专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5564121A Microcell layout having directional and omnidirectional antennas defining a rectilinear layout in a building 失效
标题翻译：具有在建筑物中定义直线布局的定向和全向天线的微小区布局
公开(公告)号：US5564121A
公开(公告)日：1996-10-08
申请号：US292275
申请日：1994-08-18
申请人： Peter E. Chow , Ali K. Karim , Victor Fung
发明人： Peter E. Chow , Ali K. Karim , Victor Fung
IPC分类号： H04B7/04 , H04W16/02 , H04W16/12 , H04W16/24 , H04W16/32 , H04B1/04
CPC分类号： H04W16/12 , H04B7/0408 , H04W16/02 , H04W16/24 , H04W16/32
摘要： A radio communication system is provided wherein radio coverage building blocks are used to provide uniform radio coverage to rectilinear floor layouts of buildings. The building blocks are comprised of directional and omnidirectional antennas which are applied to rectangular and irregular layouts. Each building block is divided into multiple small zones and each zone is covered by an antenna. Each antenna in the building block is connected to the same base station through a low loss coupling matrix and all antennas transmit and receive simultaneously. The directional antennas are located near the boundary of the service area. An omnidirectional or directional antenna at the center of the zone may be used to fill the rest of the area.
摘要翻译：提供了一种无线电通信系统，其中无线电覆盖构建块用于向建筑物的直线地板布局提供统一的无线电覆盖。构造块由方向和全向天线组成，应用于矩形和不规则布局。每个建筑块分为多个小区域，每个区域都被天线覆盖。构建块中的每个天线通过低损耗耦合矩阵连接到同一基站，并且所有天线同时发射和接收。定向天线位于服务区域边界附近。区域中心的全向或定向天线可用于填充该区域的其余部分。

2. 发明申请

US20050266567A1 Methods for generating high titer helper-free preparations of released recombinant AAV vectors 审中-公开
标题翻译：用于产生释放的重组AAV载体的高滴度无助剂制剂的方法
公开(公告)号：US20050266567A1
公开(公告)日：2005-12-01
申请号：US11170269
申请日：2005-06-28
申请人： Edward Atkinson , Victor Fung , Perry Wilkins , Ryan Takeya , Thomas Reynolds , Ian Aranha
发明人： Edward Atkinson , Victor Fung , Perry Wilkins , Ryan Takeya , Thomas Reynolds , Ian Aranha
IPC分类号： A61K48/00 , C07C2/32 , C07D207/32 , C07D207/34 , C07D207/50 , C07D295/30 , C07D401/14 , C07D409/14 , C07F7/08 , C07F9/572 , C07F9/58 , C07F15/04 , C07K14/015 , C08F4/659 , C08F10/00 , C08F110/02 , C08F110/14 , C08F210/16 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/861 , C12N15/864
CPC分类号： C07D207/32 , A61K48/0091 , C07C2/32 , C07C2531/22 , C07D207/34 , C07D207/50 , C07D295/30 , C07D401/14 , C07D409/14 , C07F7/0812 , C07F9/572 , C07F9/58 , C07F15/045 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152
摘要： This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication.
摘要翻译：本发明提供用于生产可用作基因递送载体的重组腺相关病毒（AAV）的高滴度，基本纯化的制剂的方法和组合物。在载体生产开始时，本发明的AAV生产细胞通常包含一个或多个AAV包装基因，包含感兴趣的异源（即非AAV）转基因的AAV载体和辅助病毒如腺病毒。产生的AAV载体制剂通常是复制无能力的，但能够介导感兴趣的转基因（例如治疗基因）到多种组织和细胞中的任何一种。根据本发明制备的AAV载体制剂也基本上不含辅助病毒以及辅助病毒和细胞蛋白质和其它污染物。本文描述的本发明提供了通过在促进病毒释放的条件例如温度和pH下培养生产细胞来生产rAAV颗粒的方法。还提供了用于评估病毒感染性和复制以及影响病毒感染性和/或复制的试剂筛选的定量，高通量测定。

3. 发明申请

US20080076155A1 Method for producing recombinant proteins 审中-公开
标题翻译：生产重组蛋白的方法
公开(公告)号：US20080076155A1
公开(公告)日：2008-03-27
申请号：US11984021
申请日：2007-11-13
申请人： Victor Fung
发明人： Victor Fung
IPC分类号： C12P21/04
CPC分类号： C07K14/7151 , C07K14/525 , C07K2319/30 , C07K2319/35
摘要： A method for producing recombinant proteins, preferably fusion proteins comprising an Fc portion of an immunoglobulin molecule, more preferably fusion proteins comprising an extracellular domain of a tumor necrosis factor receptor fused to the Fc portion of an immunoglobulin molecule, is disclosed. The method of the present invention allows a reduction of misfolding of the protein, thereby giving rise to a higher yield of the desired protein.
摘要翻译：公开了一种生产重组蛋白的方法，优选包含免疫球蛋白分子的Fc部分的融合蛋白，更优选包含与免疫球蛋白分子的Fc部分融合的肿瘤坏死因子受体的细胞外结构域的融合蛋白。本发明的方法允许减少蛋白质的错误折叠，从而产生更高的所需蛋白质的产率。

4. 发明授权

US5985262A Method of treatment with epithelium derived T-cell factor 失效
标题翻译：用上皮衍生的T细胞因子治疗的方法
公开(公告)号：US5985262A
公开(公告)日：1999-11-16
申请号：US794524
申请日：1997-02-03
申请人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active EMF, expression vectors which direct the expression of ETF, ETE polypeptides, antibodies which specffically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译：公开了编码生物活性EMF的核酸序列，指导ETF表达的表达载体，ETE多肽，特异性结合ETF的抗体及其制备方法。还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。

5. 发明授权

US5892001A Epithelium-derived T-cell factor antibodies 失效
标题翻译：上皮来源的T细胞因子抗体
公开(公告)号：US5892001A
公开(公告)日：1999-04-06
申请号：US725969
申请日：1996-10-04
申请人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译：公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。

6. 发明授权

US5552303A DNA encoding epithelium-derived T-cell factor 失效
标题翻译：编码上皮衍生的T细胞因子的DNA
公开(公告)号：US5552303A
公开(公告)日：1996-09-03
申请号：US31399
申请日：1993-03-08
申请人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
IPC分类号： A61K38/00 , C07K14/54 , C12P21/06 , C12N5/10 , C12N15/24
CPC分类号： C07K14/5443 , A61K38/00 , C07K2319/02
摘要： There is disclosed a mammalian epithelium-derived T-cell factor (EFT) polypeptide, derivatives thereof, DNA sequences, recombinant DNA molecules and transformed host cells that produce ETF polypeptides. More particularly, this invention provides isolated mammalian ETF polypeptides and derivatives thereof that regulate events in T-lymphocyte proliferation.
摘要翻译：公开了哺乳动物上皮衍生的T细胞因子（EFT）多肽，其衍生物，DNA序列，重组DNA分子和产生ETF多肽的转化的宿主细胞。更具体地，本发明提供分离的哺乳动物ETF多肽及其衍生物，其调节T淋巴细胞增殖中的事件。

7. 发明授权

US07625553B2 Method of treating cancer by administering an epithelum-derived T-cell factor 失效
标题翻译：通过施用上皮衍生的T细胞因子治疗癌症的方法
公开(公告)号：US07625553B2
公开(公告)日：2009-12-01
申请号：US11704726
申请日：2007-02-09
申请人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
IPC分类号： A61K38/19 , A61K38/20
CPC分类号： C07K14/5443 , A61K38/00
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译：公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。

8. 发明授权

US06184359B2 Antibodies to epithelium-derived T-cell factor 有权
标题翻译：上皮衍生的T细胞因子的抗体
公开(公告)号：US06184359B2
公开(公告)日：2001-02-06
申请号：US09189193
申请日：1998-11-09
申请人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
IPC分类号： C07K1624
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译：公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。

9. 发明授权

US5574138A Epithelium-derived T-cell factor 失效
标题翻译：上皮衍生的T细胞因子
公开(公告)号：US5574138A
公开(公告)日：1996-11-12
申请号：US393305
申请日：1995-02-22
申请人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth H. Grabstein , Dirk M. Anderson , June R. Eisenman , Victor Fung , Charles Rauch
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译：公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。

10. 发明授权

US5233628A Computer-based bit error simulation for digital wireless communications 失效
标题翻译：用于数字无线通信的基于计算机的比特误差模拟
公开(公告)号：US5233628A
公开(公告)日：1993-08-03
申请号：US706806
申请日：1991-05-29
申请人： Theodore S. Rappaport , Victor Fung , Michael D. Keitz
发明人： Theodore S. Rappaport , Victor Fung , Michael D. Keitz
IPC分类号： H04B17/00
CPC分类号： H04B17/3912 , H04B17/373
摘要： A communications stimulation system allows a user to perform a quantitative or subjective test of digital baseband devices over wireless channels using actual measured or modeled propagation data. The digital wireless communication simulation system is capable of simulating the transient nature of channels and radio hardware so that loss of synchronization can be included in the simulation. The simulator is a combination of computer software and hardware that computes a convolution, in the time domain, of a sequence of binary digits or data symbols (i.e., the data stream) with a computer model of a radio transmitter, a propagation channel or channels and a receiver. The transmitter typically comprises a coder, a pulse shaper, a modulator, and a spreader. The propagation channel or channels may include impulsive and average noise levels, co-channel interference and adjacent interference levels, fading and multipath propagation events, and non-linear channel and radio system effects. The receiver system typically comprises at least a filter bank, a demodulator, a despreader, a synchronizer, a detector, and a decoder. The data stream may either be random or applied by the user. The software computes the bit-by-bit sequence for replay at a later time. Once stored, the bit-by-bit error sequence can be clocked through a hardware data port and compared with an applied data stream in real time. The output of the hardware data port is a real time sequence of bits that has errors due to the bit-by-bit simulation computed earlier by the software.
摘要翻译：通信刺激系统允许用户使用实际测量或建模的传播数据通过无线信道对数字基带设备进行定量或主观测试。数字无线通信仿真系统能够模拟信道和无线电硬件的瞬态特性，从而可以在仿真中包含同步丢失。模拟器是计算机软件和硬件的组合，其在时域中使用无线电发射机的计算机模型，传播信道或信道计算二进制数字或数据符号（即，数据流）序列的卷积和接收器。发射机通常包括编码器，脉冲整形器，调制器和扩展器。传播信道或信道可以包括脉冲和平均噪声电平，同信道干扰和相邻干扰电平，衰落和多径传播事件以及非线性信道和无线电系统效应。接收机系统通常至少包括滤波器组，解调器，解扩器，同步器，检测器和解码器。数据流可以是用户随机的或应用的。该软件将在稍后的时间内逐行计算重播。一旦存储，逐位错误序列可以通过硬件数据端口进行计时，并与应用的数据流进行实时比较。硬件数据端口的输出是由于软件较早计算的逐位仿真而具有错误的实时比特序列。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式