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1. 发明授权

US08273770B2 5-pyridinone substituted indazoles 失效
标题翻译： 5-吡啶酮取代的吲唑
公开(公告)号：US08273770B2
公开(公告)日：2012-09-25
申请号：US12176144
申请日：2008-07-18
申请人： Peter Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden
发明人： Peter Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/08
摘要： 5-pyridinone substituted indazoles of the formula and methods of their use are presented.
摘要翻译：提出了下式的5-吡啶酮取代的吲唑及其使用方法。

2. 发明授权

US08716308B2 (1-azinone)-substituted pyridoindoles 有权
标题翻译：（1-氮杂酮） - 取代吡啶并吲哚
公开(公告)号：US08716308B2
公开(公告)日：2014-05-06
申请号：US12351561
申请日：2009-01-09
申请人： Peter Guzzo , Matthew David Surman , Alan John Henderson , May Xiaowu Jiang , Mark Hadden , James Grabowski , Alexander Usyatinsky
发明人： Peter Guzzo , Matthew David Surman , Alan John Henderson , May Xiaowu Jiang , Mark Hadden , James Grabowski , Alexander Usyatinsky
IPC分类号： A01N43/42 , A61K31/44 , C07D471/00
CPC分类号： C07D471/04 , C07D519/00 , C07D521/00
摘要： Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5; is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R6, —C(═O)—O—R7, or —C(═O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.
摘要翻译：用于并入用于治疗各种疾病的药物组合物中的取代的吡啶并吲哚对应于其中R 1为H或任选取代的烷基的式（I） R 2，R 3，R 4各自独立地选自H，-O-烷基，-S-烷基，烷基，卤素，-CF 3和-CN; G为-CR12R13-NR5-或-NR5-CR12R13; R5; 是任选取代的烷基，任选取代的杂环，-C（= O）-R 6，-C（= O）-O-R7或-C（= O）-NR 19 R 20; R6和R7各自为任选取代的烷基或任选取代的杂环; R 8，R 9，R 10，R 11，R 12，R 13，R 19和R 20各自独立地选自H或任选取代的烷基; R 14和R 15各自独立地为H或卤素; L是-CH 2 -O-，-CH 2 CH 2 - ， - CH = CH-或键; 和B是芳基或杂芳基或环烷基; 条件是当L是直接键时，B不能是被氟单取代的未取代的杂芳基或杂芳基。

3. 发明申请

US20090082359A1 5-PYRIDINONE SUBSTITUTED INDAZOLES 失效
标题翻译： 5-吡啶酮取代的吲哚
公开(公告)号：US20090082359A1
公开(公告)日：2009-03-26
申请号：US12176144
申请日：2008-07-18
申请人： Peter Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden
发明人： Peter Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden
IPC分类号： A61K31/501 , C07D401/02 , A61K31/4439 , C07D405/14 , A61P3/04 , A61P25/24 , A61P25/22 , A61K31/4545 , A61K31/444 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/08
摘要： 5-pyridinone substituted indazoles of the formula and methods of their use are presented.
摘要翻译：提出了下式的5-吡啶酮取代的吲唑及其使用方法。

4. 发明授权

US08629158B2 Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof 失效
标题翻译：氮杂双环烷基 - 吲哚和氮杂双环链烷基 - 吡咯并 - 吡啶MCH-1拮抗剂，其制备方法和用途
公开(公告)号：US08629158B2
公开(公告)日：2014-01-14
申请号：US12828855
申请日：2010-07-01
申请人： Peter R. Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden , Emily Elizabeth Freeman
发明人： Peter R. Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden , Emily Elizabeth Freeman
IPC分类号： A61K31/437 , A61K31/4412 , C07D471/18
CPC分类号： C07D471/22
摘要： Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.
摘要翻译：公开了新的MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖症，焦虑症，抑郁症，非酒精性脂肪性肝病和精神疾病。制备这些化合物的方法也在本发明中描述。

5. 发明申请

US20100105679A1 5-PYRIDINONE SUBSTITUTED INDAZOLES 失效
标题翻译： 5-吡啶酮取代的吲哚
公开(公告)号：US20100105679A1
公开(公告)日：2010-04-29
申请号：US12522657
申请日：2008-01-09
申请人： Peter Robert Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden , May Xiaowu Jiang
发明人： Peter Robert Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden , May Xiaowu Jiang
IPC分类号： A61K31/4439 , C07D401/14 , C07D413/14 , C07D401/10 , A61K31/5377 , A61K31/4545 , A61K31/444 , A61P3/04 , A61P25/22 , A61P1/16
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D487/04 , C07D498/08
摘要： Various 5-substituted 1-substituted indazoles are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.
摘要翻译：描述了各种5-取代的1-取代的吲唑，以及含有这些化合物的药物组合物和使用这些化合物治疗疾病的方法。还描述了其它实施例。

6. 发明授权

US08268868B2 5-pyridinone substituted indazoles 失效
标题翻译： 5-吡啶酮取代的吲唑
公开(公告)号：US08268868B2
公开(公告)日：2012-09-18
申请号：US12522657
申请日：2008-01-09
申请人： Peter Robert Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden , May Xiaowu Jiang
发明人： Peter Robert Guzzo , Matthew David Surman , Alan John Henderson , Mark Hadden , May Xiaowu Jiang
IPC分类号： A61K31/416 , C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D487/04 , C07D498/08
摘要： Various 5-substituted 1-substituted indazoles are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.
摘要翻译：描述了各种5-取代的1-取代的吲唑，以及含有这些化合物的药物组合物和使用这些化合物治疗疾病的方法。还描述了其它实施例。

7. 发明授权

US08618299B2 Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof 有权
标题翻译：氮杂酮取代的azapolycycle MCH-1拮抗剂，其制备方法和用途
公开(公告)号：US08618299B2
公开(公告)日：2013-12-31
申请号：US12828890
申请日：2010-07-01
申请人： Peter R. Guzzo , Matthew David Surman , Alan John Henderson , May Xiaowu Jiang
发明人： Peter R. Guzzo , Matthew David Surman , Alan John Henderson , May Xiaowu Jiang
IPC分类号： A61K31/44 , C07D471/00
CPC分类号： C07D471/14 , C07D471/22
摘要： MCH-1 receptor antagonists are disclosed having the general formula These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.
摘要翻译：公开了具有通式的MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖症，焦虑症，抑郁症，非酒精性脂肪性肝病和精神疾病。制备这些化合物的方法也在本发明中描述。

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