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    • 8. 发明授权
    • Demonstration by in vivo measurement of reflection ultrasound analysis
of improved bone quality following slow-release fluoride treatment in
osteoporosis patients
    • 在骨质疏松症患者缓释氟化物治疗后体内测量体内测量反射超声分析改善骨质量
    • US5228445A
    • 1993-07-20
    • US813383
    • 1991-12-26
    • Charles Y. C. PakPeter Antich
    • Charles Y. C. PakPeter Antich
    • A61B8/08
    • A61B8/0875G01N2291/0258G01N2291/02827G01N2291/102G01N2291/269
    • The invention involves a treatment process for improving the intrinsic quality of bone in osteoporotic patients. This can reduce the frequency of spinal fractures by inducing formation of bone which is mechanically stronger than that which it replaces. The process preferably comprises: administering an enteral form of sodium fluoride to maintain an individual's serum fluoride level from about 100 to about 200 ng/ml with a circadian fluctuation of less than about 75 ng/ml, and dietarily supplementing said individual with absorbable calcium (preferably calcium citrate). In one embodiment, sodium fluoride administration is interrupted temporarily (for about 30 to about 60 days in a 13 or 14 month cycle) to prevent loss of fluoride effectiveness and avert impaired mineralization of bone. Calcium is preferably maintained by an enteral dose of about 400 mg calcium twice daily. A vitamin D preparation may also be administered to the individual to further enhance bone strengthening. As a method for assessing response, periodic noninvasive in vivo measurements of intrinsic bone quality are made by reflection ultrasound, and the treatment regimen is maintained, altered or discontinued based on clinical assessment of the results. In this way, clinical response to the treatment is evaluated to guide its continued application.
    • 本发明涉及用于改善骨质疏松患者骨质量的治疗方法。 这可以通过诱导骨的形成来降低脊柱骨折的频率,该骨比机械地强于骨代替骨。 该方法优选包括:施用肠内形式的氟化钠以维持个体的血清氟化物水平为约100至约200ng / ml,昼夜波动小于约75ng / ml,并且用所述个体用可吸收的钙进行膳食补充( 优选柠檬酸钙)。 在一个实施方案中,氟化钠施用暂时中断(在13或14个月周期中约30至约60天),以防止氟化物失效的丧失,并避免骨质矿化。 钙优选通过约400mg钙的肠内剂量每天维持两次。 还可以向个体施用维生素D制剂以进一步增强骨骼的强化。 作为评估反应的方法,通过反射超声进行固有骨质量的周期性非侵入性体内测量,并且基于结果的临床评估来维持,改变或停止治疗方案。 以这种方式,对治疗的临床反应进行评估以指导其继续应用。