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1. 发明申请

US20050261332A1 Sulfonamides and uses thereof 审中-公开
标题翻译：磺酰胺及其用途
公开(公告)号：US20050261332A1
公开(公告)日：2005-11-24
申请号：US11098315
申请日：2005-04-04
申请人： Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Jean-Francois Pons , Russell Thomas , Manuel Navia , Thomas Coulter , Jeffrey Saunders , Bard Geesaman
发明人： Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Jean-Francois Pons , Russell Thomas , Manuel Navia , Thomas Coulter , Jeffrey Saunders , Bard Geesaman
IPC分类号： A61K31/422 , A61K31/4245 , A61K31/454 , A61K31/4745 , C07C311/32 , C07D413/02 , C07D471/02 , C07D471/10 , C07D43/02
CPC分类号： C07D471/10 , C07C311/32 , C07D401/12
摘要： Compounds of formulas (I), (II), (III), and (IV) and methods of treating disorders by administering a compound of formula (I), (II), (III), or (IV) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.
摘要翻译：本文描述式（I），（II），（III）和（IV）的化合物和通过施用式（I），（II），（III）或（IV）的化合物来治疗病症的方法。病症的实例包括肿瘤性疾病，脂肪细胞相关疾病，神经变性疾病和代谢紊乱。

2. 发明申请

US20050187237A1 Therapeutic compounds and uses thereof 失效
标题翻译：治疗化合物及其用途
公开(公告)号：US20050187237A1
公开(公告)日：2005-08-25
申请号：US10982997
申请日：2004-11-04
申请人： Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel Navia , Russell Thomas , Jean-Francois Pons , Jeffrey Saunders
发明人： Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel Navia , Russell Thomas , Jean-Francois Pons , Jeffrey Saunders
IPC分类号： A61K31/438 , A61K31/4747 , A61K31/5377 , C07D413/14 , C07D471/10
CPC分类号： C07D471/10 , C07D221/20 , C07D401/12
摘要： Compounds of formula (I) are described herein The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to treat obesity.
摘要翻译：式（I）化合物在本文中描述。该化合物可用于例如调节生长激素促分泌素受体（GHS-R）。在一些情况下，化合物可用于治疗肥胖症。

3. 发明申请

US20070270473A1 Sulfonamide Compounds and Uses Thereof 失效
标题翻译：磺酰胺类化合物及其用途
公开(公告)号：US20070270473A1
公开(公告)日：2007-11-22
申请号：US11564815
申请日：2006-11-29
申请人： Jeffrey Saunders , Thomas Coulter , Paul Mortenson , Manuel Navia , Jean-Francois Pons
发明人： Jeffrey Saunders , Thomas Coulter , Paul Mortenson , Manuel Navia , Jean-Francois Pons
IPC分类号： A61K31/44 , A61K31/40 , C07D211/82 , C07D207/30
CPC分类号： C07D249/08 , C07D271/06 , C07D401/04
摘要： Compounds that modulate GHS-R are described, for examples compounds formula (I)
摘要翻译：描述了调节GHS-R的化合物，例如化合物式（I）

4. 发明申请

US20060293370A1 Sulfonamide compounds and uses thereof 审中-公开
标题翻译：磺酰胺化合物及其用途
公开(公告)号：US20060293370A1
公开(公告)日：2006-12-28
申请号：US11451086
申请日：2006-06-12
申请人： Jeffrey Saunders , Thomas Coulter , Paul Mortenson , Manuel Navia , Jean-Francois Pons
发明人： Jeffrey Saunders , Thomas Coulter , Paul Mortenson , Manuel Navia , Jean-Francois Pons
IPC分类号： A61K31/4245 , A61K31/4196 , C07D271/06 , C07D249/12 , C07D249/14
CPC分类号： C07D249/08 , C07D271/06 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04
摘要： Compounds that modulate GHS-R are described, for examples compounds formula (I)
摘要翻译：描述了调节GHS-R的化合物，例如化合物式（I）

5. 发明授权

US09115086B2 Therapeutic compositions and related methods of use 有权
标题翻译：治疗组合物和相关使用方法
公开(公告)号：US09115086B2
公开(公告)日：2015-08-25
申请号：US13339719
申请日：2011-12-29
申请人： Francesco G. Salituro , Jeffrey Saunders
发明人： Francesco G. Salituro , Jeffrey Saunders
IPC分类号： C07D213/30 , C07D215/36 , C07D257/04 , C07D263/58 , C07D401/14 , C07D295/26 , C07D319/18 , A61K31/538 , C07D265/36 , C07D339/06 , C07D401/12
CPC分类号： C07D215/36 , C07D213/30 , C07D257/04 , C07D263/58 , C07D265/36 , C07D295/26 , C07D319/18 , C07D339/06 , C07D401/12 , C07D401/14
摘要： Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
摘要翻译：包含调节丙酮酸激酶M2（PKM2）的化合物的组合物在本文中描述。本文还描述了使用调节PKM2的化合物治疗癌症的方法。

6. 发明申请

US20120165324A1 THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE 有权
标题翻译：治疗组合物及相关使用方法
公开(公告)号：US20120165324A1
公开(公告)日：2012-06-28
申请号：US13339719
申请日：2011-12-29
申请人： Francesco G. Salituro , Jeffrey Saunders
发明人： Francesco G. Salituro , Jeffrey Saunders
IPC分类号： A61K31/538 , C07D403/12 , C07D295/26 , A61P35/00 , C07D417/12 , A61K31/496 , A61K31/495 , C07D401/14 , C07D401/12
CPC分类号： C07D215/36 , C07D213/30 , C07D257/04 , C07D263/58 , C07D265/36 , C07D295/26 , C07D319/18 , C07D339/06 , C07D401/12 , C07D401/14
摘要： Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
摘要翻译：包含调节丙酮酸激酶M2（PKM2）的化合物的组合物在本文中描述。本文还描述了使用调节PKM2的化合物治疗癌症的方法。

7. 发明申请

US20050231279A1 Method and apparatus for adaptive digital predistortion using nonlinear and feedback gain parameters 有权
标题翻译：使用非线性和反馈增益参数的自适应数字预失真的方法和装置
公开(公告)号：US20050231279A1
公开(公告)日：2005-10-20
申请号：US10825614
申请日：2004-04-15
申请人： James Moffatt , Jeffrey Saunders
发明人： James Moffatt , Jeffrey Saunders
IPC分类号： H03F1/26 , H03F1/32
CPC分类号： H03F1/3247 , H03F1/3252 , H03F1/3258 , H03F1/3294
摘要： A predistorter is disclosed that predistorts an input signal based on one or more static coefficients that are representative of a non-linear distortion characteristic of an amplifier. The input signal is also processed based on a non-linear gain parameter that reduces an error metric between the input signal and a feedback signal. The nonlinear gain parameter adapts an amount of nonlinearity introduced by the predistorter. The non-linear gain adaptation is performed, for example, when the input voltage is above a threshold input voltage. The input signal can be processed by multiplying the input signal by the non-linear gain parameter followed by table-coefficient processing, or by both multiplying the input by the non-linear gain parameter followed by dividing the table-coefficient processed output signal by the same non-linear gain parameter. The input signal can also be processed based on a feedback gain parameter that compensates for a small-signal gain of the feedback loop. The feedback gain parameter attempts to maintain a small-signal gain of approximately unity.
摘要翻译：公开了一种预失真器，其基于代表放大器的非线性失真特性的一个或多个静态系数来预失真输入信号。还基于减小输入信号和反馈信号之间的误差度量的非线性增益参数来处理输入信号。非线性增益参数适应预失真器引入的非线性量。例如，当输入电压高于阈值输入电压时执行非线性增益适配。输入信号可以通过将输入信号乘以非线性增益参数，然后进行表格系数处理，或者将输入乘以非线性增益参数，然后将表格系数处理的输出信号除以相同的非线性增益参数。还可以基于补偿反馈回路的小信号增益的反馈增益参数来处理输入信号。反馈增益参数尝试维持近似一致的小信号增益。

8. 发明申请

US20060033569A1 Method and apparatus for performing digital pre-distortion 有权
标题翻译：用于执行数字预失真的方法和装置
公开(公告)号：US20060033569A1
公开(公告)日：2006-02-16
申请号：US10919029
申请日：2004-08-16
申请人： Mohammad Mobin , Jeffrey Saunders , Lane Smith
发明人： Mohammad Mobin , Jeffrey Saunders , Lane Smith
IPC分类号： H03F1/26
CPC分类号： H03F1/3241 , H03F2200/468
摘要： A pre-distorter that compensates for amplitude and phase distortion created by an amplifier. During a training session, the amplifier is stimulated with input signals of pre-selected amplitude and phase at various temperatures and the amplifier output is captured and converted into data sets. Polynomials are then fitted to the data sets and inverses of the polynomials are determined. The coefficients of the inverse polynomials are then saved for each temperature. During operation, the amplifier temperature is predicted based on the amplifier input signal and the coefficients associated with the predicted temperature are selected to be applied to the input signal to compensate for amplitude and phase distortion caused by the amplifier.
摘要翻译：一个预失真器，用于补偿放大器产生的幅度和相位失真。在训练期间，放大器用各种温度的预选幅度和相位的输入信号进行激励，并且放大器输出被捕获并转换为数据集。然后将多项式拟合到数据集中，并确定多项式的倒数。然后针对每个温度保存逆多项式的系数。在操作期间，基于放大器输入信号预测放大器温度，并且选择与预测温度相关联的系数以施加到输入信号以补偿由放大器引起的幅度和相位失真。

9. 发明申请

US20070139108A1 METHOD AND APPARATUS FOR PERFORMING DIGITAL PRE-DISTORTION 失效
标题翻译：用于执行数字预失真的方法和装置
公开(公告)号：US20070139108A1
公开(公告)日：2007-06-21
申请号：US11672272
申请日：2007-02-07
申请人： Mohammad Mobin , Jeffrey Saunders , Lane Smith
发明人： Mohammad Mobin , Jeffrey Saunders , Lane Smith
IPC分类号： H03F1/26
CPC分类号： H03F1/3241 , H03F2200/468
摘要： A pre-distorter that compensates for amplitude and phase distortion created by an amplifier. During a training session, the amplifier is stimulated with input signals of pre-selected amplitude and phase at various temperatures and the amplifier output is captured and converted into data sets. Polynomials are then fitted to the data sets and inverses of the polynomials are determined. The coefficients of the inverse polynomials are then saved for each temperature. During operation, the amplifier temperature is predicted based on the amplifier input signal and the coefficients associated with the predicted temperature are selected to be applied to the input signal to compensate for amplitude and phase distortion caused by the amplifier.
摘要翻译：一个预失真器，用于补偿放大器产生的幅度和相位失真。在训练期间，放大器用各种温度的预选幅度和相位的输入信号进行激励，并且放大器输出被捕获并转换为数据集。然后将多项式拟合到数据集中，并确定多项式的倒数。然后针对每个温度保存逆多项式的系数。在操作期间，基于放大器输入信号预测放大器温度，并且选择与预测温度相关联的系数以施加到输入信号以补偿由放大器引起的幅度和相位失真。

10. 发明授权

US07087642B2 Inhibitors of IMPDH enzyme 有权
公开(公告)号：US07087642B2
公开(公告)日：2006-08-08
申请号：US10287405
申请日：2002-11-04
申请人： Dean Stamos , Martin Trudeau , Scott Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
发明人： Dean Stamos , Martin Trudeau , Scott Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
IPC分类号： A61K47/00 , A61K31/27 , C07C229/00 , C07C255/00
CPC分类号： C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
摘要： The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

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