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1. 发明授权

US07022721B1 Method and composition for rejuvenating cells, tissues, organs, hair and nails 失效
标题翻译：振兴细胞，组织，器官，头发和指甲的方法和组成
公开(公告)号：US07022721B1
公开(公告)日：2006-04-04
申请号：US10794024
申请日：2004-03-08
申请人： Peter C Ulrich , Sheng Ding Fang , Michael L Brines , Qiao-Wen Xie , Anthony Cerami
发明人： Peter C Ulrich , Sheng Ding Fang , Michael L Brines , Qiao-Wen Xie , Anthony Cerami
IPC分类号： A61K31/428 , C07D277/84
CPC分类号： A61K31/428 , A61K8/49 , A61Q3/02 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/08 , C07D277/84
摘要： In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue diffusion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.
摘要翻译：在一个实施方案中，本发明涉及包含药物组合物的化合物和组合物，所述药物组合物含有化合物和解离糖介导的蛋白质，脂质，核酸和其他生物材料偶联的相关方法及其任何组合。在另一个实施方案中，组合物和相关方法在体内通过摄入，经皮施用或其它方式在生物体内部暴露于化合物或组合物时，有效地降低糖介导的生物体中的偶联过程的有害作用。在另一个实施方案中，组合物和相关方法可用于器官，细胞和组织的离体处理以及毛发，指甲和皮肤的外部治疗，以通过改变变形性和增加组织扩散系数使其恢复活力。在另一个实施方案中，本发明涉及新化合物和药物组合物。

2. 发明授权

US06777557B2 Method and composition for rejuvenating cells, tissues organs, hair and nails 失效
标题翻译：振兴细胞，组织器官，头发和指甲的方法和组成
公开(公告)号：US06777557B2
公开(公告)日：2004-08-17
申请号：US10072712
申请日：2002-02-07
申请人： Peter C Ulrich , Sheng Ding Fang , Michael L Brines , Qiao-Wen Xie , Anthony Cerami
发明人： Peter C Ulrich , Sheng Ding Fang , Michael L Brines , Qiao-Wen Xie , Anthony Cerami
IPC分类号： C07D27784
CPC分类号： C07D213/20 , A61K8/49 , A61K8/4986 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61Q3/00 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q19/08 , A61Q19/10 , C07D213/50 , C07D213/57 , C07D213/73 , C07D231/12 , C07D233/54 , C07D233/56 , C07D233/64 , C07D239/26 , C07D239/42 , C07D249/08 , C07D277/22 , C07D277/24 , C07D277/84 , C07D417/06 , C07D487/04 , C07D513/04
摘要： In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue diffusion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.
摘要翻译：在一个实施方案中，本发明涉及包含药物组合物的化合物和组合物，所述药物组合物含有化合物和解离糖介导的蛋白质，脂质，核酸和其他生物材料偶联的相关方法及其任何组合。在另一个实施方案中，组合物和相关方法在体内通过摄入，经皮施用或其它方式在生物体内部暴露于化合物或组合物时，有效地降低糖介导的生物体中的偶联过程的有害作用。在另一个实施方案中，组合物和相关方法可用于器官，细胞和组织的离体处理以及毛发，指甲和皮肤的外部治疗，以通过改变变形性和增加组织扩散系数使其恢复活力。在另一个实施方案中，本发明涉及新化合物和药物组合物。

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