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1. 发明申请

US20130324820A1 TISSUE IMPLANTABLE MICROBIOSENSOR 有权
标题翻译：组织可植入式微生物传感器
公开(公告)号：US20130324820A1
公开(公告)日：2013-12-05
申请号：US13991113
申请日：2011-12-01
申请人： Peter A. Petillo , George S. Wilson , Judy Z. Wu , Mark L. Richter , David A. Johnson , Daniel V. Aillon
发明人： Peter A. Petillo , George S. Wilson , Judy Z. Wu , Mark L. Richter , David A. Johnson , Daniel V. Aillon
IPC分类号： A61B5/1486 , C25D7/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B2562/12 , C25D7/00
摘要： A biosensor system comprises a capillary substrate, conductive electrode, and a plurality of nanoparticles having an enzyme deposited thereon formed in a cavity at one end of the capillary substrate. The substrate may have an optional reinforcing layer (which may be conductive or non-conductive) and optional insulating layer thereon. A cannula having an optional conductive layer, insulating layer, and reference electrode may also form part of the system.
摘要翻译：生物传感器系统包括毛细管基底，导电电极和在毛细管基底的一端形成在腔中的沉积有酶的多个纳米颗粒。衬底可以具有可选的增强层（其可以是导电的或不导电的）和其上的可选的绝缘层。具有可选导电层，绝缘层和参考电极的插管也可以形成系统的一部分。

2. 发明授权

US09468402B2 Tissue implantable microbiosensor 有权
标题翻译：组织植入式微生物传感器
公开(公告)号：US09468402B2
公开(公告)日：2016-10-18
申请号：US13991113
申请日：2011-12-01
申请人： Peter A. Petillo , George S. Wilson , Judy Z. Wu , Mark L. Richter , David A. Johnson , Daniel V. Aillon
发明人： Peter A. Petillo , George S. Wilson , Judy Z. Wu , Mark L. Richter , David A. Johnson , Daniel V. Aillon
IPC分类号： A61B5/05 , A61B5/1486 , A61B5/145 , C25D7/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B2562/12 , C25D7/00
摘要： A biosensor system comprises a capillary substrate, conductive electrode, and a plurality of nanoparticles having an enzyme deposited thereon formed in a cavity at one end of the capillary substrate. The substrate may have an optional reinforcing layer (which may be conductive or non-conductive) and optional insulating layer thereon. A cannula having an optional conductive layer, insulating layer, and reference electrode may also form part of the system.
摘要翻译：生物传感器系统包括毛细管基底，导电电极和在毛细管基底的一端形成在腔中的沉积有酶的多个纳米颗粒。衬底可以具有可选的增强层（其可以是导电的或不导电的）和其上的可选的绝缘层。具有可选导电层，绝缘层和参考电极的插管也可以形成系统的一部分。

3. 发明申请

US20130172705A1 ENZYME CO-FACTOR ENHANCEMENT OF BIOSENSOR PERFORMANCE 审中-公开
标题翻译：生物传感器性能的酶合成因子增强
公开(公告)号：US20130172705A1
公开(公告)日：2013-07-04
申请号：US13821903
申请日：2011-09-12
申请人： Peter A. Petillo , Daniel V. Aillon , Brian S. Barrett
发明人： Peter A. Petillo , Daniel V. Aillon , Brian S. Barrett
IPC分类号： C12N9/96 , A61B5/145 , A61B5/1486
CPC分类号： C12N9/96 , A61B5/14532 , A61B5/14865 , C12Q1/004 , G01N33/573
摘要： The present invention is broadly concerned with the crafting and manufacturability of an implantable enzymatic-based sensor characterized by a small size, optimum geometry, linearity of response over the concentration range of interest, extended shelf-life, selectivity for the analyte in question, and the ability to exclude bioactive interferents. More particularly, it is preferably concerned with a general approach to optimize the performance of the biorecognition elements required to produce biosensors of the type designed to provide, and in conjunction with a suitable signal processing unit, a current which is proportional to the concentration of the analyte of interest. The biosensors described herein may be implanted in vivo, including intra-cerebral, sub-cutaneous, intra-muscular, inter-peritoneal oral, serum, and vascular implantation, the majority of which may act as a surrogate for systemic monitoring and used to monitor analytes of interest in real-time. Multiple biosensors can be joined together to allow for the simultaneous recording of multiple analytes of interest. In addition to the in vivo applications, sensors of the design described herein may also find use in medical monitoring, industrial processes, fermentation, environmental monitoring, and waste water stream monitoring. The present invention offers co-factor enhancement of the biorecognition element, providing access to a range of biorecognition elements heretofore difficult to incorporate into a manufacturing process for the large-scale production of biosensors.
摘要翻译：本发明广泛涉及可植入酶基传感器的制作和可制造性，其特征在于在所关注的浓度范围内具有小尺寸，最佳几何形状，响应线性，延长的保质期，所述分析物的选择性，以及排除生物活性干扰物的能力。更具体地，优选地涉及优化生物识别元件的性能的一般方法，所述生物识别元件产生生物传感器的类型，所述生物传感器被设计成提供并与合适的信号处理单元结合，其电流与感兴趣的分析物本文描述的生物传感器可以植入体内，包括脑内，皮下，肌内，腹膜内口服，血清和血管植入，其中大多数可以用作系统监测的替代物并用于监测实时分析物。多个生物传感器可以连接在一起以允许同时记录多个感兴趣的分析物。除了体内应用之外，本文所述设计的传感器还可用于医疗监测，工业过程，发酵，环境监测和废水流监测。本发明提供了生物识别元件的辅因子增强，提供了到目前难以并入用于大规模生产生物传感器的制造过程中的一系列生物识别元件的获取。

4. 发明申请

US20090312349A1 ANTI-INFLAMMATORY MEDICAMENTS 审中-公开
标题翻译：抗炎药物
公开(公告)号：US20090312349A1
公开(公告)日：2009-12-17
申请号：US11721026
申请日：2005-12-23
申请人： Daniel L. Flynn , Peter A. Petillo
发明人： Daniel L. Flynn , Peter A. Petillo
IPC分类号： A61K31/519 , C07D401/12 , A61K31/4439 , C07D471/04 , A61P35/00 , C12N9/12
CPC分类号： C07D487/04 , C07D209/46 , C07D231/40 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/10 , C07D417/10 , C07D417/12 , C07D417/14 , C12Q1/485
摘要： Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, hyperproliferative diseases, cancer, and diseases characterized by hyper-vascularization are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein, abl kinase protein, bcr-abl kinase protein, braf kinase protein, VEGFR kinase protein, or PDGFR kinase protein comprises the step of contacting said kinase protein with the novel compounds.
摘要翻译：提供了新型化合物和使用这些化合物治疗炎性病症，过度增殖性疾病，癌症和以血管新生血管瘤为特征的疾病的方法。在优选的实施方案中，调节p38激酶蛋白，abl激酶蛋白，bcr-abl激酶蛋白，braf激酶蛋白，VEGFR激酶蛋白或PDGFR激酶蛋白的激活状态包括使所述激酶蛋白与新化合物接触的步骤。

5. 发明申请

US20080299639A1 Anti-inflammatory medicaments 失效
公开(公告)号：US20080299639A1
公开(公告)日：2008-12-04
申请号：US11450850
申请日：2006-06-09
申请人： Daniel L. Flynn , Peter A. Petillo
发明人： Daniel L. Flynn , Peter A. Petillo
IPC分类号： C12N9/12
CPC分类号： C07D239/42 , C07D295/10 , C07D401/04 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.

6. 发明授权

US07342037B2 Anti-inflammatory medicaments 失效
公开(公告)号：US07342037B2
公开(公告)日：2008-03-11
申请号：US11450840
申请日：2006-06-09
申请人： Daniel L. Flynn , Peter A. Petillo
发明人： Daniel L. Flynn , Peter A. Petillo
IPC分类号： A61K31/4155 , A61K31/4196 , A61K31/433 , A61K31/5377 , A61K31/422 , C07D231/40 , C07D263/06 , C07D413/10 , C07D285/06 , C07D249/12
CPC分类号： A61K31/4184 , A61K31/426 , A61K31/4745 , A61K31/496 , A61K31/517 , A61K31/53 , A61K31/5377 , C07C271/56 , C07C2601/10 , C07D231/38 , C07D231/40 , C07D285/10 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.

7. 发明授权

US07144911B2 Anti-inflammatory medicaments 失效
公开(公告)号：US07144911B2
公开(公告)日：2006-12-05
申请号：US10746460
申请日：2003-12-24
申请人： Daniel L. Flynn , Peter A. Petillo
发明人： Daniel L. Flynn , Peter A. Petillo
IPC分类号： C07D231/40 , A61K31/4155 , A61K31/4196 , C07D263/06 , C07D413/10 , C07D285/06 , C07D249/12 , A61K31/433 , A61K31/5377 , A61K31/422
CPC分类号： C07D239/42 , C07D295/10 , C07D401/04 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.

8. 发明授权

US08486951B2 Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities 失效
标题翻译：表现出抗癌和抗增殖活性的环丙酰胺和类似物
公开(公告)号：US08486951B2
公开(公告)日：2013-07-16
申请号：US13590955
申请日：2012-08-21
申请人： Daniel L. Flynn , Peter A. Petillo , Michael D. Kaufman
发明人： Daniel L. Flynn , Peter A. Petillo , Michael D. Kaufman
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07D413/04 , A61K31/555 , C07D401/04 , C07D401/14 , C07D403/04
摘要： Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilia syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-α kinase, PDGFR-β kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases.
摘要翻译：本发明的化合物可用于治疗哺乳动物癌症，特别是人类癌症，包括但不限于恶性黑素瘤，实体瘤，成胶质细胞瘤，卵巢癌，胰腺癌，前列腺癌，肺癌，乳腺癌，肾癌，肝癌，宫颈癌，原发性肿瘤部位转移，骨髓增生性疾病，慢性骨髓性白血病，白血病，甲状腺乳头状癌，非小细胞肺癌，间皮瘤，嗜酸性粒细胞增多综合征，胃肠道间质瘤，结肠癌，以过度增生为特征的眼部疾病包括各种视网膜病变，糖尿病性视网膜病变，类风湿性关节炎，哮喘，慢性阻塞性肺病，肥大细胞增多症，肥大细胞白血病和由PDGFR-α激酶，PDGFR-β激酶，c-KIT激酶，cFMS激酶，c-MET引起的疾病激酶和致癌形式，异常融合蛋白和任何前体的多态性激酶。

9. 发明授权

US08278331B2 N-acyl ureas exhibiting anti-cancer and anti-proliferative activities 有权
标题翻译：表现出抗癌和抗增殖活性的N-酰基脲
公开(公告)号：US08278331B2
公开(公告)日：2012-10-02
申请号：US12608578
申请日：2009-10-29
申请人： Daniel L. Flynn , Peter A. Petillo , Michael D. Kaufman
发明人： Daniel L. Flynn , Peter A. Petillo , Michael D. Kaufman
IPC分类号： A61K31/44
CPC分类号： C07D413/04 , A61K31/555 , C07D401/04 , C07D401/14 , C07D403/04
摘要： Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-α kinase, PDGFR-β kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases.
摘要翻译：本发明的化合物可用于治疗哺乳动物癌症，特别是人类癌症，包括但不限于恶性黑素瘤，实体瘤，成胶质细胞瘤，卵巢癌，胰腺癌，前列腺癌，肺癌，乳腺癌，肾癌，肝癌，宫颈癌，原发性肿瘤部位转移，骨髓增生性疾病，慢性骨髓性白血病，白血病，甲状腺乳头状癌，非小细胞肺癌，间皮瘤，嗜酸性粒细胞综合征，胃肠道间质瘤，结肠癌，以过度增生为特征的眼部疾病包括各种视网膜病变，糖尿病性视网膜病变，类风湿性关节炎，哮喘，慢性阻塞性肺疾病，肥大细胞增多症，肥大细胞白血病和由PDGFR-α激酶引起的疾病，PDGFR-＆bgr; 激酶，c-KIT激酶，cFMS激酶，c-MET激酶和致癌形式，异常融合蛋白和任何前述激酶的多态性。

10. 发明授权

US08143293B2 Kinase inhibitors useful for the treatment of myleoprolific diseases and other proliferative diseases 失效
标题翻译：激酶抑制剂可用于治疗myleoprolific疾病和其他增殖性疾病
公开(公告)号：US08143293B2
公开(公告)日：2012-03-27
申请号：US12105408
申请日：2008-04-18
申请人： Daniel L. Flynn , Peter A. Petillo , Michael D. Kaufman
发明人： Daniel L. Flynn , Peter A. Petillo , Michael D. Kaufman
IPC分类号： A61K31/44 , C07D417/00 , C07D401/00
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant, melanomas, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, leukemias, papillary thyroid carcinoma, non small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocyclosis, mast cell leukemia, a disease caused by c-Abl kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, or a disease caused by c-Kit kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof.
摘要翻译：本发明的化合物可用于治疗哺乳动物癌症，特别是人类癌症，包括但不限于恶性，黑素瘤，成胶质细胞瘤，卵巢癌，胰腺癌，前列腺癌，肺癌，乳腺癌，肾癌，宫颈癌，转移原发性肿瘤部位，骨髓增生性疾病，白血病，甲状腺乳头状癌，非小细胞肺癌，间皮瘤，嗜酸性粒细胞综合征，胃肠道间质瘤，结肠癌，以过度增生为特征的眼部疾病导致失明，包括各种视网膜病变，类风湿关节炎，哮喘，慢性阻塞性肺疾病，乳腺增生症，肥大细胞白血病，由c-Abl激酶引起的疾病，其致癌形式，异常融合蛋白及其多形体，或由c-Kit激酶，其致癌形式，异常融合蛋白引起的疾病，以及其多晶型。

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