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1. 发明申请

US20070131576A1 Receptacle packaging with inhaler-accommodating geometry 审中-公开
标题翻译：带吸入器容纳几何形状的容器包装
公开(公告)号：US20070131576A1
公开(公告)日：2007-06-14
申请号：US11592987
申请日：2006-11-06
申请人： Peter Ehling , William Hundley , Ethan Jacoby , Rodney Monson
发明人： Peter Ehling , William Hundley , Ethan Jacoby , Rodney Monson
IPC分类号： B65D85/42 , B65D83/04
CPC分类号： B65D83/04 , A61J1/035 , A61J2205/30 , A61M15/0028 , A61M2202/064 , A61M2209/06 , B65D75/527 , B65D85/42
摘要： A packaging for a receptacle loadable into an inhaler for pulmonary delivery of the contents of the receptacle. The packaging includes a base and a cover, which base has a surface defining a well that accommodates the receptacle. The well-defining surface includes a first region and a differently shaped second region, which first surface region is shaped to support the receptacle in alignment within the well, and which second surface region accommodates a first end of the receptacle aligned in the well and has a mouth geometry enlarged from the first surface region to allow a portion of an inhaler to be inserted therein to receive the first end of the receptacle for scooping the receptacle into the inhaler from the well.
摘要翻译：用于容纳在吸入器中用于肺部输送容器内容物的容器的包装。该包装包括底座和盖，该底座具有限定容纳容器的孔的表面。良好限定的表面包括第一区域和不同形状的第二区域，该第一表面区域被成形为在井内对准地支撑容器，并且该第二表面区域容纳与孔对准的容器的第一端，并且具有从第一表面区域扩大的嘴部几何形状，以允许吸入器的一部分插入其中，以接收容器的第一端，用于将容器从井中舀出到吸入器中。

2. 发明申请

US20070236491A1 CARDIAC VISUALIZATION SYSTEMS FOR DISPLAYING 3-D IMAGES OF CARDIAC VOXEL INTENSITY DISTRIBUTIONS WITH OPTIONAL PHYSICIAN INTERACTIVE BOUNDARY TRACING TOOLS 有权
标题翻译：用于显示具有可选物理交互式边界跟踪工具的心脏瓣膜强度分布的三维图像的心脏可视化系统
公开(公告)号：US20070236491A1
公开(公告)日：2007-10-11
申请号：US11626958
申请日：2007-01-25
申请人： William Hundley , Craig Hamilton , Ralph D'Agostino
发明人： William Hundley , Craig Hamilton , Ralph D'Agostino
IPC分类号： G06T1/00
CPC分类号： G06T7/0012 , A61B5/0044 , A61B5/055 , A61B5/7285 , A61B6/466 , A61B6/503 , A61B6/504 , A61B6/506 , A61B6/541 , G01R33/283 , G01R33/546 , G06T2207/10088 , G06T2207/20104 , G06T2207/30048 , Y10S128/92 , Y10S128/921 , Y10S128/922 , Y10S128/923 , Y10S128/924
摘要： Physician interactive workstations with global cardiac voxel distribution visualization may also include one or more of a 3-D color scale image of a population of voxel in the heart and/or an electronic boundary-tracing tool configured to accept user input to electronically define at least one boundary of a target region of a heart in a medical image of a patient on a display. The workstation may be configured to evaluate intensity of voxels associated with tissue within the defined boundary of the target region of the heart whereby cardiotoxicity is evaluated.
摘要翻译：具有全球心脏体素分布可视化的医师交互式工作站还可以包括心脏中体素群体的3-D色标图像中的一个或多个，和/或配置成接受用户输入至少以电子方式定义的电子边界跟踪工具在显示器上患者的医学图像中的心脏的目标区域的一个边界。工作站可以被配置为评估与心脏的目标区域的限定边界内的组织相关联的体素的强度，其中评估心脏毒性。

3. 发明申请

US20080119718A1 NON-INVASIVE IMAGING FOR DETERMINATION OF GLOBAL TISSUE CHARACTERISTICS 有权
标题翻译：非侵入式成像确定全球组织特征
公开(公告)号：US20080119718A1
公开(公告)日：2008-05-22
申请号：US12019457
申请日：2008-01-24
申请人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
发明人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
IPC分类号： A61B5/00
CPC分类号： A61B5/0033 , A61B5/055 , A61B5/42 , A61B5/4519 , A61B6/032 , A61B6/503 , A61B6/504 , A61B6/506 , G01R33/281 , G01R33/56 , G06T7/0014 , G06T7/41 , G06T2200/24 , G06T2207/10088 , G06T2207/30048
摘要： Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent to the patient, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent to the patient. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. The region of interest may include heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver, kidney, lung, pancreas, endocrine, gastrointestinal and/or genitourinary tissue. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
摘要翻译：评估组织特征，包括识别损伤的组织或改变天然组织成分的比例，例如改变心脏中正常心肌细胞和纤维组织的量，鉴定细胞外组分或液体量的增加（如水肿或细胞外基质蛋白）或通过例如在给药后从第一次采集获得包括感兴趣区域的组织的第一图像来提供肿瘤细胞或炎症介质的浸润到患者（例如人）中的感兴趣组织中的造影剂，并且在第二次后续获取期间，例如在向患者施用造影剂之后，获得包括感兴趣区域的组织的第二图像。随后的收购可能会在一段时间后获得，以确定在此期间是否发生损伤。感兴趣的区域可以包括心脏，血液，肌肉，脑，神经，骨骼，骨骼肌，肝，肾，肺，胰腺，内分泌，胃肠和/或泌尿生殖组织。确定第一图像和第二图像的感兴趣区域的全局特征，以允许比较第一图像和第二图像的全局特征，以确定全局组织特征变化的可能性。这种比较可以包括平均值，平均特征，直方图形状（例如偏斜和峰度）或直方图内的强度分布的比较。

4. 发明申请

US20080004521A1 Non-invasive systems and methods for the determination of cardiac injury using a characterizing portion of a voxel histogram 有权
标题翻译：使用体素直方图的特征部分来确定心脏损伤的非侵入性系统和方法
公开(公告)号：US20080004521A1
公开(公告)日：2008-01-03
申请号：US11346527
申请日：2006-02-02
申请人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti , Ralph D'Agostino
发明人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti , Ralph D'Agostino
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B6/506 , G06K9/6212 , G06K2209/05 , G06T7/0012 , G06T2207/10088 , G06T2207/10096 , G06T2207/30048
摘要： Methods, systems and circuits predict cardiotoxicity induced cardiac injury prior to an irreversible state by electronically generating at least one histogram of mean intensities of voxels/pixels in an MRI image of a left ventricle myocardium and electronically determining a likelihood of cardiac injury due to cardiotoxicity based on data from the at least one histogram.
摘要翻译：方法，系统和电路通过电子地生成左心室心肌的MRI图像中的体素/像素的平均强度的至少一个直方图，在不可逆状态之前预测心脏毒性引起的心脏损伤，并且电子地确定由于心脏毒性引起的心脏损伤的可能性来自至少一个直方图的数据。

5. 发明申请

US20050215883A1 Non-invasive imaging for determination of global tissue characteristics 有权
标题翻译：用于确定全局组织特征的非侵入性成像
公开(公告)号：US20050215883A1
公开(公告)日：2005-09-29
申请号：US11051304
申请日：2005-02-04
申请人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
发明人： William Hundley , Craig Hamilton , Kimberly Lane , Tim Morgan , Frank Torti
IPC分类号： A61B5/05 , A61B5/055 , A61B6/03 , G01R33/28 , G01R33/56 , G06T7/00
CPC分类号： A61B5/0033 , A61B5/055 , A61B5/42 , A61B5/4519 , A61B6/032 , A61B6/503 , A61B6/504 , A61B6/506 , G01R33/281 , G01R33/56 , G06T7/0014 , G06T7/41 , G06T2200/24 , G06T2207/10088 , G06T2207/30048
摘要： Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent to the patient, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent to the patient. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. The region of interest may include heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver, kidney, lung, pancreas, endocrine, gastrointestinal and/or genitourinary tissue. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
摘要翻译：评估组织特征，包括识别损伤的组织或改变天然组织成分的比例，例如改变心脏中正常心肌细胞和纤维组织的量，鉴定细胞外组分或液体量的增加（如水肿或细胞外基质蛋白）或通过例如在给药后从第一次采集获得包括感兴趣区域的组织的第一图像来提供肿瘤细胞或炎症介质的浸润到患者（例如人）中的感兴趣组织中的造影剂，并且在第二次后续获取期间，例如在向患者施用造影剂之后，获得包括感兴趣区域的组织的第二图像。随后的收购可能会在一段时间后获得，以确定在此期间是否发生损伤。感兴趣的区域可以包括心脏，血液，肌肉，脑，神经，骨骼，骨骼肌，肝，肾，肺，胰腺，内分泌，胃肠和/或泌尿生殖组织。确定第一图像和第二图像的感兴趣区域的全局特征，以允许比较第一图像和第二图像的全局特征，以确定全局组织特征变化的可能性。这种比较可以包括平均值，平均特征，直方图形状（例如偏斜和峰度）或直方图内的强度分布的比较。

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