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1. 发明授权

US07348355B2 Triamide-substituted heterobicyclic compounds 失效
标题翻译：三酰胺取代的杂双环化合物
公开(公告)号：US07348355B2
公开(公告)日：2008-03-25
申请号：US11351571
申请日：2006-02-10
申请人： Peter Bertinato , Alan E. Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Alan E. Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/40 , C07D209/42
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
摘要翻译：本发明涉及式1的三酰胺MTP / ApoB抑制剂，其中R 1 -R 8如本说明书中所定义，以及其药物组合物及其用途，以及制备化合物的方法。本发明的化合物可用于治疗肥胖症和脂质疾病。

2. 发明授权

US07482368B2 Triamide-substituted heterobicyclic compounds 失效
标题翻译：三酰胺取代的杂双环化合物
公开(公告)号：US07482368B2
公开(公告)日：2009-01-27
申请号：US11196563
申请日：2005-08-02
申请人： Peter Bertinato , Brian Bronk , Alan E. Blize , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Brian Bronk , Alan E. Blize , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/44
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
摘要翻译：本发明涉及式1的三酰胺MTP / ApoB抑制剂，其中R 1 -R 8如说明书中所定义，以及其药物组合物及其用途，以及制备该化合物的方法。本发明的化合物可用于治疗肥胖症和脂质疾病。

3. 发明申请

US20060194772A1 Triamide-substituted heterobicyclic compounds 失效
标题翻译：三酰胺取代的杂双环化合物
公开(公告)号：US20060194772A1
公开(公告)日：2006-08-31
申请号：US11351571
申请日：2006-02-10
申请人： Peter Bertinato , Alan Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Alan Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/655 , A61K31/405 , A61K31/381 , A61K31/343 , C07D333/56 , C07D307/87 , C07D209/42
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
摘要翻译：本发明涉及式1的三酰胺MTP / ApoB抑制剂，其中R 1 -R 8如本说明书中所定义，以及其药物组合物及其用途，以及制备化合物的方法。本发明的化合物可用于治疗肥胖症和脂质疾病。

4. 发明申请

US20050288335A1 Triamide-substituted heterobicyclic compounds 失效
公开(公告)号：US20050288335A1
公开(公告)日：2005-12-29
申请号：US11196563
申请日：2005-08-02
申请人： Peter Bertinato , Alan Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Alan Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/341 , A61K31/343 , A61K31/397 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4439 , A61K31/4525 , A61K31/4709 , A61K31/501 , A61K31/5377 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00 , C07D209/42 , C07D307/85 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.

5. 发明申请

US20050080108A1 Triamide-substituted heterobicyclic compounds 失效
标题翻译：三酰胺取代的杂双环化合物
公开(公告)号：US20050080108A1
公开(公告)日：2005-04-14
申请号：US10639854
申请日：2003-08-13
申请人： Peter Bertinato , Alan Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Alan Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/341 , A61K31/343 , A61K31/397 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4439 , A61K31/4525 , A61K31/4709 , A61K31/501 , A61K31/5377 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00 , C07D209/42 , C07D307/85 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D333/66
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1—R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
摘要翻译：本发明涉及式1的三酰胺MTP / ApoB抑制剂，其中R 1 -R 8如说明书中所定义，以及其药物组合物及其用途，以及制备该化合物的方法。本发明的化合物可用于治疗肥胖症和脂质疾病。

6. 发明申请

US20080103176A1 Substituted Hydroxyethylamines 审中-公开
标题翻译：取代的羟乙胺
公开(公告)号：US20080103176A1
公开(公告)日：2008-05-01
申请号：US11815034
申请日：2006-02-02
申请人： Brian Bronk , Todd Butler
发明人： Brian Bronk , Todd Butler
IPC分类号： A61K31/445 , A61P25/28 , C07D211/06
CPC分类号： C07C233/36 , C07C233/41 , C07C237/24 , C07C251/42 , C07C271/20 , C07C271/34 , C07C275/26 , C07C311/07 , C07C311/36 , C07C2602/10 , C07D213/61 , C07D233/64 , C07D239/30 , C07D295/135
摘要： This invention is directed to compounds of the formula (I), as defined herein. The compound of formula I may be used, for example, to treat a disorder or condition that may be treated by inhibiting 13-secretase.
摘要翻译：本发明涉及如本文所定义的式（I）化合物。式I化合物可用于例如治疗可通过抑制13-分泌酶治疗的病症或病症。

7. 发明申请

US20050256112A1 Combination of atypical antipsychotics and 5HT-1B receptor antagonists 审中-公开
标题翻译：非典型抗精神病药和5HT-1B受体拮抗剂的组合
公开(公告)号：US20050256112A1
公开(公告)日：2005-11-17
申请号：US11128146
申请日：2005-05-11
申请人： Michael Brodney , Christopher Helal , Brian Bronk , Spiros Liras
发明人： Michael Brodney , Christopher Helal , Brian Bronk , Spiros Liras
IPC分类号： A61K31/541 , A61K45/06 , A61P25/00
CPC分类号： A61K31/541 , A61K45/06
摘要： The present invention relates to a pharmaceutical composition for treating, for example, a disorder or condition selected from the group consisting of hypertension, depression, generalized anxiety disorder, phobias, posttraumatic stress disorder, avoidant personality disorder, sexual dysfunction, eating disorders, obesity, chemical dependencies, cluster headache, migraine, pain, Alzheimer's disease, obsessive-compulsive disorder, panic disorder, memory disorders, Parkinson's diseases, endocrine disorders, cerebellar ataxia, gastrointestinal tract disorders, negative symptoms of schizophrenia, premenstrual syndrome, Fibromyalgia Syndrome, stress incontinence, Tourette syndrome, trichotillomania, kleptomania, male impotence, cancer, chronic paroxysmal hemicrania and headache in a mammal, preferably a human, comprising (i) an atypical antipsychotic or a pharmaceutically acceptable salt thereof, (ii) a 5-HT1B receptor antagonist or a pharmaceutically acceptable salt thereof, wherein the 5-HT1B receptor antagonist is selected from the group consisting of (A) a compound of the formula I as described in the specification and (B) a compound of the formula II as described in the specification, and optionally (iii) a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及一种用于治疗例如选自高血压，抑郁症，广泛性焦虑症，恐惧症，创伤后应激障碍，避孕人格障碍，性功能障碍，进食障碍，肥胖症，化学依赖性，丛集性头痛，偏头痛，疼痛，阿尔茨海默病，强迫症，恐慌症，记忆障碍，帕金森病，内分泌紊乱，小脑共济失调，胃肠道疾病，精神分裂症阴性症状，经前综合征，纤维肌痛综合征，压力性尿失禁（I）非典型抗精神病药或其药学上可接受的盐，（ii）5-HT受体拮抗剂，尤其是缬氨酸， 1B受体拮抗剂或其药学上可接受的盐，所述5-HT 1B受体拮抗剂选自（A）如说明书中所述的式（I）化合物和（B）式II化合物，如说明书，和任选地（iii）药学上可接受的载体。

8. 发明申请

US20050159413A1 Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors 审中-公开
标题翻译：螺 - 嘧啶-2,4,6-三酮金属蛋白酶抑制剂
公开(公告)号：US20050159413A1
公开(公告)日：2005-07-21
申请号：US11009631
申请日：2004-12-10
申请人： Mark Noe , Martin Wythes , Brian Bronk
发明人： Mark Noe , Martin Wythes , Brian Bronk
IPC分类号： C07D471/10 , C07D487/10 , C07D498/10 , A61K31/515 , A61K31/5415
CPC分类号： C07D471/10 , C07D487/10
摘要： The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said “A” is a 5-7 membered heterocyclic ring as defined in the specification and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.
摘要翻译：本发明涉及下式的5-螺 - 嘧啶-2,4,6-三酮金属蛋白酶抑制剂，其中所述“A”是本说明书中定义的5-7元杂环，以及治疗炎症的药物组合物和方法，癌症等疾病。

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