmonson
IPC分类号： G01N33/53 , H01L29/80
CPC分类号： G01N33/54373
摘要： A method of detecting and identifying bacteria, micro-organisms or plants in a liquid or gaseous medium, the bacteria, micro-organisms or plants being of the kind which produce signaling molecules in intercellular space, includes positioning a biosensor in the liquid or gaseous medium, the biosensor having a biolayer matched to specific signaling molecules to be detected whereby the biolayer is reactive thereto in a manner which varies operation of the sensor. Such variation of the operation of the biosensor is detected to thereby determine the presence and purpose of the bacteria, micro-organisms or plants in the liquid or gaseous medium.
摘要翻译：一种在液体或气体介质中检测和鉴定细菌，微生物或植物的方法，所述细菌，微生物或植物是在细胞间隙中产生信号分子的细菌，微生物或植物，包括将生物传感器定位在液体或气体介质中具有生物层的生物传感器与要检测的特定信号分子匹配，由此生物层以改变传感器操作的方式与其反应。检测生物传感器的操作的这种变化，从而确定液体或气体介质中的细菌，微生物或植物的存在和目的。

6. 发明授权

US07229821B1 Acoustic wave RFID/biosensor assemblies 有权
标题翻译：声波RFID /生物传感器组件
公开(公告)号：US07229821B1
公开(公告)日：2007-06-12
申请号：US11354814
申请日：2006-02-16
申请人： Peter J. Edmonson , William D. Hunt , Desmond D. Stubbs , Stephen T. Makk
发明人： Peter J. Edmonson , William D. Hunt , Desmond D. Stubbs , Stephen T. Makk
IPC分类号： C12M3/00 , H01L41/00
CPC分类号： B01L3/502707 , B01L2200/10 , B01L2200/18 , B01L2300/022 , B01L2300/0636 , B01L2400/0442 , G01N35/00732 , G01N2035/00782
摘要： A deployable acoustic wave RFID/biosensor assembly has at least one protective layer, and an acoustic wave RFID/biosensor within the protective layer or layers. The acoustic wave RFID/biosensor includes an acoustic wave device, a biolayer mounted on the acoustic wave device, an electric circuit operable to actuate the acoustic wave device, and a fluidic chamber associated with the biolayer. In use, the fluidic chamber contains fluid which, if a predetermined substance to be sensed is present, operates to modify the biolayer which in turn affects the operation of the acoustic wave device. Protective fluid is provided within the protective layer or layers substantially surrounds the acoustic wave RFID/biosensor to protect the acoustic wave RFID/biosensor from damage when the RFID/biosensor assembly impacts a target and to protect the biolayer from deterioration during storage and use.
摘要翻译：可部署的声波RFID /生物传感器组件具有至少一个保护层和保护层内的声波RFID /生物传感器。声波RFID /生物传感器包括声波装置，安装在声波装置上的生物层，可操作以致动声波装置的电路和与生物层相连的流体腔。在使用中，流体腔室含有流体，如果存在待检测的预定物质，则其操作以改变生物层，其又影响声波装置的操作。保护层内设置保护层，基本上围绕着声波RFID /生物传感器，以保护RFID /生物传感器组件碰撞目标时保护声波RFID /生物传感器免受损伤，并保护生物层在储存和使用过程中不会恶化。

7. 发明申请

US20080142366A1 Incorporation of biomolecules in thin films 审中-公开
标题翻译：在薄膜中掺入生物分子
公开(公告)号：US20080142366A1
公开(公告)日：2008-06-19
申请号：US11637831
申请日：2006-12-13
申请人： Prabhakar Apparao Tamirisa , Sang Hun Lee , William D. Hunt , Dennis William Hess , Peter J. Edmonson
发明人： Prabhakar Apparao Tamirisa , Sang Hun Lee , William D. Hunt , Dennis William Hess , Peter J. Edmonson
IPC分类号： C25D15/00
CPC分类号： C25D13/04 , C25D13/20
摘要： A method of incorporating biomolecules in a thin film mounted on a substrate, with the film having a thickness of not more than about 10 microns, includes providing a metal structure on the substrate between the thin film and the substrate, positioning a medium containing biomolecules in contact with a side of the film remote from the metal substrate, and applying a predetermined electrical voltage between the metal substrate and the medium to cause biomolecules to migrate in an electrophoretic manner from the medium into the thin film.
摘要翻译：一种将生物分子掺入安装在基底上的薄膜中的方法，其膜厚度不超过约10微米，包括在薄膜和基底之间的基底上提供金属结构，将包含生物分子的培养基定位在与薄膜远离金属基板的一侧接触，并在金属基板和介质之间施加预定的电压，使生物分子以电泳方式从介质迁移到薄膜中。

8. 发明授权

US07053524B2 Surface acoustic wave sensor or identification device with biosensing capability 有权
公开(公告)号：US07053524B2
公开(公告)日：2006-05-30
申请号：US11139477
申请日：2005-05-31
申请人： Peter J. Edmonson , Colin K. Campbell , William D. Hunt
发明人： Peter J. Edmonson , Colin K. Campbell , William D. Hunt
IPC分类号： G01S13/80 , H04Q5/22
CPC分类号： G01N29/022 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , H03H9/14552 , H03H9/6406
摘要： A surface acoustic wave sensor or identification device has a piezoelectric material, and an interdigitated transducer (IDT) input/output mounted on the piezoelectric material for receiving a radio frequency (RF) signal and propagating a corresponding surface acoustic wave along a surface of the piezoelectric material. An IDT finger electrode array is mounted on the piezoelectric material and is operable to communicate with the IDT input/output for transmission of a modified RF signal from the device. The IDT finger electrode array has at least one finger electrode segment whose propagating characteristics are controlled to control the nature of the modified RF signal. A biolayer is mounted on the piezoelectric material and is associated with the finger electrode segment, and a fluidic chamber is associated with the biolayer. In use, the fluidic chamber contains fluid which, if a predetermined substance to be sensed or detected is present, operates to modify the biolayer which in turn controls the nature of the modified RF signal.

9. 发明申请

US20080315718A1 Sensing systems utilizing acoustic wave devices 有权
标题翻译：利用声波装置的感应系统
公开(公告)号：US20080315718A1
公开(公告)日：2008-12-25
申请号：US11812687
申请日：2007-06-21
申请人： Peter J. Edmonson , William D. Hunt , Christopher D. Corso , Anthony Dickherber , Marie E. Csete
发明人： Peter J. Edmonson , William D. Hunt , Christopher D. Corso , Anthony Dickherber , Marie E. Csete
IPC分类号： H01L41/08
CPC分类号： H01L41/1132 , G01N29/022 , G01N29/024 , G01N29/036 , G01N2291/02466
摘要： A sensing system includes an acoustic wave device comprising a body of piezoelectric material, and a first electrode assembly mounted on the piezoelectric body whereby an appropriate input applied to the electrode assembly produces an acoustic wave in the piezoelectric body and a first frequency response. The acoustic wave device also has a second electrode assembly to produce a second frequency response, the second electrode assembly being in contact with an area sensitive to a supplied stimulus to cause a characteristic of the sensitive area to change when a supplied stimulus is sensed to thereby change the second frequency response. The acoustic wave device has an output connected to the input of an amplifier, the amplifier having an output connected to the input of a coupling device. The coupling device is connected to the input of the acoustic wave device and has an output connected to a detector. The acoustic wave device, the amplifier and the coupling device are configured to be in an “off” condition when no supplied stimulus is sensed by the sensitive area of the acoustic wave device and to be in an “on” condition when a supplied stimulus is sensed by the sensitive area. The coupling device is configured to send a change signal to the detector when a change from the “off” condition to the “on” condition occurs.
摘要翻译：感测系统包括包括压电材料体的声波装置和安装在压电体上的第一电极组件，由此施加到电极组件的合适的输入在压电体中产生声波和第一频率响应。声波装置还具有产生第二频率响应的第二电极组件，第二电极组件与所提供的刺激敏感的区域接触，以在感测到所提供的刺激时敏感区域的特性变化，从而改变第二个频率响应。声波装置具有连接到放大器的输入的输出，该放大器具有连接到耦合装置的输入的输出。耦合装置连接到声波装置的输入端并具有连接到检测器的输出端。声波装置，放大器和耦合装置被配置为处于“关闭”状态，当没有提供的刺激被声波装置的敏感区域感测并且当所提供的刺激为感觉敏感的地区。耦合装置被配置为当从“关闭”状态到“接通”状态的变化发生时，向检测器发送改变信号。

10. 发明授权

US08168424B2 Differentiation and identification of analogous chemical and biological substances with biosensors 有权
标题翻译：用生物传感器分化和鉴定类似的化学和生物物质
公开(公告)号：US08168424B2
公开(公告)日：2012-05-01
申请号：US12636827
申请日：2009-12-14
申请人： Peter J. Edmonson , William D. Hunt
发明人： Peter J. Edmonson , William D. Hunt
IPC分类号： C12M1/34
CPC分类号： G01N29/022 , G01N29/036 , G01N29/4481 , G01N33/54373 , G01N2291/0255 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2291/045
摘要： A biosensor for detecting particular substances biosensor comprises a piezoelectric material, an input transducer supported by the piezoelectric material to receive an input signal and propagate a corresponding acoustic wave within the piezoelectric material and an output transducer supported by the piezoelectric material to receive the acoustic wave. At least two chemically orthogonal or semi-orthogonal biolayers are supported by the piezoelectric material to receive substances to be tested and cause corresponding changes in the acoustic wave. The output transducer can transmit a corresponding output signal embodying separate channel data indicative of the substances received.
摘要翻译：用于检测特定物质生物传感器的生物传感器包括压电材料，由压电材料支撑的输入传感器，用于接收输入信号并传播压电材料内的对应声波，以及由压电材料支撑以接收声波的输出换能器。至少两个化学正交或半正交的生物层被压电材料支撑以接收待测物质并引起声波的相应变化。输出传感器可以发送相应的输出信号，该输出信号体现指示所接收的物质的单独信道数据。

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