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1. 发明申请

US20140336117A1 MODIFIED RECEPTOR FUSION PROTEINS 有权
标题翻译：改良受体融合蛋白
公开(公告)号：US20140336117A1
公开(公告)日：2014-11-13
申请号：US14004684
申请日：2012-03-14
申请人： Peter Artymiuk , Ian Wilkinson , Richard Ross
发明人： Peter Artymiuk , Ian Wilkinson , Richard Ross
IPC分类号： C07K14/61 , C07K14/72
CPC分类号： C07K14/61 , A61K38/00 , C07K14/71 , C07K14/72 , C07K2319/00 , C07K2319/02 , C07K2319/21
摘要： We disclose growth hormone fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of treatment of growth hormone related diseases that would benefit from growth hormone agonists or antagonists.
摘要翻译：我们公开了具有增加的体内稳定性和活性的生长激素融合蛋白; 编码所述蛋白质的核酸分子和治疗生长激素相关疾病的方法，其将受益于生长激素激动剂或拮抗剂。

2. 发明授权

US09493536B2 Growth hormone receptor antagonists 有权
标题翻译：生长激素受体拮抗剂
公开(公告)号：US09493536B2
公开(公告)日：2016-11-15
申请号：US14004684
申请日：2012-03-14
申请人： Peter Artymiuk , Ian Wilkinson , Richard Ross
发明人： Peter Artymiuk , Ian Wilkinson , Richard Ross
IPC分类号： A61K38/27 , C07K14/61 , C07K14/72 , C07K14/71
CPC分类号： C07K14/61 , A61K38/00 , C07K14/71 , C07K14/72 , C07K2319/00 , C07K2319/02 , C07K2319/21
摘要： We disclose growth hormone fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of treatment of growth hormone related diseases that would benefit from growth hormone agonists or antagonists.
摘要翻译：我们公开了具有增加的体内稳定性和活性的生长激素融合蛋白; 编码所述蛋白质的核酸分子和治疗生长激素相关疾病的方法，其将受益于生长激素激动剂或拮抗剂。

3. 发明授权

US10030062B2 Growth hormone fusion proteins with growth hormone receptor agonist activity 有权
公开(公告)号：US10030062B2
公开(公告)日：2018-07-24
申请号：US15283404
申请日：2016-10-02
申请人： Peter Artymiuk , Ian Wilkinson , Richard Ross
发明人： Peter Artymiuk , Ian Wilkinson , Richard Ross
IPC分类号： A61K38/27 , C07K14/61 , C07K14/72 , C12N5/10 , C12N15/63 , C07K14/71 , A61K38/00
摘要： We disclose growth hormone fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of treatment of growth hormone related diseases that would benefit from growth hormone agonists or antagonists.

4. 发明申请

US20090096453A1 PASSIVE SHIMMING OF MAGNET SYSTEMS 审中-公开
标题翻译：磁体系统被动遮蔽
公开(公告)号：US20090096453A1
公开(公告)日：2009-04-16
申请号：US12301139
申请日：2007-07-05
申请人： Timothy Barnes , Benjamin John Catmull , John Hedley Toyer , Ian Wilkinson
发明人： Timothy Barnes , Benjamin John Catmull , John Hedley Toyer , Ian Wilkinson
IPC分类号： G01R33/38
CPC分类号： G01R33/3873
摘要： In a method and an arrangement for shimming a cylindrical magnet system, that has a cylindrical magnet having a bore therein with an axis extending therethrough, and a gradient coil assembly located within the bore, shimming is accomplished by stacking a number of planar pieces of shim material in each of said tubes, with each of the tubes having an axis parallel to the axis of the cylindrical magnet, and with the planar pieces of shim material and stacked in the tubes in respective planes that are perpendicular to the axis fo the cylindrical magnet.
摘要翻译：在用于对圆柱形磁体系统进行匀场的方法和装置中，其具有圆柱形磁体，其中具有延伸穿过其中的轴的孔，以及位于孔内的梯度线圈组件，通过将多个平板片每个所述管中的材料，其中每个管具有平行于圆柱形磁体的轴线的轴线，并且具有平面的垫片材料，并且在垂直于圆柱形磁体的轴线的各个平面中堆叠在管中。

5. 发明申请

US20090085567A1 MAGNETIC RESONANCE APPARATUS WITH SHIM ARRANGEMENT 审中-公开
标题翻译：磁性共振装置与SHIM ARRANGEMENT
公开(公告)号：US20090085567A1
公开(公告)日：2009-04-02
申请号：US12243044
申请日：2008-10-01
申请人： Ralph Kimmlingen , David Melotte , Wolfgang Renz , Ian Wilkinson
发明人： Ralph Kimmlingen , David Melotte , Wolfgang Renz , Ian Wilkinson
IPC分类号： G01R33/32 , A61B5/055
CPC分类号： G01R33/3873 , A61B5/055 , G01R33/34076 , G01R33/3875 , G01R33/422
摘要： A magnetic resonance apparatus has an examination region to accommodate a patient to be examined, and a body coil that circumferentially encompasses the examination region and is designed for magnetic resonance examination of the patient. A gradient coil circumferentially encompasses the examination region and the body coil and is designed to detect the position of magnetic resonance measurement values. A basic field magnet is designed to form a basic magnetic field in the examination region for a patient examination to be conducted. The basic field magnet at least partially encompasses the examination region, the body coil and the gradient coil. A shim device is used that is designed to influence the basic magnetic field. Components of the shim device and components of the body coil are associated to exhibit a common distance relative to the longitudinal axis of symmetry of the examination region and thus encompass the examination region.
摘要翻译：磁共振装置具有容纳被检查患者的检查区域和周向包围检查区域并被设计用于患者的磁共振检查的体线圈。梯度线圈周向地包围检查区域和体线圈，并被设计成检测磁共振测量值的位置。基本场磁体被设计成在检查区域中形成用于进行患者检查的基本磁场。基本场磁体至少部分地包围检查区域，身体线圈和梯度线圈。使用设计用于影响基本磁场的垫片装置。垫片装置的组件和身体线圈的部件相关联，以显示相对于检查区域的纵向对称轴线的公共距离，并且因此包含检查区域。

6. 发明申请

US20100207630A1 PASSIVE SHIMMING OF MAGNET SYSTEMS 审中-公开
标题翻译：磁体系统被动遮蔽
公开(公告)号：US20100207630A1
公开(公告)日：2010-08-19
申请号：US12767270
申请日：2010-04-26
申请人： Timothy Barnes , Benjamin John Catmull , John Hedley Toyer , Ian Wilkinson
发明人： Timothy Barnes , Benjamin John Catmull , John Hedley Toyer , Ian Wilkinson
IPC分类号： G01R33/48
CPC分类号： G01R33/3873
摘要： In a method and an arrangement for shimming a cylindrical magnet system, that has a cylindrical magnet having a bore therein with an axis extending therethrough, and a gradient coil assembly located within the bore, shimming is accomplished by stacking a number of planar pieces of shim material in each of said tubes, with each of the tubes having an axis parallel to the axis of the cylindrical magnet, and with the planar pieces of shim material and stacked in the tubes in respective planes that are perpendicular to the axis of the cylindrical magnet.
摘要翻译：在用于对圆柱形磁体系统进行匀场的方法和装置中，其具有圆柱形磁体，其中具有延伸穿过其中的轴的孔，以及位于孔内的梯度线圈组件，通过将多个平板片每个所述管中的材料，其中每个管具有平行于圆柱形磁体的轴线的轴线，并且与平面的垫片材料片堆叠在垂直于圆柱形磁体的轴线的各个平面中的管中。

7. 发明申请

US20130200081A1 BAKING PAN 审中-公开
标题翻译：烤锅
公开(公告)号：US20130200081A1
公开(公告)日：2013-08-08
申请号：US13879070
申请日：2011-08-31
申请人： Ian Wilkinson
发明人： Ian Wilkinson
IPC分类号： A47J37/01
CPC分类号： A47J37/01 , A21B3/13 , A21B3/137
摘要： A baking pan including a body and a detachable base, wherein the body includes at least one wall and the base includes a rigid portion and a flexible seal, the seal being located between the rigid portion and the body. In a further embodiment, the body includes at least one wall and a flexible seal, the seal being located between the base and the body.
摘要翻译：一种包括主体和可拆卸底座的烤盘，其中所述主体包括至少一个壁，并且所述基部包括刚性部分和柔性密封件，所述密封件位于所述刚性部分和所述主体之间。在另一个实施例中，主体包括至少一个壁和柔性密封件，密封件位于基部和主体之间。

8. 发明申请

US20130177555A1 Monomeric Polypeptides Comprising Variant FC Regions And Methods Of Use 审中-公开
标题翻译：包含变异FC区域的单体多肽和使用方法
公开(公告)号：US20130177555A1
公开(公告)日：2013-07-11
申请号：US13814657
申请日：2011-08-11
申请人： Ian Wilkinson , Carl Innes Webster , David Christopher Lowe
发明人： Ian Wilkinson , Carl Innes Webster , David Christopher Lowe
IPC分类号： C07K16/00 , C07K14/00
CPC分类号： C07K16/00 , C07K14/00 , C07K16/28 , C07K2317/35 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/76 , C07K2317/94
摘要： Provided are monomeric polypeptides comprising variant Fc regions and methods of using them. In certain embodiments, monomeric polypeptides of the invention are fusion proteins. In certain embodiments, monomeric polypeptides of the invention are antibodies.
摘要翻译：提供包含变体Fc区的单体多肽和使用它们的方法。在某些实施方案中，本发明的单体多肽是融合蛋白。在某些实施方案中，本发明的单体多肽是抗体。

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