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1. 发明授权

US07867718B2 Methods for determining conformational changes and self-assembly of proteins 失效
标题翻译：测定蛋白质构象变化和自组装的方法
公开(公告)号：US07867718B2
公开(公告)日：2011-01-11
申请号：US11579741
申请日：2005-02-22
申请人： Peter Nilsson , Anna Herland , Per Hammarstrom , Peter Asberg , Olle Inganas
发明人： Peter Nilsson , Anna Herland , Per Hammarstrom , Peter Asberg , Olle Inganas
IPC分类号： G01N33/53
CPC分类号： G01N33/68
摘要： The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.
摘要翻译：本发明涉及使用共轭聚电解质测量蛋白质的构象变化和自组装/聚集，特别是淀粉样蛋白原纤维的形成的方法。将共轭聚电解质暴露于蛋白质，由此共轭聚电解质和感兴趣的蛋白质相互作用，并且观察到响应于蛋白质的构象变化的聚电解质的性质的变化。检测到的变化用于确定蛋白质的不同构象，特别是淀粉样蛋白原纤维的形成。

2. 发明申请

US20080038751A1 Methods for Determining Conformational Changes and Self-Assembly of Proteins 失效
标题翻译：确定蛋白质构象变化和自组装的方法
公开(公告)号：US20080038751A1
公开(公告)日：2008-02-14
申请号：US11579741
申请日：2005-02-22
申请人： Peter Asberg , Peter Nilsson , Olle Inganas , Anna Herland , Per Hammarstrom
发明人： Peter Asberg , Peter Nilsson , Olle Inganas , Anna Herland , Per Hammarstrom
IPC分类号： C12M1/34 , G01N33/53
CPC分类号： G01N33/68
摘要： The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.
摘要翻译：本发明涉及使用共轭聚电解质测量蛋白质的构象变化和自组装/聚集，特别是淀粉样蛋白原纤维的形成的方法。将共轭聚电解质暴露于蛋白质，由此共轭聚电解质和感兴趣的蛋白质相互作用，并且观察到响应于蛋白质的构象变化的聚电解质的性质的变化。检测到的变化用于确定蛋白质的不同构象，特别是淀粉样蛋白原纤维的形成。

3. 发明申请

US20070196819A1 Patterning Method For Biosensor Applications And Devices Comprising Such Patterns 审中-公开
标题翻译：用于生物传感器应用的图案化方法和包含这种图案的设备
公开(公告)号：US20070196819A1
公开(公告)日：2007-08-23
申请号：US10593893
申请日：2005-03-22
申请人： Peter Asberg , Peter Nilsson , Olle Inganas
发明人： Peter Asberg , Peter Nilsson , Olle Inganas
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53 , G01N33/554 , G01N33/569 , C12M3/00
CPC分类号： B82Y30/00 , B01J2219/00382 , B01J2219/00527 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01L3/5085 , B01L3/5088 , B01L2300/0819 , B01L2300/165 , C40B40/06 , C40B40/10 , C40B60/14
摘要： A patterned substrate for biosensing applications, wherein the pattern includes hydrophilic and hydrophobic areas, and selected ones of the areas include at least at least one reporter molecule, a property of which is detectable. A method of making a patterned substrate includes performing a stamping procedure to provide a pattern of hydrophilic and hydrophobic areas on a substrate of a suitable material. One step of the stamping procedure includes attaching at least one reporter molecule to at least selected ones of the areas, the fluorescence of the conjugated polyelectrolyte being detectable and which will change as a result of interaction with a biomolecule.
摘要翻译：用于生物感测应用的图案化衬底，其中所述图案包括亲水和疏水区域，并且所选区域中的选定区域包括至少一个报告分子，其性质是可检测的。制造图案化衬底的方法包括执行冲压程序以在合适材料的衬底上提供亲水和疏水区域的图案。冲压程序的一个步骤包括将至少一个报告分子附着到至少选定的区域中，共轭聚电解质的荧光是可检测的，并且由于与生物分子的相互作用而将会改变。

4. 发明申请

US20060175193A1 Polyelectrolyte complex(e.g.zwitterionic polythiophenes) with a receptor (e.g.polynucleotide, antibody etc.) for biosensor applications 审中-公开
标题翻译：具有用于生物传感器应用的受体（例如多核苷酸，抗体等）的聚电解质复合物（例如两性离子聚噻吩）
公开(公告)号：US20060175193A1
公开(公告)日：2006-08-10
申请号：US10514191
申请日：2003-05-09
申请人： Olle Inganas , Peter Asborg , Peter Nilsson
发明人： Olle Inganas , Peter Asborg , Peter Nilsson
IPC分类号： C25B9/00
CPC分类号： G01N33/566 , C12Q1/6825 , C12Q1/6827 , G01N33/531 , G01N33/54366 , C12Q2565/628 , C12Q2563/125
摘要： A complex between a conjugated polyelectrolyte, and one or more receptor molecules specific for a target biomolecule analyte, the polyelectrolyte and the receptor being non-covalently bound to each other, is usable as a probe for biomolecular interactions. It also relates to a method of determining selected properties of biomolecules. Thereby, a complex as above is exposed to a target biomolecule analyte whereby the analyte and the receptor interact, and a change of a property of the polyelectrolyte in response to the interaction between the receptor and the analyte is detected. The detected change is used to determine the selected property of the biomolecule.
摘要翻译：共轭聚电解质与对靶生物分子分析物特异性的一种或多种受体分子之间的复合物，聚电解质和彼此非共价结合的受体可用作生物分子相互作用的探针。它还涉及确定生物分子的选定性质的方法。因此，如上所述的复合物暴露于目标生物分子分析物，由此分析物和受体相互作用，并且响应于受体和分析物之间的相互作用而检测聚电解质的性质的变化。检测到的变化用于确定生物分子的选定性质。

5. 发明申请

US20090197343A1 METHODS FOR DETECTION OF PATHOGENIC PRION PROTEINS ASSOCIATED WITH PRION DISEASES, USING CONJUGATED POLYELECTROLYTES 审中-公开
标题翻译：检测与疫苗相关的病原体蛋白质的方法，使用共轭聚电解质
公开(公告)号：US20090197343A1
公开(公告)日：2009-08-06
申请号：US12278786
申请日：2007-02-09
申请人： Peter Nilsson , Per Hammarstrom
发明人： Peter Nilsson , Per Hammarstrom
IPC分类号： G01N33/50
CPC分类号： G01N33/6896 , G01N21/64 , G01N2800/2828
摘要： The present invention relates to a method for detecting the presence of a pathogenic prion species in a sample comprising the steps—bringing the sample in contact with at least one conjugated polyelectrolyte (CPE)—irradiating the CPE with electromagnetic radiation—measuring the radiation emitted or absorbed by the CPE at at least one wavelength, and—comparing the measured emitted or absorbed radiation to at least one reference value corresponding to the CPE interacting with a known prion species. Optionally, the emitted or absorbed radiation is measured at least two wavelengths and a ratio is formed of the values of the measured radiation. The method facilitates differentiation between different strains of pathogenic prion species. The invention also relates to devices for performing the method.
摘要翻译：本发明涉及一种用于检测样品中病原性朊病毒物质存在的方法，包括以下步骤：使样品与至少一种利用电磁辐射测量辐射的辐射CPE进行接触，共聚聚电解质（CPE）由CPE在至少一个波长处吸收，并且将测量的发射或吸收的辐射与对应于与已知朊病毒物种相互作用的CPE的至少一个参考值进行比较。可选地，发射或吸收的辐射被测量至少两个波长，并且比例由测量的辐射的值形成。该方法有助于分化不同病原性朊病毒株。本发明还涉及用于执行该方法的装置。

6. 发明授权

US09012656B2 Oligothiophene derivate as molecular probes 有权
标题翻译：寡聚噻吩衍生物作为分子探针
公开(公告)号：US09012656B2
公开(公告)日：2015-04-21
申请号：US13577561
申请日：2011-02-15
申请人： Ola Hermansson , Peter Konradsson , Andreas Aslund , Shirin Ilkhanizadeh , Rozalyn Simon , Peter Nilsson
发明人： Ola Hermansson , Peter Konradsson , Andreas Aslund , Shirin Ilkhanizadeh , Rozalyn Simon , Peter Nilsson
IPC分类号： C07D409/14 , A61K49/00
CPC分类号： C07D409/14 , A61K49/0021 , A61K49/006
摘要： The present invention relates to oligothiophene derivatives binding specifically to neural stem cells and neural cancer stem cells. More specifically, the invention relates to methods for detecting neural stem cells or neural cancer stem cells using said oligothiophene derivatives in a biological sample, as well as uses and kits relating thereto.
摘要翻译：本发明涉及特异性结合神经干细胞和神经癌干细胞的寡聚噻吩衍生物。更具体地，本发明涉及使用生物样品中的所述低聚噻吩衍生物检测神经干细胞或神经癌干细胞的方法，以及与之相关的用途和试剂盒。

7. 发明申请

US20120315646A1 OLIGOTHIOPHENE DERIVATE AS MOLECULAR PROBES 有权
标题翻译：作为分子探针的二氢胆碱衍生物
公开(公告)号：US20120315646A1
公开(公告)日：2012-12-13
申请号：US13577561
申请日：2011-02-15
申请人： Ola Hermansson , Peter Konradsson , Andreas Aslund , Shirin Ilkhanizadeh , Rozalyn Simon , Peter Nilsson
发明人： Ola Hermansson , Peter Konradsson , Andreas Aslund , Shirin Ilkhanizadeh , Rozalyn Simon , Peter Nilsson
IPC分类号： C07D409/14 , G01N21/76
CPC分类号： C07D409/14 , A61K49/0021 , A61K49/006
摘要： The present invention relates to oligothiophene derivatives binding specifically to neural stem cells and neural cancer stem cells. More specifically, the invention relates to methods for detecting neural stem cells or neural cancer stem cells using said oligothiophene derivatives in a biological sample, as well as uses and kits relating thereto.
摘要翻译：本发明涉及特异性结合神经干细胞和神经癌干细胞的寡聚噻吩衍生物。更具体地，本发明涉及使用生物样品中的所述低聚噻吩衍生物检测神经干细胞或神经癌干细胞的方法，以及与之相关的用途和试剂盒。

8. 发明授权

US08209975B2 Arrangement for operating a hydraulic device 有权
标题翻译：操作液压装置的装置
公开(公告)号：US08209975B2
公开(公告)日：2012-07-03
申请号：US12429686
申请日：2009-04-24
申请人： Bengt Goran Persson , Peter Nilsson
发明人： Bengt Goran Persson , Peter Nilsson
IPC分类号： F16D31/02
CPC分类号： F15B21/14 , F15B1/024
摘要： A fluid system includes a controllable first pump unit for supplying fluid pressure to at least one implement; a prime mover arranged to supply a driving torque to the first pump The first pump unit is arranged to supply fluid pressure to the implement. The fluid system further includes a controllable second pump unit connected to a fluid accumulator. The prime mover is arranged to supply a driving torque to the second pump unit in order to accumulate fluid pressure in the accumulator during periods of low demand. Fluid pressure from the accumulator is arranged to drive the second pump unit to assist the prime mover during periods of high demand in order to supply an additional driving torque in excess of the available driving torque from the prime mover.
摘要翻译：流体系统包括用于向至少一个器具提供流体压力的可控制的第一泵单元; 被布置成向第一泵提供驱动扭矩的原动机。第一泵单元布置成向工具提供流体压力。流体系统还包括连接到流体储存器的可控的第二泵单元。原动机布置成向第二泵单元提供驱动扭矩，以在低需求期间累积蓄液器中的流体压力。来自蓄能器的流体压力被布置成驱动第二泵单元以在高需求期间辅助原动机，以便提供超过来自原动机的可用驱动转矩的附加驱动转矩。

9. 发明申请

US20120004244A1 Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors 审中-公开
标题翻译：用作LTC4合酶抑制剂的双芳香族化合物
公开(公告)号：US20120004244A1
公开(公告)日：2012-01-05
申请号：US13256003
申请日：2010-03-12
申请人： Peter Nilsson , Benjamin Pelcman , Martins Katkevics
发明人： Peter Nilsson , Benjamin Pelcman , Martins Katkevics
IPC分类号： A61K31/44 , C07D401/10 , A61K31/4439 , C07D405/10 , A61K31/443 , C07D239/42 , A61K31/505 , C07D213/79 , A61P37/08 , A61P11/00 , A61P17/00 , A61P1/00 , A61P29/00 , A61P9/00 , A61P11/02 , A61P31/04 , A61P31/12 , A61P31/10 , A61P27/02 , A61P25/00 , C07D213/74
CPC分类号： C07D405/12 , C07D213/50 , C07D213/65 , C07D213/74 , C07D401/10 , C07D409/12
摘要： There is provided compounds of formula I, wherein E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译：提供式I化合物，其中E1，E2a，E2b，E2c，E4，D1，D2，D3，L1，Y1，L2和Y2具有说明书中给出的含义及其药学上可接受的盐，该化合物是有用的用于治疗期望和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。

10. 发明申请

US20110319431A1 Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors 审中-公开
标题翻译：用作LTC4合酶抑制剂的双芳香族化合物
公开(公告)号：US20110319431A1
公开(公告)日：2011-12-29
申请号：US13256122
申请日：2010-03-15
申请人： Peter Nilsson , Benjamin Pelcman , Martins Katkevics
发明人： Peter Nilsson , Benjamin Pelcman , Martins Katkevics
IPC分类号： A61K31/505 , A61K31/196 , C07D239/47 , C07D213/78 , C07C59/84 , A61P31/12 , A61P11/00 , A61P29/00 , A61P37/08 , A61P11/06 , A61P9/00 , A61P27/16 , A61P27/02 , A61P17/00 , A61P1/00 , A61P13/00 , A61P25/00 , A61P7/06 , A61P31/04 , A61P31/10 , A61K31/44
CPC分类号： C07C323/63 , C07C317/48 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D213/50 , C07D213/65 , C07D213/74 , C07D317/46 , C07D335/02 , C07D401/10 , C07D405/12 , C07D409/12
摘要： There is provided compounds of formula I, wherein Y, ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译：提供了式I化合物，其中Y，环A，D1，D2a，D2b，D3，L1，Y1，L3和Y3具有说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗需要和/或需要抑制白细胞三烯C4合酶的疾病，特别是治疗呼吸障碍和/或炎症的疾病。

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