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1. 发明专利

JP2007326788A Tissue fluorescent-staining agent composition for endoscopic use 有权
标题翻译：用于内镜使用的组织荧光染色剂组合物
公开(公告)号：JP2007326788A
公开(公告)日：2007-12-20
申请号：JP2006156924
申请日：2006-06-06
申请人： Pentax Corp , ペンタックス株式会社
发明人： YAMAMOTO AKIRA , IIMORI YUSUKE , SASE MIZUE , ISHIGURO MARIKO , LEE PILRYON , SASAKI HIROYUKI
IPC分类号： A61K49/00 , G01N21/64
摘要： PROBLEM TO BE SOLVED: To provide a fluorescent-staining agent clearing the shapes of the surface of digestive tract interior lumen, etc., in visible light wavelength region and at the same time having a function of emitting fluorescent light excited by a specific wavelength light and further biologically suitable for endoscopic observation.
SOLUTION: This tissue fluorescent-staining agent composition for the endoscopic use contains a spirulina blue pigment. Also the staining agent is used for a cofocal endoscope, for an oral administration, a direct administration in digestive tract or an submucosa administration, and also for fluorescent-staining of the surface of digestive tract interior lumen and/or the inside of the cells of digestive tract interior lumen.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供在可见光波长区域中清除消化道内腔表面形状的荧光染色剂，同时具有发出由特异性波长光，进一步生物学适用于内窥镜观察。解决方案：用于内窥镜使用的该组织荧光染色剂组合物含有螺旋藻蓝色素。染色剂也用于共焦内窥镜，口服给药，消化道直接给药或粘膜下层给药，还用于消化道内腔表面和/或细胞内部的荧光染色消化道内腔。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2007304313A Method for specifying enlarged observation region by confocal endoscope 有权
标题翻译：通过共焦内窥镜指定放大观察区域的方法
公开(公告)号：JP2007304313A
公开(公告)日：2007-11-22
申请号：JP2006132208
申请日：2006-05-11
申请人： Pentax Corp , ペンタックス株式会社
发明人： YAMAMOTO AKIRA , NAKAMURA TETSUYA , KUROSAWA YAE , IIMORI YUSUKE , LEE PILRYON
IPC分类号： G02B23/24 , A61B1/00
摘要： PROBLEM TO BE SOLVED: To provide a method for specifying an enlarged observation region by a confocal endoscope, by which a position at which a minute observation image obtained by microscopic enlarged observation exists is easily and exactly specified by wide-field ordinary observation.
SOLUTION: After performing the microscopic enlarged observation through an observation window for enlarged observation 15 in such a state that fluorochrome discolored by the irradiation of a laser beam is scattered on a subject, the discolored region of the fluorochrome made by the irradiation of the laser beam during the microscopic enlarged observation is observed through an observation window for ordinary observation 12, whereby a microscopic enlarged observation region is specified.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：解决问题的方案：提供一种通过共聚焦内窥镜指定放大的观察区域的方法，通过该方法，存在通过微观扩大观察获得的微小观察图像的位置容易且精确地通过广泛的普通观察。解决方案：通过用于放大观察的观察窗15进行微观放大观察之后，在通过激光束的照射使荧光染料变色的物质散射在受试者上的状态下，通过照射产生的荧光染料的变色区域通过用于普通观察12的观察窗观察微观放大观察期间的激光束，由此指定微观放大观察区域。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2007167095A Medical solution sprayer for endoscope 有权
标题翻译：医疗解决方案喷雾器内窥镜
公开(公告)号：JP2007167095A
公开(公告)日：2007-07-05
申请号：JP2005364521
申请日：2005-12-19
申请人： Pentax Corp , ペンタックス株式会社
发明人： YAMAMOTO AKIRA , NAKAMURA TETSUYA , KUROSAWA YAE , IIMORI YUSUKE , LEE PILRYON
IPC分类号： A61B1/00 , B67D7/56 , A61M31/00 , G02B23/24
CPC分类号： A61B1/012 , A61B5/4839
摘要： PROBLEM TO BE SOLVED: To provide a medical solution sprayer for an endoscope, capable of smoothly spraying an appropriate quantity of a medical solution into a living body without leaking the medical solution to soil hands of an operator or the periphery under the operator's hands.
SOLUTION: The medical solution sprayer has a flexible tube 11, a solution filling bag 12 and a solution measuring bag 13, which are integrally formed. The flexible tube 11 can be inserted into/detached from an instrument insertion channel 3 of the endoscope. The solution filling bag 12 is filled with the medical solution to be fed into the flexible tube 11 and is made of an elastic material. The solution measuring bag 13 is connected/disposed between the rear end of the flexible tube 11 and the distal end of the solution filling bag 12, and is made of a transparent and elastic material. The medical solution sprayer also has a check valve 14 disposed between the solution filling bag 12 and the solution measuring bag 13. The check valve 14 lets the medical solution pass from inside the solution filling bag 12 to the inside of the solution measuring bag 13, while preventing the medical solution from passing from inside the solution measuring bag 13 into the solution filling bag 12.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种内窥镜用医疗用喷雾器，其能够将适量的医用溶液顺利地喷洒到生物体中，而不会使医疗液体泄漏到操作者的手或操作者的外围的手手中。解决方案：医用溶液喷雾器具有一体形成的柔性管11，溶液填充袋12和溶液测量袋13。柔性管11可以从内窥镜的器具插入通道3插入/分离。溶液填充袋12填充有待供给到柔性管11中的药液并且由弹性材料制成。溶液测量袋13连接/设置在柔性管11的后端和溶液填充袋12的远端之间，并且由透明和弹性材料制成。医用溶液喷雾器还具有设置在溶液填充袋12和溶液测量袋13之间的止回阀14.止回阀14使药液从溶液填充袋12内通过溶液测量袋13的内部，同时防止医用溶液从溶液测量袋13内部流入溶液填充袋12.版权所有：（C）2007，JPO＆INPIT

4. 发明专利

JP2007332073A Contrast enhancer of fluorescent staining image of digestive tract lumen 审中-公开
标题翻译：荧光增白剂的荧光增白剂
公开(公告)号：JP2007332073A
公开(公告)日：2007-12-27
申请号：JP2006165712
申请日：2006-06-15
申请人： Pentax Corp , ペンタックス株式会社
发明人： YAMAMOTO AKIRA , IIMORI YUSUKE , SASE MIZUE , ISHIGURO MARIKO , LEE PILRYON
IPC分类号： A61K49/00
CPC分类号： A61K49/0043 , A61K49/0071
摘要： PROBLEM TO BE SOLVED: To obtain a means for making the fluorescent staining image of digestive tract lumen more clear. SOLUTION: The contrast enhancer of fluorescent staining image of digestive tract lumen is an agent for digestive tract lumen, containing an aqueous solution having buffering ability of pH 6-10 and is achieved by intravenously administered fluorescent pigment. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：获得使消化道腔的荧光染色图像更清晰的手段。解决方案：消化道腔的荧光染色图像的对比度增强剂是消化道腔的药剂，含有pH 6-10的缓冲能力的水溶液，并通过静脉内施用的荧光颜料实现。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2007159814A Liquid applicator for endoscope 有权
标题翻译：内窥镜液体应用者
公开(公告)号：JP2007159814A
公开(公告)日：2007-06-28
申请号：JP2005360094
申请日：2005-12-14
申请人： Pentax Corp , ペンタックス株式会社
发明人： YAMAMOTO AKIRA , NAKAMURA TETSUYA , KUROSAWA YAE , IIMORI YUSUKE , LEE PILRYON
IPC分类号： A61M31/00 , A61B1/00
CPC分类号： A61M31/00
摘要： PROBLEM TO BE SOLVED: To provide a liquid applicator for an endoscope which can accurately apply a proper amount of a dye liquid, chemical, etc. to a narrow range in a body utilizing the endoscope. SOLUTION: At the distal end of of a flexible tube 11 inserted into and pulled out from the inside of a treatment tool insertion channel 3 of the endoscope, a writing brush bristle tuft 12 obtained by bundling a large number of writing brush bristles fixedly projects forward. At a part projecting from the distal end of the flexible tube 11 of the writing brush bristle tuft 12, the respective writing brush bristles are arranged to be capable of bending independently, and the distal end of the writing brush bristle bundle 12 is communicates with a liquid channel 11a of the flexible tube 11. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种内窥镜用液体涂布器，其可以利用内窥镜在身体的狭窄范围内精确地施加适量的染料液体，化学品等。解决方案：在插入内窥镜的治疗工具插入通道3的内部的柔性管11的远端，通过将大量笔刷刷毛捆扎而获得的书写刷毛刷毛簇12 固定项目前进。在从笔刷刷毛簇12的柔性管11的远端突出的部分，相应的笔刷刷毛被布置成能够独立地弯曲，并且笔刷刷毛束12的远端与柔性管11的液体通道11a。（C）2007，JPO＆INPIT

6. 发明专利

JP2007326789A Tissue fluorescent-staining agent composition for endoscopic use 审中-公开
标题翻译：用于内镜使用的组织荧光染色剂组合物
公开(公告)号：JP2007326789A
公开(公告)日：2007-12-20
申请号：JP2006156925
申请日：2006-06-06
申请人： Pentax Corp , ペンタックス株式会社
发明人： YAMAMOTO AKIRA , IIMORI YUSUKE , SASE MIZUE , ISHIGURO MARIKO , LEE PILRYON , SASAKI HIROYUKI
IPC分类号： A61K49/00 , A61B1/00
CPC分类号： A61K49/0023
摘要： PROBLEM TO BE SOLVED: To provide a fluorescent-staining agent, biologically safe and suitable for endoscopic observation.
SOLUTION: This tissue fluorescent-staining agent composition for the endoscopic observation contains a compound expressed by formula (1) [wherein, R
1 is H or hydroxy; R
3 is phenyl or methyl bonded with R
2c ; and 1 to 3 among R
2a , R
2b and R
2c are each -SO
3 M (wherein, M is an alkali metal atom or an alkaline earth metal atom) or -SO
3 NH
4 , one of them is -SO
3
- and rests are each H].
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种生物安全且适合内窥镜观察的荧光染色剂。解决方案：用于内窥镜观察的该组织荧光染色剂组合物含有由式（1）表示的化合物[其中，R 1 = H或羟基; R 3是苯基或与R 2c键合的甲基; 在R＆lt; SP＆gt; 2a，＆lt; SP＆gt; 2b＆lt; SP＆gt;和＆lt; SP＆gt; 2c＆lt; SP＆gt;中的1〜3中， M是碱金属原子或碱土金属原子）或-SO 3 SB 3，其中之一是-SO 3 S > - ，休息每个H]。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2007151873A Magnifying observation endoscope 有权
标题翻译：放大观察内窥镜
公开(公告)号：JP2007151873A
公开(公告)日：2007-06-21
申请号：JP2005351954
申请日：2005-12-06
申请人： Pentax Corp , ペンタックス株式会社
发明人： NAKAMURA TETSUYA , YAMAMOTO AKIRA , KUROSAWA YAE , IIMORI YUSUKE , LEE PILRYON
IPC分类号： A61B1/00 , G02B23/24 , G02B23/26
CPC分类号： A61B1/012 , A61B1/0008 , A61B1/00165 , A61B1/00172 , A61B1/00181 , A61B1/00188 , A61B1/04 , G02B23/2423
摘要： PROBLEM TO BE SOLVED: To provide a magnifying observation endoscope capable of easily and correctly specifying where a fine observation image, which is obtained by microscopic super-magnifying observation, is positioned in a living body.
SOLUTION: The magnifying observation endoscope is abutted onto or made to come very close to the surface of an intracorporal mucosa so as to fetch the magnifying observation image of the intracorporal mucosa, having an observation window 10 for the magnifying observation which is placed on the tip part 2 of an insert part 1. In the endoscope, a marking means 20 for applying a marking liquid onto the surface of the intracorporal mucosa and changing the visual outer appearance state of the part is arranged to enclose the observation window 10 for the magnifying observation.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种放大观察内窥镜，能够容易且正确地指定通过微观超放大观察获得的精细观察图像位于生物体中的位置。解决方案：放大观察内窥镜靠在体外粘膜表面或靠近体内粘膜的表面，以获取体内粘膜的放大观察图像，具有用于放大观察的观察窗10 在内窥镜中，用于将标记液施加到体内粘膜的表面上并改变部件的视觉外观状态的标记装置20被布置成将观察窗10包围在放大观察。版权所有（C）2007，JPO＆INPIT

8. 发明专利

DE102007027689A1 Contrast improving agent from an aqueous solution useful for a fluorescence coloring of the lumen of the digestive tract through intravenously obtained fluorescence dye 未知
公开(公告)号：DE102007027689A1
公开(公告)日：2008-01-03
申请号：DE102007027689
申请日：2007-06-15
申请人： PENTAX CORP
发明人： YAMAMOTO AKIRA , IIMORI YUSUKE , SAZE MIZUE , ISHIGURO MARIKO , LEE PILRYON
IPC分类号： A61K49/10
摘要： Contrast improving agent, for a fluorescence coloring of the lumen of the digestive tract through intravenously obtained fluorescence dye, from an aqueous solution with a buffer capacity and a pH value of 6-10.

9. 发明专利

DE102007026410A1 Use of triphenylmethane-type dyes with amino groups and sulphonic acid groups as histofluorescent dyes for endoscopy, especially medical endoscopy, e.g. for the diagnosis of gastro-intestinal disease 未知
公开(公告)号：DE102007026410A1
公开(公告)日：2008-01-17
申请号：DE102007026410
申请日：2007-06-06
申请人： PENTAX CORP
发明人： YAMAMOTO AKIRA , IIMORI YUSUKE , SAZE MIZUE , ISHIGURO MARIKO , LEE PILRYON , SASAKI HIROYUKI
IPC分类号： C09B11/10 , C09B11/22
摘要： The use of triphenylmethane derivatives as histofluorescent dyes for use in endoscopy, where one phenyl group is substituted with sulphonic acid and/or sulphonate groups, another is 4-substituted with a diethylamino or benzyl-ethyl-amino group (each carrying a terminal sulphonic acid group) and the third is in the quinone form and also 4-substituted with a corresponding imino group. The use of compounds of formula (1) for the production of histo-fluorescent dyes for use in endoscopy, in which R1>H or hydroxyl; R3>phenyl or methyl with a group R2c> attached; R2a> and/or R2b> and/or R2c>-SO3M, -SO3NH4 or -SO3H; M : alkali or alkaline earth metal An independent claim is included for histofluroescent dyes of formula (1) for endoscopy. [Image].

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